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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2024-1-172-185</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-2308</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЙ СЛУЧАЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASE REPORT</subject></subj-group></article-categories><title-group><article-title>Современные подходы в диагностике и лечении поражений роговицы у детей. Клинический случай</article-title><trans-title-group xml:lang="en"><trans-title>Modern Approaches in the Diagnosis and Treatment of Corneal Lesions in Children. Clinical Case</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4981-0755</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маркова</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Markova</surname><given-names>E. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Маркова Елена Юрьевна — доктор медицинских наук, заведующая отделом микрохирургии и функциональной реабилитации глаза у детей</p><p>Бескудниковский бульвар, 59а, Москва, 127486</p></bio><bio xml:lang="en"><p>Markova Elena Yu. — MD, Head of the Microsurgery and functional rehabilitation of children,s eye Department</p><p>Beskudnikovsky blvd, 59A, Moscow, 127486</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0925-3146</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никитина</surname><given-names>А. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikitina</surname><given-names>A. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Никитина Анастасия Евгеньевна — врач-ординатор второго года обучения</p><p>Бескудниковский бульвар, 59а, Москва, 127486</p></bio><bio xml:lang="en"><p>Nikitina Anastasia E. — Resident</p><p>Beskudnikovsky blvd, 59A, Moscow, 127486</p></bio><email xlink:type="simple">anastasianik2403@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-1667-6115</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Наврузалиева</surname><given-names>Д. Я.</given-names></name><name name-style="western" xml:lang="en"><surname>Navruzalieva</surname><given-names>D. Ya.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наврузалиева Джанета Якубовна — врач-ординатор первого года обучения</p><p>Бескудниковский бульвар, 59а, Москва, 127486</p></bio><bio xml:lang="en"><p>Navruzalieva Dzhanetta Ya. — Resident</p><p>Beskudnikovsky blvd, 59A, Moscow, 127486</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7577-1289</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Майчук</surname><given-names>Д. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Maychuk</surname><given-names>D. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Майчук Дмитрий Юрьевич — доктор медицинских наук, заведующий отделом терапевтической офтальмологии</p><p>Бескудниковский бульвар, 59а, Москва, 127486</p><p> </p></bio><bio xml:lang="en"><p>Maychuk Dmitry Yu. — MD, head of the Therapeutic ophthalmology department</p><p>Beskudnikovsky blvd, 59A, Moscow, 127486</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1674-4656</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Головин</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Golovin</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Головин Андрей Владимирович — кандидат медицинских наук, заведующий оперблоком</p><p>Бескудниковский бульвар, 59а, Москва, 127486</p></bio><bio xml:lang="en"><p>Golovin Andrey V. — PhD, head of Operating unit</p><p>Beskudnikovsky blvd, 59A, Moscow, 127486</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1013-6924</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Таевере</surname><given-names>М. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Taevere</surname><given-names>M. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Таевере Мариям Рамазановна — кандидат медицинских наук, врач-офтальмолог</p><p>Бескудниковский бульвар, 59а, Москва, 127486</p></bio><bio xml:lang="en"><p>Taevere Mariyam R. — PhD, ophthalmologist</p><p>Beskudnikovsky blvd, 59A, Moscow, 127486</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАУ «НМИЦ «МНТК “Микрохирургия глаза” им. академика С.Н. Федорова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>S.N. Fyodorov Eye Microsurgery Federal State Institution of the Russian Ministry of Health</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>01</day><month>04</month><year>2024</year></pub-date><volume>21</volume><issue>1</issue><fpage>172</fpage><lpage>177</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Маркова Е.Ю., Никитина А.Е., Наврузалиева Д.Я., Майчук Д.Ю., Головин А.В., Таевере М.Р., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Маркова Е.Ю., Никитина А.Е., Наврузалиева Д.Я., Майчук Д.Ю., Головин А.В., Таевере М.Р.</copyright-holder><copyright-holder xml:lang="en">Markova E.Y., Nikitina A.E., Navruzalieva D.Y., Maychuk D.Y., Golovin A.V., Taevere M.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/2308">https://www.ophthalmojournal.com/opht/article/view/2308</self-uri><abstract><sec><title>Цель</title><p>Цель: представить результаты успешного лечения пациентки с поражением роговицы, вызванным Acanthamoeba spp., получавшей длительное консервативное лечение.</p></sec><sec><title>Методы</title><p>Методы. В МНТК МГ был направлен ребенок с язвой роговицы смешанной этиологии в анамнезе, у которого имело место ношение ортокератологических линз, а также длительное малоэффективное лечение в стационарах Москвы. Пациентке было проведено полное офтальмологическое обследование, в том числе конфокальная микроскопия.</p></sec><sec><title>Результаты</title><p>Результаты. Состояние глаза ребенка было крайне тяжелым, в центральной зоне роговицы на глубине 113–149 мкм обнаружены гомогенно окрашенная, способная к переходу в торофизоид «живая» и запустевшие и разрушившиеся, дегенерировавшие «мертвые» цисты Acantamoeba spp. Наряду с проведением интенсивного консервативного лечения с катетеризацией ретробульбарного пространства и введением препаратов в ирригационную систему двукратно проведен УФкросслинкинг роговичного коллагена.</p></sec><sec><title>Заключение</title><p>Заключение. Лечение по предложенной методике позволило получить хорошие результаты: корнеальный синдром купировался, достигнута полная эпителизация роговичного дефекта, исчез отек роговицы и наступила ремиссия увеита. По данным конфокальной микроскопии рост микрофлоры, а также цист акантамебы отсутствует.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective. To present the results of successful treatment of a patient with corneal lesions caused by Acanthamoeba spp. receiving long-term conservative treatment.</p></sec><sec><title>Methods</title><p>Methods. A child with corneal ulcer of mixed etiology with a history of wearing orthokeratology lenses and long-term ineffective treatment in Moscow hospitals was referred to Moscow in S.N. Fyodorov Eye Microsurgery Federal State Institution. The patient underwent a complete ophthalmological examination, including confocal microscopy.</p></sec><sec><title>Results</title><p>Results. The condition of the child’s eye was extremely severe, live and dead cysts of Acantamoeba spp were found in the central zone of the cornea at the depth of 113–149 μm, Along with intensive conservative treatment with catheterisation of the retrobulbar space and introduction of drugs into the irrigation system, UV corneal crosslinking was performed twice.