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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2023-4-634-640</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-2231</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Латанопрост в лечении первичной открытоугольной глаукомы. Обзор</article-title><trans-title-group xml:lang="en"><trans-title>Xalatan in the Treatment of Primary Open-Angle Glaucoma. Review</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0057-3338</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лоскутов</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Loskutov</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лоскутов Игорь Анатольевич доктор медицинских наук, руководитель офтальмологического отделения</p><p>ул. Щепкина, 61/2, Москва, 129110</p></bio><bio xml:lang="en"><p>Loskutov Igor A. MD, the head of Ophthalmologic department</p><p>Schepkina str., 61/2, Moscow, 129110</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7242-8781</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Андрюхина</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Andruhina</surname><given-names>O. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Андрюхина Ольга Михайловна кандидат медицинских наук, старший научный сотрудник офтальмологического отделения</p><p>ул. Щепкина, 61/2, Москва, 129110</p></bio><bio xml:lang="en"><p>Andruhina Olga M. PhD, senior research officer</p><p>129110, Schepkina str. 61/2, Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М. Ф. Владимирского»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Regional Research and Clinical Institute (MONIKI)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>27</day><month>12</month><year>2023</year></pub-date><volume>20</volume><issue>4</issue><fpage>634</fpage><lpage>640</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лоскутов И.А., Андрюхина О.М., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Лоскутов И.А., Андрюхина О.М.</copyright-holder><copyright-holder xml:lang="en">Loskutov I.A., Andruhina O.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/2231">https://www.ophthalmojournal.com/opht/article/view/2231</self-uri><abstract><p>За последние 25 лет Ксалатан (латанапрост) стал одним из наиболее эффективных препаратов первой линии в лечении глаукомы из-за выраженного гипотензивного действия, безопасности и удобства однократного инстиллирования. В обзорной статье представлены исторические аспекты создания и механизмы действия аналогов простагландина, нейропротекторные свойства латанапроста, а также данные метаанализов и клинических исследований об эффективности препарата в лечении глаукомы.</p></abstract><trans-abstract xml:lang="en"><p>Over the past 25 years, Xalatan (Latanaprost) has become one of the most effective first-line drugs in the treatment of glaucoma, due to its pronounced hypotensive effect, safety and convenience of a single instillation. The review article presents the historical aspects of the creation and mechanisms of action of prostaglandin analogs, the neuroprotective properties of latanoprost, as well as data from meta-analyses and clinical studies on the effectiveness of the drug in the treatment of glaucoma.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>глаукома</kwd><kwd>латанопрост</kwd><kwd>Ксалатан</kwd><kwd>аналоги простагландинов</kwd><kwd>нейропротекция</kwd><kwd>лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>glaucoma</kwd><kwd>latanoprost</kwd><kwd>Xalatan</kwd><kwd>prostaglandin analogues</kwd><kwd>neuroprotection</kwd><kwd>treatment</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">обзор подготовлен при поддержке компании «Виатрис»</funding-statement><funding-statement xml:lang="en">The review is supported by Viatris.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Senjam SS. 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