<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2021-4-807-814</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-1683</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Микропериметрия в детской практике</article-title><trans-title-group xml:lang="en"><trans-title>Microperimetry in Children’s Practice</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хубиева</surname><given-names>Р. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Khubieva</surname><given-names>R. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хубиева Регина Расуловна, аспирантка отдела патологии рефракции бинокулярного зрения и офтальмоэргономики</p><p>ул. Садовая-Черногрязская, 14/19, Москва, 105062</p></bio><bio xml:lang="en"><p>Khubieva Regina R., postgraduate of the Pathology of Binocular Vision Refraction and Ophthalmoergonomics Department</p><p>Sadovaya-Chernogryazskaya str., 14/19, Moscow, 105062</p></bio><email xlink:type="simple">reginahubieva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр глазных болезней им. Гельмгольца» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Helmholtz National Medical Research Center of Eye Diseases</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>28</day><month>12</month><year>2021</year></pub-date><volume>18</volume><issue>4</issue><fpage>807</fpage><lpage>814</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Хубиева Р.Р., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Хубиева Р.Р.</copyright-holder><copyright-holder xml:lang="en">Khubieva R.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/1683">https://www.ophthalmojournal.com/opht/article/view/1683</self-uri><abstract><p>Охрана здоровья детей относится к приоритетным направлениям здравоохранения во всем мире. В программе ВОЗ «Ликвидация устранимой слепоты в мире Vision - 2020» проблемам детской офтальмопатологии отдано четвертое место и созданыцелевые программы для их устранения. Внедрение современного оборудования в клиническую практику детских офтальмологовпозволило расширить границы традиционной диагностики. Микропериметрия — инновационное количественное неинвазивноедиагностическое исследование, направленное на оценку функциональной способности сетчатки в строгой корреляции с морфологией. Наряду с оценкой световой чувствительности микропериметр позволяет измерять параметры фиксации, что служитнадежным критерием ее устойчивости и косвенно отражает функциональную организацию центрального зрения. В связи с этимв литературном обзоре представлены результаты отечественных и зарубежных исследователей, которые использовали микропериметрическое тестирование как основной или дополнительный метод исследования при заболеваниях различной этиологии,таких как наследственные заболевания сетчатки, амблиопия, нистагм. Большинством авторов продемонстрирована высокаядиагностическая значимость этого метода, возможность оценки светочувствительности сетчатки, выявление нарушений со стороны фиксации, таких как эксцентричность и нестабильность, даже у пациентов детского возраста. Также было показаноиспользование микропериметрии в качестве нового метода лечения при данных заболеваниях. Зрительная реабилитация на основе обратной биологической связи, предусмотренной данным прибором, показала высокую эффективность при заболеваниях центральной области. Еще предстоит провести дополнительные исследования, чтобы определить будущие потенциальные возможности применения этой технологии, в частности в детской практике, а также развить потенциал микропериметрии как инструмента для зрительной реабилитации пациентов.</p></abstract><trans-abstract xml:lang="en"><p>Child health is a global health priority. The program “Elimination of Eliminable Blindness in the World of Vision-2020” gives the fourth place to the problems of pediatric ophthalmopathology and creates targeted programs for their elimination. The introduction of modern equipment in the clinical practice of pediatric ophthalmologists has expanded the boundaries of traditional diagnostics. Microperimetry is an innovative, quantitative, non-invasive diagnostic study aimed at assessing the functional ability of the retina in strict correlation with morphology. Along with the assessment of light sensitivity, the device allows you to measure fixation parameters, which serves as a reliable criterion for its stability and indirectly reflects the functional organization of central vision. In