<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2022-3-549-556</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-1919</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ И ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL &amp; EXPERIMENTAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Методы машинного обучения в сравнительной оценке различных подходов к хирургическому лечению первичного закрытия угла передней камеры глаза</article-title><trans-title-group xml:lang="en"><trans-title>Machine Learning Methods in the Comparative Evaluation of Various Approaches to the Surgical Treatment of Primary Angle Closure</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2265-6671</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Курышева</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kurysheva</surname><given-names>N. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор, заведующая кафедрой глазных болезней, ул. Живописная, 46, корп. 8, Москва, 123098;руководитель консультативно-диагностического отдела, ул. Гамалеи, 15, Москва, 123098</p></bio><bio xml:lang="en"><p>МD, Professor, head of the Ophthalmology department, Zhivopisnaya str., 46, bld. 8, Moscow, 123098;</p><p>head of the Consultative and diagnostic department, Gamalei str., 15, Moscow, 123098</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7402-4011</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Померанцев</surname><given-names>А. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Pomerantsev</surname><given-names>A. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор физико-математических наук, главный научный сотрудник,</p><p>пр. Косыгина, 4, Москва, 119991</p></bio><bio xml:lang="en"><p>Dr. of Phys. and Math., principal researcher,</p><p>Kosygin ave., 4, Moscow, 119991,</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0146-8284</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Родионова</surname><given-names>О. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Rodionova</surname><given-names>O. Ye.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор физико-математических наук, главный научный сотрудник,</p><p>пр. Косыгина, 4, Москва, 119991</p></bio><bio xml:lang="en"><p>Dr. of Phys. and Math., principal researcher,</p><p>Kosygin ave., 4, Moscow, 119991</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7163-4858</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шарова</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sharova</surname><given-names>G. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>заведующая диагностическим офтальмологическим отделением, лазерный хирург,</p><p>пр. Буденного, 26, корп. 2, Москва, 105118</p></bio><bio xml:lang="en"><p>head of the Diagnostic ophthalmology department, laser surgeon,</p><p>Budenny ave., 26/2, Moscow, 105118</p></bio><email xlink:type="simple">galina.shar@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Медико-биологический университет инноваций и непрерывного образования ФГБУ ГНЦ РФ «Федеральный биофизический центр им. А.И. Бурназяна» Федерального медико-биологического агентства;&#13;
Консультативно-диагностический отдел Центра офтальмологии ФГБУ ГНЦ РФ «Федеральный биофизический центр им. А.И. Бурназяна» Федерального медико-биологического агентства</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Medical Biological University of Innovations and Continuing Education of the Federal Biophysical Center&#13;
named after A.I. Burnazyan;&#13;
