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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2022-1-58-62</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-1771</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Хирургические аспекты лечения рецидивирующих макулярных отверстий</article-title><trans-title-group xml:lang="en"><trans-title>Surgical Aspects of Recurrent Macular Holes Treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0863-7762</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Самойлов</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Samoylov</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Самойлов Александр Николаевич, заведующий кафедрой офтальмологии; профессор, доктор медицинских наук, заслуженный врач РФ, РТ, главный специалист ГАУЗ «РКОБ МЗ РТ им. проф. Е.В. Адамюка»</p><p>ул. Бутлерова, 49, Казань, 420012; ул. Бутлерова, 14, Казань, 420012</p></bio><bio xml:lang="en"><p>Samoylov Alexander N., MD, Professor, Head of the Department of ophthalmology</p><p>Butlerov str., 49, Kazan, 420012; Butlerov str., 14, Kazan, 420012</p></bio><email xlink:type="simple">samoilovan16@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хайбрахманов</surname><given-names>Т. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Khaibrakhmanov</surname><given-names>T. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хайбрахманов Тимур Рамилевич, ординатор кафедры офтальмологии</p><p>ул. Бутлерова, 49, Казань, 420012</p></bio><bio xml:lang="en"><p>Khaibrakhmanov Timur R., Resident of Ophthalmology Department</p><p>Butlerov str., 49, Kazan, 420012</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хайбрахманова</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Khaibrakhmanova</surname><given-names>G. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хайбрахманова Гульчачак Айратовна, ординатор кафедры офтальмологии</p><p>ул. Бутлерова, 49, Казань, 420012</p></bio><bio xml:lang="en"><p>Khaibrakhmanova Gulchachak A., Resident of Ophthalmology Department</p><p>Butlerov str., 49, Kazan, 420012</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Самойлова</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Samoilova</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Самойлова Полина Александровна, студентка</p><p>ул. Бутлерова, 49, Казань, 420012</p></bio><bio xml:lang="en"><p>Samoilova Polina A., Student</p><p>Butlerov str., 49, Kazan, 420012</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ «Казанский государственный медицинский университет» Министерства здравоохранения Российской Федерации; ГАУЗ «Республиканская клиническая офтальмологическая больница имени профессора Е.В. Адамюка» Министерства здравоохранения Республики Татарстан</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kazan State Medical University; Republican Clinical Ophthalmologic Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ «Казанский государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kazan State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>07</day><month>04</month><year>2022</year></pub-date><volume>19</volume><issue>1</issue><fpage>58</fpage><lpage>62</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Самойлов А.Н., Хайбрахманов Т.Р., Хайбрахманова Г.А., Самойлова П.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Самойлов А.Н., Хайбрахманов Т.Р., Хайбрахманова Г.А., Самойлова П.А.</copyright-holder><copyright-holder xml:lang="en">Samoylov A.N., Khaibrakhmanov T.R., Khaibrakhmanova G.A., Samoilova P.