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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2020-1-105-110</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-1141</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОФТАЛЬМОФАРМАКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PHARMACOLOGY</subject></subj-group></article-categories><title-group><article-title>Изменения передней поверхности глаза у пациентов с впервые выявленной глаукомой</article-title><trans-title-group xml:lang="en"><trans-title>Ocular Surface Status in Newly Diagnosed Glaucoma Cases</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Макашова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Makashova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Макашова Надежда Васильевна доктор медицинских наук, старший научный сотрудник</p><p>ул. Россолимо, 11a, б, Москва, 119021</p></bio><bio xml:lang="en"><p>Makashova Nadezhda V. MD, senior research officer</p><p>Rossolimo str., 11a, b, Moscow, 119021</p></bio><email xlink:type="simple">nvmakashova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васильева</surname><given-names>А. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasilyeva</surname><given-names>A. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Васильева Анастасия Евгеньевна кандидат медицинских наук, председатель</p><p>ул. Братиславская, 18-1-483, Москва, 109451</p></bio><bio xml:lang="en"><p>Vasilyeva Anastasia E. PhD, president</p><p>Bratislavskaya str., 18-1-483, Moscow, 109451</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Колосова</surname><given-names>О. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kolosova</surname><given-names>O. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Колосова Ольга Юрьевна аспирант</p><p>ул. Россолимо, 11a, б, Москва, 119021</p></bio><bio xml:lang="en"><p>Kolosova Olga Yu. postgraduate</p><p>Rossolimo str., 11a, b, Moscow, 119021</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт глазных болезней»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Research Institute of Eye Diseases</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Межрегиональный профессиональный союз работников здравоохранения «Альянс врачей»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Interregional Health Workers Union “Alyans vrachey”</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>03</day><month>04</month><year>2020</year></pub-date><volume>17</volume><issue>1</issue><fpage>105</fpage><lpage>110</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Макашова Н.В., Васильева А.Е., Колосова О.Ю., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Макашова Н.В., Васильева А.Е., Колосова О.Ю.</copyright-holder><copyright-holder xml:lang="en">Makashova N.V., Vasilyeva A.E., Kolosova O.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/1141">https://www.ophthalmojournal.com/opht/article/view/1141</self-uri><abstract><p>Бесконтрольное назначение и длительное использование гипотензивных препаратов с консервантами при глаукоме часто приводит не только к субъективно плохой переносимости лечения, но и к ухудшению результатов последующего хирургического лечения, если оно требуется. Проявления синдрома сухого глаза и усугубление его течения в результате применения таких капель могут приводить к самовольному отказу пациентов от терапии и ухудшению прогноза относительно сохранности зрительных функций. Часто проявления синдрома сухого глаза выявляются еще до начала любой гипотензивной терапии, так как функции секреторных клеток изменяются с возрастом и всегда имеет место влияние неблагоприятных факторов окружающей среды. Всем пациентам перед применением гипотензивной терапии необходимо исследовать состояние передней поверхности глаза для решения вопроса о необходимости назначения препаратов без консервантов. Однако часто такой возможности нет в связи с недостатком времени или оборудования. Поэтому важно исследовать состояние передней поверхности глаза у пациентов с впервые выявленной глаукомой до и на фоне лечения бесконсервантными формами гипотензивных препаратов, чтобы определить целесообразность и необходимость первоочередного назначения именно таких форм для дальнейшей интерполяции результатов использования в практические рекомендации. В данном исследовании выявлено, что медикаментозное лечение пациентов с впервые выявленной глаукомой инстилляциями препарата β-блокатора Тимолол-ПОС® на бесконсервантной основе, наряду с компенсацией ВГД, улучшает как субъективные, так и объективные показатели состояния передней поверхности глаза с максимальным эффектом через 3 месяца лечения. Данный вывод предполагает преимущественную важность первоочередного назначения таким пациентам капель на бесконсервантной основе.</p></abstract><trans-abstract xml:lang="en"><p>Uncontrolled administration and prolonged use of antihypertensive drugs with preservatives often leads not only to subjectively poor tolerance of treatment, but also to a deterioration in the results of subsequent surgery, if required. The manifestations of dry eye syndrome and its aggravation as a result of such drops use can lead the patients to refuse therapy and worsening the prognosis. The manifestations of dry syndrome are often detected before any hypotensive therapy begins, since the functions of secretory cells change with age and there is always the influence of adverse environmental factors. It is necessary to examine the condition of the anterior surface of the eye to resolve the issue of the need to prescribe drugs without preservatives for all patients before the appointment of antihypertensive therapy. However, sometimes it is not possible due to lack of time or equipment. Therefore, it is important to study the condition of the anterior eye surface in patients with newly diagnosed glaucoma before and during treatment with nonpreservative forms of antihypertensive drugs in order to determine the necessity of the first prescription of non-preservative forms of antihypertensive drops to further interpolate its results into practical recommendations. This study revealed that drug treatment of patients with newly diagnosed glaucoma with the drug Timolol-POS® β-blocker on a non-preservative basis along with IOP compensation improves both subjective and objective indicators of the condition of the anterior surface of the eye with maximum effect after 3 months of treatment. This conclusion suggests the importance of the primary appointment for such patients with instillation drops on a preservative basis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>впервые выявленная глаукома</kwd><kwd>внутриглазное давление</kwd><kwd>Ocular Response Analyzer</kwd><kwd>передняя поверхность глаза</kwd><kwd>проба Ширмера</kwd><kwd>проба Норна</kwd><kwd>β-блокатор Тимолол ПОС</kwd></kwd-group><kwd-group xml:lang="en"><kwd>newly diagnosed glaucoma</kwd><kwd>intraocular pressure</kwd><kwd>Ocular Response Analyzer</kwd><kwd>eye surface</kwd><kwd>Schirmer test</kwd><kwd>Norn test</kwd><kwd>β-blocker</kwd><kwd>Timolol POS</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">European Glaucoma Society Terminology and Guidelines for Glaucoma, 4th Edition — Chapter 3: Treatment principles and options Supported by the EGS Foundation: Part 1: Foreword; Introduction; Glossary; Chapter 3 Treatment principles and options. 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