Diagnostic Department of the Ophthalmological Center of Federal Medical-Biological Agency</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУН «Федеральный исследовательский центр химической физики им. Н.Н. Семенова» Российской академии наук</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research Center for Chemical Physics of RAS</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ООО «Глазная клиника доктора Беликовой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Ophthalmology Clinic of Dr. Belikova</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>05</day><month>10</month><year>2022</year></pub-date><volume>19</volume><issue>3</issue><fpage>549</fpage><lpage>556</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Курышева Н.И., Померанцев А.Л., Родионова О.Е., Шарова Г.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Курышева Н.И., Померанцев А.Л., Родионова О.Е., Шарова Г.А.</copyright-holder><copyright-holder xml:lang="en">Kurysheva N.I., Pomerantsev A.L., Rodionova O.Y., Sharova G.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/1919">https://www.ophthalmojournal.com/opht/article/view/1919</self-uri><abstract><sec><title>Цель</title><p>Цель: оценить применение метода главных компонент (МГК) и DD-SIMCA в сравнительном анализе хирургического лечения первичного закрытия угла передней камеры глаза.</p></sec><sec><title>Пациенты и методы</title><p>Пациенты и методы. Проспективное исследование включало 90 пациентов. Группа 1 — 30 пациентов с первичным закрытием угла (ПЗУ) с запланированной периферической лазерной иридотомией (ПЛИТ). Группа 2 — 30 пациентов с ПЗУ с запланированной факоэмульсификацией и имплантацией интраокулярной линзы (ФЭ + ИОЛ). Группа 3 — 30 глаз без офтальмопатологии. Всем обследуемым проведена SS-OCT. Проанализировано 37 показателей, включая внутриглазное давление, толщину хориоидеи в макуле, глубину передней камеры, высоту свода хрусталика, кривизну и толщину радужки, дистанцию открытия угла и иридотрабекулярное пространство в 500 и 750 мкм от склеральной шпоры. Поскольку все указанные параметры коррелируют между собой, то были использованы методы машинного обучения: МГК и метод одноклассовой классификации DD-SIMCA. Для этого были построены графики счетов и нагрузок в модели МГК для групп 1 и 2. При этом на графике счетов определены пациенты с ПЗУ со среднестатистическими и экстремальными параметрами глаза, а на графике нагрузок построены взаимосвязи параметров пациентов с ПЗУ между собой для анализа корреляций в будущем. В методе DD-SIMCA в качестве представителей целевого класса взята группа 1.</p></sec><sec><title>Результаты</title><p>Результаты. Модель классификации на основе двух главных компонент с заданным уровнем ошибки 1-го рода α = 0,01 продемонстрировала чувствительность 100 % для пациентов своей группы и чувствительность 93 % для пациентов группы 2. Эти результаты подтверждают сходство групп 1 и 2. Специфичность для группы контроля, расположенной далеко от целевой группы, составила 100 %.</p></sec><sec><title>Заключение</title><p>Заключение. Методы многомерного анализа дают возможность сравнивать группы с большим набором взаимосвязанных показателей. МГК позволяет выявлять пациентов с экстремальными параметрами и оценивать корреляции между множественными параметрами. DD-SIMCA подтверждает правомерность сравнения результатов лечения методом ПЛИТ и ФЭ + ИОЛ. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Purpose</title><p>Purpose. To evaluate the application of the principal component analysis (PCA) and DD-SIMCA in a comparative analysis of the surgical treatment of primary angle closure.</p></sec><sec><title>Material and methods</title><p>Material and methods. The prospective study included 90 patients. Group 1 — 30 patients with primary angle closure (PAC) with planned laser peripheral iridotomy (LPI). Group 2 — 30 patients with PAC, with planned phacoemulsification with intraocular lens implantation (PE+IOL). Group 3 — 30 eyes without ophthalmic pathology. All subjects underwent SS-OCT. Thirty-seven parameters were analyzed, including intraocular pressure, choroidal thickness in the macula, anterior chamber depth, lens vault, iris curvature and thickness, angle opening distance, and iridotrabecular space at 500 µm and 750 µm from the scleral spur. Since all these parameters correlate with each other, machine learning methods were used: PCA and the DD-SIMCA one-class classification method. For this purpose graphs of scores and loads in the PCA model for groups 1 and 2 were plotted. In the score plot, patients with PAC with average and extreme eye parameters were identified, and in the loading plot, relationships between the parameters of patients with PM were used to analyze correlations in the future. In the DD-SIMCA method, group 1 is taken as representatives of the target class.