ophthalmologyОфтальмологияOphthalmology in Russia1816-50952500-0845Ophthalmology10.18008/1816-5095-2014-3-28-32ophthalmology-185Research ArticleКЛИНИЧЕСКИЕ И ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯCLINICAL & EXPERIMENTAL RESEARCHДиагностическая точность некоторых показателей карты ганглиозно-клеточного комплекса, измеренных с помощью SD-ОСТ при первичной открытоугольной глаукомеDiagnostic accuracy of the parameters from ganglion cell complex map, evaluated with SD-OCT in primary open-angle glaucomaАнгеловБ.AnguelovB.botio.ang@abv.bgПетроваК.PetrovaK.Кафедра офтальмологии, МУ, МБАЛ «Александровская»РоссияDepartment of Ophthalmology, Medical University «Alexandrovska» HospitalRussian Federation2014111020141132832Copyright © Ангелов Б., Петрова К., 20142014Ангелов Б., Петрова К.Anguelov B., Petrova K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.ophthalmojournal.com/opht/article/view/185Цель

Цель: Анализ чувствительности и специфичности показателей карты ганглиозно-клеточного комплекса (GCC) с помощью оптической когерентной томографии (OCT) и определение их роли для диагностики первичной открытоугольной глаукомы.

Пациенты и методы

Пациенты и методы. Обследовано 84 глаза пациентов с первичной открытоугольной глаукомой (ПОУГ) и 40 глаз здоровых лиц. Всем проведено полное офтальмологическое обследование, включая стандартную автоматизированную компьютерную периметрию (HFA II) и OCT (RTVue-100). Анализировали следующие параметры: Avg. GCC (average GCC), Sup. GCC (superior GCC), Inf. GCC (inferior GCC), GLV (global loss volume), FLV (focal loss volume) и RNFL (ретинальный нейрофибриллярный слой — ONH map). Для каждого параметра определили чувствительность, специфичность, также была построена ROC кривая.

Результаты

Результаты. Самая высокая чувствительность и специфичность отмечена у пациентов с глаукомой для GLV, а самая низкая — для Sup. GCC. Зона под ROC кривой (AUC) при GLV явилась наибольшей, а наименьшей — при Sup. GCC.

Выводы

Выводы. Параметры карты GCC имеют высокую чувствительность и специфичность. Обнаружено, что их диагностическая точность является соизмеримой, а иногда и более значимой, в сравнении с показателем RNFL. Самую высокую диагностическую точность при первичной открытоугольной глаукоме в этом исследовании имеет GLV.

Purpose

Purpose: To evaluate the sensitivity and specificity of ganglion cell complex (GCC) parameters, obtained with optical coherence tomography (OCT) and to determine their accuracy and ability to differentiate healthy from primary open-angle glaucoma patients.

Patients and methods

Patients and methods. 84 eyes of primary open-angle glaucoma patients and 40 eyes of healthy individuals were enrolled in the study. All of them underwent complete eye examination, including standard automated perimetry (HFA II) and OCT (RTVue-100). Avg. GCC (average GCC), Sup. GCC (superior GCC), Inf. GCC (inferior GCC), GLV (globаl loss volume), FLV (focal loss volume) and RNFL (retinal nerve fiber layer — ONH map) were measured. ROC curveswere created and sensitivity and specificity were calculated for each of these parameters.

Results

Results.The highest sensitivity and specificity was found for GLV and the lowest for Sup. GCC. Area under the ROC curves (AUC) for GLV was found to be the largest and the smallest for Sup. GCC.

Conclusion

Conclusion. Parameters from GCC map have high sensitivity and specificity. Their diagnostic capability is similar, even slightly better than the one of RNFL. GLV has the highest diagnostic accuracy for primary open-angle glaucoma detection in this study.

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The authors declare that there are no conflicts of interest present.