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/1771">https://www.ophthalmojournal.com/opht/article/view/1771</self-uri><abstract><p>Несмотря на высокий уровень развития современной хирургии полных макулярных отверстий, рецидивирующие макулярные отверстия остаются довольно серьезной проблемой для витреоретинальных хирургов и по происхождению могут быть двух типов: макулярные отверстия, не закрывшиеся после первичной хирургии, и макулярные отверстия, вновь развившиеся после успешной первой операции. В зарубежной литературе эти типы принято выделять как персистирующие и рецидивирующие макулярные отверстия. Обзор содержит сведения о современной отечественной и зарубежной научной литературе, посвященной эпидемиологии, причинам развития и хирургическому лечению рецидивирующих макулярных отверстий. Представлены сведения о рациональности и эффективности современных хирургических подходов к лечению данного состояния. Освещены наиболее эффективные методы лечения полных макулярных отверстий большого диаметра, являющихся одной из основных причин незакрытия дефекта в ходе первой операции или при рецидиве данного состояния после первого успешного вмешательства. Основываясь на анализе данных научной литературы, можно сказать, что основными методами выбора в хирургии рецидивирующих макулярных отверстий в настоящее время являются применение богатой тромбоцитами плазмы и различных модификаций методики инвертированного клапана внутренней пограничной мембраны, трансплантации аутологичной внутренней пограничной мембраны, в том числе метод перемещенного клапана внутренней пограничной мембраны.</p></abstract><trans-abstract xml:lang="en"><p>Despite the high level of development of modern macular surgery, recurrent macular holes remain a rather serious problem for vitreoretinal surgeons. Recurrent macular holes can be of two types: macular holes that have not closed after primary surgery, and macular holes that have reopened after a successful initial surgery. In foreign literature they are called persistent and recurrent macular holes. This article presents a review of modern scientific literature on epidemiology, causes of development and surgical treatment of recurrent macular holes. This review provides information on the rationality and effectiveness of modern surgical approaches to the treatment of this condition. The most effective methods for treating large macular holes, which are one of the main causes of failure to close a defect during the first surgery or the development of a recurrence of this condition sometime after the first surgery, are covered. Based on the literature data, we can say that the main methods of choice in surgery for recurrent macular holes today are the use of platelet-rich plasma and various modifications of the inverted internal limiting membrane flap technique, transplantation of the autologous internal limiting membrane, including the displaced internal limiting membrane flap technique patented in the Russian Federation.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рецидивирующее макулярное отверстие</kwd><kwd>макулярное отверстие большого диаметра</kwd><kwd>инвертированный клапан ВПМ</kwd><kwd>перемещенный клапан ВПМ</kwd><kwd>богатая тромбоцитами плазма</kwd></kwd-group><kwd-group xml:lang="en"><kwd>recurrent macular hole</kwd><kwd>large macular hole</kwd><kwd>inverted internal limiting membrane flap technique</kwd><kwd>displaced internal limiting membrane flap</kwd><kwd>platelet-rich plasma</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Joachim N., Mitchell P., Burlutsky G. The Incidence and Progression of Age-Related Macular Degeneration over 15 Years. The Blue Mountains Eye Study. 2015;122(12):2482–2489. DOI: 10.1016/j.ophtha.2015.08.002</mixed-citation><mixed-citation xml:lang="en">Joachim N., Mitchell P., Burlutsky G. The Incidence and Progression of Age-Related Macular Degeneration over 15 Years. The Blue Mountains Eye Study. 2015;122(12):2482–2489. DOI: 10.1016/j.ophtha.2015.08.002</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Klein R., Klein B.E., Knudtson M.D., Fifteen-year cumulative incidence of age-related macular degeneration. The Beaver Dam Eye Study. 2007;114(2):253–262. DOI: 10.1016/j.ophtha.2006.10.040</mixed-citation><mixed-citation xml:lang="en">Klein R., Klein B.E., Knudtson M.D., Fifteen-year cumulative incidence of age-related macular degeneration. The Beaver Dam Eye Study. 2007;114(2):253–262. DOI: 10.1016/j.ophtha.2006.10.040</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">McCannel C.A., Ensminger J.L., Diehl N.N., Population-based incidence of macular holes. Ophthalmology. 2009;116(7):1366–1369. DOI: 10.1016/j.ophtha.2009.01.052</mixed-citation><mixed-citation xml:lang="en">McCannel C.A., Ensminger J.L., Diehl N.N., Population-based incidence of macular holes. Ophthalmology. 