this regard, the literature review presents the results of domestic and foreign researchers who used microperimetric testing as the main or additional research method for diseases of various etiologies, such as hereditary retinal diseases, amblyopia, and nystagmus. Most authors have demonstrated the high diagnostic significance of this method, the ability to assess photosensitivity of the retina, the detection of fixation disorders, such as eccentricity and instability, even in pediatric patients. The use of microperimetry as a new method of treatment for these diseases has also been shown. Visual rehabilitation based on biofeedback provided by this device has shown high efficiency in diseases of the central region. More research remains to be done to determine future potential applications of this technology, in particular in pediatric practice, and to develop the potential of microperimetry as a tool for the visual rehabilitation of patients.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>микропериметрия</kwd><kwd>болезнь Штаргарта</kwd><kwd>пигментный ретинит</kwd><kwd>амблиопия</kwd><kwd>нистагм</kwd><kwd>светочувствительность сетчатки</kwd><kwd>фиксация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>microperimetry</kwd><kwd>Stargardt disease</kwd><kwd>retinitis pigmentosa</kwd><kwd>amblyopia</kwd><kwd>nystagmus</kwd><kwd>retinal photosensitivity</kwd><kwd>fixation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Нероев В.В. Организация офтальмологической помощи населению Российской Федерации. Вестник офтальмологии. 2014;130(6):8–12.</mixed-citation><mixed-citation xml:lang="en">Neroev V.V. Eye care management in Russian Federation. Annals of Ophthalmology = Vestnik oftal’mologii. 2014;130(6):8–12 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Нероев В.В., Катаргина Л.А., Коголева Л.В. Профилактика слепоты и слабовидения у детей с ретинопатией недоношенных. Вопросы современной педиатрии. 2015;14(2):265–270. DOI: 10.15690/vsp.v14i2.1296</mixed-citation><mixed-citation xml:lang="en">Neroev V.V., Katargina L.A., Kogoleva L.V. The Prevention of Blindness and Visual Impairment in Children with Retinopathy of Prematurity. Current Pediatrics = Voprosy sovremennoi pediatrii. 2015;14(2):265– 270 (In Russ.). DOI: 10.15690/vsp.v14i2.1296</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Баранов А.А., Ильин Г.А. Актуальные проблемы сохранения и укрепления здоровья детей в Российской Федерации. Российский педиатрический журнал. 2011;4:7–12.</mixed-citation><mixed-citation xml:lang="en">Baranov A.A., Ilyin G.A. Children’s health preservation and promotion in the Russian Federation: Topical problems. The Russian Journal of Pediatrics = Rossiyskiy pediatricheskiy zhurnal. 2011;4:7–12 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Fujii G.Y., de Juan E., Sunness J.S., Humayum M.S., Pieramici D.J., Chang T.S. Patient selection for macular translocation surgery using the scanning laser ophthalmoscope. Ophthalmology. 2002;109:1737–1744. DOI: 10.1016/S0161-6420(02)01120-X</mixed-citation><mixed-citation xml:lang="en">Fujii G.Y., de Juan E., Sunness J.S., Humayum M.S., Pieramici D.J., Chang T.S. Patient selection for macular translocation surgery using the scanning laser ophthalmoscope. Ophthalmology. 2002;109:1737–1744. DOI: 10.1016/S0161-6420(02)01120-X</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Longhin E., Convento E., Pilotto E., Bonin G., Vujosevic S., Kotsafti O., Midena E. Static and dynamic retinal fixation stability in microperimetry. Can J Ophthalmol. 2013;48:375–380. DOI: 10.1016/j.jcjo.2013.05.021</mixed-citation><mixed-citation xml:lang="en">Longhin E., Convento E., Pilotto E., Bonin G., Vujosevic S., Kotsafti O., Midena E. Static and dynamic retinal fixation stability in microperimetry. Can J Ophthalmol. 2013;48:375–380. DOI: 10.1016/j.jcjo.2013.05.021</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Castet E., Crossland M. Quantifying eye stability during a fixation task: a review of definitions and methods. Seeing Perceiving. 2012;25(5):449–469. DOI: 10.1163/187847611X620955</mixed-citation><mixed-citation xml:lang="en">Castet E., Crossland M. Quantifying eye stability during a fixation task: a review of definitions and methods. Seeing Perceiving. 2012;25(5):449–469. DOI: 10.1163/187847611X620955</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Новиков С.А., Нечипоренко П.