</p></sec><sec><title>Conclusion</title><p>Conclusion. Treatment according to the proposed method allowed to achieve excellent results: there was no corneal syndrome, complete epithelialisation of the corneal defect, disappearance of corneal edema and remission of uveitis manifestations. According to the data of confocal microscopy there is no growth of microflora and acanthamoeba cysts.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>язва роговицы</kwd><kwd>иридоциклит</kwd><kwd>акантамеба</kwd><kwd>конфокальная микроскопия</kwd><kwd>ретробульбарная катетеризация</kwd><kwd>УФ-кросслинкинг</kwd></kwd-group><kwd-group xml:lang="en"><kwd>corneal ulcer</kwd><kwd>iridocyclitis</kwd><kwd>acanthamoeba</kwd><kwd>confocal microscopy</kwd><kwd>retrobulbar catheterisation</kwd><kwd>UV crosslinking</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Малюгин БЭ, Борзенок СА, Мороз ЗИ, Шацких АВ, Горохова МВ. Экспериментальное изучение ферментативной устойчивости донорской роговицы, обработанной по методике уф-кросслинкинга. Офтальмохирургия. 2014;1:20–23.</mixed-citation><mixed-citation xml:lang="en">Malyugin BE, Borzenok SA, Moroz ZI, Shatskikh AV, Gorokhov MV. Experimental investigation of the enzymatic stability of the donor cornea, treated by the method of UV cross-linking. Ophthalmosurgery. 2014;1:20–23 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Каспарова ЕА, Марченко НР, Нарбут МН, Сурнина ЗВ, Криволапова ДА. Острый гнойный кератит смешанной этиологии, развившийся на фоне ношения контактных линз. Клинический случай. Офтальмология. 2022;19(4):898–905. doi: 10.18008/1816-5095-2022-4-898-905.</mixed-citation><mixed-citation xml:lang="en">Kasparova EA, Marchenko NR, Narbut MN, Surnina ZV, Krivolapova DA. Acute Purulent Keratitis of Mixed Etiology Developed during Contact Lens Wearing. Clinical Case. Ophthalmology in Russia. 2022;19(4):898–905 (In Russ.). doi: 10.18008/1816-5095-2022-4-898-905.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Каспарова Е, Бяо Я, Собкова ОИ. Модифицированный кросслинкинг в лечении гнойной язвы роговицы. клинический случай. Офтальмология. 2017;14(3):274–277. doi: 10.18008/1816-5095-2017-3-274-277.</mixed-citation><mixed-citation xml:lang="en">Kasparova E, Biao Y, Sobkova OI. Мodified crosslinking in treatment of Festering ulcer of the cornea. A clinical case. Ophthalmology. 2017;14(3):274–277 (In Russ.). doi: 10.18008/1816-5095-2017-3-274-277.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Каспарова ЕА, Федоров АА, Бяо Ян Клинические результаты модифицированного кросслиникинга в лечении гнойных кератитов и язв роговицы. Вестник офтальмологии. 2020;136(3):64–73. doi: 10.17116/oftalma202013603164.</mixed-citation><mixed-citation xml:lang="en">Kasparova EA, Fedorov AA, Biao Yang. Clinical results of modified crosslinking in the treatment of purulent keratitis and corneal ulcers. Vestnik Oftalmologii. 2020;136(3):64–73 (In Russ.). doi: 10.17116/oftalma202013603164.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Маркова ЕЮ, Авакянц ГВ. Кератоконус у детей. Российская детская офтальмология. 2021;2:56–60. doi: 10.25276/2307-6658-2021-2-56-60.</mixed-citation><mixed-citation xml:lang="en">Markova EYu, Avakyants GV. Keratoconus in children. Russian pediatric ophthalmology. 2021;2:56–60 (In Russ.). doi: 10.25276/2307-6658-2021-2-56-60.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Труфанов СВ, Зайцев АВ, Шахбазян НП. Кросслинкинг и фульгурация в лечении акантамебного кератита. Офтальмология. 2020;17(4):725–732. doi: 10.18008/1816-5095-2020-4-725-732.</mixed-citation><mixed-citation xml:lang="en">Trufanov SV, Zaitsev AV, Shakhbazyan NP. Crosslinking and Fulguration in the Treatment of Acanthamoebic Keratitis. Ophthalmology in Russia. 2020;17(4):725– 732 (In Russ.). doi: 10.18008/1816-5095-2020-4-725-732.