<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2023-1-53-60</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-2041</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Импрессионная цитология как метод цитологической диагностики в офтальмологии. Обзор литературы</article-title><trans-title-group xml:lang="en"><trans-title>Impression Cytology as a Method of Cytological Diagnostics in Ophthalmology. Literature Review</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0981-8370</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Злобин</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zlobin</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Злобин Илья Александрович - клинический ординатор</p><p>ул. Академика Лебедева, 6, Санкт‑Петербург, 194044, Российская Федерации</p></bio><bio xml:lang="en"><p>Zlobin Ilia A. - clinical resident of the Ophthalmology department named after Prof. V.V. Volkov </p><p> Academician Lebedev str., 6, Saint Petersburg, 194044, Russian Federation </p></bio><email xlink:type="simple">iliavma2020@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1197-9237</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чурашов</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Churashov</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чурашов Сергей Викторович - доктор медицинских наук, профессор, профессор кафедры  офтальмологии им. профессора В.В. Волкова</p><p>ул. Академика Лебедева, 6, Санкт‑Петербург, 194044, Российская Федерация</p></bio><bio xml:lang="en"><p>Churashov Sergey V. - MD, Professor, Professor of the Ophthalmology department named after Prof. V.V. Volkov </p><p> Academician Lebedev str., 6, Saint Petersburg, 194044, Russian Federation </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5274-6993</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куликов</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulikov</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Куликов Алексей Николаевич - доктор медицинских наук, профессор, начальник кафедры офтальмологии им. профессора В.В. Волкова</p><p>ул. Академика Лебедева, 6, Санкт‑Петербург, 194044, Российская Федерация</p></bio><bio xml:lang="en"><p>Kulikov Alexey N. - MD, Professor, head of the Department and Clinic of ophthalmology; chief ophthalmologist of the Ministry of Defense of the Russian Federation </p><p> Academician Lebedev str., 6, Saint Petersburg, 194044, Russian Federation </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3215-3901</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чирский</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Chirsky</surname><given-names>V. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чирский Вадим Семенович - доктор медицинских наук, профессор, начальник кафедры патологической анатомии</p><p>ул. Академика Лебедева, 6, Санкт‑Петербург, 194044, Российская Федерация</p></bio><bio xml:lang="en"><p>Chirsky Vadim S. - MD, Professor, head of the Department of pathological anatomy; chief pathologist of the Russian Ministry of Defence </p><p> Academician Lebedev str., 6, Saint Petersburg, 194044, Russian Federation </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0122-4164</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черныш</surname><given-names>В. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernysh</surname><given-names>V. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Черныш Валерий Федорович - кандидат медицинских наук, доцент, доцент кафедры офтальмологии им. профессора В.