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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2020-2-165-171</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-1192</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Нутрицевтики в профилактике возрастной патологии сетчатки. Обзор</article-title><trans-title-group xml:lang="en"><trans-title>Nutritional Supplements in the Prevention of Age-Related Retinal Pathology</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3806-3985</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дуржинская</surname><given-names>М. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Durzhinskaya</surname><given-names>M. H.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дуржинская Мадина Хикметовнакандидат медицинских наук, младший научный сотрудник ул. Россолимо, 11а, б, Москва, 119021 </p></bio><bio xml:lang="en"/><email xlink:type="simple">m.h.efendieva@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5507-8775</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Будзинская</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Budzinskaya</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Будзинская Мария Викторовнадоктор медицинских наук, заместитель директора по научной работе ФГБНУ«НИИГБ», доцент кафедры офтальмологии ФГБОУ ВО Тверского ГМУ МЗ РФ ул. Россолимо, 11а, б, Москва, 119021</p><p>ул. Советская, 4, Тверь, 170100</p></bio><bio xml:lang="en"/><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт глазных болезней»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Eye Diseases</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт глазных болезней»;&#13;
ФГБОУ ВО «Тверской государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Eye Diseases;&#13;
 Tver State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>23</day><month>06</month><year>2020</year></pub-date><volume>17</volume><issue>2</issue><fpage>165</fpage><lpage>171</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дуржинская М.Х., Будзинская М.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Дуржинская М.Х., Будзинская М.В.</copyright-holder><copyright-holder xml:lang="en">Durzhinskaya M.H., Budzinskaya M.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/1192">https://www.ophthalmojournal.com/opht/article/view/1192</self-uri><abstract><p>Оксидативный стресс, обусловленный дисбалансом продукции и детоксикации активных форм кислорода в системе антиоксидантной защиты организма, наряду с последующим хроническим воспалением, связан со многими хроническими дегенеративными заболеваниями глаза. Особый интерес представляет профилактика таких хронических дегенеративных заболеваний, как возрастная макулярная дегенерация (ВМД) и первичная открытоугольная глаукома. В последнее десятилетие были достигнуты огромные успехи в лечении возрастной патологии сетчатки; тем не менее эти виды лечения являются дорогостоящими и требуют частого наблюдения, а в ряде случаев инъекций, которые ложатся огромным бременем как на систему здравоохранения, так и на пациентов. Сохраняется значительный интерес к предотвращению или замедлению прогрессирования этих заболеваний. Эпидемиологические исследования показали, что диета является фактором риска ВМД, на который можно воздействовать, и модификация питания с помощью пищевых антиоксидантных добавок является особенно привлекательным средством профилактики по причине потенциальной пользы и относительно низких затрат. Большое количество экспериментальных и клинических исследований предоставили подтверждающие доказательства того, что антиоксидантные пищевые добавки ингибируют окисление макромолекул, а также воспалительный ответ, имеющий место в патогенезе инволюционной патологии сетчатки, что в итоге препятствует ее развитию и прогрессированию. В данном обзоре рассмотрена роль антиоксидантных биодобавок в профилактике возрастной патологии сетчатки.