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Плескова АВ, Катаргина ЛА, Иомдина ЕН, Мамакаева ИР, Панова АЮ. Первый опыт комбинированного лечения язвы роговицы и трансплантата у детей дошкольного возраста с применением локального ультрафиолетового кросслинкинга (клинические случаи). Офтальмология. 2023;20(2):358–362. doi: 10.18008/1816-5095-2023-2-358-362.</mixed-citation><mixed-citation xml:lang="en">Pleskova AV, Katargina LA, Iomdina EN, Mamakaeva IR, Panova AYu. First Experience of Combined Treatment of Corneal and Graft Ulcers in Preschool Children Using Local Ultraviolet Crosslinking (Clinical Cases). Ophthalmology in Russia. 2023;20(2):358–362 (In Russ.). doi: 10.18008/1816-5095-2023-2-358-362.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Яни ЕВ, Иомдина ЕН, Позднякова ВВ, Голикова ВА, Селиверстова КЕ. Лечение язв роговицы затяжного течения с помощью ультрафиолетового кросслинкинга роговичного коллагена. Клинические случаи. Российский офтальмологический журнал. 2021;14(3):106–112. doi: 10.21516/20720076-2021-14-3-106-112.</mixed-citation><mixed-citation xml:lang="en">Yani EV, Iomdina EN, Pozdniakova VV, Golikova VA, Seliverstova KE. Treating protracted corneal ulcers with UVA corneal collagen crosslinking: clinical cases. Russian Ophthalmological Journal. 2021;14(3):106–112 (In Russ.). doi:21516/20720076-2021-14-3-106-112.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Маркова ЕЮ, Овчинникова АВ, Труфанов СВ. Фемтолазерная кератопластика у ребенка с помутнением роговицы. Клинический случай. Офтальмология. 2014;11(1):79–83. doi: 10.18008/1816-5095-2014-1-79-83.</mixed-citation><mixed-citation xml:lang="en">Markova EYu, Ovchinnicova AV, Truphanov SV. Femtosecond laser-assisted keratoplasty in a child with corneal opacity:case report. Ophthalmology in Russia. 2014;11(1):79–83 (In Russ.). doi: 10.18008/1816-5095-2014-1-79-83.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Нероев ВВ, Яни ЕВ, Иомдина ЕН, Хорошилова-Маслова ИП, Голикова ВА, Кирюхин АВ. Лечение язв роговицы с помощью локального ультрафиолетового кросслинкинга (экспериментальное исследование). Российский офтальмологический журнал. 2020;13(4):48–57. doi: 10.21516/2072-0076-2020-13-4-48-57.</mixed-citation><mixed-citation xml:lang="en">Neroev VV, Yani EV, Iomdina EN, Khoroshilova-Maslova IP, Golikova VA, Kiryukhin AV. Treatment of corneal ulcers by local ultraviolet crosslinking (an experimental study). Russian Ophthalmological Journal. 2020;13(4):48–57 (In Russ.). doi: 10.21516/2072-0076-2020-13-4-48-57.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Arora R, Gupta D, Goyal JL, Jain P. Results of corneal collagen cross-linking in pediatric patients. J Refract Surg. 2012;28:759–762. doi: 10.3928/1081597X20121011-02.</mixed-citation><mixed-citation xml:lang="en">Arora R, Gupta D, Goyal JL, Jain P. Results of corneal collagen cross-linking in pediatric patients. J Refract Surg. 2012;28:759–762. doi: 10.3928/1081597X20121011-02.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Маркова ЕЮ, Авакянц ГВ. Кросслинкинг роговичного коллагена у ребенка с кератоконусом. Российская детская офтальмология. 2021;3:33–38. doi: 10.25276/23076658-2021-3-33-38.</mixed-citation><mixed-citation xml:lang="en">Markova EYu, Avakyants GV..Corneal collagen crosslinking in a child with keratoconus. Russian pediatric ophthalmology. 2021;3:33–38 (In Russ.). doi: 10.25276/23076658-2021-3-33-38.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Маркова ЕЮ, Авакянц ГВ, Кечин ЕВ. Кератоконус у детей. Современные возможности лечения. Офтальмология. 2021;18(4):840–844. doi: 10.18008/1816-5095-2021-4-840-844.