А., Рыжова Д.В., Сельцова К.Н., Юрьева А.В., Мухлисова Н.Р. Специальные методы диагностики в офтальмологии: аккомодография, мезотест, микропериметрия. Современная оптометрия. 2016;10(100):15–24.</mixed-citation><mixed-citation xml:lang="en">Novikov S.A., Nechiporenko P.A., Ryzhova D.V., Seltsova K.N., Yuryeva A.V., Mukhlisova N.R. Specific diagnostic methods in ophthalmology: accomodography, mesotest, and microperimetry. Modern optometry  = Sovremennaya optometriya. 2016;10(100):15–24 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Лисочкина А. Б., Нечипоренко П.А. Микропериметрия — преимущества метода и возможности практического применения. Офтальмологические ведомости. 2009;1:18–23.</mixed-citation><mixed-citation xml:lang="en">Lisochkina A.B., Nechiporenko P.A. Microperimetry — the advantages of the method and its practical capabilities. Ophthalmology journal  = Oftal’mologicheskie vedomosti. 2009;1:18–23 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Wu Z., Ayton L.N., Luu C.D., Guymer R.H. Longitudinal Changes in Microperimetry and Low Luminance Visual Acuity in Age-Related Macular Degeneration. JAMA Ophthalmol. 2015;133(4):442–448. DOI: 10.1001/jamaophthalmol.2014.5963</mixed-citation><mixed-citation xml:lang="en">Wu Z., Ayton L.N., Luu C.D., Guymer R.H. Longitudinal Changes in Microperimetry and Low Luminance Visual Acuity in Age-Related Macular Degeneration. JAMA Ophthalmol. 2015;133(4):442–448. DOI: 10.1001/jamaophthalmol.2014.5963</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Midena E., Pilotto E. Microperimetry in age: related macular degeneration. Eye. 2017;31:985–994. DOI: 10.1038/eye.2017.34</mixed-citation><mixed-citation xml:lang="en">Midena E., Pilotto E. Microperimetry in age: related macular degeneration. Eye. 2017;31:985–994. DOI: 10.1038/eye.2017.34</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Parravano M.C., Oddone F., Tedeschi M., Chiaravallotti A., Perillo L., Boccassini B., Varano M. Retinal functional changes measured by microperimetry in neovascular age-related macular degeneration patients treated with ranibizumab. Retina. 2010;30:1017–1024. DOI: 10.1097 / IAE.0b013e3181cfd3c6</mixed-citation><mixed-citation xml:lang="en">Parravano M.C., Oddone F., Tedeschi M., Chiaravallotti A., Perillo L., Boccassini B., Varano M. Retinal functional changes measured by microperimetry in neovascular age-related macular degeneration patients treated with ranibizumab. Retina. 2010;30:1017–1024. DOI: 10.1097 / IAE.0b013e3181cfd3c6</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Sulzbacher F., Roberts P., Munk M.R., Kaider A., Kroh M.E., Sacu S., Schmidt-Erfurth U. Relationship of retinal morphology and retinal sensitivity in the treatment of neovascular age-related macular degeneration using aflibercept. Invest Ophthalmol Vis Sci. 2014;56:1158–1167. DOI: 10.1167/iovs.14-14298</mixed-citation><mixed-citation xml:lang="en">Sulzbacher F., Roberts P., Munk M.R., Kaider A., Kroh M.E., Sacu S., Schmidt-Erfurth U. Relationship of retinal morphology and retinal sensitivity in the treatment of neovascular age-related macular degeneration using aflibercept. Invest Ophthalmol Vis Sci. 2014;56:1158–1167. DOI: 10.1167/iovs.14-14298</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Raman R., Nittala M.G., Gella L., Pal S.S., Sharma T. Retinal sensitivity over hard exudates in diabetic retinopathy. J Ophthalmic Vis Res. 2015;10:160–164. DOI: 10.4103/2008-322X.163771</mixed-citation><mixed-citation xml:lang="en">Raman R., Nittala M.G., Gella L., Pal S.S., Sharma T. Retinal sensitivity over hard exudates in diabetic retinopathy. J Ophthalmic Vis Res. 2015;10:160–164. DOI: 10.4103/2008-322X.163771</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Okada K., Yamamoto S., Mizunoya S., Hoshino A., Arai M., Takatsuna Y. Correlation of retinal sensitivity measured with fundus-related microperimetry to visual acuity and retinal thickness in eyes with diabetic macular edema. Eye (Lond). 2006;20:805–809. DOI: 10,1038 / sj.eye.6702014</mixed-citation><mixed-citation xml:lang="en">Okada K., Yamamoto S., Mizunoya S., Hoshino A., Arai M., Takatsuna Y. Correlation of retinal sensitivity measured with fundus-related microperimetry to visual acuity and retinal thickness in eyes with diabetic macular edema. Eye (Lond). 