</p></abstract><trans-abstract xml:lang="en"><p>Oxidative stress due to the imbalance in the production and detoxification of reactive oxygen species in antioxidant defence system of the body, as well as subsequent chronic inflammation, is believed to be associated with age-related eye diseases. Prevention of chronic degenerative diseases such as age-related macular degeneration (AMD) and primary open-angle glaucoma are of particular interest. In the last decade, tremendous success has been achieved in the treatment of age-related retinal pathology. However, these treatments are expensive and require frequent monitoring and, in some cases, injections, which place a huge burden on both the healthcare system and patients. Consequently, considerable interest remains in preventing or slowing the progression of these diseases. Epidemiological studies have shown that diet is a modifiable risk factor for AMD, and nutritional modification with food antioxidant supplements is a particularly attractive method of prevention because of its potential benefits and relatively low cost. A large number of experimental studies, including clinical studies in animals and humans, have provided supporting evidence that antioxidant food additives inhibit the oxidation of macromolecules, as well as an inflammatory response that occurs in the pathogenesis of involutional retinal pathology, which ultimately inhibits its development and progression. This review discusses the role of antioxidant dietary supplements in the prevention of age-related retinal pathology.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ВМД</kwd><kwd>глаукома</kwd><kwd>нутрицевтики</kwd><kwd>лютеин</kwd><kwd>зеаксантин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>AMD</kwd><kwd>glaucoma</kwd><kwd>nutritional supplements</kwd><kwd>lutein</kwd><kwd>zeaxanthin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Flaxman S.R., Bourne R.R.A., Resnikoff S., Ackland P., Braithwaite T., Cicinelli M.V., et. al. Global causes of blindness and distance vision impairment 1990–2020: A systematic review and meta-analysis. Lancet Glob. Health. 2017;5:e1221-e1234. DOI: 10.1016/S2214-109X(17)30393-5</mixed-citation><mixed-citation xml:lang="en">Flaxman S.R., Bourne R.R.A., Resnikoff S., Ackland P., Braithwaite T., Cicinelli M.V., et. al. Global causes of blindness and distance vision impairment 1990–2020: A systematic review and meta-analysis. Lancet Glob. Health. 2017;5:e1221-e1234. DOI: 10.1016/S2214-109X(17)30393-5</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Sideri O., Tsaousis K.T., Li H.J., Viskadouraki M., Tsinopoulos I.T. The potential role of nutrition on lens pathology: A systematic review and meta-analysis. Surv. Ophthalmol. 2019;64:668–678. DOI: 10.1016/j.survophthal.2019.03.003</mixed-citation><mixed-citation xml:lang="en">Sideri O., Tsaousis K.T., Li H.J., Viskadouraki M., Tsinopoulos I.T. The potential role of nutrition on lens pathology: A systematic review and meta-analysis. Surv. Ophthalmol. 2019;64:668–678. DOI: 10.1016/j.survophthal.2019.03.003</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Loskutova E., O’Brien C., Loskutov I., Loughman J. Nutritional supplementation in the treatment of glaucoma: A systematic review. Surv. Ophthalmol. 2019;64:195– 216. DOI: 10.1016/j.survophthal.2018.09.005</mixed-citation><mixed-citation xml:lang="en">Loskutova E., O’Brien C., Loskutov I., Loughman J. Nutritional supplementation in the treatment of glaucoma: A systematic review. Surv. Ophthalmol. 2019;64:195– 216. DOI: 10.1016/j.survophthal.2018.09.005</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Nangia V., Jonas J.B., George R. on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study, et al Prevalence and causes of blindness and vi sion impairment: magnitude, temporal trends and projections in South and Central Asia British. Journal of Ophthalmology. 2019;103:871–877. DOI: 10.1136/bjophthal- mol-2018-312292</mixed-citation><mixed-citation xml:lang="en">Nangia V., Jonas J.B., George R. on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study, et al Prevalence and causes of blindness and vi sion impairment: magnitude, temporal trends and projections in South and Central Asia British. Journal of Ophthalmology. 2019;103:871–877. DOI: 10.1136/bjophthal- mol-2018-312292</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Tham Y.C., Li X., Wong T.Y., Quigley H.A., Aung T., Cheng C.Y. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic re view and meta-analysis. Ophthalmology. 2014;121:2081–2090. DOI: 10.1016/j.oph tha.2014.05.013</mixed-citation><mixed-citation xml:lang="en">Tham Y.C., Li X., Wong T.Y., Quigley H.A., Aung T., Cheng C.Y. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic re view and meta-analysis. Ophthalmology. 2014;121:2081–2090. DOI: 10.1016/j.oph tha.2014.05.013</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Aslam T., Delcourt C., Holz F., García-Layana A., Leys A., Silva R.M., Souied E. European survey on the opinion and use of micronutrition in age-related macular degeneration: 10 years on from the Age-Related Eye Disease Study. Clinical ophthalmology. 