</p></sec><sec><title>Results</title><p>Results. A classification model based on 2 principal components with a given type I error α = 0.01 demonstrated a sensitivity of 100 % for patients in its own group and a sensitivity of 93 % for patients in group 2. These results confirm similarity of group 1 and group 2. The specificity for the control group was 100 %, and this group located far from the target group.</p></sec><sec><title>Conclusion</title><p>Conclusion. Machine learning methods make it possible to compare groups with multivariate and correlated parameters. PCA allows the identification of patients with extreme parameters and the evaluation of correlations between multiple parameters. DDSIMCA confirms the validity of comparing the results of treatment with LPI and FE + IOL. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>метод главных компонент (МГК)</kwd><kwd>метод DD-SIMCA</kwd><kwd>методы машинного обучения</kwd><kwd>первичный закрытый угол</kwd><kwd>SS-OCT</kwd><kwd>оптическая когерентная томография переднего отрезка (AS-OCT)</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Principal Component Analysis (PCA)</kwd><kwd>Data Driven Soft Independent Modelling of Class Analogies (DD-SIMCA)</kwd><kwd>machine learning</kwd><kwd>primary angle closure</kwd><kwd>SS-OCT</kwd><kwd>optical coherence tomography of the anterior segment (AS-OCT)</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Quigley H.A. Long-term follow-up of laser iridotomy. Ophthalmology. 1981;88(3):218–224. DOI: 10.1016/s0161-6420(81)35038-6</mixed-citation><mixed-citation xml:lang="en">Quigley H.A. Long-term follow-up of laser iridotomy. Ophthalmology. 1981;88(3):218–224. DOI: 10.1016/s0161-6420(81)35038-6</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Sihota R., Rishi K., Srinivasan G., Gupta V., Dada T., Singh K. Functional evaluation of an iridotomy in primary angle closure eyes. Graefe’s Arch Clin Exp Ophthalmol = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 2016;254(6):1141–1149. DOI: 10.1007/s00417-016-3298-x</mixed-citation><mixed-citation xml:lang="en">Sihota R., Rishi K., Srinivasan G., Gupta V., Dada T., Singh K. Functional evaluation of an iridotomy in primary angle closure eyes. Graefe’s Arch Clin Exp Ophthalmol = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 2016;254(6):1141–1149. DOI: 10.1007/s00417-016-3298-x</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Курышева Н.И., Шарова Г.А. Роль селективной лазерной трабекулопластики в лечении заболевания первичного закрытия угла передней камеры. Эффективная фармакотерапия. 2022;18(11):22–28. DOI: 10.33978/2307-3586-2022-18-11-22-28</mixed-citation><mixed-citation xml:lang="en">Kurysheva N.I., Sharova G.A. Role of Selective Laser Trabeculoplasty in the Treatment of Primary Angle Closure of the Anterior Chamber. Effective Pharmacotherapy = Effektivnaya farmakoterapiya. 2022;18(11):22–28 (In Russ.). DOI: 10.33978/2307-3586-2022-18-11-22-28</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Курышева Н.И., Шарова Г.А. Сравнительное исследование ретинальной микроциркуляции при заболевании первичного закрытого угла и начальной первичной открытоугольной глаукоме. Вестник офтальмологии. 2022;138(1):44–51. DOI: 10.17116/oftalma202213801144</mixed-citation><mixed-citation xml:lang="en">Kurysheva N.I., Sharova G.A. Comparative study of retinal microcirculation in primary angle closure disease and early primary open-angle glaucoma. Annals of Ophthalmology = Vestnik oftal’mologii. 2022;138(1):44–51 (In Russ.). DOI: 10.17116/oftalma202213801144</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Курышева Н.