ophthalmologyОфтальмологияOphthalmology in Russia1816-50952500-0845Ophthalmology10.18008/1816-5095-2022-4-719-726ophthalmology-1974Research ArticleОБЗОРЫREVIEWSКлинические вариации увеитов при иммуновоспалительных заболеваниях. Обзор литературы. Часть 2Clinical Variations of Uveitis in Immuno-Inflammatory Diseases. Review of the Literature. Part 2https://orcid.org/0000-0003-4215-7084ДавыдоваГ. А.DavydovaG. A.

 кандидат медицинских наук, научный сотрудник отдела патологии сетчатки и зрительного нерва

 ул. Садовая-Черногрязская, 14/19, Москва, 105062, Российская Федерация 

PhD, research officer of Retina and optic nerve pathology department

Sadovaya Chernogryazskaya str., 14/19, Moscow, 105062, Russian Federation 

6298685@mail.ruhttps://orcid.org/0000-0001-9437-406XЛисицынаТ. А.LisitsynaT. A.

 доктор медицинских наук, ведущий научный сотрудник лаборатории сосудистой ревматологии

Каширское шоссе, 34а, Москва, 115522, Российская Федерация 

МD, senior scientific researcher of the Vascular rheumatology laboratory

Kashirskoe highway, 34A, Moscow 115522, Russian Federation 

https://orcid.org/0000-0001-6239-9553КовалеваЛ. А.KovalevaL. A.

кандидат медицинских наук, научный сотрудник отдела инфекционных и аллергических заболеваний глаз

 ул. Садовая-Черногрязская, 14/19, Москва, 105062, Российская Федерация 

PhD, research officer of Infectious and allergic eye diseases department

Sadovaya Chernogryazskaya str., 14/19, Moscow, 105062, Russian Federation 

https://orcid.org/0000-0002-8568-8689СорожкинаЕ. С.SorozhkinaE. S.

научный сотрудник отдела иммунологии и вирусологии

ул. Садовая-Черногрязская, 14/19, Москва, 105062, Российская Федерация 

Research officer of Immunology and virology department

Sadovaya Chernogryazskaya str., 14/19, Moscow, 105062, Russian Federation 

https://orcid.org/0000-0001-8852-3305ЗайцеваА. А.ZaitsevaA. A.

врач‑офтальмолог взрослого консультативно–поликлинического отделения

 ул. Садовая-Черногрязская, 14/19, Москва, 105062, Российская Федерация 

ophthalmologist of the Adult consulting and polyclinic department

Sadovaya Chernogryazskaya str., 14/19, Moscow, 105062, Russian Federation 

https://orcid.org/0000-0002-8014-667XБайсангуроваА. А.BaisangurovaA. A.

врач‑офтальмолог взрослого  консультативно‑поликлинического отделения 

 ул. Садовая-Черногрязская, 14/19, Москва, 105062, Российская Федерация 

ophthalmologist, of the Adult consulting and polyclinic department

Sadovaya Chernogryazskaya str., 14/19, Moscow, 105062, Russian Federation 

ФГБУ «Национальный медицинский исследовательский центр глазных болезней им. Гельмгольца» Министерства здравоохранения Российской ФедерацииРоссияHelmholtz National Medical Research Center of Eye DiseasesRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation202228122022194719726Copyright © Давыдова Г.А., Лисицына Т.А., Ковалева Л.А., Сорожкина Е.С., Зайцева А.А., Байсангурова А.А., 20232023Давыдова Г.А., Лисицына Т.А., Ковалева Л.А., Сорожкина Е.С., Зайцева А.А., Байсангурова А.А.Davydova G.A., Lisitsyna T.A., Kovaleva L.A., Sorozhkina E.S., Zaitseva A.A., Baisangurova A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.ophthalmojournal.com/opht/article/view/1974

В предыдущей части обзора обсуждались актуальные клинические и диагностические аспекты некоторых неинфекционных увеитов у больных с иммуновоспалительными заболеваниями. В этой части будет продолжено обсуждение современного состояния вопроса в отношении глазных манифестаций ряда других иммуновоспалительных состояний. Помимо увеитов, ассоциированных со спондилоартропатиями, ревматоидным артритом, болезнью Стилла, ювенильным идиопатическим артритом и системным саркоидозом, описанных в предыдущей части, нередки также глазные проявления при системных васкулитах, системной красной волчанке, синдроме Фогта — Коянаги — Харада. Несмотря на разработанные многочисленные схемы диагностики и алгоритмы терапии, многое в патогенезе увеитов, связанных с иммуновоспалительными заболеваниями, остается неизученным. Не теряет актуальность необходимость разработки персонализированных и мультидисциплинарных подходов для лечения и диагностики неинфекционных увеитов при многочисленных системных иммуновоспалительных заболеваниях. Углубленное понимание механизмов этиопатогенеза иммуновоспалительных процессов позволит определить новые подходы в лечении пациентов с увеитами.

In the previous part of the review clinical and diagnostic aspects of some non-infectious uveitis in patients with immunoinflammatory diseases were discussed. In this part we proceed the discussion of ocular manifestations of a number of other immunoinflammatory conditions. In addition to uveitis associated with spondyloarthropathies, rheumatoid arthritis, Still’s disease, juvenile idiopathic arthritis and systemic sarcoidosis described in the previous part, ocular manifestations are also common in systemic vasculitis, systemic lupus erythematosus, Vogt—Koyanagi—Harada syndrome. Despite the numerous diagnostic schemes and therapy algorithms developed to date, much in the pathogenesis of uveitis associated with immuno-inflammatory diseases remains unclear. The need to develop personalized and multidisciplinary approaches for the treatment and diagnosis of non-infectious uveitis in numerous systemic immunoinflammatory diseases remains relevant. In-depth understanding of etiopathogenetic mechanisms of immunoinflammatory processes will allow to develop new approaches in the treatment of patients with uveitis.

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The authors declare that there are no conflicts of interest present.