2014;8:2045–2053. DOI: 2147/OPTH.S63937</mixed-citation><mixed-citation xml:lang="en">Aslam T., Delcourt C., Holz F., García-Layana A., Leys A., Silva R.M., Souied E. European survey on the opinion and use of micronutrition in age-related macular degeneration: 10 years on from the Age-Related Eye Disease Study. Clinical ophthalmology. 2014;8:2045–2053. DOI: 2147/OPTH.S63937</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Lawrenson J., Downie L. Nutrition and Eye Health. Nutrients. 2019;11: 2123. DOI: 10.3390/nu11092123</mixed-citation><mixed-citation xml:lang="en">Lawrenson J., Downie L. Nutrition and Eye Health. Nutrients. 2019;11: 2123. DOI: 10.3390/nu11092123</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang X., Bullard K.M., Cotch M.F., Wilson M.R., Rovner B.W., McGwin G. Jr., et. al. Association between depression and functional vision loss in persons 20 years of age or older in the United States, NHANES 2005-2008. JAMA Ophthalmol. 2013;131(5):573–581. DOI: 10.1001/jamaophthalmol.2013.2597</mixed-citation><mixed-citation xml:lang="en">Zhang X., Bullard K.M., Cotch M.F., Wilson M.R., Rovner B.W., McGwin G. Jr., et. al. Association between depression and functional vision loss in persons 20 years of age or older in the United States, NHANES 2005-2008. JAMA Ophthalmol. 2013;131(5):573–581. DOI: 10.1001/jamaophthalmol.2013.2597</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Tan B.L., Norhaizan M.E., Liew W.P., Sulaiman Rahman H. Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases. Front Pharmacol. 2018;9:1162. DOI: 10.3389/fphar.2018.01162</mixed-citation><mixed-citation xml:lang="en">Tan B.L., Norhaizan M.E., Liew W.P., Sulaiman Rahman H. Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases. Front Pharmacol. 2018;9:1162. DOI: 10.3389/fphar.2018.01162</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Sayama A., Okado K., Nakamura K., Kawaguchi T., Iguchi T., Makino T., Mori K. UNC569-induced Morphological Changes in Pigment Epithelia and Photorecep tor Cells in the Retina through MerTK Inhibition in Mice. Toxicologic Pathology. 2018;46(2):193–201. DOI: 10.1177/0192623317749469</mixed-citation><mixed-citation xml:lang="en">Sayama A., Okado K., Nakamura K., Kawaguchi T., Iguchi T., Makino T., Mori K. UNC569-induced Morphological Changes in Pigment Epithelia and Photorecep tor Cells in the Retina through MerTK Inhibition in Mice. Toxicologic Pathology. 2018;46(2):193–201. DOI: 10.1177/0192623317749469</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Moreno-García A., Kun A., Calero O., Medina M., Calero M. An Overview of the Role of Lipofuscin in Age-Related Neurodegeneration. Front Neurosci. 2018;12:464. DOI: 10.3389/fnins.2018.00464</mixed-citation><mixed-citation xml:lang="en">Moreno-García A., Kun A., Calero O., Medina M., Calero M. An Overview of the Role of Lipofuscin in Age-Related Neurodegeneration. Front Neurosci. 2018;12:464. DOI: 10.3389/fnins.2018.00464</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Blasiak J. Senescence in the pathogenesis of age-related macular degeneration. Cell. Mol. Life Sci. 2020;77(5):789–805. DOI: 10.1007/s00018-019-03420-x</mixed-citation><mixed-citation xml:lang="en">Blasiak J. Senescence in the pathogenesis of age-related macular degeneration. Cell. Mol. Life Sci. 2020;77(5):789–805. DOI: 10.1007/s00018-019-03420-x</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Ly A., Nivison-Smith L., Assaad N., Kalloniatis M. Fundus Autofluorescence in Age-related Macular Degeneration. Optom Vis Sci. 2017;94(2):246–259. DOI: 10.1097/OPX.0000000000000997</mixed-citation><mixed-citation xml:lang="en">Ly A., Nivison-Smith L., Assaad N., Kalloniatis M. Fundus Autofluorescence in Age-related Macular Degeneration. Optom Vis Sci. 2017;94(2):246–259. DOI: 10.1097/OPX.0000000000000997</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Ablonczy Z., Higbee D., Anderson D.M., Dahrouj M., Grey A.C., Gutierrez D., et. al. Lack of correlation between the spatial distribution of A2E and lipofuscin fluorescence in the human retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2013;54(8):5535–5542. DOI: 10.1167/iovs.13-12250</mixed-citation><mixed-citation xml:lang="en">Ablonczy Z., Higbee D., Anderson D.M., Dahrouj M., Grey A.C., Gutierrez D., et. al. Lack of correlation between the spatial distribution of A2E and lipofuscin fluorescence in the human retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2013;54(8):5535–5542. DOI: 10.1167/iovs.13-12250</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Handa J.T., Bowes Rickman C., Dick A.D., Gorin M.B., Miller J.W., Toth C.A., et. al. A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration. Nat Commun. 