И., Шарова Г.А. Эффективность лазерной иридотомии при подозрении на первичное закрытие угла и при первичной закрытоугольной глаукоме. ГЛАЗ. 2022;24(1):20–33. DOI: 10.33791/2222-4408-2022-1-20-33</mixed-citation><mixed-citation xml:lang="en">Kurysheva N.I., Sharova G.A. Efficacy of laser iridotomy in primary angle closure suspects and primary angle closure glaucoma. Eye = Glaz 2022;24(1):20–33 (In Russ.). DOI: 10.33791/2222-4408-2022-1-20-33</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Song M.K., Sung K.R., Shin J.W., Jo Y.H., Won H.J. Glaucomatous Progression After Lens Extraction in Primary Angle Closure Disease Spectrum. J Glaucoma. 2020;29(8):711–717. DOI: 10.1097/IJG.0000000000001537</mixed-citation><mixed-citation xml:lang="en">Song M.K., Sung K.R., Shin J.W., Jo Y.H., Won H.J. Glaucomatous Progression After Lens Extraction in Primary Angle Closure Disease Spectrum. J Glaucoma. 2020;29(8):711–717. DOI: 10.1097/IJG.0000000000001537</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Song,M.K., Shin J.W., Sung, K.R. Factors Associated with Deterioration of Primary Angle Closure after Lens Extraction. J.Clin. Med. 2022;11:2557. DOI: 10.3390/jcm11092557</mixed-citation><mixed-citation xml:lang="en">Song,M.K., Shin J.W., Sung, K.R. Factors Associated with Deterioration of Primary Angle Closure after Lens Extraction. J.Clin. Med. 2022;11:2557. DOI: 10.3390/jcm11092557</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Azuara-Blanco A., Burr J., Ramsay C., Cooper D. Effectiveness of early lens extraction for the treatment of primary angle-closure glaucoma (EAGLE): a andomized controlled trial. Lancet. 2016;388(10052):1389–1397. DOI: 10.1016/S0140-6736(16)30956-4</mixed-citation><mixed-citation xml:lang="en">Azuara-Blanco A., Burr J., Ramsay C., Cooper D. Effectiveness of early lens extraction for the treatment of primary angle-closure glaucoma (EAGLE): a andomized controlled trial. Lancet. 2016;388(10052):1389–1397. DOI: 10.1016/S0140-6736(16)30956-4</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Родионова О.Е., Померанцев А.Л. Хемометрика: достижения и перспективы. Успехи химии. 2006;75(4):302–317. DOI: 10.1070/RC2006v075n04ABEH003599</mixed-citation><mixed-citation xml:lang="en">Rodionova O.Ye, Pomerantsev A.L. Chemometrics: achievements and prospects. Russian Chemical Reviews  = Uspehi himii. 2006;75(4):302–317 (In Russ.). DOI: 10.1070/RC2006v075n04ABEH003599</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Pomerantsev A.L. Acceptance areas for multivariate classification derived by projection methods. J. Chemometrics. 2008;22:601–609. DOI: 10.1002/cem.1147</mixed-citation><mixed-citation xml:lang="en">Pomerantsev A.L. Acceptance areas for multivariate classification derived by projection methods. J. Chemometrics. 2008;22:601–609. DOI: 10.1002/cem.1147</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Shehab M., Abualigah L., Shambour Q. Machine learning in medical applications: A review of state-of-the-art methods [published online ahead of print, 2022 Mar 28]. Comput Biol Med. 2022;145:105458. DOI: 10.1016/j.compbiomed.2022.10</mixed-citation><mixed-citation xml:lang="en">Shehab M., Abualigah L., Shambour Q. Machine learning in medical applications: A review of state-of-the-art methods [published online ahead of print, 2022 Mar 28]. Comput Biol Med. 2022;145:105458. DOI: 10.1016/j.compbiomed.2022.10</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Busnatu Ș., Niculescu A.G., Bolocan A. Clinical Applications of Artificial Intelligence-An Updated Overview. J Clin Med. 2022;11(8):2265. DOI: 10.3390/jcm11082265</mixed-citation><mixed-citation xml:lang="en">Busnatu Ș., Niculescu A.G., Bolocan A. Clinical Applications of Artificial Intelligence-An Updated Overview. J Clin Med. 2022;11(8):2265. DOI: 10.3390/jcm11082265</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Shah S.M., Khan R.A., Arif S., Sajid U. Artificial intelligence for breast cancer analysis: Trends &amp; directions. Comput Biol Med. 2022;142:105221. DOI: 10.1016/j.compbiomed.2022.105221</mixed-citation><mixed-citation xml:lang="en">Shah S.M., Khan R.A., Arif S., Sajid U. Artificial intelligence for breast cancer analysis: Trends &amp; directions. Comput Biol Med. 2022;142:105221. DOI: 10.1016/j.compbiomed.2022.105221</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Nuzzi R., Boscia G., Marolo P., Ricardi F. The Impact of Artificial Intelligence and Deep Learning in Eye Diseases: A Review. Front Med (Lausanne). 