2006;20:805–809. DOI: 10,1038 / sj.eye.6702014</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Vujosevic S., Pilotto E., Bottega E., Benetti E., Cavarzeran F., Midena E. Retinal fixation impairment in diabetic macular edema. Retina. 2008;28:1443–1450. DOI: 10,1097 / IAE.0b013e318183571e</mixed-citation><mixed-citation xml:lang="en">Vujosevic S., Pilotto E., Bottega E., Benetti E., Cavarzeran F., Midena E. Retinal fixation impairment in diabetic macular edema. Retina. 2008;28:1443–1450. DOI: 10,1097 / IAE.0b013e318183571e</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Cappello E., Virgili G., Tollot L., Del Borrello M., Menchini U., Zemella M. Reading ability and retinal sensitivity after surgery for macular hole and macular pucker. Retina. 2009 Sep;29(8):1111–1118. DOI: 10.1097/IAE.0b013e3181a3b832</mixed-citation><mixed-citation xml:lang="en">Cappello E., Virgili G., Tollot L., Del Borrello M., Menchini U., Zemella M. Reading ability and retinal sensitivity after surgery for macular hole and macular pucker. Retina. 2009 Sep;29(8):1111–1118. DOI: 10.1097/IAE.0b013e3181a3b832</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Giorgi, D., Contestabile M.T., Pacella E., Balacco Gabrieli С. An Instrument for Biofeedback Applied to Vision. Psychophysiol Biofeedback. 2005;30:389–395. DOI: 10.1007/s10484-005-8424-1</mixed-citation><mixed-citation xml:lang="en">Giorgi, D., Contestabile M.T., Pacella E., Balacco Gabrieli С. An Instrument for Biofeedback Applied to Vision. Psychophysiol Biofeedback. 2005;30:389–395. DOI: 10.1007/s10484-005-8424-1</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Midena E., Radin P.P., Pilotto E., Ghirlando A., Convento E., Varano M. Fixation pattern and macular sensitivity in eyes with subfoveal choroidal neovascularization secondary to age-related macular degeneration. A microperimetry study, Seminars in Ophthalmology. 2004;19(1–2):55–61. DOI: 10.1080/08820530490882896</mixed-citation><mixed-citation xml:lang="en">Midena E., Radin P.P., Pilotto E., Ghirlando A., Convento E., Varano M. Fixation pattern and macular sensitivity in eyes with subfoveal choroidal neovascularization secondary to age-related macular degeneration. A microperimetry study, Seminars in Ophthalmology. 2004;19(1–2):55–61. DOI: 10.1080/08820530490882896</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Mori F., IshiKo S., Kitaya N., Takamiya A., Sato E., Hikichi T., Yoshida A. Scotoma and fixation patterns using scanning laser ophthalmoscope microperimetry in patients with macular dystrophy. Am J Ophthalmol. 2001;132:897–902. DOI: 10.1016/ S0002-9394(01)01216-8</mixed-citation><mixed-citation xml:lang="en">Mori F., IshiKo S., Kitaya N., Takamiya A., Sato E., Hikichi T., Yoshida A. Scotoma and fixation patterns using scanning laser ophthalmoscope microperimetry in patients with macular dystrophy. Am J Ophthalmol. 2001;132:897–902. DOI: 10.1016/ S0002-9394(01)01216-8</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Fujinami K., Sergouniotis P.I., Davidson A.E., Wright G., Chana R.K., Tsunoda K., Tsubota K., Egan C.A., Robson A.G., Moore A.T., Holder G.E., Michaelides M., Webster A.R. Clinical and molecular analysis of Stargardt disease with preserved foveal structure and function. Am J Ophthalmol. 2013;156(3):487–501. DOI: 10.1016/j.ajo.2013.05.003</mixed-citation><mixed-citation xml:lang="en">Fujinami K., Sergouniotis P.I., Davidson A.E., Wright G., Chana R.K., Tsunoda K., Tsubota K., Egan C.A., Robson A.G., Moore A.T., Holder G.E., Michaelides M., Webster A.R. Clinical and molecular analysis of Stargardt disease with preserved foveal structure and function. Am J Ophthalmol. 2013;156(3):487–501. DOI: 10.1016/j.ajo.2013.05.003</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Аветисов С.Э., Киселева Т.Н., Majumdar Z., Bonner R.F., Meyers S.M., Аветисов К.С., Будзинская М.В. Метод аутофлюоресценции глазного дна в ранней диагностике возрастной макулярной дегенерации. Вестник офтальмологии. 2009;125(6):37–42.</mixed-citation><mixed-citation xml:lang="en">Avetisov S.E., Kiseleva T.N., Majumdar Z., Bonner R.F., Meyers S.M., Avetisov K.S., Budzinskaya M.V. Eye fundus autofluorescence technique in the early diagnosis of age-related macular degeneration. Annals of Ophthalmology = Vestnik oftal’mologii. 2009;125(6):37–42 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Шеремет Н.Л., Ронзина И.А., Жоржоладзе Н.В., Стрельников В.В. Взаимосвязь структурных и функциональных изменений сетчатки при болезни Штаргардта. Вестник офтальмологии. 