2019;10(1):3347. DOI: 10.1038/s41467-019-11262-1</mixed-citation><mixed-citation xml:lang="en">Handa J.T., Bowes Rickman C., Dick A.D., Gorin M.B., Miller J.W., Toth C.A., et. al. A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration. Nat Commun. 2019;10(1):3347. DOI: 10.1038/s41467-019-11262-1</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Evans J. R., Lawrenson J.G. Antioxidant vitamin and mineral supplements for preventing age‐related macular degeneration. Cochrane Database of Systematic Reviews. 2012;14(11):CD000254. DOI: 10.1002/14651858.CD000254.pub3</mixed-citation><mixed-citation xml:lang="en">Evans J. R., Lawrenson J.G. Antioxidant vitamin and mineral supplements for preventing age‐related macular degeneration. Cochrane Database of Systematic Reviews. 2012;14(11):CD000254. DOI: 10.1002/14651858.CD000254.pub3</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Datta S., Cano M., Ebrahimi K., Wang L., Handa J.T. The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD. Progress in Retinal and Eye Research. 2017;60:201–218. DOI: 10.1016/j.preteyeres.2017.03.002</mixed-citation><mixed-citation xml:lang="en">Datta S., Cano M., Ebrahimi K., Wang L., Handa J.T. The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD. Progress in Retinal and Eye Research. 2017;60:201–218. DOI: 10.1016/j.preteyeres.2017.03.002</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Sun M., Finnemann S.C., Febbraio M., Shan L., Annangudi S.P., Podrez E.A., et. al. Light-induced oxidation of photoreceptor outer segment phospholipids generates ligands for CD36-mediated phagocytosis by retinal pigment epithelium: a potential mechanism for modulating outer segment phagocytosis under oxidant stress condi tions. The Journal of Biological Chemistry. 2006;281(7):4222–4230. DOI: 10.1074/jbc.M509769200</mixed-citation><mixed-citation xml:lang="en">Sun M., Finnemann S.C., Febbraio M., Shan L., Annangudi S.P., Podrez E.A., et. al. Light-induced oxidation of photoreceptor outer segment phospholipids generates ligands for CD36-mediated phagocytosis by retinal pigment epithelium: a potential mechanism for modulating outer segment phagocytosis under oxidant stress condi tions. The Journal of Biological Chemistry. 2006;281(7):4222–4230. DOI: 10.1074/jbc.M509769200</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Mares J. Lutein and Zeaxanthin Isomers in Eye Health and Disease. Annu Rev Nutr. 2016;36:571–602. DOI: 10.1146/annurev-nutr-071715-051110</mixed-citation><mixed-citation xml:lang="en">Mares J. Lutein and Zeaxanthin Isomers in Eye Health and Disease. Annu Rev Nutr. 2016;36:571–602. DOI: 10.1146/annurev-nutr-071715-051110</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Buscemi S., Corleo D., Di Pace D. Petroni M.L., Satriano A., Marchesini G. The Ef fect of Lutein on Eye and Extra-Eye Health. Nutrients. 2018;10(9):1321. DOI: 10.3390/nu10091321</mixed-citation><mixed-citation xml:lang="en">Buscemi S., Corleo D., Di Pace D. Petroni M.L., Satriano A., Marchesini G. The Ef fect of Lutein on Eye and Extra-Eye Health. Nutrients. 2018;10(9):1321. DOI: 10.3390/nu10091321</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Михайлова М.А., Сизова М.В., Шеланкова А.В. Патогенез ретинальных венозных окклюзий. Вестник офтальмологии. 2014;130(2):88–92. [Mikhaylova M.A., Sizova M.V., Shelankova A.V. Pathogenesis of retinal vein occlusions. The Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2014;130(2):88– 92 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Михайлова М.А., Сизова М.В., Шеланкова А.В. Патогенез ретинальных венозных окклюзий. Вестник офтальмологии. 2014;130(2):88–92. [Mikhaylova M.A., Sizova M.V., Shelankova A.V. Pathogenesis of retinal vein occlusions. The Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2014;130(2):88– 92 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Carneiro A., Andrade J.P. Nutritional and lifestyle interventions for age-related macular degeneration: a review. Oxidative Medicine and Cellular Longevity. 2017;6469138. DOI: 10.1155/2017/6469138</mixed-citation><mixed-citation xml:lang="en">Carneiro A., Andrade J.P. Nutritional and lifestyle interventions for age-related macular degeneration: a review. Oxidative Medicine and Cellular Longevity. 