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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2022-1-133-140</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-1782</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ И ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL &amp; EXPERIMENTAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Морфометрические показатели сетчатки при первичном гипотиреозе и первичном тиреотоксикозе</article-title><trans-title-group xml:lang="en"><trans-title>Retinal Morphometric Indicators in Primary Hypothyroidosis and Primary Thyrotoxicosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лихванцева</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Likhvantseva</surname><given-names>V. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лихванцева Вера Геннадьевна, доктор медицинских наук, профессор</p><p>ул. Маршала Новикова, 23, Москва, 123098; Волоколамское шоссе, 91, Москва, 125310</p></bio><bio xml:lang="en"><p>Likhvantseva Vera G., MD, Professor</p><p>Marshal Novikov str., 23, Moscow, 123098; Volokolamskoye highway, 91, Moscow, 125310</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трубилин</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Trubilin</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Трубилин Владимир Николаевич, доктор медицинских наук, профессор, заведующий кафедрой</p><p>ул. Маршала Новикова, 23, Москва, 123098; Волоколамское шоссе, 91, Москва, 125310</p></bio><bio xml:lang="en"><p>Trubilin Vladimir N., MD, Professor, Head of Ophthalmology Department</p><p>Marshal Novikov str., 23, Moscow, 123098; Volokolamskoye highway, 91, Moscow, 125310</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коростелёва</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Korosteleva</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Коростелёва Екатерина Викторовна, кандидат медицинских наук, врач-офтальмолог</p><p>ул. Татарская, 33, Рязань, 390044</p></bio><bio xml:lang="en"><p>Korosteleva Ekaterina V., PhD, ophthalmologist</p><p>Tatarskaya str., 33, Ryazan, 390044</p></bio><email xlink:type="simple">ekaterina---@list.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Капкова</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kapkova</surname><given-names>S. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Капкова Светлана Георгиевна, кандидат медицинских наук, врач-офтальмолог</p><p>ул. Маршала Новикова, 23, Москва, 123098; Волоколамское шоссе, 91, Москва, 125310</p></bio><bio xml:lang="en"><p>Kapkova Svetlana G., PhD, ophthalmologist</p><p>Marshal Novikov str., 23, Moscow, 123098; Volokolamskoye highway, 91, Moscow, 125310</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Выгодин</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vygodin</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Выгодин Владимир Анатольевич, старший научный сотрудник</p><p>Петроверигский пер., 10, Москва, 101990</p></bio><bio xml:lang="en"><p>Vygodin Vladimir A., Senior Researcher</p><p>Petroverigskiy lane, 10, Moscow, 101990</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Государственный научный центр — Федеральный медицинский биофизический центр имени А.И. Бурназяна» Федерального медико-биологического агентства; Академия постдипломного образования «Федеральный научно-клинический центр специализированных видов медицинской помощи и медицинских технологий Федерального медико-биологического агентства»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Biophysical Center named after A.I. Burnazyan; Institute for Advanced Training of Federal Medical-Biological Agency</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ООО «Офтальмологическая клиника»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Оphthalmology clinic</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр профилактической медицины» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>The Federal State Institution of Scientific Research Center of Prophylactic Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>08</day><month>04</month><year>2022</year></pub-date><volume>19</volume><issue>1</issue><fpage>133</fpage><lpage>140</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лихванцева В.Г., Трубилин В.Н., Коростелёва Е.В., Капкова С.Г., Выгодин В.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Лихванцева В.Г., Трубилин В.Н., Коростелёва Е.В., Капкова С.Г., Выгодин В.А.</copyright-holder><copyright-holder xml:lang="en">Likhvantseva V.G., Trubilin V.N., Korosteleva E.V., Kapkova S.G., Vygodin V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/1782">https://www.ophthalmojournal.com/opht/article/view/1782</self-uri><abstract><sec><title>Цель</title><p>Цель: изучить морфометрические показатели сетчатки у больных с первичным гипотиреозом и первичным тиреотоксикозом методом оптической когерентной томографии.