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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2015-1-63-68</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-226</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ И ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL &amp; EXPERIMENTAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Корреляция формирования демодекозных поражений кожи лица и век и некоторые подходы к их комплексному лечению</article-title><trans-title-group xml:lang="en"><trans-title>The correlation between facial and eyelid demodicosis. Complex therapeutic approaches</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Майчук</surname><given-names>Д. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Maychuk</surname><given-names>D. Yu.</given-names></name></name-alternatives><email xlink:type="simple">maychuk@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шокирова</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Shokirova</surname><given-names>M. M.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Симонова</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Simonova</surname><given-names>T. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малышева</surname><given-names>З. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Malysheva</surname><given-names>Z. G.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Федеральное государственное бюджетное учреждение «Межотраслевой научно-технический комплекс «Микрохирургия глаза» им. акад. С.Н. Федорова» Министерства здравоохранения Российской Федерации, Бескудниковский бульвар, д. 59а, Москва, 127486, Россия<country>Россия</country></aff><aff xml:lang="en">The S. Fyodorov Eye Microsurgery Federal State Institution, 59A, Beskudnikovsky Blvd Moscow, 127486, Russia<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>31</day><month>03</month><year>2015</year></pub-date><volume>12</volume><issue>1</issue><fpage>63</fpage><lpage>68</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Майчук Д.Ю., Шокирова М.М., Симонова Т.А., Малышева З.Г., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Майчук Д.Ю., Шокирова М.М., Симонова Т.А., Малышева З.Г.</copyright-holder><copyright-holder xml:lang="en">Maychuk D.Y., Shokirova M.M., Simonova T.A., Malysheva Z.G.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/226">https://www.ophthalmojournal.com/opht/article/view/226</self-uri><abstract><sec><title>Цель</title><p>Цель. Оценить корреляцию частоты встречаемости демодекоза краев век и кожи лица и предложить оптимальную схему противопаразитарной терапии при задних блефаритах, сочетанных с демодекозным поражением век. </p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В исследование включены 100 пациентов с задним блефаритом, сочетанным с демодекозным поражением век. В зависимости от численности особей клеща на краях век пациенты были разделены на две группы — с пороговым (до 4 особей) и патологическим числом (более 4 особей). 60 пациентов с патологическим значением численности Demodex на краях век были разделены на две подгруппы: основная (n = 30) и контрольная (n = 30). В основной подгруппе назначена противопаразитарная терапия (Гликодем 2 раза в день в течение 45 дней) с предварительным противовоспалительным лечением, гигиеной и массажем век. В контрольной группе противопаразитарная терапия проводилась без предварительной гигиены век. Пациенты с выявленным демодекозом кожи лица получали лечение у дерматолога. Во всех случаях производился расчет интегральных показателей субъективного дискомфорта и объективных проявлений хронического заднего блефарита, выполнялись тесты Ширмера 1 и Норна, определялось функциональное состояние мейбомиевых желез (компрессионный тест). </p></sec><sec><title>Результаты</title><p>Результаты. В 48% случаев демодекоз краев век сочетался с демодекозом кожи лица, причем у 10% пациентов численность особей клещей не превышала 4, а у 38% пациентов имела место патологическая численность особей клещей (более 4). Патологические изменения кожи лица выявлены у 1% пациентов с численностью особей клещей до 4 и у 20% пациентов с численностью особей клещей более 4. Противопаразитарное лечение с предварительной противовоспалительной терапией, гигиеной и массажем век позволило добиться улучшения функционального состояния мейбомиевых желез и купирования объективных проявлений хронического мейбомиевого блефарита. Через 1,5 месяца после лечения Demodex отсутствовал у 80% пациентов основной группы и 56,6% пациентов контрольной группы. </p></sec><sec><title>Заключение</title><p>Заключение. Поэтапное лечение задних блефаритов, сочетанных с демодекозным поражением век, — противовоспалительная терапия, гигиена век и противопаразитарное лечение — является эффективным и способствует длительной ремиссии. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To assess the correlation between eyelid and facial demodicosis and to develop an optimal anti-parasitic treatment schedule for posterior blepharitis associated with eyelid demodicosis. </p></sec><sec><title>Materials and methods</title><p>Materials and methods. 100 patients with posterior blepharitis associated with eyelid demodicosis were enrolled in the study. The patients were divided into 2 groups depending on Demodex count. Demodex count less than 4 mites was considered normal while Demodex count more than 4 mites was considered pathological. 60 patients with Demodex count more than 4 mites were subdivided into 2 groups. Study group patients (n = 30) received anti-parasitic therapy with preceding anti-inflammatory treatment, eyelid hygiene and massage. Control group patients (n = 30) received antiparasitic therapy only. Patients with verified facial demodicosis received dermatological treatment as well. In all patients, integral indices of subjective discomfort and objective signs of posterior blepharitis were measured, Schirmer’s and Norn’s tests were performed, functional state of meibomian glands was evaluated (compressive test). </p></sec><sec><title>Results</title><p>Results. Eyelid demodicosis was associated with facial demodicosis in 48% of patients. In 10%, Demodex count was less than 4 mites. In 38%, Demodex count was more than 4 mites. Skin lesions were revealed in 1% of patients with Demodex count less than 4 mites and in 20% of patients with Demodex count more than 4 mites. Anti-parasitic therapy with preceding anti-inflammatory treatment, eyelid hygiene and massage improved functional state of meibomian glands and objective signs of posterior meibomian blepharitis. In 1.5 months after the treatment, Demodex was absent in 80% of study group patients and 56.6% of controls. </p></sec><sec><title>Conclusion</title><p>Conclusion. Stepwise treatment of posterior blepharitis associated with eyelid demodicosis (anti-inflammatory and anti-parasitic therapy, eyelid hygiene) is effective and provides prolonged remission. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>задний блефарит</kwd><kwd>дисфункция мейбомиевых желез</kwd><kwd>демодекоз</kwd><kwd>гигиена век</kwd><kwd>противовоспалительная терапия</kwd><kwd>противопаразитарная терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>posterior blepharitis</kwd><kwd>meibomian gland dysfunction</kwd><kwd>demodicosis</kwd><kwd>eyelid hygiene</kwd><kwd>anti-inflammatory treatment</kwd><kwd>anti-parasitic treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Akbulatova L.Kh. [Pathogenic role of Demodex and clinical variants of human demodicosis]. Patogennaya rol’ kleshcha Demodex i klinicheskie formy demodikoza u cheloveka. 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