</mixed-citation><mixed-citation xml:lang="en">Markova EYu, Avakyants GV, Kechin EV. Keratoconus in Children. Мodern Treatment Options. Ophthalmology in Russia. 2021;18(4):840–844 (In Russ.). doi: 10.18008/1816-5095-2021-4-840-844.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Musayeva A, Riedl JC, Schuster AK, Wasielica-Poslednik J, Pfeiffer N, Gericke A. Topical Voriconazole as Supplemental Treatment for Acanthamoeba Keratitis. Cornea. 2020 Aug;39(8):986–990. doi: 10.1097/ICO.0000000000002315.</mixed-citation><mixed-citation xml:lang="en">Musayeva A, Riedl JC, Schuster AK, Wasielica-Poslednik J, Pfeiffer N, Gericke A. Topical Voriconazole as Supplemental Treatment for Acanthamoeba Keratitis. Cornea. 2020 Aug;39(8):986–990. doi: 10.1097/ICO.0000000000002315.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Marciano-Cabral F, Cabral G. Acanthamoeba spp. as agents of disease in humans. Clin Microbiol Rev. 2003:16(2):273–307. doi: 10.1128/CMR.16.2.273-307.2003.</mixed-citation><mixed-citation xml:lang="en">Marciano-Cabral F, Cabral G. Acanthamoeba spp. as agents of disease in humans. Clin Microbiol Rev. 2003:16(2):273–307. doi: 10.1128/CMR.16.2.273-307.2003.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Lorenzo-Morales J, Martín-Navarro CM, López-Arencibia A, Arnalich-Montiel F, Piñero JE, Valladares B. Acanthamoeba keratitis: an emerging disease gathering importance worldwide? Trends in Parasitology. 2013;29(4):181–187. doi: 10.1016/j.pt.2013.01.006.</mixed-citation><mixed-citation xml:lang="en">Lorenzo-Morales J, Martín-Navarro CM, López-Arencibia A, Arnalich-Montiel F, Piñero JE, Valladares B. Acanthamoeba keratitis: an emerging disease gathering importance worldwide? Trends in Parasitology. 2013;29(4):181–187. doi: 10.1016/j.pt.2013.01.006.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Buzzonetti L, Petrocelli G. Transepithelial corneal cross-linking in pediatric patients: Early results. J Refract Surg. 2012;28:763–767. doi: 10.3928/1081597X-20121011-03.</mixed-citation><mixed-citation xml:lang="en">Buzzonetti L, Petrocelli G. Transepithelial corneal cross-linking in pediatric patients: Early results. J Refract Surg. 2012;28:763–767. doi: 10.3928/1081597X-20121011-03.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Wittig-Silva C, Chan E, Islam FM, Wu T, Whiting M, Snibson GR. A randomized, controlled trial of corneal collagen cross-linking in progressive keratoconus: three-year results. Ophthalmology. 2014;121(4):812–821. doi: 10.1016/j.ophtha.2013.10.028.</mixed-citation><mixed-citation xml:lang="en">Wittig-Silva C, Chan E, Islam FM, Wu T, Whiting M, Snibson GR. A randomized, controlled trial of corneal collagen cross-linking in progressive keratoconus: three-year results. Ophthalmology. 2014;121(4):812–821. doi: 10.1016/j.ophtha.2013.10.028.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Tabibian D, Richoz O, Hafezi F. PACK-CXL: Corneal cross-linking for treatment of infectious keratitis. Journal of ophthalmic &amp; vision research. 2015;10(1):77–80. doi: 10.4103/2008-322X.156122.</mixed-citation><mixed-citation xml:lang="en">Tabibian D, Richoz O, Hafezi F. PACK-CXL: Corneal cross-linking for treatment of infectious keratitis. Journal of ophthalmic &amp; vision research. 2015;10(1):77–80. doi: 10.4103/2008-322X.156122.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Spoerl E, Hoyer A, Pillunat LE, Raiskup F. Corneal crosslinking and safety issues. Open Ophthalmol J. 2011;5:14–16. doi: 10.2174/1874364101105010014.</mixed-citation><mixed-citation xml:lang="en">Spoerl E, Hoyer A, Pillunat LE, Raiskup F. Corneal crosslinking and safety issues. Open Ophthalmol J. 2011;5:14–16. doi: 10.2174/1874364101105010014.