ophthalmologyОфтальмологияOphthalmology in Russia1816-50952500-0845Ophthalmology10.18008/1816-5095-2022-2-265-271ophthalmology-1842Research ArticleОБЗОРЫREVIEWSНейротрофический кератит: консервативное и хирургическое лечение. Обзор литературы. Часть 2Neurotrophic Keratitis. Etiology, Pathogenesis, Clinical Manifestations. Review. Part 2https://orcid.org/0000-0001-8594-2395КаспароваЕ. А.KasparovaE. A.

кандидат медицинских наук, ведущий научный сотрудник отдела патологии оптических сред глаза,

ул. Россолимо, 11а, б, Москва, 119021

PhD, leading research officer of the optical media of the Eye pathology department,

Rossolimo str., 11A, B, Moscow, 119021

likhvantseva-4@yandex.ruhttps://orcid.org/0000-0001-6945-237XМарченкоН. Р.MarchenkoN. R.

кандидат медицинских наук, научный сотрудник отдела патологии оптических сред глаза,

ул. Россолимо, 11а, б, Москва, 119021

PhD, research officer of the optical media of the Eye pathology department,

Rossolimo str., 11A, B, Moscow, 119021

ФГБНУ «Научно-исследовательский институт глазных болезней»РоссияResearch Institute of Eye Diseases SciencesRussian Federation202230062022192265271Copyright © Каспарова Е.А., Марченко Н.Р., 20222022Каспарова Е.А., Марченко Н.Р.Kasparova E.A., Marchenko N.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.ophthalmojournal.com/opht/article/view/1842

Нейротрофический кератит (также называемый нейротрофической кератопатией) (НТК) представляет собой дегенеративное заболевание роговицы, сопровождающееся нейрогенным воспалением. Оно обусловлено нарушением чувствительной иннервации тройничного нерва. Лечебные мероприятия в основном сводятся к поддерживающей терапии (антисептики, слезозаместительная терапия, корнеопротекторы), не оказывающей влияния на причину заболевания. Наиболее доступной и эффективной терапией в настоящее время является длительное местное применение ауто- или гетерологичной сыворотки. Новые многообещающие специфические подходы к лечению НТК — местная терапия рекомбинантным фактором роста нервов ценегермином и операции невротизации роговицы — направлены на патогенетические звенья заболевания и могут восстановить иннервацию и чувствительность роговицы. 

Neurotrophic keratitis (neurotrophic keratopathy) (NTC) is a degenerative disease of the cornea accompanied with neurogenic inflammation. It is caused by a loss of sensitive innervation of the trigeminal nerve. Therapeutic measures are mainly reduced to maintenance therapy (antiseptics, artificial tears, corneal protectors), which does not affect the cause of the disease. The most affordable and updated therapy is the long-term topical use of auto- or heterologous serum. Recently developed specific approaches to the treatment of NTK — local therapy with recombinant nerve growth factor Cenegermin and corneal neurotization are aimed at the pathogenetic links of the disease and can restore the innervation and sensitivity of the cornea.

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The authors declare that there are no conflicts of interest present.