В. Волкова</p><p>ул. Академика Лебедева, 6, Санкт‑Петербург, 194044, Российская Федерация</p></bio><bio xml:lang="en"><p>Chernysh Valery F. - PhD, Associate Professor of the Ophthalmology department named after Prof. V.V. Volkov </p><p> Academician Lebedev str., 6, Saint Petersburg, 194044, Russian Federation </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0932-2818</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гаврилюк</surname><given-names>И. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Gavrilyuk</surname><given-names>I. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гаврилюк Илья Олегович - кандидат медицинских наук, преподаватель кафедры офтальмологии им. профессора В.В. Волкова</p><p>ул. Академика Лебедева, 6, Санкт‑Петербург, 194044, Российская Федерация</p></bio><bio xml:lang="en"><p>Gavrilyuk Ilia O. - PhD, lecturer of the Ophthalmology department named after Prof. V.V. Volkov </p><p> Academician Lebedev str., 6, Saint Petersburg, 194044, Russian Federation </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБВОУ ВО «Военно-медицинская академия им. С.М. Кирова» Министерства обороны Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Military Medical Academy named after S.M. Kirov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>04</day><month>04</month><year>2023</year></pub-date><volume>20</volume><issue>1</issue><fpage>53</fpage><lpage>60</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Злобин И.А., Чурашов С.В., Куликов А.Н., Чирский В.С., Черныш В.Ф., Гаврилюк И.О., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Злобин И.А., Чурашов С.В., Куликов А.Н., Чирский В.С., Черныш В.Ф., Гаврилюк И.О.</copyright-holder><copyright-holder xml:lang="en">Zlobin I.A., Churashov S.V., Kulikov A.N., Chirsky V.S., Chernysh V.F., Gavrilyuk I.O.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/2041">https://www.ophthalmojournal.com/opht/article/view/2041</self-uri><abstract><p>Импрессионная цитология (от латинского impressio — воздействие, вдавливание) — минимально инвазивный метод цитологического исследования поверхностного эпителия роговицы, лимба и конъюнктивы с применением для забора клеточного материала различных сорбирующих аппликаторов. Спектр заболеваний, в диагностике которых традиционно применяют импрессионную цитологию, в основном связан с патологическими процессами, происходящими в конъюнктиве. Такими заболеваниями являются синдром Шегрена, синдром сухого глаза, мукополисахаридоз, дефицит витамина А, трахома, плоскоклеточная неоплазия глазной поверхности и др. Появление концепции лимбальных эпителиальных стволовых клеток роговичного эпителия открыло новые диагностические возможности импрессионной цитологии в офтальмологии.</p></abstract><trans-abstract xml:lang="en"><p>Impression cytology (from the Latin impressio — impact, indentation) is a minimally invasive method of cytological examination of the surface epithelium of the cornea, limbus and conjunctiva using various sorbing applicators for the collection of cellular material. The spectrum of diseases, in the diagnosis of which impression cytology is traditionally used, is mainly associated with pathological processes occurring in the conjunctiva. Such diseases as: Sjogren’s syndrome, dry eye syndrome, mucopolysaccharidosis, vitamin A deficiency, trachoma, squamous cell neoplasia of the ocular surface, etc. With the advent of the concept of limbal epithelial stem cell, new diagnostic possibilities of impression cytology in ophthalmology occurred.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>импрессионная цитология</kwd><kwd>заболевания глазной поверхности</kwd><kwd>лимбальная недостаточность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>impression cytology</kwd><kwd>ocular surface diseases</kwd><kwd>limbal stem cells deficiency</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Nelson JD. Impression cytology. Cornea. 1988;7(1):71–81.</mixed-citation><mixed-citation xml:lang="en">Nelson JD. Impression cytology. Cornea. 