ophthalmologyОфтальмологияOphthalmology in Russia1816-50952500-0845Ophthalmology10.18008/1816-5095-2022-3-465-474ophthalmology-1908Research ArticleОБЗОРЫREVIEWSКлинические вариации увеитов при иммуновоспалительных заболеваниях. Обзор литературы. Часть 1Clinical Variations of Uveitis in Immuno-Inflammatory Diseases. Review of the Literature. Part 1https://orcid.org/0000-0003-4215-7084ДавыдоваГ. А.DavydovaG. A.

кандидат медицинских наук, научный сотрудник отдела патологии сетчатки и зрительного нерва

ул. Садовая-Черногрязская, 14/19, Москва, 105062

PhD, research officer of Retina and optic nerve pathology department

Sadovaya-Chernogryazskaya str., 14/19, Moscow, 105062

6298685@mail.ruhttps://orcid.org/0000-0001-9437-406XЛисицынаТ. А.LisitsynaT. A.

доктор медицинских наук, ведущий научный сотрудник лаборатории сосудистой ревматологии

Каширское шоссе, 34а, Москва, 115522

МD, senior scientific researcher of the Vascular rheumatology laboratory

Kashirskoe highway, 34A, Moscow, 115522

https://orcid.org/0000-0001-6239-9553КовалеваЛ. А.KovalevaL. A.

кандидат медицинских наук, научный сотрудник отдела инфекционных и аллергических заболеваний глаз

ул. Садовая-Черногрязская, 14/19, Москва, 105062

PhD, research officer of Infectious and allergic eye diseases department

Sadovaya-Chernogryazskaya str., 14/19, Moscow, 105062

https://orcid.org/0000-0002-8568-8689СорожкинаЕ. С.SorozhkinaE. S.

научный сотрудник отдела иммунологии и вирусологии

ул. Садовая-Черногрязская, 14/19, Москва, 105062

research officer of Immunology and virology department

Sadovaya-Chernogryazskaya str., 14/19, Moscow, 105062

https://orcid.org/0000-0001-8852-3305ЗайцеваА. А.ZaitsevaA. A.

врач-офтальмолог взрослого консультативно-поликлинического отделения

ул. Садовая-Черногрязская, 14/19, Москва, 105062

ophthalmologist of the Adult consulting and polyclinic department

Sadovaya-Chernogryazskaya str., 14/19, Moscow, 105062

https://orcid.org/0000-0002-8014-667XБайсангуроваА. А.BaisangurovaA. A.

врач-офтальмолог взрослого консультативно-поликлинического отделения

ул. Садовая-Черногрязская, 14/19, Москва, 105062

ophthalmologist, of the Adult consulting and polyclinic department

Sadovaya-Chernogryazskaya str., 14/19, Moscow, 105062

ФГБУ «Национальный медицинский исследовательский центр глазных болезней им. Гельмгольца» Министерства здравоохранения Российской ФедерацииРоссияHelmholtz National Medical Research Center of Eye DiseasesRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation202203102022193465474Copyright © Давыдова Г.А., Лисицына Т.А., Ковалева Л.А., Сорожкина Е.С., Зайцева А.А., Байсангурова А.А., 20222022Давыдова Г.А., Лисицына Т.А., Ковалева Л.А., Сорожкина Е.С., Зайцева А.А., Байсангурова А.А.Davydova G.A., Lisitsyna T.A., Kovaleva L.A., Sorozhkina E.S., Zaitseva A.A., Baisangurova A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.ophthalmojournal.com/opht/article/view/1908

Неинфекционный увеит — одна из главных и недостаточно изученных причин инвалидизации и слепоты у больных с иммуновоспалительными заболеваниями. Чаще встречаются и лучше других описаны увеиты, ассоциирующиеся со спондилоартритами, болезнью Бехчета, ювенильным идиопатическим артритом, системным саркоидозом и синдромом Фогта — Коянаги — Харада, но недостаточно изучен патогенез различных вариантов их течения. Сохраняется необходимость исследования клинических и патогенетических особенностей увеитов при редко встречающихся аутоиммунных воспалительных заболеваниях. Несмотря на существующие в настоящее время схемы диагностики и терапии, требуется дальнейшее изучение патогенеза увеитов, ассоциированных с иммуновоспалительными заболеваниями, разработка персонализированного подхода и алгоритма совместной мультидисциплинарной диагностики специалистами различных областей. Более глубокое понимание специфических патогенетических механизмов позволит определить новые возможности в лечении пациентов с аутоиммунными увеитами. Настоящая статья посвящена актуальным клиническим и дифференциально-диагностическим аспектам, общим чертам и отличительным признакам, связанным с различными вариантами течения неинфекционных увеитов у больных с иммуновоспалительными заболеваниями. 

Non-infectious uveitis is one of the main and insufficiently studied causes of disability and blindness in patients with immuno-inflammatory diseases. Uveitis associated with spondyloarthritis, Behcet’s disease, juvenile idiopathic arthritis, systemic sarcoidosis and Vogt-Koyanagi-Harada syndrome are described more often and better than others, but the pathogenesis of different variants of their course is not well understood. Also, there remains a need to study the clinical and pathogenetic features of uveitis in rare autoimmune inflammatory diseases. Despite the currently existing diagnostic and therapeutic schemes, further study of the pathogenesis of uveitis associated with immune-inflammatory diseases is required, the research of a personalized approach and an algorithm for joint multidisciplinary diagnosis by specialists in various fields. A deeper understanding of the specific pathogenetic mechanisms will reveal new possibilities in the treatment of patients with autoimmune uveitis. This article is devoted to the current clinical and differential diagnostic aspects, common features and distinctive features associated with various variants of the course of non-infectious uveitis in patients with immuno-inflammatory diseases. 

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The authors declare that there are no conflicts of interest present.