2009;116(7):1366–1369. DOI: 10.1016/j.ophtha.2009.01.052</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Rahmani B., Tielsch J.M., Katz J. The cause-specific prevalence of visual impairment in an urban population. The Baltimore Eye Survey. Ophthalmology. 1996;103(11):1721–1726.</mixed-citation><mixed-citation xml:lang="en">Rahmani B., Tielsch J.M., Katz J. The cause-specific prevalence of visual impairment in an urban population. The Baltimore Eye Survey. Ophthalmology. 1996;103(11):1721–1726.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Kelly N.E., Wendel R.T., Vitreous surgery for idiopathic macular holes. Results of a pilot study. Arch Ophthalmol. 1991;109(5):654–659. DOI: 10.1001/archopht.1991.01080050068031</mixed-citation><mixed-citation xml:lang="en">Kelly N.E., Wendel R.T., Vitreous surgery for idiopathic macular holes. Results of a pilot study. Arch Ophthalmol. 1991;109(5):654–659. DOI: 10.1001/archopht.1991.01080050068031</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Самойлов А.Н., Фазлеева Г.А., Хайбрахманов Т.Р., Самойлова П.А., Фазлеева М.А. Ретроспективный анализ результатов хирургического лечения макулярных разрывов большого диаметра. Казанский медицинский журнал. 2018;99(2):341–344. DOI: 10.17816/KMJ2018-341</mixed-citation><mixed-citation xml:lang="en">Samoylov A.N., Fazleeva G.A., Khaibrakhmanov T.R., Samoylova P.A., Fazleeva M.A. A retrospective analysis of the results of surgical treatment of large macular holes. Kazan medical journal = Kazanskiy meditsinskiy zhurnal. 2018;99(2):341–344 (In Russ.)]. DOI: 10.17816/KMJ2018-341</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Wendel R.T., Patel A.C., Kelly N.E., Vitreous surgery for macular holes. Ophthalmology. 1993;100(11):1671–1676. DOI: 10.1016/s0161-6420(93)31419-3</mixed-citation><mixed-citation xml:lang="en">Wendel R.T., Patel A.C., Kelly N.E., Vitreous surgery for macular holes. Ophthalmology. 1993;100(11):1671–1676. DOI: 10.1016/s0161-6420(93)31419-3</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Tognetto D., Grandin R., Sanguinetti G. Internal limiting membrane removal during macular hole surgery: results of a multicenter retrospective study. Ophthalmology. 2006;113(8):1401–1410. DOI: 10.1016/j.ophtha.2006.02.061</mixed-citation><mixed-citation xml:lang="en">Tognetto D., Grandin R., Sanguinetti G. Internal limiting membrane removal during macular hole surgery: results of a multicenter retrospective study. Ophthalmology. 2006;113(8):1401–1410. DOI: 10.1016/j.ophtha.2006.02.061</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Самойлов А.Н., Хайбрахманов Т.Р., Фазлеева Г.А., Самойлова П.А. Идиопатический макулярный разрыв: история и современное состояние проблемы. Вестник офтальмологии. 2017;133(6):128–134. DOI: 10.17116/oftalma20171336131-137</mixed-citation><mixed-citation xml:lang="en">Samoylov A.N., Khaibrakhmanov T.R., Fazleeva G.A., Samoylova P.A. Idiopathic macular hole: history and status quo review. Annals of Ophthalmology = Vestnik oftal’mologii. 2017;133(6):128–134 (in Russ.)]. DOI: 10.17116/oftalma20171336131-137</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Самойлов А.Н., Хайбрахманов Т.Р., Фазлеева Г.А. Сравнительный анализ результатов хирургического лечения идиопатических макулярных разрывов большого диаметра в зависимости от способа тампонады витреальной полости. Международный студенческий научный вестник. 2017;4(7):993–995.</mixed-citation><mixed-citation xml:lang="en">Samoylov A.N., Khaibrakhmanov T.R., Fazleeva G.A. Comparative analysis of the results of surgical treatment of idiopathic macular holes of large diameter depending on the method of tamponade of the vitreous cavity. International student science newsletter = Mezhdunarodnyy studencheskiy nauchnyy vestnik. 2017;4(7):993–995 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Paques M., Massin P., Blain P., Duquesnoy A.S. A GaudricLong-term incidence of reopening of macular holes. Ophthalmology. 