1988;7(1):71–81.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Thoft RA, Friend J. The X, Y, Z-hypothesis of corneal epithelial maintenance. Invest. Ophthalmol. Vis. Sci. 1983;24:1442–1443.</mixed-citation><mixed-citation xml:lang="en">Thoft RA, Friend J. The X, Y, Z-hypothesis of corneal epithelial maintenance. Invest. Ophthalmol. Vis. Sci. 1983;24:1442–1443.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Thatcher RW, Darougar S, Jones, B. Conjunctival impression cytology. Arch Ophthalmol. 1977;95(4):678–681. DOI: 10.1001/archopht.1977.04450040144022</mixed-citation><mixed-citation xml:lang="en">Thatcher RW, Darougar S, Jones, B. Conjunctival impression cytology. Arch Ophthalmol. 1977;95(4):678–681. DOI: 10.1001/archopht.1977.04450040144022</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Egbert PR, Lauber S, Maurice DM. A simple conjunctival biopsy. Am J Ophthalmol. 1977;84(6):798–801. DOI: 10.1016/0002-9394(77)90499-8</mixed-citation><mixed-citation xml:lang="en">Egbert PR, Lauber S, Maurice DM. A simple conjunctival biopsy. Am J Ophthalmol. 1977;84(6):798–801. DOI: 10.1016/0002-9394(77)90499-8</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">McKelvie P. Ocular surface impression cytology. Adv Anat Pathol. 2003;10(6):328–337. DOI: 10.1097/00125480-200311000-00003</mixed-citation><mixed-citation xml:lang="en">McKelvie P. Ocular surface impression cytology. Adv Anat Pathol. 2003;10(6):328–337. DOI: 10.1097/00125480-200311000-00003</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Nelson JD, Havener VR, Cameron JD. Cellulose acetate impressions of the ocular surface. Dry eye states. Arch Ophthalmol. 1983;101(12):1869–1872. DOI: 10.1001/archopht.1983.01040020871007</mixed-citation><mixed-citation xml:lang="en">Nelson JD, Havener VR, Cameron JD. Cellulose acetate impressions of the ocular surface. Dry eye states. Arch Ophthalmol. 1983;101(12):1869–1872. DOI: 10.1001/archopht.1983.01040020871007</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Singh R, Joseph A, Umapathy T. Impression cytology of the ocular surface. Br J Ophtalmol. 2005;89(12):1655–1659. DOI: 10.1136 / bjo.2005.073916</mixed-citation><mixed-citation xml:lang="en">Singh R, Joseph A, Umapathy T. Impression cytology of the ocular surface. Br J Ophtalmol. 2005;89(12):1655–1659. DOI: 10.1136 / bjo.2005.073916</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Tseng SC. Staging of conjunctival squamous metaplasia by impression cytology. Ophthalmology. 1985;92(6):728–733. DOI: 10.1016/s0161-6420(85)33967-2</mixed-citation><mixed-citation xml:lang="en">Tseng SC. Staging of conjunctival squamous metaplasia by impression cytology. Ophthalmology. 1985;92(6):728–733. DOI: 10.1016/s0161-6420(85)33967-2</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Dart J. Impression cytology of the ocular surface — Research tool or routine clinical investigation? Br J Ophthalmol. 1997;81(11):930. DOI: 10.1136/bjo.81.11.930</mixed-citation><mixed-citation xml:lang="en">Dart J. Impression cytology of the ocular surface — Research tool or routine clinical investigation? Br J Ophthalmol. 1997;81(11):930. DOI: 10.1136/bjo.81.11.930</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Lopin E, Deveney T, Asbell PA. Impression Cytology: Recent Advances and Applications in Dry Eye Disease. Ocul Surf. 2009;7(2):93–110. DOI: 10.1016/s1542-0124(12)70301-4</mixed-citation><mixed-citation xml:lang="en">Lopin E, Deveney T, Asbell PA. Impression Cytology: Recent Advances and Applications in Dry Eye Disease. Ocul Surf. 2009;7(2):93–110. DOI: 10.1016/s1542-0124(12)70301-4</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Nolan GR, Hirst LW, Wright RG. Application of impression cytology to the diagnosis of conjunctival neoplasms. Diagn Cytopathol. 