2017;6469138. DOI: 10.1155/2017/6469138</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Rezende F.A., Lapalme E., Qian C.X., Smith L.E., SanGiovanni J.P., Sapieha P. Omega-3 supplementation combined with anti-vascular endothelial growth factor lowers vitreal levels of vascular endothelial growth factor in wet age-related macular degeneration. Am J Ophthalmol. 2014;158(5):1071–1078. DOI: 10.1016/j.ajo.2014.07.036</mixed-citation><mixed-citation xml:lang="en">Rezende F.A., Lapalme E., Qian C.X., Smith L.E., SanGiovanni J.P., Sapieha P. Omega-3 supplementation combined with anti-vascular endothelial growth factor lowers vitreal levels of vascular endothelial growth factor in wet age-related macular degeneration. Am J Ophthalmol. 2014;158(5):1071–1078. DOI: 10.1016/j.ajo.2014.07.036</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Semeraro F., Gambicordi E., Cancarini A., Morescalchi F., Costagliola C., Russo A. Treatment of exudative age-related macular degeneration with aflibercept combined with pranoprofen eye drops or nutraceutical support with omega-3: A randomized trial. Br J Clin Pharmacol. 2019;85: 908–913. DOI: 10.1111/bcp.13871</mixed-citation><mixed-citation xml:lang="en">Semeraro F., Gambicordi E., Cancarini A., Morescalchi F., Costagliola C., Russo A. Treatment of exudative age-related macular degeneration with aflibercept combined with pranoprofen eye drops or nutraceutical support with omega-3: A randomized trial. Br J Clin Pharmacol. 2019;85: 908–913. DOI: 10.1111/bcp.13871</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Stahl A., Sapieha P., Connor K.M. Sangiovanni J.P., Chen J., Aderman C.M., Willett K.L., Krah N.M., Dennison R.J., Seaward M.R., Guerin K.I., Hua J., Smith L.E. Short communication: PPAR gamma mediates a direct antiangiogenic effect of omega 3-PUFAs in proliferative retinopathy. Circ Res. 2010;107(4):495–500. DOI: 10.1161/CIRCRESAHA.110.221317</mixed-citation><mixed-citation xml:lang="en">Stahl A., Sapieha P., Connor K.M. Sangiovanni J.P., Chen J., Aderman C.M., Willett K.L., Krah N.M., Dennison R.J., Seaward M.R., Guerin K.I., Hua J., Smith L.E. Short communication: PPAR gamma mediates a direct antiangiogenic effect of omega 3-PUFAs in proliferative retinopathy. Circ Res. 2010;107(4):495–500. DOI: 10.1161/CIRCRESAHA.110.221317</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Connor K.M., SanGiovanni J.P., Lofqvist C., Aderman C.M., Chen J., Higuchi A., et. al. Increased dietary intake of omega‐3‐polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med. 2007;13(7):868–873. DOI: 10.1038/nm1591</mixed-citation><mixed-citation xml:lang="en">Connor K.M., SanGiovanni J.P., Lofqvist C., Aderman C.M., Chen J., Higuchi A., et. al. Increased dietary intake of omega‐3‐polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med. 2007;13(7):868–873. DOI: 10.1038/nm1591</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Cohen L.P., Pasquale L.R. Clinical characteristics and current treatment of glaucoma. Cold Spring Harb Perspect Med. 2014;4(6):a017236. DOI: 10.1101/cshperspect.a017236</mixed-citation><mixed-citation xml:lang="en">Cohen L.P., Pasquale L.R. Clinical characteristics and current treatment of glaucoma. Cold Spring Harb Perspect Med. 2014;4(6):a017236. DOI: 10.1101/cshperspect.a017236</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Sayner R., Carpenter D.M., Blalock S.J. Robin A.L., Muir K.W., Hartnett M.E., et. al. Accuracy of Patient-reported Adherence to Glaucoma Medications on a Visual Analog Scale Compared With Electronic Monitors. Clin Ther. 2015;37(9):1975–1985. DOI: 10.1016/j.clinthera.2015.06.008</mixed-citation><mixed-citation xml:lang="en">Sayner R., Carpenter D.M., Blalock S.J. Robin A.L., Muir K.W., Hartnett M.E., et. al. Accuracy of Patient-reported Adherence to Glaucoma Medications on a Visual Analog Scale Compared With Electronic Monitors. Clin Ther. 2015;37(9):1975–1985. DOI: 10.1016/j.clinthera.2015.06.008</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Nucci C., Di Pierro D., Varesi C., Ciuffoletti E., Russo R., Gentile R., Cedrone C., Pinazo Duran M.D., Coletta M., Mancino R. Increased malondialdehyde concentration and reduced total antioxidant capacity in aqueous humor and blood samples from patients with glaucoma. Mol. Vis. 2013;19:1841–1846.</mixed-citation><mixed-citation xml:lang="en">Nucci C., Di Pierro D., Varesi C., Ciuffoletti E., Russo R., Gentile R., Cedrone C., Pinazo Duran M.D., Coletta M., Mancino R. Increased malondialdehyde concentration and reduced total antioxidant capacity in aqueous humor and blood samples from patients with glaucoma. Mol. Vis. 2013;19:1841–1846.