2000;107(4):760–765. DOI: 10.1016/s0161-6420(99)00182-7</mixed-citation><mixed-citation xml:lang="en">Paques M., Massin P., Blain P., Duquesnoy A.S. A GaudricLong-term incidence of reopening of macular holes. Ophthalmology. 2000;107(4):760–765. DOI: 10.1016/s0161-6420(99)00182-7</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Kumagai K., Furukawa M., Ogino N., Larson E. Incidence and factors related to macular hole reopening. Am. J. Ophthalmol. 2010;149:127–132. DOI: 10.1016/j.ajo.2009.08.002</mixed-citation><mixed-citation xml:lang="en">Kumagai K., Furukawa M., Ogino N., Larson E. Incidence and factors related to macular hole reopening. Am. J. Ophthalmol. 2010;149:127–132. DOI: 10.1016/j.ajo.2009.08.002</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bhatnagar P. Reopening of previously closed macular holes after cataract extraction. Am. J. Ophthalmol. 2007;144(2):252–259. DOI: 10.1016/j.ajo.2007.04.041</mixed-citation><mixed-citation xml:lang="en">Bhatnagar P. Reopening of previously closed macular holes after cataract extraction. Am. J. Ophthalmol. 2007;144(2):252–259. DOI: 10.1016/j.ajo.2007.04.041</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Uemoto R., Yamamoto S., Tsukahara I Efficacy of internal limiting membrane removal for retinal detachments resulting from a myopic macular hole. Retina. 2004;24(4):560–566. DOI: 10.1097/00006982-200408000-00009</mixed-citation><mixed-citation xml:lang="en">Uemoto R., Yamamoto S., Tsukahara I Efficacy of internal limiting membrane removal for retinal detachments resulting from a myopic macular hole. Retina. 2004;24(4):560–566. DOI: 10.1097/00006982-200408000-00009</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Lim L.S., Tsai A., Wong D. Prognostic factor analysis of vitrectomy for retinal detachment associated with myopic macular holes. Ophthalmology. 2014;121:305–310. DOI: 10.1016/j.ophtha.2013.08.033</mixed-citation><mixed-citation xml:lang="en">Lim L.S., Tsai A., Wong D. Prognostic factor analysis of vitrectomy for retinal detachment associated with myopic macular holes. Ophthalmology. 2014;121:305–310. DOI: 10.1016/j.ophtha.2013.08.033</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Michalewska Z., Michalewski J., Adelman R., Nawrocki J. Inverted internal limiting membrane flap technique for large macular holes. Ophthalmology. 2010;117(10):2018–2025. DOI: 10.1016/j.ophtha.2010.02.011</mixed-citation><mixed-citation xml:lang="en">Michalewska Z., Michalewski J., Adelman R., Nawrocki J. Inverted internal limiting membrane flap technique for large macular holes. Ophthalmology. 2010;117(10):2018–2025. DOI: 10.1016/j.ophtha.2010.02.011</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Mahalingam P., Sambhav K. Surgical outcomes of inverted internal limiting membrane flap technique for large macular hole. Indian J. Ophthalmol. 2013;61(10):601–603. DOI: 10.4103/0301-4738.121090</mixed-citation><mixed-citation xml:lang="en">Mahalingam P., Sambhav K. Surgical outcomes of inverted internal limiting membrane flap technique for large macular hole. Indian J. Ophthalmol. 2013;61(10):601–603. DOI: 10.4103/0301-4738.121090</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Kuriyama S., Hayashi H., Jingami Y. Efficacy of inverted internal limiting membrane flap technique for the treatment of macular hole in high myopia. Am. J. Ophthalmol. 2013;156(1):125–131. DOI: 10.1016/j.ajo.2013.02.014</mixed-citation><mixed-citation xml:lang="en">Kuriyama S., Hayashi H., Jingami Y. Efficacy of inverted internal limiting membrane flap technique for the treatment of macular hole in high myopia. Am. J. Ophthalmol. 2013;156(1):125–131. DOI: 10.1016/j.ajo.2013.02.014</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Shin M.K., Park K.H., Park S.W. Perfluoro-n-octane-assisted single-layered inverted internal limiting membrane flap technique for macular hole surgery. Retina. 2014;34(9):1905–1910. DOI: 10.1097/IAE.0000000000000339</mixed-citation><mixed-citation xml:lang="en">Shin M.K., Park K.H., Park S.W. Perfluoro-n-octane-assisted single-layered inverted internal limiting membrane flap technique for macular hole surgery. Retina. 2014;34(9):1905–1910. DOI: 10.1097/IAE.0000000000000339</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Самойлов А.