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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2024-1-214-219</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-2313</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ЕXPERIMENTAL STUDIES</subject></subj-group></article-categories><title-group><article-title>Сравнительное изучение методов удаления стекловидного тела при экспериментальных витреоретинальных операциях</article-title><trans-title-group xml:lang="en"><trans-title>Investigation of Differences in the Techniques of Experimental Vitreo-retinal Operations on Laboratory Animals</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3906-0479</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алексеев</surname><given-names>И. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Alekseev</surname><given-names>I. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алексеев Игорь Борисович — доктор медицинских наук, профессор кафедры офтальмологии</p><p>ул. Баррикадная, 2/1, стр. 1, Москва, 125993, </p><p>2-й Боткинский проезд, 5, корп. 19, Москва, 125284</p></bio><bio xml:lang="en"><p>Alekseev Igor B. — MD, Professor of the Ophthalmology department</p><p>Barrikadnaya str., 2/1, Moscow, 125993,</p><p>2nd Botkinsky lane, 5/19, Moscow, 125284</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-2158-5277</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белкин</surname><given-names>В. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Belkin</surname><given-names>V. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Белкин Виталий Евгеньевич — заведующий витреоретинальным отделением</p><p>2-й Боткинский проезд, 5, корп. 19, Москва, 125284</p></bio><bio xml:lang="en"><p>Belkin Vitaly E. — Head of Vitreoretinal Departmen</p><p>2nd Botkinsky lane, 5/19, Moscow, 125284</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6156-6126</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абрамова</surname><given-names>О. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Abramova</surname><given-names>O. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Абрамова Ольга Игоревна — кандидат медицинских наук, врач-офтальмолог отделения лазерной микрохирургии</p><p>2-й Боткинский проезд, 5, корп. 19, Москва, 125284</p></bio><bio xml:lang="en"><p>Abramova Olga I. — PhD, ophthalmologist, Department of Laser Microsurgery</p><p>2nd Botkinsky lane, 5/19, Moscow, 125284</p></bio><email xlink:type="simple">abramovao2019@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации;&#13;
ГБУЗ «Городская клиническая больница имени С.П. Боткина Департамента здравоохранения города Москвы», Московский городской офтальмологический центр</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuous Professional Education;&#13;
Botkin City Clinical Hospital, Moscow Ophthalmological Center</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ «Городская клиническая больница имени С.П. Боткина Департамента здравоохранения города Москвы», Московский городской офтальмологический центр</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Botkin City Clinical Hospital, Moscow Ophthalmological Center</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>01</day><month>04</month><year>2024</year></pub-date><volume>21</volume><issue>1</issue><fpage>214</fpage><lpage>219</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Алексеев И.Б., Белкин В.Е., Абрамова О.И., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Алексеев И.Б., Белкин В.Е., Абрамова О.И.</copyright-holder><copyright-holder xml:lang="en">Alekseev I.B., Belkin V.E., Abramova O.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/2313">https://www.ophthalmojournal.com/opht/article/view/2313</self-uri><abstract><p>Непрерывное развитие витреоретинальной хирургии дает возможность оказывать высокотехнологичную помощь пациентам при отслойке сетчатки с минимизацией интраи постоперационных осложнений. Однако их процент все равно остается существенно большим. Это толкает современную офтальмологическую науку на новые исследования и поиски решения существующих проблем. В решении этой задачи, как никто, помогают лабораторные животные, на которых уже более 100 лет тестируются новейшие достижения медицины. К сожалению, высокая затратность экспериментов зачастую отталкивает и/ или отодвигает их на неопределенный срок. Учитывая клиническую значимость экспериментальных исследований, касающихся хирургического лечения отслойки сетчатки, в рамках исследования нового гидрогелевого препарата «Витреолон» проведен анализ способов удаления стекловидного тела и их влияния на результат операционного вмешательства.</p><sec><title>Цель работы</title><p>Цель работы: сравнительный анализ методов удаления стекловидного тела при экспериментальной отслойке сетчатки.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Эксперимент проведен на 12 глазах (6 кроликов) с индуцированной отслойкой сетчатки. На 6 глазах витрэктомия была выполнена с помощью витреотома, на 6 парных глазах — с использованием шприца 21G. Затем выполняли тампонаду витреальной полости новым гидрогелевым препаратом «Витреолон». Офтальмологические осмотры проводили на 1-е сутки, 1-й и 2-й неделе, через 1 и 3 мес. после оперативного вмешательства. Энуклеированные через 3 мес. после операции глаза использовались для морфологического исследования макропрепаратов и гистологических срезов.</p></sec><sec><title>Результаты</title><p>Результаты. Результаты офтальмологических и лабораторных исследований не выявили статистически значимой разницы между использованными техниками удаления стекловидного тела. У одного кролика (на 2 глазах) была зафиксирована гипертензия и катаракта, что, очевидно, связано с индивидуальной реакцией на оперативное вмешательство. Осложнений, которые могли бы привести к досрочному завершению эксперимента, не зафиксировано.</p></sec><sec><title>Заключение</title><p>Заключение. Отсутствие статистически значимой разницы между клинико-морфологическими показателями глаз кроликов с отслойкой сетчатки, оперированных с применением различных техник удаления стекловидного тела, свидетельствует о правомерности использования для этой цели вместо витреотома шприца необходимого калибра.</p></sec></abstract><trans-abstract xml:lang="en"><p>The continuous development of vitreoretinal surgery makes it possible to provide high-tech care to patients with retinal detachment while minimizing intraand postoperative complications. However, their percentage still remains significantly high. This pushes modern ophthalmological science to new research and search for solutions to existing problems. In this task, laboratory animals, on which the latest advances in medicine have been tested for more than 100 years, help like no one else. Unfortunately, the high cost of experiments often repels and/or pushes them back indefinitely. Given the clinical significance of experimental studies of surgical treatment of retinal detachment, as part of the study of the new hydrogel preparation Vitreolon, an analysis was made of methods for removing the vitreous body and their effect on the result of surgical intervention.</p><sec><title>Purpose</title><p>Purpose: analysis of differences in vitreous removal techniques in laboratory rabbits.</p></sec><sec><title>Material and methods</title><p>Material and methods. The experiment involved 6 rabbits (12 eyes) with induced retinal detachment. In 6 eyes, vitrectomy was performed using a vitreotome, in the others, using a syringe (21G). Subsequently, tamponade of the vitreal cavity was performed with the new hydrogel preparation “Vitreolon”. Ophthalmological examinations were performed on the 1st day, 1st and 2nd week, 1st and 3rd months after surgery. After that, the eyes were enucleated to conduct a morphological study of macropreparations and histological sections of the eyes.</p></sec><sec><title>Results</title><p>Results. According to the results of ophthalmological and laboratory studies, there was no statistically significant difference between the techniques for removing the vitreous body. One rabbit had hypertension and cataracts, which indicates its individual response to surgery. There were no complications that could lead to early termination of the experiment.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>удаление стекловидного тела</kwd><kwd>отслойка сетчатки</kwd><kwd>тампонада витреальной полости</kwd><kwd>тампонирующий агент</kwd><kwd>хирургия отслойки сетчатки</kwd><kwd>витреоретинальная хирургия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>removal of the vitreous</kwd><kwd>retinal detachment</kwd><kwd>vitreous cavity tamponade</kwd><kwd>plugging agent</kwd><kwd>retinal detachment surgery</kwd><kwd>vitreoretinal surgery</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Lake SR, Bottema MJ, Williams KA, Lange T, Reynolds KJ. Retinal Shape-Based Classification of Retinal Detachment and Posterior Vitreous Detachment Eyes. 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