ophthalmologyОфтальмологияOphthalmology in Russia1816-50952500-0845Ophthalmology10.18008/1816-5095-2022-1-53-57ophthalmology-1770Research ArticleОБЗОРЫREVIEWSРоль белков теплового шока при системных сосудистых катастрофах и острых сосудистых заболеваниях органа зренияThe Role of Heat Shock Proteins in Systemic Vascular Catastrophes and in Acute Vascular Diseases of an Eyehttps://orcid.org/0000-0002-5899-2714МошетоваЛ. К.MoshetovaL. K.

Мошетова Людмила Константиновна, доктор медицинских наук, президент, заведующая кафедрой офтальмологии, профессор, академик РАН, pаслуженный врач РФ

ул. Баррикадная, 2/1, стр. 1, Москва, 125993

Moshetova Larisa K., head of ophthalmology department, MD, Professor, academician of the RAS

Barrikadnaya str., 2/1, bld. 1. Moscow, 125993

https://orcid.org/0000-0002-0862-514XУшароваС. А.UsharovaS. A.

Ушарова Светлана Александровна, аспирант кафедры офтальмологии

ул. Баррикадная, 2/1, стр. 1, Москва, 125993

Usharova Svetlana A., postgraduate

Barrikadnaya str., 2/1, bld. 1. Moscow, 125993

svetlalextar@gmail.comhttps://orcid.org/0000-0002-1271-1630СимоноваС. В.SimonovaS. V.

Симонова Симона Валентиновна, ассистент кафедры офтальмологии; заведующая организационно-методическим отделом по офтальмологии

ул. Баррикадная, 2/1, стр. 1, Москва, 125993; ул. Шарикоподшипниковская, 9, Москва, 115088

Simonova Simona V., assistant of ophthalmology department, head of organization and methodology department for ophthalmology

Barrikadnaya str., 2/1, bld. 1. Moscow, 125993; Sharikopodshipnikovskaya str., 9, Moscow, 115088

https://orcid.org/0000-0002-4989-7467ТуркинаК. И.TurkinaK. I.

Туркина Ксения Ивановна, кандидат медицинских наук, доцент кафедры офтальмологии

ул. Баррикадная, 2/1, стр. 1, Москва, 125993

Turkina Ksenia I., PhD, Associate Professor of ophthalmology department

Barrikadnaya str., 2/1, bld. 1. Moscow, 125993

https://orcid.org/0000-0003-2014-2535СабуринаИ. Н.SaburinaI. N.

Сабурина Ирина Николаевна, доктор биологических наук, заведующая лабораторией клеточной биологии и патологии развития

ул. Балтийская, 8, Москва, 125315

Saburina Irina N., doctor in Biology, head of laboratory of cell biology and developmental pathology

Baltiyskaya str., 8, Moscow, 125315

ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской ФедерацииРоссияRussian Medical Academy of Continuous Professional EducationRussian FederationФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации; ГБУ «Научно-исследовательский институт организации здравоохранения и медицинского менеджмента» Департамента здравоохранения г. МосквыРоссияRussian Medical Academy of Continuous Professional Education; Research Institute for Healthcare Organization and Medical ManagementRussian FederationФГБНУ «Научно-исследовательский институт общей патологии и патофизиологии»РоссияInstitute of General Pathology and PathophysiologyRussian Federation2022070420221915357Copyright © Мошетова Л.К., Ушарова С.А., Симонова С.В., Туркина К.И., Сабурина И.Н., 20222022Мошетова Л.К., Ушарова С.А., Симонова С.В., Туркина К.И., Сабурина И.Н.Moshetova L.K., Usharova S.A., Simonova S.V., Turkina K.I., Saburina I.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.ophthalmojournal.com/opht/article/view/1770

Нарушение кровообращения по сосудам сетчатки, несомненно, является стрессовой для организма ситуацией. В ответ на любой стресс в организме вырабатываются белки теплового шока (HSP — heat schok proteins), или так называемые стресс-белки. Более того, ряд современных исследований свидетельствует о том, что HSP могут выступать в качестве аутоантигенов, являющихся компонентами иммунной системы, вовлеченной в патогенез сосудистых патологий. К настоящему времени уже доказано, что ряд определенных белов теплового шока (HSP 60, 70) играет значимую роль в патогенезе атеросклероза, а также различных нарушений кровообращения в сосудах головного мозга. Кроме того, рассматривается возможность использования данных о содержании и концентрации определенных HSP и антител к ним в плазме крови пациентов в качестве диагностических и прогностических маркеров системных сосудистых заболеваний. Со стороны органа зрения выявлено, что HSP оказывают повреждающее действие на ганглиозные клетки сетчатки, а также совместно с антителами, вырабатывающимися в ответ на их присутствие, участвуют в патогенезе глаукомы. Однако пока нет данных о роли HSP в патогенезе нарушения кровообращения в сосудах сетчатки и возможности использования данных молекул в качестве диагностических или прогностических маркеров подобных состояний.

The disruption of blood flow through the retinal vessels is undoubtedly a stressful situation for the body. In response to any stress, the body produces heat shock proteins or so-called stress proteins. Moreover, a number of modern studies indicate that HSP may act as autoantigens, which are components of the immune system involved in the pathogenesis of vascular pathologies. By now, a number of certain heat shock proteins (HSP 60, 70) have already been proven to play a significant role in the pathogenesis of atherosclerosis as well as various circulatory disorders in the cerebral vessels. In addition, the possibility of using the data on the content and concentration of certain HSPs and antibodies to them in the blood plasma of patients as diagnostic and prognostic markers of systemic vascular diseases is considered. On the visual organ side, HSPs have been found to have damaging effects on retinal ganglion cells and, together with antibodies produced in response to their presence, are involved in the pathogenesis of glaucoma. However, there is currently no data on the role of HSP in the pathogenesis of retinal blood flow disorders and the possibility of using these molecules as diagnostic or prognostic markers of such conditions.

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The authors declare that there are no conflicts of interest present.