2021;8:710329. DOI: 10.3389/fmed.2021.710329</mixed-citation><mixed-citation xml:lang="en">Nuzzi R., Boscia G., Marolo P., Ricardi F. The Impact of Artificial Intelligence and Deep Learning in Eye Diseases: A Review. Front Med (Lausanne). 2021;8:710329. DOI: 10.3389/fmed.2021.710329</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Asaoka R., Murata H., Hirasawa K. Using Deep Learning and Transfer Learning to Accurately Diagnose Early-Onset Glaucoma From Macular Optical Coherence Tomography Images. Am J Ophthalmol. 2019;198:136–145. DOI: 10.1016/j.ajo.2018.10.007</mixed-citation><mixed-citation xml:lang="en">Asaoka R., Murata H., Hirasawa K. Using Deep Learning and Transfer Learning to Accurately Diagnose Early-Onset Glaucoma From Macular Optical Coherence Tomography Images. Am J Ophthalmol. 2019;198:136–145. DOI: 10.1016/j.ajo.2018.10.007</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Shibata N., Tanito M., Mitsuhashi K. Development of a deep residual learning algorithm to screen for glaucoma from fundus photography. Sci Rep. 2018;8(1):14665. DOI: 10.1038/s41598-018-33013-w</mixed-citation><mixed-citation xml:lang="en">Shibata N., Tanito M., Mitsuhashi K. Development of a deep residual learning algorithm to screen for glaucoma from fundus photography. Sci Rep. 2018;8(1):14665. DOI: 10.1038/s41598-018-33013-w</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Hood D.C., De Moraes C.G. Efficacy of a Deep Learning System for Detecting Glaucomatous Optic Neuropathy Based on Color Fundus Photographs. Ophthalmology. 2018;125(8):1207–1208. DOI: 10.1016/j.ophtha.2018.04.020</mixed-citation><mixed-citation xml:lang="en">Hood D.C., De Moraes C.G. Efficacy of a Deep Learning System for Detecting Glaucomatous Optic Neuropathy Based on Color Fundus Photographs. Ophthalmology. 2018;125(8):1207–1208. DOI: 10.1016/j.ophtha.2018.04.020</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Asaoka R., Murata H., Iwase A., Araie M. Detecting Preperimetric Glaucoma with Standard Automated Perimetry Using a Deep Learning Classifier. Ophthalmology. 2016;123(9):1974–1980. DOI: 10.1016/j.ophtha.2016.05.029</mixed-citation><mixed-citation xml:lang="en">Asaoka R., Murata H., Iwase A., Araie M. Detecting Preperimetric Glaucoma with Standard Automated Perimetry Using a Deep Learning Classifier. Ophthalmology. 2016;123(9):1974–1980. DOI: 10.1016/j.ophtha.2016.05.029</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Y., Cun Q., Li J. Prevalence, ethnic differences and risk factors of primary angle-closure glaucoma in a multiethnic Chinese adult population: the Yunnan Minority Eye Study [published online ahead of print, 2021 Dec 21]. Br J Ophthalmol. 2021;bjophthalmol-2021-320241. DOI: 10.1136/bjophthalmol-2021-320241</mixed-citation><mixed-citation xml:lang="en">Wang Y., Cun Q., Li J. Prevalence, ethnic differences and risk factors of primary angle-closure glaucoma in a multiethnic Chinese adult population: the Yunnan Minority Eye Study [published online ahead of print, 2021 Dec 21]. Br J Ophthalmol. 