<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2021-2-253-259</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-1541</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ И ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL &amp; EXPERIMENTAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Особенности заболеваний переднего отдела глаза у пациентов, перенесших COVID-19</article-title><trans-title-group xml:lang="en"><trans-title>Features of Diseases of the Anterior Part of the Eye in Patients after COVID-19</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яни</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Yani</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, начальник отдела инфекционных и аллергических заболеваний глаз,</p><p>ул. Садовая-Черногрязская, 14/19, Москва, 105062</p></bio><bio xml:lang="en"><p>PhD, head of the Infectious and Allergic Eye Diseases Department,</p><p>Sadovaya Chernogryazskaya str., 14/19, Moscow, 105062</p></bio><email xlink:type="simple">e_yani@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Орлова</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Orlova</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, ученый секретарь,</p><p>ул. Садовая-Черногрязская, 14/19, Москва, 105062</p></bio><bio xml:lang="en"><p>PhD, scientific secretary,</p><p>Sadovaya Chernogryazskaya str., 14/19, Moscow, 105062</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Селиверстова</surname><given-names>К. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Seliverstova</surname><given-names>K. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>заведующая отделением инфекционных и аллергических заболеваний глаз, врачофтальмолог,</p><p>ул. Садовая-Черногрязская, 14/19, Москва, 105062</p></bio><bio xml:lang="en"><p>head of the Infectious and Allergic Eye Diseases Department, ophthalmologist,</p><p>Sadovaya Chernogryazskaya str., 14/19, Moscow, 105062</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр глазных болезней им. Гельмгольца» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Helmholts National Medical Research Center of Eye Diseases</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>05</day><month>07</month><year>2021</year></pub-date><volume>18</volume><issue>2</issue><fpage>253</fpage><lpage>259</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Яни Е.В., Орлова Е.Н., Селиверстова К.Е., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Яни Е.В., Орлова Е.Н., Селиверстова К.Е.</copyright-holder><copyright-holder xml:lang="en">Yani E.V., Orlova E.N., Seliverstova K.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/1541">https://www.ophthalmojournal.com/opht/article/view/1541</self-uri><abstract><p>Об офтальмологических проявлениях при SARS-CoV-2, о наличии конъюнктивита у заболевших COVID-19 пациентов, а также об обнаружении вирусов в слезной жидкости и тканях глаза в медицинской литературе имеются достаточно систематизированные данные. И хотя офтальмологические проявления считаются довольно редкими для COVID-19 и не входят в список важных для диагностики, нет достаточного количества достоверных данных о воспалительных процессах переднего отдела глаза и связи их с COVID-19, а также возникающих на фоне проводимого лечения.</p><sec><title>Цель</title><p>Цель: изучить развитие воспалительных заболеваний переднего отдела глаза у пациентов, перенесших новую коронавирусную инфекцию COVID-19.</p></sec><sec><title>Пациенты и методы</title><p>Пациенты и методы. В Отделе инфекционных и аллергических заболеваний глаз ФГБУ «НМИЦ ГБ им. Гельмгольца» МЗ РФ наблюдались 88 пациентов с подтвержденной перенесенной новой коронавирусной инфекцией COVID-19 различной степени тяжести. Основным методом лабораторной диагностики является выявление РНК SARS-CoV-2 в мазках из носоглотки, мокроты больного. Серодиагностика COVID-19 включает определение IgG-, IgM-антител к SARS-CoV-2 в крови с помощью иммуноферментного анализа.