ophthalmologyОфтальмологияOphthalmology in Russia1816-50952500-0845Ophthalmology10.18008/1816-5095-2023-4-731-736ophthalmology-2244Research ArticleКЛИНИЧЕСКИЕ И ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯCLINICAL & EXPERIMENTAL RESEARCHВлияние сезонного аллергического конъюнктивита и его лечения на хориоидальный сосудистый индексThe Influence of Seasonal Allergic Conjunctivitis and Its Treatment on Choroidal Vascular Indexhttps://orcid.org/0000-0002-8557-4673КутеНеслиханSevimliNeslihan

İçerenköy, D100 Üzeri D:İ, 34752 Ataşehir/İstanbul

MD, Assistant Professor, Department of ophthalmology

İçerenköy, D100 Üzeri D:İ, 34752 Ataşehir/İstanbul

https://orcid.org/0000-0003-0931-8157ЧаллиУмитÇallıÜmit

İçerenköy, D100 Üzeri D:İ, 34752 Ataşehir/İstanbul

MD, Department of ophthalmology

İçerenköy, D100 Üzeri D:İ, 34752 Ataşehir/İstanbul

КобатФатинÇobanFatin

İçerenköy, D100 Üzeri D:İ, 34752 Ataşehir/İstanbul

MD, Department of ophthalmology

İçerenköy, D100 Üzeri D:İ, 34752 Ataşehir/İstanbul

Стамбульское провинциальное управление здравоохранения, учебно-исследовательская больница Фати Султан МехметТурцияFatih Sultan Mehmet Training and Research HospitalTurkey202327122023204731736Copyright © Куте Н., Чалли У., Кобат Ф., 20232023Куте Н., Чалли У., Кобат Ф.Sevimli N., Çallı Ü., Çoban F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.ophthalmojournal.com/opht/article/view/2244

Цель: оценить влияние сезонного аллергического конъюнктивита (АС) и его лечения с помощью местных антигистаминных препаратов на толщину хориоидеи (ХТ) и хориоидальный сосудистый индекс (ХВН). Методы. В группу AC были включены 60 глаз 30 пациентов. 30 пациентов вошли в контрольную группу. Сосудистую оболочку визуализировали с помощью прибора оптической когерентной томографии с улучшенной глубинной визуализацией (EDI-OCT) без расширения зрачков. ХТ определяли как площадь между внешней гиперрефлективной границей РПЭ и склерохориоидальной границей в ямке, 750 мкм в височную сторону от ямки и 750 мкм в носовую сторону. Изображение J использовалось для измерения CVI. На изображениях, полученных с помощью EDI-OCT, с использованием метода бинаризации рассчитывали общую площадь хориоидеи (TCA), площадь просвета (LA), площадь стромы (SA) и CVI. Результаты. Среднее значение ХТ в группе AC составило 358,5 ± 93,8 мкм исходно и 356,8 ± 86,6 мкм через 1 месяц лечения. При этом средний ХТ в контрольной группе составил 316,6 ± 60,7 мкм. Среднее значение CVI составляло 66,65 ± 2,98 в контрольной группе, 70,75 ± 3,26 в группе AC на исходном уровне и 69,50 ± 3,17 через 1 месяц лечения. Статистически значимая разница наблюдалась между контролем и группой АК (р = 0,028) после лечения (р = 0,031). Заключение. ХТ и ХВН могут увеличиваться у больных АК вследствие воспаления и повышения проницаемости сосудов. Хотя симптомы и признаки, связанные с ОХ, могут исчезнуть после лечения, эффекты в сосудистой оболочке не нормализуются сразу.

Purpose: To evaluate the the effects of seasonal allergic counjunctivitis (AC) and its treatment upon choroidal structure such as choroidal thickness (ChT) and choroidal vascular index (CVI) through the use of topical antihistamine agents. Methods. The 60 eyes of 30 patients were included in the AC group. Another 30 patients were included in the control group. The choroid was imaged by using enhanced depth imaging optical coherence tomography (EDI-OCT) instrument without pupillary dilation. ChT was defined as the area between the outer hyperreflective border of the RPE and the sclerochoroidal border at the fovea, 750 µm temporal to the fovea and 750 µm nasal to the fovea. Image J was used to measure CVI. With the images obtained from EDI-OCT, the total choroidal area (TCA), luminal area (LA), stromal area (SA), and CVI were calculated using the binarization method. Results. The mean ChT value in the AC group was 358.5 ± 93.8 µm at baseline and 356.8 ± 86.6 µm following 1 month of treatment. Meanwhile, the mean ChT in the control group was 316.6 ± 60.7 µm. The mean CVI value was 66.65 ± 2.98 in the control group, 70.75 ± 3.26 in the AC group at baseline, and 69.50 ± 3.17 following 1 month of treatment. Statistically significant difference was tracked between control and AC group (p = 0.028) and control group and posttreatment values (p=0,031). There were no statistically significant difference between initial AC treatment values and posttreatment values for all of the measurements. Conclusion. ChT and CVI can increase in patients with AC due to inflammation and increased vascular permeability. Although symptoms and signs related to AC may disappear after the treatment, effects in the choroid do not immediately normalize.

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The authors declare that there are no conflicts of interest present.