2021;bjophthalmol-2021-320241. DOI: 10.1136/bjophthalmol-2021-320241</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Quinn B., McCarron P., Hong Y. Elementomics combined with dd-SIMCA and K-NN to identify the geographical origin of rice samples from China, India, and Vietnam. Food Chem. 2022;386:132738. DOI: 10.1016/j.foodchem.2022.132738</mixed-citation><mixed-citation xml:lang="en">Quinn B., McCarron P., Hong Y. Elementomics combined with dd-SIMCA and K-NN to identify the geographical origin of rice samples from China, India, and Vietnam. Food Chem. 2022;386:132738. DOI: 10.1016/j.foodchem.2022.132738</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Pinto F.G., Mahmud I., Rubio V.Y. Data-Driven Soft Independent Modeling of Class Analogy in Paper Spray Ionization Mass Spectrometry-Based Metabolomics for Rapid Detection of Prostate Cancer. Anal Chem. 2022;94(4):1925–1931. DOI: 10.1021/acs.analchem.1c04004</mixed-citation><mixed-citation xml:lang="en">Pinto F.G., Mahmud I., Rubio V.Y. Data-Driven Soft Independent Modeling of Class Analogy in Paper Spray Ionization Mass Spectrometry-Based Metabolomics for Rapid Detection of Prostate Cancer. Anal Chem. 2022;94(4):1925–1931. DOI: 10.1021/acs.analchem.1c04004</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Ferreira R., Marcos A.S., Anjos M., Maia C., Pinto A.R.G., de Azevedo A., de Brito J. Long-term analysis of the physical properties of the mixed recycled aggregate and their effect on the properties of mortars. Construction and Building Materials. 2021;274:121796. DOI: 10.1016/j.conbuildmat.2020.121796</mixed-citation><mixed-citation xml:lang="en">Ferreira R., Marcos A.S., Anjos M., Maia C., Pinto A.R.G., de Azevedo A., de Brito J. Long-term analysis of the physical properties of the mixed recycled aggregate and their effect on the properties of mortars. Construction and Building Materials. 2021;274:121796. DOI: 10.1016/j.conbuildmat.2020.121796</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Nazarenko R.V., Irzhak A.V., Pomerantsev A.L., Rodionova O.Y. Confocal Raman spectroscopy and multivariate data analysis for evaluation of spermatozoa with normal and abnormal morphology. A feasibility study. Chemom. Intell. Lab. Syst. 2018;182(October):172–179. DOI: 10.1016/j.chemolab.2018.10.002</mixed-citation><mixed-citation xml:lang="en">Nazarenko R.V., Irzhak A.V., Pomerantsev A.L., Rodionova O.Y. Confocal Raman spectroscopy and multivariate data analysis for evaluation of spermatozoa with normal and abnormal morphology. A feasibility study. Chemom. Intell. Lab. Syst. 2018;182(October):172–179. DOI: 10.1016/j.chemolab.2018.10.002</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Belyaev I., Marolda A., Praetorius J.-P., Sarkar A., Medyukhina A., Hünniger K., Kurzai O., Thilo Figge M. Automated Characterisation of Neutrophil Activation Phenotypes in Ex Vivo Human Candida Blood Infections. Computational and Structural Biotechnology Journal. 2022;10;20:2297-2308. DOI: 10.1016/j.csbj.2022.05.007</mixed-citation><mixed-citation xml:lang="en">Belyaev I., Marolda A., Praetorius J.-P., Sarkar A., Medyukhina A., Hünniger K., Kurzai O., Thilo Figge M. Automated Characterisation of Neutrophil Activation Phenotypes in Ex Vivo Human Candida Blood Infections. Computational and Structural Biotechnology Journal. 2022;10;20:2297-2308. DOI: 10.1016/j.csbj.2022.05.007</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Foster P.J., Buhrmann R., Quigley H.A., Johnson G.J. The definition and classification of glaucoma in prevalence surveys. Br J Ophthalmol. 2002;86(2):238–242. DOI: 10.1136/bjo.86.2.238</mixed-citation><mixed-citation xml:lang="en">Foster P.J., Buhrmann R., Quigley H.A., Johnson G.J. The definition and classification of glaucoma in prevalence surveys. Br J Ophthalmol. 2002;86(2):238–242. DOI: 10.1136/bjo.86.2.238</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Chylack L.T. Jr, Wolfe J.K., Singer D.M. The Lens Opacities Classification System III. The Longitudinal Study of Cataract Study Group. Arch Ophthalmol. 1993;111(6):831–836. DOI: 10.1001/archopht.1993.01090060119035</mixed-citation><mixed-citation xml:lang="en">Chylack L.T. Jr, Wolfe J.K., Singer D.M. The Lens Opacities Classification System III. The Longitudinal Study of Cataract Study Group. Arch Ophthalmol. 1993;111(6):831–836. DOI: 10.1001/archopht.1993.01090060119035</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Курышева Н.