<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2023-3-572-579</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-2190</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЙ СЛУЧАЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASE REPORT</subject></subj-group></article-categories><title-group><article-title>Тактика ведения пациентов с бактериальными язвами роговицы в условиях многопрофильного стационара (серия клинических случаев)</article-title><trans-title-group xml:lang="en"><trans-title>Tactics of Managing Patients with Bacterial Corneal Ulcers in a Multidisciplinary Hospital (Series of Clinical Cases)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9080-3170</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аржиматова</surname><given-names>Г. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Arzhimatova</surname><given-names>G. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аржиматова Гульжиян Шевкетовна, кандидат медицинских наук, доцент, руководитель центра</p><p>2-й Боткинский проезд, 5, Москва, 125284</p></bio><bio xml:lang="en"><p>Arzhimatova Gulzhiyan S., PhD, Associate Professor, head of center</p><p>2nd Botkinsky travel, 5, Moscow, 125284</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9630-6076</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чернакова</surname><given-names>Г. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernakova</surname><given-names>G. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чернакова Галина Мэлсовна, кандидат медицинских наук, заведующая консультативно-поликлиническим отделением № 2</p><p>2-й Боткинский проезд, 5, Москва, 125284</p></bio><bio xml:lang="en"><p>Chernakova Galina M., PhD, head of the Consultative polyclinic department No. 2</p><p>2nd Botkinsky travel, 5, Moscow, 125284</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-0189-8600</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ширшова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shirshova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ширшова Елена Васильевна, заведующая офтальмологическим отделением № 64</p><p>2-й Боткинский проезд, 5, Москва, 125284</p></bio><bio xml:lang="en"><p>Shirshova Elena V., head of Ophthalmology department No. 64</p><p>2nd Botkinsky travel, 5, Moscow, 125284</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1537-1405</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шемякин</surname><given-names>М. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Shemyakin</surname><given-names>M. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шемякин Матвей Юрьевич, врач- офтальмолог офтальмологического отделения № 64</p><p>2-й Боткинский проезд, 5, Москва, 125284</p></bio><bio xml:lang="en"><p>Shemyakin Matvey Yu., ophthalmologist of the Ophthalmological department No. 64 </p><p>2nd Botkinsky travel, 5, Moscow, 125284</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Емельянова</surname><given-names>Э. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Emelyanova</surname><given-names>E. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Емельянова Эльвира Борисовна, заведующая клинико-диагностической лабораторией, врач клинической лабораторной диагностики</p><p>2-й Боткинский проезд, 5, Москва, 125284</p></bio><bio xml:lang="en"><p>Emelyanova Elvira B., head of the Clinical diagnostic laboratory, doctor of Clinical laboratory diagnostics</p><p>2nd Botkinsky travel, 5, Moscow, 125284</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0456-9435</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Угольникова</surname><given-names>А. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Ugolnikova</surname><given-names>A. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Угольникова Анастасия Олеговна, врач-бактериолог клинико-диагностической лаборатории</p><p>2-й Боткинский проезд, 5, Москва, 125284</p></bio><bio xml:lang="en"><p>Ugolnikova Anastasia O., bacteriologist at the Clinical diagnostic laboratory</p><p>2nd Botkinsky travel, 5, Moscow, 125284</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский городской офтальмологический центр ГБУЗ «Городская клиническая больница имени С.П. Боткина» Департамента здравоохранения г. Москвы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow City Ophthalmological Center of the S.P. Botkin City Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ «Городская клиническая больница имени С.П. Боткина» Департамента здравоохранения г. Москвы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Botkin City Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>03</day><month>10</month><year>2023</year></pub-date><volume>20</volume><issue>3</issue><fpage>572</fpage><lpage>579</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Аржиматова Г.Ш., Чернакова Г.М., Ширшова Е.В., Шемякин М.Ю., Емельянова Э.Б., Угольникова А.О., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Аржиматова Г.Ш., Чернакова Г.М., Ширшова Е.В., Шемякин М.Ю., Емельянова Э.Б., Угольникова А.О.</copyright-holder><copyright-holder xml:lang="en">Arzhimatova G.S., Chernakova G.M., Shirshova E.V., Shemyakin M.Y., Emelyanova E.B., Ugolnikova A.O.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/2190">https://www.ophthalmojournal.com/opht/article/view/2190</self-uri><abstract><p>Бактериальные язвы роговицы у пациентов с коморбидной патологией представляют собой сложную клиническую ситуацию с высоким риском осложнений в виде перфорации роговицы. В статье представлены четыре клинических случая развития бактериальных язв роговицы у пациентов с хроническими латентными синуситами. В публикации обсуждаются вопросы диагностической тактики, проводится анализ результатов инструментальных и лабораторных исследований в каждом случае. Результаты терапии язв роговицы представлены с учетом антибиотикограмм.</p></abstract><trans-abstract xml:lang="en"><p>Bacterial corneal ulcers in patients with comorbid pathology are a complex clinical situation with a high risk of complications — corneal perforation. The article presents four clinical cases of bacterial corneal ulcers in patients with chronic latent sinusitis. The publication discusses the issues of diagnostic tactics, provides an analysis of the results of instrumental and laboratory tests in each case. The results of corneal ulcer therapy are presented taking into account antibioticograms.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>язва роговицы</kwd><kwd>многопрофильный стационар</kwd><kwd>коморбидность</kwd><kwd>латентный синусит</kwd><kwd>антибактериальная терапия</kwd><kwd>мягкие контактные линзы</kwd><kwd>нетилмицин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>corneal ulcer</kwd><kwd>multidisciplinary hospital</kwd><kwd>comorbidity</kwd><kwd>latent sinusitis</kwd><kwd>antibacterial therapy</kwd><kwd>soft contact lenses</kwd><kwd>nethylmycin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Каспарова Е.А. Гнойные язвы роговицы: клиника, диагностика, консервативное лечение. Вестник офтальмологии. 2015;131(6):106–121.</mixed-citation><mixed-citation xml:lang="en">Kasparova EA. Purulent corneal ulcers: clinical presentation, diagnosis, and conservative treatment. Annals of Ophthalmology 2015;131(6):106–121 (In Russ.). doi: 10.17116/oftalma20151316106-119.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Schmack I, Müller M, Kohnen T. Microbial Keratitis: Understand, Recognize, and Treat — Part 1: General Aspects and Characteristics of Bacterial Keratitis. Klin. Monbl. Augenheilkd. 2018;235(3):331–350. doi: 10.1055/s‑0044‑101286.</mixed-citation><mixed-citation xml:lang="en">Schmack I, Müller M, Kohnen T. Microbial Keratitis: Understand, Recognize, and Treat — Part 1: General Aspects and Characteristics of Bacterial Keratitis. Klin. Monbl. Augenheilkd. 2018;235(3):331–350. doi: 10.1055/s‑0044‑101286.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Gurnani B, Kaur K. Bacterial Keratitis. 2022 Dec 6. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023.</mixed-citation><mixed-citation xml:lang="en">Gurnani B, Kaur K. Bacterial Keratitis. 2022 Dec 6. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Общероссийская общественная организация «Ассоциация врачей-офтальмологов». Клинические рекомендации «Бактериальные язвы роговицы». М. 2017 г.</mixed-citation><mixed-citation xml:lang="en">Russian public organization “Association of Ophthalmologists”. Clinical recommendations “Bacterial corneal ulcers”. Moscow, 2017 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Lin A, Rhee MK, Akpek EK, Amescua G, Farid M, Garcia-Ferrer FJ, Varu DM, Musch DC, Dunn SP, Mah FS; American Academy of Ophthalmology Preferred Practice Pattern Cornea and External Disease Panel. Bacterial Keratitis Preferred Practice Pattern®. Ophthalmology. 2019;126(1):1–55. doi: 10.1016/j.ophtha.2018.10.018.</mixed-citation><mixed-citation xml:lang="en">Lin A, Rhee MK, Akpek EK, Amescua G, Farid M, Garcia-Ferrer FJ, Varu DM, Musch DC, Dunn SP, Mah FS; American Academy of Ophthalmology Preferred Practice Pattern Cornea and External Disease Panel. Bacterial Keratitis Preferred Practice Pattern®. Ophthalmology. 2019;126(1):1–55. doi: 10.1016/j.ophtha.2018.10.018.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Околов И.Н., Кафтырева Л.А. Резистентность коагулазонегативных стафилококков, выделенных от больных с конъюнктивитами к антибактериальным препаратам. Новое в офтальмологии. 2006;4:34–36.</mixed-citation><mixed-citation xml:lang="en">Okolov IN, Kaftyreva LA. Resistance of coagulazonegative staphylococci isolated from patients with conjunctivitis to antibacterial drugs. New in ophthalmology. 2006;4:34–36 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Самуйло Е.