2016;132(3):42–48. DOI: 10.17116/oftalma2016132342-48</mixed-citation><mixed-citation xml:lang="en">Sheremet N.L., Ronzina  I.A., Zhorzholadze N.V., Strel’nikov V.V. Relationship between structural and functional changes in retina in Stargardt disease. Annals of Ophthalmology  = Vestnik oftal’mologii. 2016;132(3):42–48 (In Russ.). DOI: 10.17116/oftalma2016132342-48</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Tanna P., Georgiou M., Aboshiha J., Strauss R.W., Kumaran N., Kalitzeos A., Weleber R.G., Michaelides M. Cross-Sectional and Longitudinal Assessment of Retinal Sensitivity in Patients With Childhood-Onset Stargardt Disease. Translational Vision Science &amp; Technology. 2018;7:10. DOI: 10.1167/tvst.7.6.10</mixed-citation><mixed-citation xml:lang="en">Tanna P., Georgiou M., Aboshiha J., Strauss R.W., Kumaran N., Kalitzeos A., Weleber R.G., Michaelides M. Cross-Sectional and Longitudinal Assessment of Retinal Sensitivity in Patients With Childhood-Onset Stargardt Disease. Translational Vision Science &amp; Technology. 2018;7:10. DOI: 10.1167/tvst.7.6.10</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Mori F., Ishiko S., Kitaya N., Takamiya A., Sato E., Hikichi T., Yoshida A. Scotoma and fixation patterns using scanning laser ophthalmoscope microperimetry in patients with macular dystrophy. Am J Ophthalmol. 2001;132:897–902. DOI: 10.1016/ S0002-9394(01)01216-8</mixed-citation><mixed-citation xml:lang="en">Mori F., Ishiko S., Kitaya N., Takamiya A., Sato E., Hikichi T., Yoshida A. Scotoma and fixation patterns using scanning laser ophthalmoscope microperimetry in patients with macular dystrophy. Am J Ophthalmol. 2001;132:897–902. DOI: 10.1016/ S0002-9394(01)01216-8</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Reinhard J., Messias A., Dietz K., Mackeben M., Lakmann R., Hendrik P.N., Alpfenstend-Sylla E., Bernhard H.F., Mathias W., Zrenner E., Trauzettel-Klosinski S. Quantifying fixation in patients with Stargardt disease. Vis Res. 2007;47:2076–2085. DOI: 10.1016/j.visres.2007.04.012</mixed-citation><mixed-citation xml:lang="en">Reinhard J., Messias A., Dietz K., Mackeben M., Lakmann R., Hendrik P.N., Alpfenstend-Sylla E., Bernhard H.F., Mathias W., Zrenner E., Trauzettel-Klosinski S. Quantifying fixation in patients with Stargardt disease. Vis Res. 2007;47:2076–2085. DOI: 10.1016/j.visres.2007.04.012</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Strauss R.W., Ho A., Muñoz B., Cideciyan A.V., Sahel J.A., Sunness J.S., Birch D.G., Bernstein P.S., Michaelides M., Traboulsi E.I., Zrenner E., Sadda S., Ervin A.M., West S., Scholl H.P. The Natural History of the Progression of Atrophy Secondary to Stargardt Disease (ProgStar) Studies: design and Baseline Characteristics: progStar Report No. 1. Ophthalmology. 2016;123(4):817–828. DOI: 10.1016/j.ophtha.2015.12.009</mixed-citation><mixed-citation xml:lang="en">Strauss R.W., Ho A., Muñoz B., Cideciyan A.V., Sahel J.A., Sunness J.S., Birch D.G., Bernstein P.S., Michaelides M., Traboulsi E.I., Zrenner E., Sadda S., Ervin A.M., West S., Scholl H.P. The Natural History of the Progression of Atrophy Secondary to Stargardt Disease (ProgStar) Studies: design and Baseline Characteristics: progStar Report No. 1. Ophthalmology. 2016;123(4):817–828. DOI: 10.1016/j.ophtha.2015.12.009</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Strauss R.W., Kong X., Bittencourt M.G., Ho A., Jha A., Schönbach E.M., Ahmed M.I., Muñoz B., Ervin A.M., Michaelides M., Birch D.G., Sahel J.A., Sunness J.S., Zrenner E., Bagheri S., Ip M6., Sadda S., West S. Scotopic Microperimetric Assessment of Rod Function in Stargardt Disease (SMART) Study: design and Baseline Characteristics (Report No. 1). Ophthalmic Res. June 2018;1–8. DOI: 10.1159/000488711</mixed-citation><mixed-citation xml:lang="en">Strauss R.W., Kong X., Bittencourt M.G., Ho A., Jha A., Schönbach E.M., Ahmed M.I., Muñoz B., Ervin A.M., Michaelides M., Birch D.G., Sahel J.A., Sunness J.S., Zrenner E., Bagheri S., Ip M6., Sadda S., West S. Scotopic Microperimetric Assessment of Rod Function in Stargardt Disease (SMART) Study: design and Baseline Characteristics (Report No. 1). Ophthalmic Res. June 2018;1–8. DOI: 10.1159/000488711</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Xue K., Jolly J.K., Barnard A.R., Rudenko A., Salvetti A.P., Patrício M.I., Edwards T.L., Groppe M., Orlans H.O., Tolmachova T., Black G.C., Webster A.R., Lotery A.J., Holder G.E., Downes S.M., Seabra M.C., MacLaren R.E. Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia. Nat Med. 2018; 24(10):1507–1512. DOI: 10.1038/s41591-018-0185-5</mixed-citation><mixed-citation xml:lang="en">Xue K., Jolly J.K., Barnard A.R., Rudenko A., Salvetti A.P., Patrício M.I., Edwards  T.L., Groppe M., Orlans H.O., Tolmachova T., Black G.C., Webster A.R., Lotery A.J., Holder G.E., Downes S.M., Seabra M.C., MacLaren R.E. Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia. Nat Med. 2018; 24(10):1507–1512. DOI: 10.1038/s41591-018-0185-5</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Lam B.L., Davis J.L., Gregori N.Z., MacLaren R.E., Girach A., Verriotto J.D., Rodriguez B., Rosa P.R., Zhang X., Feuer W.J. Choroideremia Gene Therapy Phase 2 Clinical Trial: 24-Month Results. Am J Ophthalmol. 2019;(197):65–73. DOI: 10.1016/j. ajo.2018.09.012.</mixed-citation><mixed-citation xml:lang="en">Lam B.L., Davis J.L., Gregori N.Z., MacLaren R.E., Girach A., Verriotto J.D., Rodriguez B., Rosa P.R., Zhang X., Feuer W.J. Choroideremia Gene Therapy Phase 2 Clinical Trial: 24-Month Results. Am J Ophthalmol. 2019;(197):65–73. DOI: 10.1016/j. ajo.2018.09.012.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Battu R., Khanna A., Hegde B. Correlation of structure and function of the macula in patients with retinitis pigmentosa. Eye (Lond) 2015 Jul; 29(7): 895–901. DOI: 10.1038/eye.2015.61</mixed-citation><mixed-citation xml:lang="en">Battu R., Khanna A., Hegde B. Correlation of structure and function of the macula in patients with retinitis pigmentosa. Eye (Lond) 2015 Jul; 29(7): 895–901. DOI: 10.1038/eye.2015.61</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Jolly J.K., Xue K., Edwards T.L., Groppe M., MacLaren R.E. Characterizing the Natural History of Visual Function in Choroideremia Using Microperimetry and Multimodal Retinal Imaging. Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5575–5583. DOI: 10.1167/iovs.17-22486</mixed-citation><mixed-citation xml:lang="en">Jolly J.K., Xue K., Edwards T.L., Groppe M., MacLaren R.E. Characterizing the Natural History of Visual Function in Choroideremia Using Microperimetry and Multimodal Retinal Imaging. Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5575–5583. DOI: 10.1167/iovs.17-22486</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Muslubas S., Karacorlu I., Hocaoglu S., Ersoz M., Giray M. Features os the macula and central visual field and fixation pattern with retinitis pigmentosa. Retina 2018;38:424–431. DOI: 10.1097/IAE.0000000000001532</mixed-citation><mixed-citation xml:lang="en">Muslubas S., Karacorlu I., Hocaoglu S., Ersoz M., Giray M. Features os the macula and central visual field and fixation pattern with retinitis pigmentosa. Retina 2018;38:424–431. DOI: 10.1097/IAE.0000000000001532</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Wallace D.K., Repka M.X., Lee K.A. Michele M., Christiansen S.P., Morse C.L., Sprunger D.T. Amblyopia preferred practice pattern. Ophthalmology. 2018;(125):105–142. DOI: 10.1016/j.ophtha.2017.10.008</mixed-citation><mixed-citation xml:lang="en">Wallace D.K., Repka M.X., Lee K.A. Michele M., Christiansen S.P., Morse  C.L., Sprunger D.T. Amblyopia preferred practice pattern. Ophthalmology. 2018;(125):105–142. DOI: 10.1016/j.ophtha.2017.10.008</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Шамшинова А.М., Кащенко Т.П., Кампф П. Амблиопия: патогенез, дифференциальная диагностика и обоснование принципов лечения. Зрительные функции при амблиопии разного генеза. М.: Медицина. 2003. C. 447–459.</mixed-citation><mixed-citation xml:lang="en">Shamshinova A.M., Kashhenko T.P., Kampf P. Amblyopia: pathogenesis, differential diagnosis and substantiation of treatment principles. Visual functions in amblyopia of various origins Moscow: Medicina, 2003. P. 447–459 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Carpineto P., Ciancaglini M., Nubile M. Fixation patterns evaluation by means of MP-1 microperimeter in microstrabismic children treated for unilateral amblyopia. Eur J Ophthalmol. 2007;17:885–890. DOI: 10.1177/112067210701700603</mixed-citation><mixed-citation xml:lang="en">Carpineto P., Ciancaglini M., Nubile M. Fixation patterns evaluation by means of MP-1 microperimeter in microstrabismic children treated for unilateral amblyopia. Eur J Ophthalmol. 