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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2022-1-141-148</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-1783</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ И ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL &amp; EXPERIMENTAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Оптическая когерентная томография с ангиографией в диагностике изменений органа зрения при атеросклерозе</article-title><trans-title-group xml:lang="en"><trans-title>Optical Coherence Tomography with Angiography in the Diagnosis of Changes in the Organ of Vision at Atherosclerosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2883-3923</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Касимова</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kasimova</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Касимова Мунирахон Садикжановна, доктор медицинских наук, профессор кафедры офтальмологии</p><p>ул. Паркент, 51, Ташкeнт, 100007, Узбeкистан</p></bio><bio xml:lang="en"><p>Kаsimovа Munirаhon S., MD, Professor of the Ophthаlmology Depаrtment</p><p>Parkent, 51. Tаshkent, 100007, Uzbekistаn</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6080-7680</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Махкамова</surname><given-names>Д. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Mahkamova</surname><given-names>D. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Махкамова Дилбар Камалджановна, PhD, старший научный сотрудник</p><p>ул. Паркент, 51, Ташкeнт, 100007, Узбeкистан</p></bio><bio xml:lang="en"><p>Mаkhkаmovа Dilbаr K., PhD, Senior Research Officer of the Ophthаlmology Depаrtment</p><p>Parkent, 51. Tаshkent, 100007, Uzbekistаn</p></bio><email xlink:type="simple">dilbarmk@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Ташкeнтский институт усовeршeнствования врачeй Министерства здравоохранения Республики Узбекистан</institution><country>Узбекистан</country></aff><aff xml:lang="en"><institution>Tаshkent Institute of Postgrаduаte Medicаl Educаtion of the Ministry of Health of Republic of Uzbekistan</institution><country>Uzbekistan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>08</day><month>04</month><year>2022</year></pub-date><volume>19</volume><issue>1</issue><fpage>141</fpage><lpage>148</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Касимова М.С., Махкамова Д.К., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Касимова М.С., Махкамова Д.К.</copyright-holder><copyright-holder xml:lang="en">Kasimova M.S., Mahkamova D.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/1783">https://www.ophthalmojournal.com/opht/article/view/1783</self-uri><abstract><p>Изучение параметров оптической когерентной томографии с ангиографией (ОКТА) расширяет представления о состоянии гемодинамики для раннего выявления сосудистых нарушений органа зрения (ОЗ) при атеросклерозе (АС).</p><sec><title>Цель</title><p>Цель: изучить параметры ОКТА при изменениях органа зрения на фоне АС.</p></sec><sec><title>Пациенты и методы</title><p>Пациенты и методы. Материалом исследования явились 26 пациентов (41 глаз) с изменениями ОЗ при АС. Возрастной контингент пациентов колебался от 32 до 78 лет, средний возраст составил 47,5 ± 2,0 года. В исследовании участвовали 10 женщин, 16 мужчин. В зависимости от поражения органов-мишеней (О-М) все пациенты условно были разделены на 2 группы: в I группу (19 глаз) вошли пациенты без поражения, а II группу (22 глаза) составили пациенты с поражением О-М.</p></sec><sec><title>Результаты</title><p>Результаты. При регистрации ОКТА у больных I группы отмечалось снижение плотности капилляров поверхностной сосудистой сети на 15 % (45,21 ± 2,62 % (р &lt; 0,05)), глубокой сосудистой сети на 19 % (45,89 ± 2,71 % (р &lt; 0,05)). В макулярной области участок гипоперфузируемой сетчатки составил 1,07 ± 0,14 мм2 (р &lt; 0,05). В области диска зрительного нерва отмечались участки гипоперфузии в поверхностных слоях на 7 глазах, в глубоких слоях — на 4 глазах. Анализ ОКТА у больных II группы выявил резкое снижение (на 48 %) плотности капилляров как в поверхностном, так и в глубоком сосудистом сплетении сетчатки, что составило 33,91 ± 3,01 % (р &lt; 0,05); 33,65 ± 2,89 % (р &lt; 0,05) соответственно. В макулярной области участок неперфузируемой сетчатки составил 2,19 ± 0,21 мм2 (р &lt; 0,05). В области диска зрительного нерва отмечались участки неперфузии как в поверхностных слоях, так и в глубоких слоях на 4 глазах.</p></sec><sec><title>Заключение</title><p>Заключение. Использование ОКТА позволяет выявить изменения гемоперфузии во всех слоях сетчатки и зрительного нерва на ранних этапах развития АС, что способствует ранней диагностике и мониторингу заболевания.  </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. The study of the parameters of optical coherence tomography with angiography (OCTA) broadens the understanding of the state of hemodynamics for the early detection of vascular disorders of the organ of vision in atherosclerosis (AS).</p></sec><sec><title>Purpose</title><p>Purpose. To study the parameters of OCTA with changes in the organ of vision against the background of AS.</p></sec><sec><title>Patients and methods</title><p>Patients and methods. 26 patients (41 eyes) with changes in the organ of vision in AS. The age contingent of patients ranged from 32 to 78 years, the average age was 47.5 ± 2.0 year, of which 10 were women, 16 men. Depending on the damage to target organs, all patients were conditionally divided into 2 groups: group I (19 eyes) included patients without damage, and group II (22 eyes) consisted of patients with target organs damage.</p></sec><sec><title>Results</title><p>Results. The registration of OCTA in patients of group I, a decrease in the density of capillaries of the superficial vascular network was 15 % and amounted to 45.21 ± 2.62 % (p &lt; 0.05), of the deep vascular plexus by 19 %, which amounted to 45.89 ± 2, 71 % (p &lt; 0.05). In the macular region, the area of the hypoperfused retina was 1.07 ± 0.14 mm2 (p &lt; 0.05). In the region of the optic nerve disc, areas of hypoperfusion were noted in the superficial layers in 7 eyes and in the deep layers in 4 eyes. Analysis of OCTA in patients of group II revealed a sharp decrease (by 48 %) in the density of capillaries in both the superficial and deep vascular plexuses of the retina, which amounted to 33.91 ± 3.01 % (p &lt; 0.05); 33.65 ± 2.89 % (p &lt; 0.05), respectively. In the macular region, the area of the non-perfused retina was 2.19 ± 0.21 mm2 (p &lt; 0.05). In the area of the optic nerve disc, areas of nonperfusion were noted both in the surface layers and in the deep layers in 4 eyes.</p></sec><sec><title>Conclusion</title><p>Conclusion. The use of OCTA allows to detect changes in hemoperfusion in all layers of the retina and optic nerve in the early stages of AS development, which will allow early diagnosis and monitoring of the disease.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>оптическая когерентная томография с ангиографией</kwd><kwd>ишемические заболевания органа зрения</kwd><kwd>атеросклероз</kwd><kwd>гемоперфузия</kwd><kwd>сосудистые сплетения сетчатки и зрительного нерва</kwd></kwd-group><kwd-group xml:lang="en"><kwd>optical coherence tomography with angiography</kwd><kwd>ischemic diseases of the organ of vision</kwd><kwd>atherosclerosis</kwd><kwd>hemoperfusion</kwd><kwd>vascular plexuses of the retina and optic nerve</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Будзинская М.В., Федоров А.А., Плюхова А.А., Воеводина Т.М., Балацкая Н.В. 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