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Alio JL, Abbouda A, Valle DD, Del Castillo JM, Fernandez JA. Corneal cross linking and infectious keratitis: a systematic review with a meta-analysis of reported cases. J Ophthalmic Inflamm Infect. 2013 May 29;3(1):47. doi: 10.1186/1869-5760-3-47.</mixed-citation><mixed-citation xml:lang="en">Alio JL, Abbouda A, Valle DD, Del Castillo JM, Fernandez JA. Corneal cross linking and infectious keratitis: a systematic review with a meta-analysis of reported cases. J Ophthalmic Inflamm Infect. 2013 May 29;3(1):47. doi: 10.1186/1869-5760-3-47.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Hafezi F, Randleman JB. PACK-CXL: defining CXL for infectious keratitis. J. Refract. Surg. 2014; 30: 438–439. doi: 10.3928/1081597X-20140609-01.</mixed-citation><mixed-citation xml:lang="en">Hafezi F, Randleman JB. PACK-CXL: defining CXL for infectious keratitis. J. Refract. Surg. 2014; 30: 438–439. doi: 10.3928/1081597X-20140609-01.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Lietman AA, Rose-Nussbaumer J. Update on the management of infectious keratitis. Ophthalmology. 2017 Nov;124(11):1678–689. doi: 10.1016/j.ophtha.2017.05.012.</mixed-citation><mixed-citation xml:lang="en">Lietman AA, Rose-Nussbaumer J. Update on the management of infectious keratitis. Ophthalmology. 2017 Nov;124(11):1678–689. doi: 10.1016/j.ophtha.2017.05.012.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Makdoumi K, Mortensen J, Sorkhabi O, Malmvall BE, Crafoord S. UVAriboflavin photochemical therapy of bacterial keratitis: A pilot study. Graefes Arch. Clin. Exp. Ophthalmol. 2012;250(1):95–102. doi: 10.1007/s00417-011-1754-1. PMID: 21874347.</mixed-citation><mixed-citation xml:lang="en">Makdoumi K, Mortensen J, Sorkhabi O, Malmvall BE, Crafoord S. UVAriboflavin photochemical therapy of bacterial keratitis: A pilot study. Graefes Arch. Clin. Exp. Ophthalmol. 2012;250(1):95–102. doi: 10.1007/s00417-011-1754-1. PMID: 21874347.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Li Z, Jhanji V, Tao X, Yu H, Chen W, Mu G. Riboflavin/ultravoilet light-mediated crosslinking for fungal keratitis. Br J Ophthalmol. 2013 May;97(5):669–671. doi: 10.1136/bjophthalmol-2012-302518.</mixed-citation><mixed-citation xml:lang="en">Li Z, Jhanji V, Tao X, Yu H, Chen W, Mu G. Riboflavin/ultravoilet light-mediated crosslinking for fungal keratitis. Br J Ophthalmol. 2013 May;97(5):669–671. doi: 10.1136/bjophthalmol-2012-302518.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Carnt N, Robaei D, Watson SL, Minassian DC, Dart JK. The Impact of Topical Corticosteroids Used in Conjunction with Antiamoebic Therapy on the Outcome of Acanthamoeba Keratitis. Ophthalmology. 2016;123(5):984–990. doi: 10.1016/j.ophtha.2016.01.020.</mixed-citation><mixed-citation xml:lang="en">Carnt N, Robaei D, Watson SL, Minassian DC, Dart JK. The Impact of Topical Corticosteroids Used in Conjunction with Antiamoebic Therapy on the Outcome of Acanthamoeba Keratitis. Ophthalmology. 2016;123(5):984–990. doi: 10.1016/j.ophtha.2016.01.020.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Khan YA, Kashiwabuchi RT, Martins SA, Castro-Combs JM, Kalyani S, Stanley P, Flikier D, Behrens A. Riboflavin and ultraviolet light a therapy as an adjuvant treatment for medically refractive Acanthamoeba keratitis: report of 3 cases. Ophthalmology. 2011;118(2):324–331. doi: 10.1016/j.ophtha.2010.06.041.</mixed-citation><mixed-citation xml:lang="en">Khan YA, Kashiwabuchi RT, Martins SA, Castro-Combs JM, Kalyani S, Stanley P, Flikier D, Behrens A. Riboflavin and ultraviolet light a therapy as an adjuvant treatment for medically refractive Acanthamoeba keratitis: report of 3 cases. Ophthalmology. 2011;118(2):324–331. doi: 10.1016/j.ophtha.2010.06.041.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