</p></sec><sec><title>Пациенты и методы</title><p>Пациенты и методы. Материалом для настоящего исследования стали результаты обследования 54 пациентов (108 глаз) с тиреоидными дисфункциями: 32 человека (64 глаза) с первичным нелеченым гипотиреозом и 22 человека (44 глаза) с первичным нелеченым тиреотоксикозом. Для оценки морфометрических показателей сетчатки выполняли оптическую когерентную томографию.</p></sec><sec><title>Результаты</title><p>Результаты. Выявлено достоверное утолщение слоя нервных волокон практически во всех секторах сетчатки глаз больных первичным гипотиреозом и первичным тиреотоксикозом, за исключением верхнего сектора при первичном тиреотоксикозе. Морфометрические параметры диска зрительного нерва в обеих группах были неоднозначны. При тиреотоксикозе диаметр и топографическая площадь экскавации были меньше нормы, а площадь нейроретинального пояска, площадь и экскавация диска зрительного нерва, отношение экскавации к площади диска зрительного нерва, горизонтальный и вертикальный размер выше. При гипотиреозе диаметр, площадь и топографический объем экскавации, отношения экскавации к площади диска зрительного нерва, горизонтального и вертикального размера экскавации к диску зрительного нерва были ниже нормы, а протяженность и площадь нейроретинального пояска выше. В обеих группах выявлено увеличение объема и толщины сетчатки всех секторов макулы в комплексе с уменьшением минимальной толщины фовеа. Определена корреляционная связь параметров оптической когерентной томографии с ранговыми показателями соотношений тиреоидных гормонов.</p></sec><sec><title>Заключение</title><p>Заключение. При первичном гипотиреозе и первичном тиреотоксикозе выявлены статистически достоверные морфометрические изменения сетчатки и диска зрительного нерва. Морфометрические данные коррелировали с ранговыми показателями соотношений тиреоидных гормонов.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Purpose</title><p>Purpose: to study the morphometric parameters of the retina in patients with primary hypothyroidism and primary thyrotoxicosis by optical coherence tomography.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The material for this study was the results of examination of 54 patients (108 eyes) with thyroid dysfunctions: 32 people (64 eyes) with primary untreated hypothyroidism and 22 people (44 eyes) with primary untreated thyrotoxicosis. To assess the morphometric parameters of the retina, optical coherence tomography was performed.</p></sec><sec><title>Results</title><p>Results. A significant thickening of the layer of nerve fibers was revealed in almost all sectors of the retina of patients with primary hypothyroidism and primary thyrotoxicosis, with the exception of the upper sector in primary thyrotoxicosis. The morphometric parameters of the optic nerve head in both groups were ambiguous. With thyrotoxicosis, the diameter and topographic area of the excavation were less than normal, while the area of the neuroretinal girdle, the area and excavation of the optic nerve head, the ratio of excavation to the area of the optic nerve head, the horizontal and vertical dimensions were higher. In hypothyroidism, the diameter, area and topographic volume of the excavation, the ratio of the excavation to the area of the optic nerve head, the horizontal and vertical dimensions of the excavation to the optic nerve head were below normal, and the length and area of the neuroretinal girdle were higher. In both groups, an increase in the volume and thickness of the retina of all macula’s sectors in combination with a decrease in the minimum thickness of the fovea was revealed. A correlation between the parameters of optical coherence tomography and the rank indicators of the ratio of thyroid hormones was revealed.</p></sec><sec><title>Conclusion</title><p>Conclusion. In primary hypothyroidism and primary thyrotoxicosis, statistically significant morphometric changes in the retina and optic nerve head were revealed. The morphometric data correlated with the rank indices of the thyroid hormone ratios.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>оптическая когерентная томография</kwd><kwd>первичный нелеченый гипотиреоз</kwd><kwd>первичный нелеченый тиреотоксикоз</kwd></kwd-group><kwd-group xml:lang="en"><kwd>optical coherence tomography</kwd><kwd>primary untreated hypothyroidism</kwd><kwd>primary untreated thyrotoxicosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Gamborino M.J., Sevilla-Romero E., Muňoz A., Hernández Yago J., Renau-Piqueras J., Pinazo-Durán M.D. Role of thyroid hormone in craniofacial and eye development using a rat model. 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