ophthalmologyОфтальмологияOphthalmology in Russia1816-50952500-0845Ophthalmology10.18008/1816-5095-2023-4-601-609ophthalmology-2227Research ArticleОБЗОРЫREVIEWSК вопросу о трансплантации лимбальных эпителиальных стволовых клеток при одностороннем синдроме лимбальной недостаточности. Обзор литературыLimbal Epithelial Stem Cells Transplantation in Cases with Unilateral Limbal Stem Cell Deficiency Syndromehttps://orcid.org/0000-0001-5666-3493МалюгинБ. Э.MalyuginB. E.

Малюгин Борис Эдуардович доктор медицинских наук, профессор, член-корреспондент РАН, заслуженный деятель науки Российской Федерации, заместитель генерального директора по научной работе

Бескудниковский бульвар, 59а, Москва, 127486

Malyugin Boris E. MD, Professor, deputy director general for science

Beskudnikovsky blvd, 59A, Moscow, 127486

https://orcid.org/0000-0001-9160-6240БорзенокС. А.BorzenokS. A.

Борзенок Сергей Анатольевич доктор медицинских наук, профессор, академик РАЕН, руководитель центра фундаментальных прикладных и медико-биологических проблем

Бескудниковский бульвар, 59а, Москва, 127486;

ул. Делегатская, 20/1, Москва, 127473

Borzenok Sergey A. MD, Professor, academician of the RANS, head of the Center for fundamental applied and biomedical problems

Beskudnikovsky blvd, 59A, Moscow, 127486;

Delegatskaya str., 20/1, Moscow, 127473

https://orcid.org/0000-0002-2126-000XНефедоваО. Н.NefedovaO. N.

Нефедова Ольга Николаевна аспирант, врач-офтальмолог

Бескудниковский бульвар, 59а, Москва, 127486

Nefedova Olga N. postgraduate

Beskudnikovsky blvd, 59A, Moscow, 127486

https://orcid.org/0000-0003-3433-8352ГерасимовМ. Ю.GerasimovM. Yu.

Герасимов Максим Юрьевич врач-офтальмолог, младший научный сотрудник лаборатории трансплантологии и клеточной биологии

Бескудниковский бульвар, 59а, Москва, 127486

Gerasimov Maxim Yu. researcher

Beskudnikovsky blvd, 59A, Moscow, 127486

ФГАУ НМИЦ «МНТК “Микрохирургия глаза” им. академика С.Н. Федорова» Министерства здравоохранения Российской ФедерацииРоссияS. Fyodorov Eye Microsurgery Federal State InstitutionRussian FederationФГАУ НМИЦ «МНТК “Микрохирургия глаза” им. академика С.Н. Федорова» Министерства здравоохранения Российской Федерации; ФГБОУ ВО «Московский государственный медико-стоматологический университет имени А.И. Евдокимова» Министерства здравоохранения Российской ФедерацииРоссияS. Fyodorov Eye Microsurgery Federal State Institution; A.I. Yevdokimov Moscow State University of Medicine and DentistryRussian Federation202327122023204601609Copyright © Малюгин Б.Э., Борзенок С.А., Нефедова О.Н., Герасимов М.Ю., 20232023Малюгин Б.Э., Борзенок С.А., Нефедова О.Н., Герасимов М.Ю.Malyugin B.E., Borzenok S.A., Nefedova O.N., Gerasimov M.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.ophthalmojournal.com/opht/article/view/2227

В данном обзоре представлены известные хирургические техники, направленные на лечение одностороннего синдрома лимбальной недостаточности. Среди множества имеющихся методик особенно следует выделить так называемую «простую лимбальную эпителиальную трансплантацию», которая зарекомендовала себя как эффективный, безопасный и общедоступный метод лечения одностороннего синдрома лимбальной недостаточности (СЛН). Следует констатировать, что риски рецидива СЛН остаются значительными, а механизмы приживления трансплантированных лимбальных эпителиальных стволовых клеток на глазу реципиента до конца не изученными. В обзоре также рассмотрены варианты новых перспективных подходов к возможному решению существующих проблем в трансплантации лимбальных эпителиальных стволовых клеток.

This review presents well-known surgical techniques aimed at the treatment of unilateral limbal insufficiency syndrome. Among the many available techniques, one should especially highlight the so-called “simple limbal epithelial transplantation”, which has proven to be an effective, safe and generally available method of treating unilateral limbal insufficiency syndrome (SLN). It should be noted that the risks of recurrence of SLN remain significant, and the mechanisms of engraftment of transplanted limbal epithelial stem cells on the recipient’s eye are not fully understood. The review also considers options for new promising approaches to the possible solution of existing problems in the transplantation of limbal epithelial stem cells.

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The authors declare that there are no conflicts of interest present.