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Sorkhabi R., Ghorbanihaghjo A., Javadzadeh A., Rashtchizadeh N., Moharrery M. Oxidative DNA damage and total antioxidant status in glaucoma patients. Mol. Vis. 2011;17:41–46.</mixed-citation><mixed-citation xml:lang="en">Sorkhabi R., Ghorbanihaghjo A., Javadzadeh A., Rashtchizadeh N., Moharrery M. Oxidative DNA damage and total antioxidant status in glaucoma patients. Mol. Vis. 2011;17:41–46.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Тренделева Т.А., Аливердиева Д.А., Звягильская Р.А. Механизмы определения низкого уровня кислорода у млекопитающих и дрожжей и их адаптационные ответы (обзор). Биохимия. 2014;79(8):750–760. [Trendeleva T.A., Zvyagilskaya R.A., Aliverdieva D.A. Mechanisms of sensing and adaptive responses to low oxygen conditions in mammals and yeasts. Biochemistry = Biohimiya. 2014;79(8):750–760 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Тренделева Т.А., Аливердиева Д.А., Звягильская Р.А. Механизмы определения низкого уровня кислорода у млекопитающих и дрожжей и их адаптационные ответы (обзор). Биохимия. 2014;79(8):750–760. [Trendeleva T.A., Zvyagilskaya R.A., Aliverdieva D.A. Mechanisms of sensing and adaptive responses to low oxygen conditions in mammals and yeasts. Biochemistry = Biohimiya. 2014;79(8):750–760 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Yıldırım O., Ates N., Ercan B., Muşlu N., Unlü A., Tamer L., Atik U., Kanik A. Role of oxidative stress enzymes in open-angle glaucoma. Eye. 2005;19:580–583. DOI: 10.1038/sj.eye.6701565</mixed-citation><mixed-citation xml:lang="en">Yıldırım O., Ates N., Ercan B., Muşlu N., Unlü A., Tamer L., Atik U., Kanik A. Role of oxidative stress enzymes in open-angle glaucoma. Eye. 2005;19:580–583. DOI: 10.1038/sj.eye.6701565</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Goyal A., Srivastava A., Sihota R., Kaur J. Evaluation of oxidative stress markers in aqueous humor of primary open angle glaucoma and primary angle closure glaucoma patients. Curr. Eye Res. 2014;39:823–829. DOI: 10.3109/02713683.2011.556299</mixed-citation><mixed-citation xml:lang="en">Goyal A., Srivastava A., Sihota R., Kaur J. Evaluation of oxidative stress markers in aqueous humor of primary open angle glaucoma and primary angle closure glaucoma patients. Curr. Eye Res. 2014;39:823–829. DOI: 10.3109/02713683.2011.556299</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Sacca S.C., Pascotto A., Camicione P., Capris P., Izzotti A. Oxidative DNA damage in the human trabecular meshwork: Clinical correlation in patients with primary open-angle glaucoma. Arch. Ophthalmol. 2005;123:458–463. DOI: 10.1001/archopht.123.4.458</mixed-citation><mixed-citation xml:lang="en">Sacca S.C., Pascotto A., Camicione P., Capris P., Izzotti A. Oxidative DNA damage in the human trabecular meshwork: Clinical correlation in patients with primary open-angle glaucoma. Arch. Ophthalmol. 2005;123:458–463. DOI: 10.1001/archopht.123.4.458</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Izzotti A., Sacca S.C., Cartiglia C., De Flora S. Oxidative deoxyribonucleic acid damage in the eyes of glaucoma patients. Am. J. Med. 2003. 114:638–646. DOI: 10.1016/s0002-9343(03)00114-1</mixed-citation><mixed-citation xml:lang="en">Izzotti A., Sacca S.C., Cartiglia C., De Flora S. Oxidative deoxyribonucleic acid damage in the eyes of glaucoma patients. Am. J. Med. 2003. 114:638–646. DOI: 10.1016/s0002-9343(03)00114-1</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Tezel G. The immune response in glaucoma: A perspective on the roles of oxidative stress. Exp. Eye Res. 2011;93:178–186. DOI: 10.1016/j.exer.2010.07.009</mixed-citation><mixed-citation xml:lang="en">Tezel G. The immune response in glaucoma: A perspective on the roles of oxidative stress. Exp. Eye Res. 2011;93:178–186. DOI: 10.1016/j.exer.2010.07.009</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Maruyama I., Ohguro H., Ikeda Y. Retinal ganglion cells recognized by serum autoantibody against gamma-enolase found in glaucoma patients. Invest Ophthalmol Vis Sci. 2000;41:1657–1665.</mixed-citation><mixed-citation xml:lang="en">Maruyama I., Ohguro H., Ikeda Y. Retinal ganglion cells recognized by serum autoantibody against gamma-enolase found in glaucoma patients. Invest Ophthalmol Vis Sci. 2000;41:1657–1665.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson E.C., Morrison J.C. Friend or foe? Resolving the impact of glial responses in glaucoma. J Glaucoma. 