</p></sec><sec><title>Результаты</title><p>Результаты. Острый конъюнктивит при COVID-19 встречается довольно редко и является ранним признаком заболевания. В комплексной неспецифической топической терапии вирусных конъюнктивитов при COVID-19 наряду с этиопатогенетическим системным лечением следует использовать местные глазные лекарственные препараты с иммуномодулирующей и противовирусной активностью. Конъюнктивит во время пандемии может быть единственным признаком COVID-19. Развитие аллергических конъюнктивитов при COVID-19, возможно, связано не только с воздействием вирусного агента, но и зависит от токсического влияния лекарственных препаратов, использующихся в комплексном лечении данного заболевания. Увеличение числа пациентов с эписклеритом после перенесенной коронавирусной инфекции нуждается в дальнейшем детальном изучении с учетом анализа данных лабораторных исследований этой группы больных и накопления клинического материала.</p></sec><sec><title>Заключение</title><p>Заключение. Офтальмологические проявления при COVID-19 носят разнообразный характер, поражая различные структуры глаза, возникают на разных сроках — как в период течения заболевания, так и после клинического выздоровления и, безусловно, нуждаются в дальнейшем учете, изучении и структуризации. </p></sec></abstract><trans-abstract xml:lang="en"><p>There are quite systematic data of the ophthalmic manifestations in SARS-CoV-2, on the presence of conjunctivitis in patients with COVID-19, as well as on the detection of viruses in the lacrimal fluid and eye tissues. And, although ophthalmic manifestations are considered rather rare for COVID-19 and are not included in the list of important for diagnosis, there is not enough reliable data on the inflammatory processes of the eye’s anterior part and their connection with COVID-19, as well as those arising against the background of the treatment.</p><sec><title>Purpose</title><p>Purpose. To study the development of inflammatory diseases of the anterior part of the eye in patients who have undergone the new coronavirus infection COVID-19.</p></sec><sec><title>resu</title><p>resu. In the Department of Infectious and Allergic Eye Diseases of the Helmholts National Medical Research Center of Eye Diseases, 88 patients with confirmed transferred new coronavirus infection COVID-19 of varying severity were observed. The main method of laboratory diagnostics is the detection of SARS-CoV-2 RNA in swabs from the nasopharynx, the patient’s sputum. Serodiagnostics of COVID-19 includes the determination of IgG-, IgM-antibodies to SARS-CoV-2 in the blood in an enzyme-linked immunosorbent assay.</p></sec><sec><title>Results</title><p>Results. Acute conjunctivitis associated with COVID-19 is quite rare and is an early sign of the disease. In the complex nonspecific topical therapy of viral conjunctivitis in COVID-19, along with etiopathogenetic systemic treatment, local eye medications with immunomodulatory and antiviral activity should be used. Conjunctivitis during a pandemic may be the only sign of COVID-19. The development of allergic conjunctivitis in COVID-19 is possibly associated not only with the effect of a viral agent, but also depends on the toxic effect of drugs used in the complex treatment of this disease. The increase in the number of patients with episcleritis after the postponed coronavirus infection needs further detailed study, with the analysis of laboratory data from this group of patients and the accumulation of clinical material.</p></sec><sec><title>Conclusion</title><p>Conclusion. Ophthalmic manifestations in COVID-19 are very different, affecting various structures of the eye, occur at different periods — both during the course of the disease and after clinical recovery, and, of course, need further consideration, study and structuring. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd><kwd>конъюнктивит</kwd><kwd>метод полимеразной цепной реакции</kwd><kwd>гиалуроновая кислота</kwd><kwd>гепарин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd><kwd>conjunctivitis</kwd><kwd>polymerase chain reaction method</kwd><kwd>hyaluronic acid</kwd><kwd>heparin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Lu R., Zhao X., Li J., Niu P., Yang B., Wu H., Wang W., Song H., Huang B., Zhu N., Bi Y., Ma X., Zhan F., Wang L., Hu T., Zhou H., Hu Z., Zhou W., Zhao L., Chen J., Meng Y., Wang J., Lin Y., Yuan J., Xie Z., Ma J., Liu WJ., Wang D., Xu W., Holmes EC., Gao GF., Wu G., Chen W., Shi W., Tan W. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020 Feb 22;395(10224):565–574. DOI: 10.1016/S01406736(20)30251-8</mixed-citation><mixed-citation xml:lang="en">Lu R., Zhao X., Li J., Niu P., Yang B., Wu H., Wang W., Song H., Huang B., Zhu N., Bi Y., Ma X., Zhan F., Wang L., Hu T., Zhou H., Hu Z., Zhou W., Zhao L., Chen J., Meng Y., Wang J., Lin Y., Yuan J., Xie Z., Ma J., Liu WJ., Wang D., Xu W., Holmes EC., Gao GF., Wu G., Chen W., Shi W., Tan W. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020 Feb 22;395(10224):565–574. DOI: 10.1016/S01406736(20)30251-8</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">To K.F., Lo A.W. Exploring the pathogenesis of severe acute respiratory syndrome (SARS): the tissue distribution of the coronavirus (SARS-CoV) and its putative receptor, angiotensin-converting enzyme 2 (ACE2). The Journal of pathology. 2004 Jul;203(3):740–743. DOI: 10.1002/path.1597</mixed-citation><mixed-citation xml:lang="en">To K.F., Lo A.W. Exploring the pathogenesis of severe acute respiratory syndrome (SARS): the tissue distribution of the coronavirus (SARS-CoV) and its putative receptor, angiotensin-converting enzyme 2 (ACE2). The Journal of pathology. 2004 Jul;203(3):740–743. DOI: 10.1002/path.1597</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Guo Y.R., Cao Q.D., Hong Z.S., Tan Y.Y., Chen S.D., Jin H.J., Tan K.S., Wang D.Y. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak — an update on the status. Military Medical Research 2020;7(1):1. DOI: 10.1186/s40779-020-00240-0</mixed-citation><mixed-citation xml:lang="en">Guo Y.R., Cao Q.D., Hong Z.S., Tan Y.Y., Chen S.D., Jin H.J., Tan K.S., Wang D.Y. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak  — an update on the status. Military Medical Research 2020;7(1):1. DOI: 10.1186/s40779-020-00240-0</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Tu H., Tu S., Gao S., Shao A., Sheng J. Current epidemiological and clinical features of COVID-19; a global perspective from China. The Journal of infection. 2020;81(1):1–9. DOI: 10.1016/j.jinf.2020.04.011</mixed-citation><mixed-citation xml:lang="en">Tu H., Tu S., Gao S., Shao A., Sheng J. Current epidemiological and clinical features of COVID-19; a global perspective from China. The Journal of infection. 2020;81(1):1–9. DOI: 10.1016/j.jinf.2020.04.011</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Peiris J.S., Yuen K.E., Osterhaus A., Stöhr K. The severe acute respiratory syndrome. The New England journal of medicine. 2003 Dec 18;349(25):2431–2441. DOI: 10.1056/NEJMra032498</mixed-citation><mixed-citation xml:lang="en">Peiris J.S., Yuen K.E., Osterhaus A., Stöhr K. The severe acute respiratory syndrome. The New England journal of medicine. 2003 Dec 18;349(25):2431–2441. DOI: 10.1056/NEJMra032498</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Xia J., Tong J., Liu M., Shen Y., Guo D. Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection. Journal of medical virology. 2020 Jun;92(6):589–594. DOI: 10.1002/jmv.25725</mixed-citation><mixed-citation xml:lang="en">Xia J., Tong J., Liu M., Shen Y., Guo D. Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection. Journal of medical virology. 2020 Jun;92(6):589–594. DOI: 10.1002/jmv.25725</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Rothe C., Schunk M., Sothmann P., Bretzel G., Froeschl G., Wallrauch C., Zimmer T., Thiel V., Janke C., Guggemos W., Seilmaier M., Drosten C., Vollmar P., Zwirglmaier K., Zange S., Wölfel R., Hoelscher M. Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany. The New England journal of medicine. 2020;382(10):970–971. DOI: 10.1056/NEJMc2001468.30</mixed-citation><mixed-citation xml:lang="en">Rothe C., Schunk M., Sothmann P., Bretzel G., Froeschl G., Wallrauch C., Zimmer T., Thiel V., Janke C., Guggemos W., Seilmaier M., Drosten C., Vollmar P., Zwirglmaier K., Zange S., Wölfel R., Hoelscher M. Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany. The New England journal of medicine. 2020;382(10):970–971. DOI: 10.1056/NEJMc2001468.30</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Zou L., Ruan F., Huang M., Liang L., Huang H., Hong Z., Yu J., Kang M., Song Y., Xia J., Guo Q., Song T., He J., Yen H.L., Peiris M., Wu J. SARS-Cov-2 Viral Load in Upper Respiratory Specimens of Infected Patients. The New England journal of medicine. 