2007;17:885–890. DOI: 10.1177/112067210701700603</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Gonzalez E.G., Wong A.M., Niechwiej-Szwedo E., Tarita-Nistor L., Steinbach M.J. Eye position stability in amblyopia and in normal binocular vision. Invest Ophthalmol Vis Sci. 2012;53:5386–5394. DOI: 10.1167/iovs.12-9941</mixed-citation><mixed-citation xml:lang="en">Gonzalez E.G., Wong A.M., Niechwiej-Szwedo E., Tarita-Nistor L., Steinbach M.J. Eye position stability in amblyopia and in normal binocular vision. Invest Ophthalmol Vis Sci. 2012;53:5386–5394. DOI: 10.1167/iovs.12-9941</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Birch E.E., Subramanian V. Fixation instability in anisometropic children with reduced stereopsis. Ophthalmology and Strabismus, San Antonio, Texas, 2012. P. 24–28. DOI: 10.1016/j.jaapos.2013.03.011</mixed-citation><mixed-citation xml:lang="en">Birch E.E., Subramanian V. Fixation instability in anisometropic children with reduced stereopsis. Ophthalmology and Strabismus, San Antonio, Texas, 2012. P. 24–28. DOI: 10.1016/j.jaapos.2013.03.011</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Subramanian V., Jost R.M., Birch E.E. A quantitative study of fixation stability in amblyopia. Invest Ophthalmol Vis Sci. 2013;54(3):1998–2003. DOI: 10.1167/ iovs.12-11054</mixed-citation><mixed-citation xml:lang="en">Subramanian V., Jost R.M., Birch E.E. A quantitative study of fixation stability in amblyopia. Invest Ophthalmol Vis Sci. 2013;54(3):1998–2003. DOI: 10.1167/ iovs.12-11054</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Trabucco P., Mafrici M., Salomone M., Valente S., Di Crescenzo Ch., Spadea L., Vingolo E.M. Microperimetric findings in children with amblyopia. Investigative Ophthalmology &amp; Visual Science. 2014;55:794. [обновлено 26 апреля 2020; процитировано 27 апреля 2020]. https://iovs.arvojournals.org/article. aspx?articleid=2272314</mixed-citation><mixed-citation xml:lang="en">Trabucco P., Mafrici M., Salomone M., Valente S., Di Crescenzo Ch., Spadea L., Vingolo E.M. Microperimetric findings in children with amblyopia. Investigative Ophthalmology &amp; Visual Science. 2014;55:794. [обновлено 26 апреля 2020; процитировано 27 апреля 2020]. https://iovs.arvojournals.org/article. aspx?articleid=2272314</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Jocelyn Zurevinsky. Eccentric Fixation and Inverse Occlusion: Renewing Our Interest?. Journal of Binocular Vision and Ocular Motility. 2019;69:136–140. DOI: 10.3109/08820538.2015.1123739</mixed-citation><mixed-citation xml:lang="en">Jocelyn Zurevinsky. Eccentric Fixation and Inverse Occlusion: Renewing Our Interest?. Journal of Binocular Vision and Ocular Motility. 2019;69:136–140. DOI: 10.3109/08820538.2015.1123739</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Кащенко М.А., Кащенко Т.П., Магарамова М.Д., Педанова Е.К., Голяховский С.Е. Влияние плеоптического лечения на отклонение точки фиксации от центра макулярной зоны у детей с амблиопией различной степени при исследовании методом микропериметрии. Российская детская офтальмология. 2019;2:22–24. DOI: 10.25276/2307-6658-2019-2-22-24</mixed-citation><mixed-citation xml:lang="en">Kashchenko M.A., Kashchenko T.P., Magaramova M.D., Pedanova E.K., Golyakhovsky S.E. Influence of pleoptic treatment on the deviation of the fixation point from the center of the macular zone in children with amblyopia of varying degrees when studied by the method microperimetry. The Russian Journal of Pediatrics = Rossijskaya detskaya oftal’mologiya. 2019;2:22–24 (In Russ.). DOI: 10.25276/2307-6658-2019-2-22-24</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Кошелев Д.И. Зрительные вызванные потенциалы и движения глаза при фиксации как средства объективного мониторинга зрительных функций у детей с нарушением центрального зрения. Практическая медицина. 2019;7(1):127– 133. DOI: 10.32000/2072-1757-2019-1-127-133</mixed-citation><mixed-citation xml:lang="en">Koshelev D.I. Visual evoked potentials and eye movements during fixation as a means of objective monitoring of visual functions in children with central vision impairment. Practical medicine  = Prakticheskaya meditsina. 2019;17(1):127–133 (In Russ.). DOI: 10.32000/2072-1757-2019-1-127-133</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Тарутта Е.П., Чернышева С.Г., Губкина Г.Л., Кантаржи Е.П., Апаев А.