И., Шарова Г.А. Роль оптической когерентной томографии в диагностике заболеваний закрытого угла передней камеры. Часть 1: Визуализация переднего сегмента глаза. Офтальмология. 2021;18(2):208–215. DOI: 10.18008/1816-5095-2021-2-208-215</mixed-citation><mixed-citation xml:lang="en">Kurysheva N.I., Sharova G.A. The Role of Optical Coherence Tomography in the Diagnosis of Angle Closed Diseases of the Anterior Chamber. Part 1: Visualization of the Anterior Segment of the Eye. Ophthalmology in Russia = Oftal’mologiya. 2021;18(2):208–215 (In Russ.). DOI: 10.18008/1816-5095-2021-2-208-215</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Курышева Н.И., Бояринцева М.А., Фомин А.В. Хориоидея при первичной закрытоугольной глаукоме: результаты исследования методом оптической когерентной томографии. Офтальмология. 2013;10(4):26–31. DOI: 10.18008/1816-5095-2013-4-26-31</mixed-citation><mixed-citation xml:lang="en">Kurysheva N.I., Boyarinceva M.A., Fomin A.V. Choroidal thickness in primary angle-closure glaucoma: the results of Measurement by Means of Optical Coherence Tomography. Ophthalmology in Russia = Oftal’mologiya.. 2013;10(4):26–31. DOI: 10.18008/1816-5095-2013-4-26-31</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">He M., Jiang Y., Huang S., Chang D.S., Munoz B., Aung T., Foster P.J., Friedman D.S. Laser peripheral iridotomy for the prevention of angle closure: a single-centre, Randomized controlled trial. Lancet. 2019 Apr 20;393(10181):1609–1618. DOI: 10.1016/S0140-6736(18)32607-2</mixed-citation><mixed-citation xml:lang="en">He M., Jiang Y., Huang S., Chang D.S., Munoz B., Aung T., Foster P.J., Friedman D.S. Laser peripheral iridotomy for the prevention of angle closure: a single-centre, Randomized controlled trial. Lancet. 2019 Apr 20;393(10181):1609–1618. DOI: 10.1016/S0140-6736(18)32607-2</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Pomerantsev A.L., Rodionova O.Ye. Concept and role of extreme objects in PCA/ SIMCA. J. Chemometrics. 2014;28:429–438. DOI: 10.1002/cem.2506 31. Pomerantsev A.L., Rodionova O.Ye. On the type II error in SIMCA method. J. Chemometrics. 2014;28:518-522. DOI: 10.1002/cem.2610</mixed-citation><mixed-citation xml:lang="en">Pomerantsev A.L., Rodionova O.Ye. Concept and role of extreme objects in PCA/ SIMCA. J. Chemometrics. 2014;28:429–438. DOI: 10.1002/cem.2506 31. Pomerantsev A.L., Rodionova O.Ye. On the type II error in SIMCA method. J. Chemometrics. 2014;28:518-522. DOI: 10.1002/cem.2610</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Щуко А.Г., Чешейко Е.Ю., Юрьева Т.Н. Критерии дифференциальной диагностики функционального ангулярного блока — латентной стадии закрытоугольной глаукомы. Вестник Оренбургского государственного университета. 2012;148(12):239–243.</mixed-citation><mixed-citation xml:lang="en">Shchuko A.G., Chesheyko Ye.Yu., Yuryeva T.N. Criteria for differential diagnostics of functional angular block — latent stage of closed — angle glaucoma. Annals of Orenburg State University = Vestnik Orenburgskogo gosudarstvennogo universiteta. 2012;148(12):239–243 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Щуко А.Г., Чешейко Е.Ю., Юрьева Т.Н., Малышев В.В. Структурно-функциональные изменения зрительной системы у пациентов с функциональным ангулярным блоком. Российский медицинский журнал. Клиническая офтальмология. 2007;8(4);137.</mixed-citation><mixed-citation xml:lang="en">Schuko A.G., Chesheiko E.Yu., Yur’eva T.N., Malyshev V.V. Structural and functional changes of visual system in patients with functional angular block. Russian Medical Journal. Clinical Ophthalmology = Rossiyskiy medicinskiy zhurnal. Klinicheskaya oftal’mologiya. 2007;8(4);137 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Bo J., Changulani T., Cheng M.L., Tatham A.J. Outcome Following Laser Peripheral Iridotomy and Predictors of Future Lens Extraction. J Glaucoma. 