2020 :382(12):1177–1179. DOI: 10.1056/NEJMc2001737</mixed-citation><mixed-citation xml:lang="en">Zou L., Ruan F., Huang M., Liang L., Huang H., Hong Z., Yu J., Kang M., Song Y., Xia J., Guo Q., Song T., He J., Yen H.L., Peiris M., Wu J. SARS-Cov-2 Viral Load in Upper Respiratory Specimens of Infected Patients. The New England journal of medicine. 2020 :382(12):1177–1179. DOI: 10.1056/NEJMc2001737</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Смирнов В.С., Тотолян Арег.А. Врожденный иммунитет при коронавирусной инфекции. Инфекция и иммунитет. 2020; 10(2):259–268. DOI: 10.15789/2220-7619-III-1440</mixed-citation><mixed-citation xml:lang="en">Smirnov V.S., Totolyan A.A. Innate immunity in coronavirus infection. Russian Journal of Infection and Immunity = Infekciya i immunitet 2020;10(2):259–268 (In Russ.). DOI: 10.15789/2220-7619-III-1440</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Wölfel R., Corman V.M., Guggemos W., Seilmaier M., Zange S., Müller M.A., Niemeyer D., Jones T.C., Vollmar P., Rothe C., Hoelscher M., Bleicker T., Brünink S., Schneider J., Ehmann R., Zwirglmaier K., Drosten C., Wendtner C. Virological assessment of hospitalized patients with COVID-2019. Nature. 2020;581(7809):465– 469. DOI: 10.1038/s41586-020-2196-x</mixed-citation><mixed-citation xml:lang="en">Wölfel R., Corman V.M., Guggemos W., Seilmaier M., Zange S., Müller M.A., Niemeyer D., Jones T.C., Vollmar P., Rothe C., Hoelscher M., Bleicker T., Brünink S., Schneider J., Ehmann R., Zwirglmaier K., Drosten C., Wendtner C. Virological assessment of hospitalized patients with COVID-2019. Nature. 2020;581(7809):465– 469. DOI: 10.1038/s41586-020-2196-x</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Javorac D., Grahovac L., Manić L., Stojilković N., Anđelković M., Bulat Z., ĐukićĆosić D., Curcic M., Djordjevic A.B. An overview of the safety assessment of medicines currently used in the COVID-19 disease treatment. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association. 2020 Oct;144:111639. DOI: 10.1016/j.fct.2020.111639</mixed-citation><mixed-citation xml:lang="en">Javorac D., Grahovac L., Manić L., Stojilković N., Anđelković M., Bulat Z., ĐukićĆosić D., Curcic M., Djordjevic A.B. An overview of the safety assessment of medicines currently used in the COVID-19 disease treatment. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association. 2020 Oct;144:111639. DOI: 10.1016/j.fct.2020.111639</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Lu C.W., Liu X.F., Jia Z.F. 2019-nCoV transmission through the ocular surface must not be ignored. Lancet. 2020;395:e39. DOI: 10.1016/S0140-6736(20)30313-5</mixed-citation><mixed-citation xml:lang="en">Lu C.W., Liu X.F., Jia Z.F. 2019-nCoV transmission through the ocular surface must not be ignored. Lancet. 2020;395:e39. DOI: 10.1016/S0140-6736(20)30313-5</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Li J.O., Lam D.S.C., Chen Y., Ting D.S. Novel Coronavirus disease 2019 (COVID-19): The importance of recognising possible early ocular manifestation and using protective eyewear. The British journal of ophthalmology. 2020;104:297– 298. DOI: 10.1136/bjophthalmol-2020-315994.</mixed-citation><mixed-citation xml:lang="en">Li J.O., Lam D.S.C., Chen Y., Ting D.S. Novel Coronavirus disease 2019 (COVID-19): The importance of recognising possible early ocular manifestation and using protective eyewear. The British journal of ophthalmology. 2020;104:297– 298. DOI: 10.1136/bjophthalmol-2020-315994.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">BenEzra D. Blepharitis and Conjunctivitis. Guidelines for diagnosis and treatment. Editonal. glosa 2006 248 p.</mixed-citation><mixed-citation xml:lang="en">BenEzra D. Blepharitis and Conjunctivitis. Guidelines for diagnosis and treatment. Editonal. glosa 2006 248 p.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Нероев В.В., Вахова Е.С. Заболевания конъюнктивы. В кн.: Офтальмология. Национальное руководство. Под ред. Аветисова С.Э., Егорова Е.А., Мошетовой Л.К., Нероева В.В., Тахчиди Х.П. М.: ГЭОТАР-Медиа, 2018. 418 с.</mixed-citation><mixed-citation xml:lang="en">Neroev V.V., Vakhova E.S. Diseases of the conjunctiva. In: Ophthalmology. National leadership. Ed. by Avetisov S.E., Egorov E.A., Moshetova L.K., Neroeva V.V., Takhchidi H.P. Moscow: GEOTAR-Media, 2018. 418 p (In Russ.)</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
