ophthalmologyОфтальмологияOphthalmology in Russia1816-50952500-0845Ophthalmology10.18008/1816-5095-2024-2-264-269ophthalmology-2355Research ArticleОБЗОРЫREVIEWSПротеомный анализ слезы как перспективный метод диагно­стики синдрома сухого глазаProteomic Analysis of Tears as a Promising Method for Diagnosing Dry Eye Syndromehttps://orcid.org/0000-0002-6261-9795ТахауоваЛ. Р.TakhauovaL. R.

Тахауова Лилия Равильевна, младший научный сотрудник отдела эпидемиологии радиогенной патологии, аспирант кафедры офтальмологии

Московский тракт, 2, Томск, 634050

пер. Чекист, 7, корп. 2, Северск, Томская область, 636039

Takhauova Lilia R., junior research associate at the Department of Epidemiology of Radiogenic Pathology, graduate student at the Department of Ophthalmology

Moskovsky trakt, 2, Tomsk, 634050

Chekist Lane, 2/7, Seversk, Tomsk Region, 636039

https://orcid.org/0000-0001-7509-5858КривошеинаО. И.KrivosheinaO. I.

Кривошеина Ольга Ивановна, доктор медицинских наук, профессор, заведующий кафедрой офтальмологии

Московский тракт, 2, Томск, 634050

Krivosheina Olga I., MD, Professor, head of the Department of Ophthalmology 

Moskovsky trakt, 2, Tomsk, 634050

https://orcid.org/0000-0002-5904-2470ПоповИ. А.PopovI. A.

Попов Игорь Алексеевич, кандидат физико‑математических наук, доцент, руководитель лаборатории ионной и молекулярной физики, руководитель лаборатории  трансляционной медицины

Московский тракт, 2, Томск, 634050

Институтский пер., 9, Долгопрудный, Московская область, 141701

Popov Igor A., PhD, Associate Professor, head of the Laboratory of ion and molecular physics, head of the Laboratory of translational medicine 

Moskovsky trakt, 2, Tomsk, 634050

Institute Lane, 9, Dolgoprudny, Moscow Region, 141701

ФГБОУ ВО «Сибирский государственный медицинский университет» Министерства здравоохранения Российской Федерации; ФГБУН «Северский биофизический научный центр» Федерального медико-­биологического агентства РоссииРоссияSiberian State Medical University of the Ministry of Health of Russia; Seversk Biophysical Research Center of the Center of the Federal Medical and Biological AgencyRussian FederationФГБОУ ВО «Сибирский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияSiberian State Medical University of the Ministry of Health of RussiaRussian FederationФГБОУ ВО «Сибирский государственный медицинский университет» Министерства здравоохранения Российской Федерации; ФГАБОУ ВО «Московский физико‑технический институт (национальный исследовательский университет)»РоссияSiberian State Medical University of the Ministry of Health of Russia; Moscow Institute of Physics and TechnologyRussian Federation202426062024212264269Copyright © Тахауова Л.Р., Кривошеина О.И., Попов И.А., 20242024Тахауова Л.Р., Кривошеина О.И., Попов И.А.Takhauova L.R., Krivosheina O.I., Popov I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.ophthalmojournal.com/opht/article/view/2355

Одним из наиболее распространенных заболеваний органа зрения, характеризующихся потерей гомеостаза слезной пленки с нарушением ее стабильности и гиперосмолярности, является синдром сухого глаза (ССГ). В статье представлен обзор современной научной литературы, отражающий распространенность и основные факторы патогенеза ССГ, а также перспективы применения протеомного картирования, оказывающего существенную помощь в изучении закономерностей развития и прогрессирования заболевания. Детально рассматриваются методологические основы забора слезной жидкости для исследования, а также анализируются современные данные об изменениях биохимического состава слезной жидкости при ССГ.

One of the most common diseases of the organ of vision, characterized by a loss of homeostasis of the tear film, with a violation of the stability of the tear film and its hyperosmolarity, is the dry eye syndrome (DES). The article presents a review of modern scientific literature, reflecting the prevalence and main factors of the pathogenesis of DES, as well as evaluating the prospects for the use of proteomic mapping, which provides significant assistance in studying the patterns of development and progression of the disease. The methodological foundations of tear collection for research are considered in detail, and current data on changes in the biochemical composition of tear fluid in DES are analyzed.

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The authors declare that there are no conflicts of interest present.