2009;18:341–353. DOI: 10.1097/IJG.0b013e31818c6ef6</mixed-citation><mixed-citation xml:lang="en">Johnson E.C., Morrison J.C. Friend or foe? Resolving the impact of glial responses in glaucoma. J Glaucoma. 2009;18:341–353. DOI: 10.1097/IJG.0b013e31818c6ef6</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Bernstein P.S., Li B., Vachali P.P., Gorusupudi A., Shyam R., Henriksen B.S. Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease. Progress in retinal and eye research. 2016;50:34–66. DOI: 10.1016/j.preteyeres</mixed-citation><mixed-citation xml:lang="en">Bernstein P.S., Li B., Vachali P.P., Gorusupudi A., Shyam R., Henriksen B.S. Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease. Progress in retinal and eye research. 2016;50:34–66. DOI: 10.1016/j.preteyeres</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Eggersdorfer M., Wyss A. Carotenoids in human nutrition and health. Archives of biochemistry and biophysics. 2018;652:18–26. DOI: 10.1016/j.abb.2018.06.001</mixed-citation><mixed-citation xml:lang="en">Eggersdorfer M., Wyss A. Carotenoids in human nutrition and health. Archives of biochemistry and biophysics. 2018;652:18–26. DOI: 10.1016/j.abb.2018.06.001</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Kijlstra A., Tian Y., Kelly E.R., Berendschot T.T. Lutein: more than just a filter for blue light. Progress in retinal and eye research. 2012;31(4):303–315. DOI: 10.1016/j.preteyeres</mixed-citation><mixed-citation xml:lang="en">Kijlstra A., Tian Y., Kelly E.R., Berendschot T.T. Lutein: more than just a filter for blue light. Progress in retinal and eye research. 2012;31(4):303–315. DOI: 10.1016/j.preteyeres</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Eisenhauer B., Natoli S., Liew G., Flood V.M. Lutein and Zeaxanthin-Food Sources, Bioavailability and Dietary Variety in Age-Related Macular Degeneration Protection. Nutrients. 2017;9(2):120. DOI: 10.3390/nu9020120</mixed-citation><mixed-citation xml:lang="en">Eisenhauer B., Natoli S., Liew G., Flood V.M. Lutein and Zeaxanthin-Food Sources, Bioavailability and Dietary Variety in Age-Related Macular Degeneration Protection. Nutrients. 2017;9(2):120. DOI: 10.3390/nu9020120</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Mukhtar S., Ambati B.K. The value of nutritional supplements in treating Age-Related Macular Degeneration: a review of the literature. Int Ophthalmo. 2019;39:2975– 2983. DOI: 10.1007/s10792-019-01140-6</mixed-citation><mixed-citation xml:lang="en">Mukhtar S., Ambati B.K. The value of nutritional supplements in treating Age-Related Macular Degeneration: a review of the literature. Int Ophthalmo. 2019;39:2975– 2983. DOI: 10.1007/s10792-019-01140-6</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Филиппова О.В. Выбор лекарственной формы для лечения и профилактики патологий сетчатки. РМЖ. Клиническая офтальмология. 2019;4:211–216. [Filippova O.V. Selecting drug formulation for the treatment and prevention of retinal disorders. Clinical ophthalmology = Klinicheskaya oftal’mologiya. 2019;19(4):211–216 (In Russ.)]. DOI: 10.32364/2311-7729-2019-19-4-211-216</mixed-citation><mixed-citation xml:lang="en">Филиппова О.В. Выбор лекарственной формы для лечения и профилактики патологий сетчатки. РМЖ. Клиническая офтальмология. 2019;4:211–216. [Filippova O.V. Selecting drug formulation for the treatment and prevention of retinal disorders. Clinical ophthalmology = Klinicheskaya oftal’mologiya. 2019;19(4):211–216 (In Russ.)]. DOI: 10.32364/2311-7729-2019-19-4-211-216</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Scripsema N.K., Hu D.N., Rosen R.B. Lutein, zeaxanthin and meso-zeaxanthin in the clinical management of eye disease. J. Ophthalmol. 2015. 2015:865179. DOI: 10.1155/2015/865179</mixed-citation><mixed-citation xml:lang="en">Scripsema N.K., Hu D.N., Rosen R.B. Lutein, zeaxanthin and meso-zeaxanthin in the clinical management of eye disease. J. Ophthalmol. 2015. 2015:865179. DOI: 10.1155/2015/865179</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Liu R., Wang T., Zhang B., et al. Lutein and zeaxanthin supplementation and association with visual function in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2014;56(1):252–258. DOI: 10.1167/iovs.14-15553</mixed-citation><mixed-citation xml:lang="en">Liu R., Wang T., Zhang B., et al. Lutein and zeaxanthin supplementation and association with visual function in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2014;56(1):252–258. DOI: 10.1167/iovs.14-15553</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Yoserizal M., Hirooka K., Yoneda M. Associations of nutrient intakes with glaucoma among Japanese Americans. Medicine (Baltimore). 