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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2020-4-789-795</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-1376</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОФТАЛЬМОФАРМАКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PHARMACOLOGY</subject></subj-group></article-categories><title-group><article-title>Диагностика и лечение хронических инфекционных процессов в офтальмологии: реальная клиническая практика</article-title><trans-title-group xml:lang="en"><trans-title>Diagnosis and Treatment of Chronic Infectious Processes in Ophthalmology: Real Clinical Practice</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8000-5757</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ковалевская</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kovalevskaya</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор, заведующая кафедрой офтальмологии,</p><p>ул. Студенческая, 10, г. Воронеж, 394036</p></bio><bio xml:lang="en"><p>MD, Professor, head of ophthalmology department,</p><p>Studencheskaya str., 10, Voronezh, 394036</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7627-0013</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Донкарева</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Donkareva</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, доцент,</p><p>ул. Студенческая, 10, г. Воронеж, 394036</p></bio><bio xml:lang="en"><p>PhD, Docent of ophthalmology department,</p><p>Studencheskaya str., 10, Voronezh, 394036</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4183-2420</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Перерва</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Pererva</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант,</p><p>ул. Студенческая, 10, г. Воронеж, 394036</p></bio><bio xml:lang="en"><p>postgraduate,</p><p>Studencheskaya str., 10, Voronezh, 394036</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Воронежский государственный медицинский университет им. Н.Н. Бурденко»&#13;
Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Voronezh State Medical University named after N.N. Burdenko</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>27</day><month>12</month><year>2020</year></pub-date><volume>17</volume><issue>4</issue><fpage>789</fpage><lpage>795</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ковалевская М.А., Донкарева О.В., Перерва О.А., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Ковалевская М.А., Донкарева О.В., Перерва О.А.</copyright-holder><copyright-holder xml:lang="en">Kovalevskaya M.A., Donkareva O.V., Pererva O.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/1376">https://www.ophthalmojournal.com/opht/article/view/1376</self-uri><abstract><p>Лечение инфекционных процессов длительного течения в конъюнктиве представляет сложную задачу для поликлинического врача-офтальмолога. Это связано со значительным изменением микрофлоры в сторону устойчивых грамотрицательных бактерий. Данные исследований говорят о том, что микробные сообщества являются причиной воспалительных процессов конъюнктивы и роговицы.</p><sec><title>Цель</title><p>Цель: повышение эффективности диагностики и лечения хронических специфических воспалительных заболеваний органа зрения.</p></sec><sec><title>Пациенты и методы</title><p>Пациенты и методы. Исследование проведено у пациентов с хламидийной инфекцией (n = 589) продолжительностью более 4 недель и включало наблюдение за партнерами пациентов, членами семей в течение 3 и более лет. За этот срок мы выполнили у каждого пациента более 3 осмотров с забором материала — для диагностического лабораторного исследования и 2 последовательных контрольных исследования через 1 и 2 месяца после лечения. Смешанная инфекция была выявлена у 256 человек (10 %), доля женщин 20–30 лет составила 67 %, мужчин — 51 %. В 27 % случаев определялись сообщества Ch. trachomatis и Ureaplasma parvum как ведущие причинные агенты глазных инфекций.</p></sec><sec><title>Заключение</title><p>Заключение. Хламидиоз чаще всего встречается в сообществе с Ureaplasma parvum (27 % случаев микст-инфекций). Лечение различных форм хламидийной инфекции осуществлялось с помощью препарата Floxal (0,3 % офлоксацин — капли и мазь). </p></sec></abstract><trans-abstract xml:lang="en"><p>Long-term conjunctival infections are challenging for the outpatient ophthalmologist. This is due to significant changes in microflora towards resistant gram-negative bacteria. Long-term conjunctival infections are challenging for the outpatient ophthalmologist. This is due to a significant change in microflora towards resistant gram-negative bacteria. The above studies are based on microbial associations, which are the causes of inflammatory processes, conjunctiva and cornea.</p><sec><title>Purpose</title><p>Purpose: to increase the effectiveness of the diagnosis and treatment of chronic specific inflammatory diseases of the organs of vision.</p></sec><sec><title>Patients and methods</title><p>Patients and methods. The study was conducted in patients with chlamydial infection (n = 589) and included chronic conjunctival infections lasting more than 4 weeks, follow-up of patients with partners, family members for 3 or more years. Results. The study was carried out in patients with chlamydial infection (n = 589) and with chronic infectious diseases that lasted more than 4 weeks, following patients and family members for 3 or more years. During this period, we performed more than 3 studies for each patient — for diagnostic laboratory studies and 2 consecutive controls 1 and 2 months after treatment, mixed infection was detected in 256 people (10 %), the proportion of women was 20–30 years is 67 %, men — 51 %. In 27 % of cases, communities of Ch. trachomatis and Ureaplasma parvum as leading causative agents of the eye infections.</p></sec><sec><title>Conclusions</title><p>Conclusions. Chlamydia is most often found together with Ureaplasma parvum (27 % of cases among mixed infections). Treatment of various forms of chlаmidia infection is carried out with the help of “Floxal” (0.3 % ofloxacin — drops and ointment). </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>хламидийная инфекция</kwd><kwd>микст-инфекция</kwd><kwd>хроническое воспаление</kwd><kwd>фторхинолоны</kwd><kwd>офлоксацин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chlamydial infection</kwd><kwd>mixed infection</kwd><kwd>chronic inflammation</kwd><kwd>fluoroquinolones</kwd><kwd>ofloxacin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Watanabe Y., Uchio E., Itoh N., Usui N., Nakagawa H., Inoue K., Ohno S. Bacterial infection in the conjunctiva of patients with adenoviral conjunctivitis. Japanese journal of ophthalmology. 2001;45(1):115.</mixed-citation><mixed-citation xml:lang="en">Watanabe Y., Uchio E., Itoh N., Usui N., Nakagawa H., Inoue K., Ohno S. 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