К. Резистентность к антибиотикам бактериальных возбудителей инфекционных заболеваний глаз в России. Клиническая микробиология и антимикробная химиотерапия. 2013;15(2):106–114.</mixed-citation><mixed-citation xml:lang="en">Samuilo EK. Resistant to antibiotics of bacterial pathogens of infectious eye diseases in Russia. Clinical microbiology and antimicrobial chemotherapy. 2013;15(2):106– 114 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Кононенко Л.А., Майчук Ю.Ф, Южаков А.М. Лечение тяжелых бактериальных кератоувеитов с изъязвлением. /Мат-лы 11 Рос. нац. конгр. «Человек и Лекарство». М., 2004. С. 447. https://www.ookob.ru/sites/default/files/kr_101_bakterialnye_yazvy_rogovicy.pdf</mixed-citation><mixed-citation xml:lang="en">Kononenko LA, Maychuk YuF, Yuzhakov AM. Treatment of severe bacterial keratouveitis with ulergization. Materials 11 Ros. Nats. Kongr. “Man and Medicine”. Moscow, 2004. P. 447 (In Russ.). https://www.ookob.ru/sites/default/files/kr_101_bakterialnye_yazvy_rogovicy.pdf</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Падейская Е.Н., Яковлев В.П. Антибиотики и химиотерапия.1998;43(2):30–38.</mixed-citation><mixed-citation xml:lang="en">Padeyskaya EN, Yakovlev VP. Antibiotics and chemotherapy.1998;43(2);30–38 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">González-Dibildox LA, Oyervidez-Alvarad JA, Vazquez-Romo KA, Ramos-Betancourt N, Hernandez-Quintela E, Beltra F, Garza-Leon M. Polymicrobial Keratitis: Risk Factors, Clinical Characteristics, Bacterial Profile, and Antimicrobial Resistance. Eye Contact Lens. 2021;47(8):465–470. doi: 10.1097/ICL.0000000000000777.</mixed-citation><mixed-citation xml:lang="en">González-Dibildox LA, Oyervidez-Alvarad JA, Vazquez-Romo KA, Ramos-Betancourt N, Hernandez-Quintela E, Beltra F, Garza-Leon M. Polymicrobial Keratitis: Risk Factors, Clinical Characteristics, Bacterial Profile, and Antimicrobial Resistance. Eye Contact Lens. 2021;47(8):465–470. doi: 10.1097/ICL.0000000000000777.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Rapisarda A, Arpa P, Fantaguzzi PM, Faraldi F, Ratiglia R, Rizzo S, Vaona P, Iannacone C, Papa V. Dexamethasone/Netilmicin Eye Drops and Eye Gel for the Treatment of Ocular Inflammation After Micro-Incisional Vitreoretinal Surgery. Clin Ophthalmol. 2020;14:3297–3303. doi: 10.2147/OPTH.S257541.</mixed-citation><mixed-citation xml:lang="en">Rapisarda A, Arpa P, Fantaguzzi PM, Faraldi F, Ratiglia R, Rizzo S, Vaona P, Iannacone C, Papa V. Dexamethasone/Netilmicin Eye Drops and Eye Gel for the Treatment of Ocular Inflammation After Micro-Incisional Vitreoretinal Surgery. Clin Ophthalmol. 2020;14:3297–3303. doi: 10.2147/OPTH.S257541.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Sueke H, Shankar J, Neal TJ, Horsburgh M, Gilbert R, Kaye SB. New Developments in Antibacterial Chemotherapy for Bacterial Keratitis. В: Reinhard T, Larkin F, eds. Corneal Disease. Springer Berlin Heidelberg; 2013. P. 19–35. doi: 10.1007/978-3642-28747-3_2.</mixed-citation><mixed-citation xml:lang="en">Sueke H, Shankar J, Neal TJ, Horsburgh M, Gilbert R, Kaye SB. New Developments in Antibacterial Chemotherapy for Bacterial Keratitis. В: Reinhard T, Larkin F, eds. Corneal Disease. Springer Berlin Heidelberg; 2013. P. 19–35. doi: 10.1007/978-3642-28747-3_2.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Faraldi F, Papa V, Rasà D, Santoro D, Russo S. Netilmicin/dexamethasone fixed combination in the treatment of conjunctival inflammation. Clin Ophthalmol. 2013;7:1239–1244. doi: 10.2147/OPTH.S44455.</mixed-citation><mixed-citation xml:lang="en">Faraldi F, Papa V, Rasà D, Santoro D, Russo S. Netilmicin/dexamethasone fixed combination in the treatment of conjunctival inflammation. Clin Ophthalmol. 2013;7:1239–1244. doi: 10.2147/OPTH.S44455.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Обрубов А.С., Слонимский А.Ю. Кератиты и гнойные язвы роговицы при контактной коррекции. Вестник офтальмологии. 2018;134(4):1724.</mixed-citation><mixed-citation xml:lang="en">Obrubov AS, Slonimskii AYu. Contact lens-related keratitis and purulent corneal ulcers. Annals of Ophthalmology 2018;134(4):1724 (In Russ.). doi: 10.17116/oftalma201813404117.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Мангутов Э.О., Харсеева Г.Г., Герасимов В.Н., Алиева А.А., Воронина Н.А., Алутина Э.Л., Слукин П.В., Хохлова О.Е., Гайтрафимова А.Р., Фурсова Н.К. Corynebacterium spp.: недооцененные патогены с высоким потенциалом вирулентности. Эпидемиология и Вакцинопрофилактика. 2022;21(4):80–88.</mixed-citation><mixed-citation xml:lang="en">Mangutov EO, Kharseeva GG, Gerasimov VN, Alieva AA, Voronina NA, Alutina EL, Slukin VP, Khokhlova OE, Gaitrafimova AR, Fursova NK. Corynebacterium spp.: Un‑ derestimated Pathogens with High Virulence Potential. Epidemiology and Vaccinal Prevention. 2022;21(4):80–88 (In Russ.). /doi: 10.31631/2073-3046-2022-21-4-80-88.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