Н., Мухаметзянова Г.М. Опыт хирургического лечения идиопатических макулярных разрывов большого диаметра. Современные технологии в офтальмологии. 2017;1(14):259–261. http://www.eyepress.ru/article.aspx?23338 (дата обращения: 12.05.2020).</mixed-citation><mixed-citation xml:lang="en">Samoylov A.N., Mukhametzyanova G.M. The experience of surgical treatment of large idiopathic macular holes. Modern technologies in ophthalmology = Sovremennye tekhnologii v oftal’mologii. 2017;1(14):259–261 (In Russ.)]. http://www.eyepress.ru/article.aspx?23338 (дата обращения: 12.05.2020).</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Andrew N., Chan W.O., Tan M., Modification of the inverted internal limiting membrane flap technique for the treatment of chronic and large macular holes. Retina. 2016;36(4):834–837. DOI: 10.1097/IAE.0000000000000931</mixed-citation><mixed-citation xml:lang="en">Andrew N., Chan W.O., Tan M., Modification of the inverted internal limiting membrane flap technique for the treatment of chronic and large macular holes. Retina. 2016;36(4):834–837. DOI: 10.1097/IAE.0000000000000931</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Charles S., Randolph J.C., Neekhra A. Arcuate retinotomy for the repair of large macular holes. Ophthalmic Surg. Lasers Imaging Retina. 2013;44(1):69–72. DOI: 10.3928/23258160-20121221-15</mixed-citation><mixed-citation xml:lang="en">Charles S., Randolph J.C., Neekhra A. Arcuate retinotomy for the repair of large macular holes. Ophthalmic Surg. Lasers Imaging Retina. 2013;44(1):69–72. DOI: 10.3928/23258160-20121221-15</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Чарльз С., Кальсада Х., Вуд Б. Микрохирургия стекловидного тела и сетчатки. Под ред. Самойлова А.Н. М.: МЕДпресс-информ, 2012. 400 p.</mixed-citation><mixed-citation xml:lang="en">Charles S., Calzada J., Wood B. Microsurgery of the vitreous body and retina. Ed. by. Samoylov A.N. Moscow: MEDpress-inform, 2012. 400 p. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Tam A.C., Yan P., Gan N.Y. The current surgical management of large, recurrent, or persistent macular holes. Retina. 2018;38(7):1263–1275. DOI: 10.1097/IAE.0000000000002020</mixed-citation><mixed-citation xml:lang="en">Tam A.C., Yan P., Gan N.Y. The current surgical management of large, recurrent, or persistent macular holes. Retina. 2018;38(7):1263–1275. DOI: 10.1097/IAE.0000000000002020</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Smiddy W.E., Glaser B.M., Green W.R. Transforming growth factor beta. A biologic chorioretinal glue. Arch. Ophthalmol. 1989;107(4):577–580</mixed-citation><mixed-citation xml:lang="en">Smiddy W.E., Glaser B.M., Green W.R. Transforming growth factor beta. A biologic chorioretinal glue. Arch. Ophthalmol. 1989;107(4):577–580</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Wells J.A., Gregor Z.J. Surgical treatment of full-thickness macular holes using autologous serum. Eye (Lond). 1996;10(5):593–599. DOI: 10.1038/eye.1996.136</mixed-citation><mixed-citation xml:lang="en">Wells J.A., Gregor Z.J. Surgical treatment of full-thickness macular holes using autologous serum. Eye (Lond). 1996;10(5):593–599. DOI: 10.1038/eye.1996.136</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Ezra E., Gregor Z.J. Surgery for idiopathic full-thickness macular hole: two-year results of a randomized clinical trial comparing natural history, vitrectomy, and vitrectomy plus autologous serum: Moorfields Macular Hole Study Group Report no. 1. Arch. Ophthalmol. 2004;122(2):224–236. DOI: 10.1001/archopht.122.2.224</mixed-citation><mixed-citation xml:lang="en">Ezra E., Gregor Z.J. Surgery for idiopathic full-thickness macular hole: two-year results of a randomized clinical trial comparing natural history, vitrectomy, and vitrectomy plus autologous serum: Moorfields Macular Hole Study Group Report no. 1. Arch. Ophthalmol. 2004;122(2):224–236. DOI: 10.1001/archopht.122.2.224</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Olsen T.W., Sternberg P. Jr., Capone A. Jr. Macular hole surgery using thrombin-activated fibrinogen and selective removal of the internal limiting membrane. Retina. 