1994;11(3):246–249. DOI: 10.1002/dc.2840110310</mixed-citation><mixed-citation xml:lang="en">Nolan GR, Hirst LW, Wright RG. Application of impression cytology to the diagnosis of conjunctival neoplasms. Diagn Cytopathol. 1994;11(3):246–249. DOI: 10.1002/dc.2840110310</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Calonge M, Diebold Y, Sáez V. Impression cytology of the ocular surface: a review. Exp Eye Res. 2004;78(3):457–472. DOI: 10.1016/j.exer.2003.09.009</mixed-citation><mixed-citation xml:lang="en">Calonge M, Diebold Y, Sáez V. Impression cytology of the ocular surface: a review. Exp Eye Res. 2004;78(3):457–472. DOI: 10.1016/j.exer.2003.09.009</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Thia Z Z, Tong L. Update on the role of impression cytology in ocular surface disease. Taiwan J Ophthalmol. 2019;9(3):141–149. DOI: 10.4103/tjo.tjo_57_19. Collection Jul Sep 2019.</mixed-citation><mixed-citation xml:lang="en">Thia Z Z, Tong L. Update on the role of impression cytology in ocular surface disease. Taiwan J Ophthalmol. 2019;9(3):141–149. DOI: 10.4103/tjo.tjo_57_19. Collection Jul Sep 2019.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Еременко А.И., Янченко С.В. Модифицированная импрессионная цитология у больных вторичным синдромом «сухого глаза», обусловленным инстилляциями глазных капель с наличием консерванта. Кубанский научный медицинский вестник. 2009;9(114):48–50.</mixed-citation><mixed-citation xml:lang="en">Eremenko AI, Yanchenko SV, Kiselyov AV. Modified impression cytology at the patients with the «dry eye», caused preservative containing eye drops. Kuban scientific medical bulletin = Kubanskiy nauchnyy meditsinskiy vestnik. 2009;9(114):48–50 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Гаврилюк И.О., Куликов А.Н., Черныш В.Ф. Усовершенствование методики подготовки препаратов эпителия роговицы для импрессионной цитологии с целью витальной оценки его фенотипа в эксперименте. Современные технологии в офтальмологии. 2017;4:55–57.</mixed-citation><mixed-citation xml:lang="en">Gavrilyuk I.O., Kulikov A.N., Chernysh V.F. Improvement of a technique for preparation of corneal epithelium preparations for impression cytology with the purpose of vitality assessment of its phenotype in experiment. Modern technologies in ophthalmology = Sovremennye tekhnologii v oftal’mologii. 2017;4:55–57 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Бржеский В.В., Егорова Г.Б., Егоров Е.А. Синдром «сухого глаза» и заболевания глазной поверхности: клиника, дагностика, лечение. М.: ГЭОТАР-Медиа, 2016.</mixed-citation><mixed-citation xml:lang="en">Brzheskiy V.V., Egorova G.B., Egorov E.A. Dry eye syndrome and ocular surface diseases: clinic, diagnostics, treatment. Moscow: GEOTAR-Media, 2016 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Волкович Т.К., Самсонова И.В., Имшенецкая Т.А. Импрессионная цитология: диагностические возможности в офтальмологии. Российская детская офтальмология. 2016;1:46–52.</mixed-citation><mixed-citation xml:lang="en">Volkovich TK, Samsonova IV, Imshenetskaya TA. Impression cytology: diagnostic possibilities in ophthalmology. Russian ophthalmology of children = Rossiyskaya detskaya oftal’mologiya. 2016;1:46–52 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Chawla F., Armstrong M, Carley F. Acanthamoeba keratitis — an increasing. Cont Lens Anterior Eye. 2014;37(2):120. DOI: 10.1016/j.clae.2013.09.002. Epub 2013 Oct 28.</mixed-citation><mixed-citation xml:lang="en">Chawla F., Armstrong M, Carley F. Acanthamoeba keratitis — an increasing. Cont Lens Anterior Eye. 2014;37(2):120. DOI: 10.1016/j.clae.2013.09.002. Epub 2013 Oct 28.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Чирский В.С., Чурашов С.