В., Киселева О.А. Новый способ диагностики и оценки эффективности лечения оптического нистагма с использованием микропериметрии. Российская педиатрическая офтальмология. 2014;1:46–48.</mixed-citation><mixed-citation xml:lang="en">Tarutta E.P., Chernysheva S.G., Gubkina G.L., Kantarzhi E.P., Apaev A.V., Kiseleva O.A. A new way of diagnostic and treatment effectiveness evaluation of the optical nystagmus using microperimetry. Russian pediatric ophthalmology  = Rossiyskaya pediatricheskaya oftal`mologiya. 2014;1:46–48 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Molina-Martín A., Piñero D.P., Pérez-Cambrodí R.J. Fixation pattern analysis with microperimetry in nystagmus patients. Can J Ophthalmol. 2015;50(6):413–421. DOI: 10.1016/ j.jcjo.2015.07.012</mixed-citation><mixed-citation xml:lang="en">Molina-Martín A., Piñero D.P., Pérez-Cambrodí R.J. Fixation pattern analysis with microperimetry in nystagmus patients. Can J Ophthalmol. 2015;50(6):413–421. DOI: 10.1016/ j.jcjo.2015.07.012</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Vingolo E.M., Cavarretta S., Domanico D., Parisi F., Malagola R. Microperimetric biofeedback in AMD patients. Appl Psychophysiol Biofeedback. 2007;32(3–4):185– 189. DOI: 10.1007/s10484-007-9038-6</mixed-citation><mixed-citation xml:lang="en">Vingolo E.M., Cavarretta S., Domanico D., Parisi F., Malagola R. Microperimetric biofeedback in AMD patients. Appl Psychophysiol Biofeedback. 2007;32(3–4):185– 189. DOI: 10.1007/s10484-007-9038-6</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Vingolo E.M., Salvatore S., Cavarretta S. Low-vision rehabilitation by means of MP-1 biofeedback examination in patients with different macular diseases: a pilot study. Appl Psychophysiol Biofeedback. 2009;34(2):127–133. DOI: 10.1007/s10484009-9083-4</mixed-citation><mixed-citation xml:lang="en">Vingolo E.M., Salvatore S., Cavarretta S. Low-vision rehabilitation by means of MP-1 biofeedback examination in patients with different macular diseases: a pilot study. Appl Psychophysiol Biofeedback. 2009;34(2):127–133. DOI: 10.1007/s10484009-9083-4</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Nistor L.T., Gonzalez E.G., Markowitz S.N., Steinbach M.J. Plasticity of fixation in patients with central vision loss. Vis Neurosci. 2009;26(5–6):487–494. DOI: 10.1017/S0952523809990265</mixed-citation><mixed-citation xml:lang="en">Nistor L.T., Gonzalez E.G., Markowitz S.N., Steinbach M.J. Plasticity of fixation in patients with central vision loss. Vis Neurosci. 2009;26(5–6):487–494. DOI: 10.1017/S0952523809990265</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Vingolo E.M., Salvatore S., Domanico D., Spadea L., Nebbioso M. Visual rehabilitation in patients with myopic maculopathy: our experience. Can J Ophthalmol. 2013;48(5):438–442. DOI: 10.1016/j.jcjo.2013.08.004</mixed-citation><mixed-citation xml:lang="en">Vingolo E.M., Salvatore S., Domanico D., Spadea L., Nebbioso M. Visual rehabilitation in patients with myopic maculopathy: our experience. Can J Ophthalmol. 2013;48(5):438–442. DOI: 10.1016/j.jcjo.2013.08.004</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Патент РФ на изобретение 2702158 C1 13.03.2019. Кащенко М.А., Кащенко Т.П., Педанова Е.К., Магамарова М.Д. Способ формирования центральной зрительной фиксации у детей и взрослых с амблиопией с нецентральной фиксацией. Обновлено 26 апреля 2020; процитировано 27 апреля 2020. https://www.elibrary.ru/item. asp?id=41276584</mixed-citation><mixed-citation xml:lang="en">patent RU 2702158 C1 13.03.2019. Kashchenko  M.A., Kashchenko T.P., Pedanova E.K., Magamarova M.D. Method for central visual fixation in children and adults with amblyopia with noncentral fixation. Обновлено 26 апреля 2020; процитировано 27 апреля 2020. https://www.elibrary.ru/item. asp?id=41276584</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Toto L., Di Antonio L., Mastropasqua A., De Nicola C., Mastropasqua L. Rehabilitation with MP1 biofeedback training of a posterior microphthalmos case. Can J Ophthalmol. 2013;48(5):107–e111. DOI: 10.1016/j.jcjo.2013.02.006</mixed-citation><mixed-citation xml:lang="en">Toto L., Di Antonio L., Mastropasqua A., De Nicola C., Mastropasqua L. Rehabilitation with MP1 biofeedback training of a posterior microphthalmos case. Can J Ophthalmol. 2013;48(5):107–e111. DOI: 10.1016/j.jcjo.2013.02.006</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