1998;18(4):322–329. DOI: 10.1097/00006982-199807000-00005</mixed-citation><mixed-citation xml:lang="en">Olsen T.W., Sternberg P. Jr., Capone A. Jr. Macular hole surgery using thrombin-activated fibrinogen and selective removal of the internal limiting membrane. Retina. 1998;18(4):322–329. DOI: 10.1097/00006982-199807000-00005</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Hoerauf H., Kluter H., Joachimmeyer E. Results of vitrectomy and the no-touchtechnique using autologous adjuvants in macular hole treatment. Int. Ophthalmol. 2001;24(3):151–159. DOI: 10.1023/A:1021566806836</mixed-citation><mixed-citation xml:lang="en">Hoerauf H., Kluter H., Joachimmeyer E. Results of vitrectomy and the no-touchtechnique using autologous adjuvants in macular hole treatment. Int. Ophthalmol. 2001;24(3):151–159. DOI: 10.1023/A:1021566806836</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Paques M., Chastang C., Mathis A. Effect of autologous platelet concentrate in surgery for idiopathic macular hole: results of a multicenter, double-masked, randomized trial. Platelets in Macular Hole Surgery Group. Ophthalmology. 1999;106(5):932–938. DOI: 10.1016/s0161-6420(99)00512-6</mixed-citation><mixed-citation xml:lang="en">Paques M., Chastang C., Mathis A. Effect of autologous platelet concentrate in surgery for idiopathic macular hole: results of a multicenter, double-masked, randomized trial. Platelets in Macular Hole Surgery Group. Ophthalmology. 1999;106(5):932–938. DOI: 10.1016/s0161-6420(99)00512-6</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Konstantinidis A., Hero M., Nanos P. Efficacy of autologous platelets in macular hole surgery. Clin. Ophthalmol. 2013;7:745–750. DOI: 10.2147/OPTH.S44440</mixed-citation><mixed-citation xml:lang="en">Konstantinidis A., Hero M., Nanos P. Efficacy of autologous platelets in macular hole surgery. Clin. Ophthalmol. 2013;7:745–750. DOI: 10.2147/OPTH.S44440</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Vote B.J., Membrey W.L., Casswell A.G. Autologous platelets for macular hole surgery: the Sussex Eye Hospital experience. Clin. Exp. Ophthalmol. 2004;32(5):472–477. DOI: 10.1111/j.1442-9071.2004.00866.x</mixed-citation><mixed-citation xml:lang="en">Vote B.J., Membrey W.L., Casswell A.G. Autologous platelets for macular hole surgery: the Sussex Eye Hospital experience. Clin. Exp. Ophthalmol. 2004;32(5):472–477. DOI: 10.1111/j.1442-9071.2004.00866.x</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">D’Souza M.J., Chaudhary V., Devenyi R. Re-operation of idiopathic full-thickness macular holes after initial surgery with internal limiting membrane peel. Br. J. Ophthalmol. 2011;95(11):1564–1567. DOI: 10.1136/bjo.2010.195826</mixed-citation><mixed-citation xml:lang="en">D’Souza M.J., Chaudhary V., Devenyi R. Re-operation of idiopathic full-thickness macular holes after initial surgery with internal limiting membrane peel. Br. J. Ophthalmol. 2011;95(11):1564–1567. DOI: 10.1136/bjo.2010.195826</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Che X., He F., Lu L. Evaluation of secondary surgery to enlarge the peeling of the internal limiting membrane following the failed surgery of idiopathic macular holes. Exp. ther. med. 2014;7:742–746. DOI: 10.3892/etm.2014.1477</mixed-citation><mixed-citation xml:lang="en">Che X., He F., Lu L. Evaluation of secondary surgery to enlarge the peeling of the internal limiting membrane following the failed surgery of idiopathic macular holes. Exp. ther. med. 2014;7:742–746. DOI: 10.3892/etm.2014.1477</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Morizane Y., Shiraga F., Kimura S. Autologous transplantation of the internal limiting membrane for refractory macular holes. Am. J. Ophthalmol. 2014;157(4):861–869. DOI: 10.1016/j.ajo.2013.12.028</mixed-citation><mixed-citation xml:lang="en">Morizane Y., Shiraga F., Kimura S. Autologous transplantation of the internal limiting membrane for refractory macular holes. Am. J. Ophthalmol. 2014;157(4):861–869. DOI: 10.1016/j.ajo.2013.12.028</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Pires J., Nadal J., Gomes N.L. Internal limiting membrane translocation for refractory macular holes. Br. J. Ophthalmol. 