В., Злобин И.А. Определение исходов раннего консервативного лечения щелочных ожогов роговицы и лимба различной протяженности с использованием импрессионной цитологии в эксперименте. Вестник Российской Военно-медицинской академии. 2016;1(53):131–137.</mixed-citation><mixed-citation xml:lang="en">Chirsky V.S., Churashov S.V., Zlobin I.A. Determination of the outcomes of early conservative treatment of alkaline burns of the cornea and limbus of different extent using impingement cytology in experiment. Bulletin of the Russian Military Medical Academy = Vestnik Rossiyskoy Voyenno-meditsinskoy akademii. 2016;1(53):131–137 (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Злобин И.А., Чурашов С.В., Черныш В.Ф. Применение импрессионной цитологии в оценке фенотипа эпителия роговицы при решении вопроса о показаниях к операции оптической кератопластики. Вестник Российской Военно-медицинской академии. 2016;1(53):46–49.</mixed-citation><mixed-citation xml:lang="en">Zlobin I.A., Churashov S.V., Chernysh V.F. Application of impression cytology in evaluation of corneal epithelium phenotype when deciding on indications for optical keratoplasty operation. Bulletin of the Russian Military Medical Academy = Vestnik Rossiyskoy Voyenno-meditsinskoy akademii. 2016;1(53):46–49 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Kanavi MR, Hosseini B, Javadi F Impression cytology in eyes with clinical and confocal scan features of acanthamoeba keratitis. J Ophthalmic Vis Res. 2013;8(3):207–212.</mixed-citation><mixed-citation xml:lang="en">Kanavi MR, Hosseini B, Javadi F Impression cytology in eyes with clinical and confocal scan features of acanthamoeba keratitis. J Ophthalmic Vis Res. 2013;8(3):207–212.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Sawada Y, Yuan C, Huang AJW. Impression cytology in the diagnosis of acanthamoeba keratitis with surface involvement. Am J Ophthalmol. 2004;137(2):323–328. DOI: 10.1016/j.ajo.2003.09.019</mixed-citation><mixed-citation xml:lang="en">Sawada Y, Yuan C, Huang AJW. Impression cytology in the diagnosis of acanthamoeba keratitis with surface involvement. Am J Ophthalmol. 2004;137(2):323–328. DOI: 10.1016/j.ajo.2003.09.019</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Graham JE, Moore JE, Jiru X Ocular pathogen or commensal: A PCR based study of surface bacterial flora in normal and dry eyes. Invest. Ophthalmol. Vis. Sci. 2007;48:5616 23. DOI: 10.1167/iovs.07-0588</mixed-citation><mixed-citation xml:lang="en">Graham JE, Moore JE, Jiru X Ocular pathogen or commensal: A PCR based study of surface bacterial flora in normal and dry eyes. Invest. Ophthalmol. Vis. Sci. 2007;48:5616 23. DOI: 10.1167/iovs.07-0588</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Thoft R.A., Friend J. Biochemical transformation of regenerating ocular surface epithelium. Invest. Ophthalmol. Vis. Sci. 1977;16(1):14–20.</mixed-citation><mixed-citation xml:lang="en">Thoft R.A., Friend J. Biochemical transformation of regenerating ocular surface epithelium. Invest. Ophthalmol. Vis. Sci. 1977;16(1):14–20.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Черныш В.Ф. Бойко Э.В. Ожоги глаз. Состояние проблемы и новые подходы. М.: ГЭОТАР-Медиа, 2017.</mixed-citation><mixed-citation xml:lang="en">Chernysh V.F. Boyko E.V. Eye burns. State of the problem and new approaches. Moscow: Geotar-Media, 2017 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Deng SX, Borderie V., Chan CC. Global consensus on definition, classification, diagnosis, and staging of limbal stem cell deficiency. Cornea. 2019;38(3):364–437. DOI: 10.1097/ICO.0000000000001820</mixed-citation><mixed-citation xml:lang="en">Deng SX, Borderie V., Chan CC. Global consensus on definition, classification, diagnosis, and staging of limbal stem cell deficiency. Cornea. 