2018;27(3):275– 280. DOI: 10.1097/IJG.0000000000000863</mixed-citation><mixed-citation xml:lang="en">Bo J., Changulani T., Cheng M.L., Tatham A.J. Outcome Following Laser Peripheral Iridotomy and Predictors of Future Lens Extraction. J Glaucoma. 2018;27(3):275– 280. DOI: 10.1097/IJG.0000000000000863</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Huang G., Gonzalez E., Peng P.H. Anterior chamber depth, iridocorneal angle width, and intraocular pressure changes after phacoemulsification: narrow vs open iridocorneal angles [published correction appears in Arch Ophthalmol. 2011 Nov;129(11):1497]. Arch Ophthalmol. 2011;129(10):1283-1290. DOI: 10.1001/archophthalmol.2011.272</mixed-citation><mixed-citation xml:lang="en">Huang G., Gonzalez E., Peng P.H. Anterior chamber depth, iridocorneal angle width, and intraocular pressure changes after phacoemulsification: narrow vs open iridocorneal angles [published correction appears in Arch Ophthalmol. 2011 Nov;129(11):1497]. Arch Ophthalmol. 2011;129(10):1283-1290. DOI: 10.1001/archophthalmol.2011.272</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Zebardast N., Kavitha S., Krishnamurthy P. Changes in Anterior Segment Morphology and Predictors of Angle Widening after Laser Iridotomy in South Indian Eyes. Ophthalmology. 2016;123(12):2519–2526. DOI: 10.1016/j.ophtha.2016.08.020</mixed-citation><mixed-citation xml:lang="en">Zebardast N., Kavitha S., Krishnamurthy P. Changes in Anterior Segment Morphology and Predictors of Angle Widening after Laser Iridotomy in South Indian Eyes. Ophthalmology. 2016;123(12):2519–2526. DOI: 10.1016/j.ophtha.2016.08.020</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Moghimi S., Chen R., Johari M., Bijani F., Mohammadi M., Khodabandeh A., He M.G., Lin S.C. Changes in anterior segment morphology after laser peripheral iridotomy in acute primary angle closure. Am J Ophthalmol. 2016;166:133–140. DOI: 10.1016/j.ajo.2016.03.032</mixed-citation><mixed-citation xml:lang="en">Moghimi S., Chen R., Johari M., Bijani F., Mohammadi M., Khodabandeh A., He M.G., Lin S.C. Changes in anterior segment morphology after laser peripheral iridotomy in acute primary angle closure. Am J Ophthalmol. 2016;166:133–140. DOI: 10.1016/j.ajo.2016.03.032</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Huang G., Gonzalez E., Lee R., Osmonavic S., Leeungurasatien T., He M., Lin S.C. Anatomic predictors for anterior chamber angle opening after laser peripheral iridotomy in narrow angle eyes. Curr Eye Res. 2012;37(7):575–582. DOI: 10.3109/02713683.2012.655396</mixed-citation><mixed-citation xml:lang="en">Huang G., Gonzalez E., Lee R., Osmonavic S., Leeungurasatien T., He M., Lin S.C. Anatomic predictors for anterior chamber angle opening after laser peripheral iridotomy in narrow angle eyes. Curr Eye Res. 2012;37(7):575–582. DOI: 10.3109/02713683.2012.655396</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Chen X., Wang X., Tang Y., Sun X., Chen Y. Optical coherence tomography analysis of anterior segment parameters before and after laser peripheral iridotomy in primary angle-closure suspects by using CASIA2. BMC Ophthalmol. 2022;22(1):144. DOI: 10.1186/s12886-022-02366-2</mixed-citation><mixed-citation xml:lang="en">Chen X., Wang X., Tang Y., Sun X., Chen Y. Optical coherence tomography analysis of anterior segment parameters before and after laser peripheral iridotomy in primary angle-closure suspects by using CASIA2. BMC Ophthalmol. 2022;22(1):144. DOI: 10.1186/s12886-022-02366-2</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Shams P.N., Foster P.J. Clinical outcomes after lens extraction for visually significant cataract in eyes with primary angle closure. J Glaucoma. 2012;21(8):545–550. DOI: 10.1097/IJG.0b013e31821db1db</mixed-citation><mixed-citation xml:lang="en">Shams P.N., Foster P.J. Clinical outcomes after lens extraction for visually significant cataract in eyes with primary angle closure. J Glaucoma. 2012;21(8):545–550. DOI: 10.1097/IJG.0b013e31821db1db</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