2017;101(3):377–382. DOI: 10.1136/bjophthalmol-2015-308299</mixed-citation><mixed-citation xml:lang="en">Pires J., Nadal J., Gomes N.L. Internal limiting membrane translocation for refractory macular holes. Br. J. Ophthalmol. 2017;101(3):377–382. DOI: 10.1136/bjophthalmol-2015-308299</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">De Novelli F.J., Preti R.C., Ribeiro Monteiro M.L. Autologous internal limiting membrane fragment transplantation for large, chronic, and refractory macular holes. Ophthalmic. Res. 2015;55(1):45–52. DOI: 10.1159/000440767</mixed-citation><mixed-citation xml:lang="en">De Novelli F.J., Preti R.C., Ribeiro Monteiro M.L. Autologous internal limiting membrane fragment transplantation for large, chronic, and refractory macular holes. Ophthalmic. Res. 2015;55(1):45–52. DOI: 10.1159/000440767</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Самойлов А.Н., Гайнутдинов Р.И. Способ хирургического лечения рецидивирующего макулярного разрыва. Патент РФ на изобретение № 2633338 от 11.10.2017.</mixed-citation><mixed-citation xml:lang="en">Samoylov A.N., Gainutdinov R.I. A method for the surgical treatment of recurrent macular rupture. Patent RU № 2633338, 11.10.2017 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Grewal D.S., Mahmoud T.H. Autologous neurosensory retinal free flap for closure of refractory myopic macular holes. JAMA Ophthalmol. 2016;134(2):229–230. DOI: 10.1001/jamaophthalmol.2015.5237</mixed-citation><mixed-citation xml:lang="en">Grewal D.S., Mahmoud T.H. Autologous neurosensory retinal free flap for closure of refractory myopic macular holes. JAMA Ophthalmol. 2016;134(2):229–230. DOI: 10.1001/jamaophthalmol.2015.5237</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Szigiato A.A., Gilani F., Walsh M.K. Induction of macular detachment for the treatment of persistent or recurrent idiopathic macular holes. Retina. 2016;36(9):1694–1698. DOI: 10.1097/IAE.0000000000000977</mixed-citation><mixed-citation xml:lang="en">Szigiato A.A., Gilani F., Walsh M.K. Induction of macular detachment for the treatment of persistent or recurrent idiopathic macular holes. Retina. 2016;36(9):1694–1698. DOI: 10.1097/IAE.0000000000000977</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Oliver A., Wojcik E.J. Macular detachment for treatment of persistent macular hole. Ophthalmic. Surg. Lasers Imaging. 2011;42(6):516–518. DOI: 10.3928/15428877-20110825-01</mixed-citation><mixed-citation xml:lang="en">Oliver A., Wojcik E.J. Macular detachment for treatment of persistent macular hole. Ophthalmic. Surg. Lasers Imaging. 2011;42(6):516–518. DOI: 10.3928/15428877-20110825-01</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Reis R., Ferreira N., Meireles A. Management of stage IV macular holes: when standard surgery fails. Case Rep. Ophthalmol. 2012;3(2):240–250. DOI: 10.1159/000342007</mixed-citation><mixed-citation xml:lang="en">Reis R., Ferreira N., Meireles A. Management of stage IV macular holes: when standard surgery fails. Case Rep. Ophthalmol. 2012;3(2):240–250. DOI: 10.1159/000342007</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Chen S.N., Yang C.M. Lens capsular flap transplantation in the management of refractory macular hole from multiple etiologies. Retina. 2016;36(1):163–170. DOI: 10.1097/IAE.0000000000000674</mixed-citation><mixed-citation xml:lang="en">Chen S.N., Yang C.M. Lens capsular flap transplantation in the management of refractory macular hole from multiple etiologies. Retina. 2016;36(1):163–170. DOI: 10.1097/IAE.0000000000000674</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Ezra E., Aylward W.G., Gregor Z.J. Membranectomy and autologous serum for the retreatment of full-thickness macular holes. Arch. Ophthalmol. 1997;115(10):1276–1280.</mixed-citation><mixed-citation xml:lang="en">Ezra E., Aylward W.G., Gregor Z.J. Membranectomy and autologous serum for the retreatment of full-thickness macular holes. Arch. Ophthalmol. 1997;115(10):1276–1280.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