2019;38(3):364–437. DOI: 10.1097/ICO.0000000000001820</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Tseng SC. Concept and application of limbal stem cells. Eye (Lond). 1989;3:141–157. DOI: 10.1038/eye.1989.22</mixed-citation><mixed-citation xml:lang="en">Tseng SC. Concept and application of limbal stem cells. Eye (Lond). 1989;3:141–157. DOI: 10.1038/eye.1989.22</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Baradaran Rafii A, Javadi M A, Kanavi MR. Limbal Stem Cell Deficiency in Chronic and Delayed onset Mustard Gas Keratopathy. Ophthalmology. 2010;117(2):246–252. DOI: 10.1016/j.ophtha.2009.07.012</mixed-citation><mixed-citation xml:lang="en">Baradaran Rafii A, Javadi M A, Kanavi MR. Limbal Stem Cell Deficiency in Chronic and Delayed onset Mustard Gas Keratopathy. Ophthalmology. 2010;117(2):246–252. DOI: 10.1016/j.ophtha.2009.07.012</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">López García JS, Rivas L, García Lozano I. Analysis of Corneal Surface Evolution After Moderate Alkaline Burns by Using Impression Cytology. Cornea. 2006;25(8):908–913. DOI: 10.1097/01.ico.0000225711.54888.e8</mixed-citation><mixed-citation xml:lang="en">López García JS, Rivas L, García Lozano I. Analysis of Corneal Surface Evolution After Moderate Alkaline Burns by Using Impression Cytology. Cornea. 2006;25(8):908–913. DOI: 10.1097/01.ico.0000225711.54888.e8</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Злобин И.А., Чурашов С.В., Куликов А.Н., Чирский В.С., Черныш В.Ф., Гаврилюк И.О. Выбор тактики хирургического лечения сосудистых бельм на основе импрессионной цитологии. Российский офтальмологический журнал. 2022;15 (2 (Прил)):61–68. DOI: 10.21516/2072-0076-2022-15-2-supplement-61-68</mixed-citation><mixed-citation xml:lang="en">Zlobin I.A., Churashov S.V., Kulikov A.N., Chirsky V.S., Chernysh V.F., Gavrilyuk I.O. Choosing the tactics of surgical treatment of vascular leukomas based on impression cytology. Russian Ophthalmological Journal = Rossiyskiy oftal’mologicheskiy zhurnal. 2022;15(2 (appl.)):61–68 (In Russ.). DOI: 10.21516/2072-0076-2022-15-2-supplement-61-68</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Sangwan VS, Murthy SI, Vemuganty GK. Cultivated corneal epithelial transplantation for severe ocular surface disease in vernal keratoconjnctivitis. Cornea. 2005;24(4):426–30. DOI: 10.1097/01.ico.0000151508.49565.8a</mixed-citation><mixed-citation xml:lang="en">Sangwan VS, Murthy SI, Vemuganty GK. Cultivated corneal epithelial transplantation for severe ocular surface disease in vernal keratoconjnctivitis. Cornea. 2005;24(4):426–30. DOI: 10.1097/01.ico.0000151508.49565.8a</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Kim KH, Park SW, Kim MK. Effect of age and early intervention with a systemic steroid, intravenous immunoglobulin or amniotic membrane transplantation on the ocular outcomes of patients with Stevens Johnson syndrome. Korean journal of ophthalmology. 2013;27:331–340. DOI: 10.3341/kjo.2013.27.5.331. Epub 2013 Sep 10.</mixed-citation><mixed-citation xml:lang="en">Kim KH, Park SW, Kim MK. Effect of age and early intervention with a systemic steroid, intravenous immunoglobulin or amniotic membrane transplantation on the ocular outcomes of patients with Stevens Johnson syndrome. Korean journal of ophthalmology. 2013;27:331–340. DOI: 10.3341/kjo.2013.27.5.331. Epub 2013 Sep 10.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Ohji M, Ohmi G, Kiritoshi A, Goblet cell density in thermal and chemical injuries. Arch Ophthalmol. 1987;105(12):1686–1688. DOI: 10.1001/ar-chopht.1987.01060120084031</mixed-citation><mixed-citation xml:lang="en">Ohji M, Ohmi G, Kiritoshi A, Goblet cell density in thermal and chemical injuries. Arch Ophthalmol. 