2019. 98(49):e18314. DOI: 10.1097/MD.0000000000018314</mixed-citation><mixed-citation xml:lang="en">Yoserizal M., Hirooka K., Yoneda M. Associations of nutrient intakes with glaucoma among Japanese Americans. Medicine (Baltimore). 2019. 98(49):e18314. DOI: 10.1097/MD.0000000000018314</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Jung K.I., Kim Y.C., Park C.K. Dietary niacin and open-angle glaucoma: The Korean National Health and Nutrition Examination Survey. Nutrients. 2018;10(4):ii:E387. DOI: 10.3390/nu10040387</mixed-citation><mixed-citation xml:lang="en">Jung K.I., Kim Y.C., Park C.K. Dietary niacin and open-angle glaucoma: The Korean National Health and Nutrition Examination Survey. Nutrients. 2018;10(4):ii:E387. DOI: 10.3390/nu10040387</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Ramdas W.D., Wolfs R.C., Kiefte-de Jong J.C. Nutrient intake and risk of open-angle glaucoma: the Rotterdam Study. Eur J Epidemiol 2012;27:385–393. DOI: 10.1007/s10654-012-9672-z</mixed-citation><mixed-citation xml:lang="en">Ramdas W.D., Wolfs R.C., Kiefte-de Jong J.C. Nutrient intake and risk of open-angle glaucoma: the Rotterdam Study. Eur J Epidemiol 2012;27:385–393. DOI: 10.1007/s10654-012-9672-z</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Cho H.-K. Neuroprotective effect of ginkgo biloba extract against hypoxic retinal ganglion cell degeneration in vitro and in vivo. Journal of Medicinal Food. 2019;22(8):771–778. DOI: 10.1089/jmf.2018.4350</mixed-citation><mixed-citation xml:lang="en">Cho H.-K. Neuroprotective effect of ginkgo biloba extract against hypoxic retinal ganglion cell degeneration in vitro and in vivo. Journal of Medicinal Food. 2019;22(8):771–778. DOI: 10.1089/jmf.2018.4350</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Lawler T., Liu Y., Christensen K., Vajaranant T.S., Mares J. Dietary antioxidants, macular pigment, and glaucomatous neurodegeneration: a review of the evidence. Nutrients. 2019;11:1002. DOI: 10.3390/nu11051002</mixed-citation><mixed-citation xml:lang="en">Lawler T., Liu Y., Christensen K., Vajaranant T.S., Mares J. Dietary antioxidants, macular pigment, and glaucomatous neurodegeneration: a review of the evidence. Nutrients. 2019;11:1002. DOI: 10.3390/nu11051002</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Mozaffarieh M., Grieshaber M.C., Orgul, S., Flammer J. The potential value of natural antioxidative treatment in glaucoma. Surv. Ophthalmol. 2008;53:479–505. DOI: 10.1016/j.survophthal.2008.06.006</mixed-citation><mixed-citation xml:lang="en">Mozaffarieh M., Grieshaber M.C., Orgul, S., Flammer J. The potential value of natural antioxidative treatment in glaucoma. Surv. Ophthalmol. 2008;53:479–505. DOI: 10.1016/j.survophthal.2008.06.006</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Kang J.H., Pasquale L.R., Willett W., Rosner B., Egan K.M., Faberowski N., Hankinson S.E. Antioxidant intake and primary open-angle glaucoma: A prospective study. Am. J. Epidemiol. 2003;158:337–346. DOI: 10.1093/aje/kwg167</mixed-citation><mixed-citation xml:lang="en">Kang J.H., Pasquale L.R., Willett W., Rosner B., Egan K.M., Faberowski N., Hankinson S.E. Antioxidant intake and primary open-angle glaucoma: A prospective study. Am. J. Epidemiol. 2003;158:337–346. DOI: 10.1093/aje/kwg167</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Wang S.Y., Singh K., Lin S.C. Glaucoma and vitamins A, C, and E supplement intake and serum levels in a population-based sample of the United States. Eye. 2013;27:487–494. DOI: 10.1038/eye.2013.10</mixed-citation><mixed-citation xml:lang="en">Wang S.Y., Singh K., Lin S.C. Glaucoma and vitamins A, C, and E supplement intake and serum levels in a population-based sample of the United States. Eye. 2013;27:487–494. DOI: 10.1038/eye.2013.10</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Yong J. J., et al. Ocular Nutritional Supplements: Are Their Ingredients and Manufacturers’ Claims Evidence-Based? Ophthalmology. 2015;122(3):595–599. DOI: 10.1016/j.ophtha.2014.09.039</mixed-citation><mixed-citation xml:lang="en">Yong J. J., et al. Ocular Nutritional Supplements: Are Their Ingredients and Manufacturers’ Claims Evidence-Based? Ophthalmology. 2015;122(3):595–599. DOI: 10.1016/j.ophtha.2014.09.039</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