1987;105(12):1686–1688. DOI: 10.1001/ar-chopht.1987.01060120084031</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Jirsova K, Dudakova L, Kalasova S, The OV TL 12/30 clone of anti cytokeratin 7 antibody as a new marker of corneal conjunctivalization in patients with limbal stem cell deficiency. Invest Ophthalmol Vis Sci. 2011;52(8):5892–5898. DOI: 10.1167/iovs.10-6748</mixed-citation><mixed-citation xml:lang="en">Jirsova K, Dudakova L, Kalasova S, The OV TL 12/30 clone of anti cytokeratin 7 antibody as a new marker of corneal conjunctivalization in patients with limbal stem cell deficiency. Invest Ophthalmol Vis Sci. 2011;52(8):5892–5898. DOI: 10.1167/iovs.10-6748</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Poli M, Janin H, Justin V. Keratin 13 immunostaining in corneal impression cytology for the diagnosis of limbal stem cell deficiency. Invest Ophthalmol Vis Sci. 2011;52(13):9411–9415. DOI: 10.1167/iovs.10-7049</mixed-citation><mixed-citation xml:lang="en">Poli M, Janin H, Justin V. Keratin 13 immunostaining in corneal impression cytology for the diagnosis of limbal stem cell deficiency. Invest Ophthalmol Vis Sci. 2011;52(13):9411–9415. DOI: 10.1167/iovs.10-7049</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Chaloin Dufau C, Pavitt I, Delorme P. Identification of keratins 3 and 12 in corneal epithelium of vertebrates. Epithelial Cell Biol. 1993;2:120–125.</mixed-citation><mixed-citation xml:lang="en">Chaloin Dufau C, Pavitt I, Delorme P. Identification of keratins 3 and 12 in corneal epithelium of vertebrates. Epithelial Cell Biol. 1993;2:120–125.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Kivela T, Uusitalo M. Structure, development and function of cytoskeletal elements in non neuronal cells of the human eye. Prog Retin Eye Res. 1998;17:385–428. DOI: 10.1016/s1350-9462(98)00001-9</mixed-citation><mixed-citation xml:lang="en">Kivela T, Uusitalo M. Structure, development and function of cytoskeletal elements in non neuronal cells of the human eye. Prog Retin Eye Res. 1998;17:385–428. DOI: 10.1016/s1350-9462(98)00001-9</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Barbaro V, Ferrari S, Fasolo A. Evaluation of ocular surface disorders: a new diagnostic tool based on impression cytology and confocal laser scanning microscopy. Br J Ophthalmol. 2010;94:926–932. DOI: 10.1136/bjo.2009.164152. Epub 2009 Sep 8.</mixed-citation><mixed-citation xml:lang="en">Barbaro V, Ferrari S, Fasolo A. Evaluation of ocular surface disorders: a new diagnostic tool based on impression cytology and confocal laser scanning microscopy. Br J Ophthalmol. 2010;94:926–932. DOI: 10.1136/bjo.2009.164152. Epub 2009 Sep 8.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Garcia I, Etxebarria J, Boto-de-Los-Bueis A. Comparative study of limbal stem cell deficiency diagnosis methods: detection of MUC5AC mRNA and goblet cells in corneal epithelium. Ophthalmology. 2012;119:923–929. DOI: 10.1016/j.oph-tha.2011.10.031</mixed-citation><mixed-citation xml:lang="en">Garcia I, Etxebarria J, Boto-de-Los-Bueis A. Comparative study of limbal stem cell deficiency diagnosis methods: detection of MUC5AC mRNA and goblet cells in corneal epithelium. Ophthalmology. 2012;119:923–929. DOI: 10.1016/j.oph-tha.2011.10.031</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Ramirez Miranda A, Nakatsu MN, Zarei Ghanavati S. Keratin 13 is a more specific marker of conjunctival epithelium than keratin 19. Molecular Vision. 2011;17:1652–1661.</mixed-citation><mixed-citation xml:lang="en">Ramirez Miranda A, Nakatsu MN, Zarei Ghanavati S. Keratin 13 is a more specific marker of conjunctival epithelium than keratin 19. Molecular Vision. 2011;17:1652–1661.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
