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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2024-2-401-411</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-2364</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ЕXPERIMENTAL STUDIES</subject></subj-group></article-categories><title-group><article-title>Маркеры и предикторы пролиферативной витреоретинопатии при открытой травме глаза в эксперименте</article-title><trans-title-group xml:lang="en"><trans-title>Markers and Predictors of Proliferative Vitreoretinopathy in Open Eye Injury in an Experiment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8305-3049</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кольбин</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kol’bin</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кольбин Алексей Анатольевич, преподаватель кафедры офтальмологии</p><p>ул. Академика Лебедева, 6 лит. Ж, Санкт­Петербург, 194044</p></bio><bio xml:lang="en"><p>Kol’bin Aleksei A., lecturer of the Ophthalmology Department</p><p>Akademician Lebedev str., 6, St. Petersburg, 194044</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5274-6993</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куликов</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulikov</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Куликов Алексей Николаевич, доктор медицинских наук, профессор, начальник кафедры (клиники) офтальмологии</p><p>ул. Академика Лебедева, 6 лит. Ж, Санкт­Петербург, 194044</p></bio><bio xml:lang="en"><p>Kulikov Aleksei N., DM, Associate Professor, head of the Department of ophthalmology</p><p>Akademician Lebedev str., 6, St. Petersburg, 194044</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1353-9358</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трояновский</surname><given-names>Р. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Troyanovsky</surname><given-names>R. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Трояновский Роман Леонидович, доктор медицинских наук, профессор, профессор кафедры офтальмологии</p><p>ул. Академика Лебедева, 6 лит. Ж, Санкт­Петербург, 194044</p></bio><bio xml:lang="en"><p>Troyanovsky Roman L., DM, Associate Professor, Professor of the Department of Ophthalmology</p><p>Akademician Lebedev str., 6, St. Petersburg, 194044</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8336-1981</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чирский</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Chirskiy</surname><given-names>V. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чирский Вадим Семенович, доктор медицинских наук, начальник кафедры патологической анатомии</p><p>ул. Академика Лебедева, 6 лит. Ж, Санкт­Петербург, 194044</p></bio><bio xml:lang="en"><p>Chirskiy Vadim S., DM, head of Chair of Pathological Anatomy</p><p>Akademician Lebedev str., 6, St. Petersburg, 194044</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Военно-медицинская академия имени С.М. Кирова» Министерства обороны Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>S.M. Kirov Military Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>27</day><month>06</month><year>2024</year></pub-date><volume>21</volume><issue>2</issue><fpage>401</fpage><lpage>411</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кольбин А.А., Куликов А.Н., Трояновский Р.Л., Чирский В.С., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Кольбин А.А., Куликов А.Н., Трояновский Р.Л., Чирский В.С.</copyright-holder><copyright-holder xml:lang="en">Kol’bin A.A., Kulikov A.N., Troyanovsky R.L., Chirskiy V.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/2364">https://www.ophthalmojournal.com/opht/article/view/2364</self-uri><abstract><sec><title>Цель работы</title><p>Цель работы: провести анализ признаков стандартизированной модели огнестрельной открытой травмы глаза типа B (проникающее ранение без внутриглазного инородного тела).</p></sec><sec><title>Методы</title><p>Методы: эксперимент выполнен на 36 кроликах (71 глаз). Моделирование огнестрельной открытой травмы глаза (ООТГ) типа B выполнено на помповой установке. Использован комплекс современных стандартных и высокотехнологичных методов диагностики для изучения признаков модели ООТГ типа B в контрольные сроки эксперимента: биомикроскопия, офтальмоскопия, оптическая когерентная томография, электроретинография, УЗИ, МРТ, иммуноферментный анализ для определения фибронектина в стекловидной камере и патоморфологическое исследование глазного яблока. Для анализа применяли непараметрические методы статистики.</p></sec><sec><title>Результаты</title><p>Результаты. При использовании указанных методов диагностики дана характеристика признаков экспериментальной модели ООТГ, в том числе пролиферативной витреоретинопатии (ПВР): частота встречаемости и динамика. Проведен анализ корреляций изученных признаков модели.</p></sec><sec><title>Заключение</title><p>Заключение. Была доказана высокая воспроизводимость (77–100 %) признаков экспериментальной модели ООТГ типа B на микроуровне, что доказало стандартизированность разработанной нами модели. В эксперименте на основе корреляционного анализа обоснована целесообразность использования гифемы и гемофтальма в качестве предикторов ПВР при ООТГ. Анализ пролиферативных признаков при использовании различных методов исследования (патоморфологический, обратная офтальмоскопия, ОКТ, УЗИ и МРТ) доказал возможность их применения в качестве маркеров ПВР. Также обоснована возможность взаимной замены указанных методов исследования при диагностике ПВР. Экспериментально доказано наличие большого количества фокусов повреждений в оболочках глазного яблока и в его внутренних структурах, в том числе ПВР, при ООТГ.</p></sec></abstract><trans-abstract xml:lang="en"><p>The objective of the study: to analyze characteristics of a standardized model of type B gunshot open global injury (open injury without intraocular foreign body).</p><sec><title>Methods</title><p>Methods: The experiment was carried out on 36 rabbits (71 eyes). Simulation of type B gunshot open global injury (GOEI) was accomplished using pump equipment. The complex of modern standard and high­technology diagnostic methods to study characteristics of type B GOEI in the control period was performed. Biomicroscopy, ophthalmoscopy, optical coherence tomography, electroretinography, ultrasound examination, MRI, enzyme multiplied immunoassay to determine vitreous fibronectin, and pathomorphological study of the eye globe were carried out. Non­parametric statistical methods of data analysis were used.</p></sec><sec><title>Results</title><p>Results: The above diagnostic methods being used, the GOEI experimental model characteristics were determined, including proliferative vitreoretinopathy (PVR) i.e.incidence rate and dynamics.</p></sec><sec><title>Conclusion</title><p>Conclusion. High reproducibility (77–100 %) of microlevel signs of type B GOEI experimental model was demonstrated, that evidenced standardization of the developed model. The viability of the use of hyphema and hemophthalmia as the PVR and GOEI predictors was justified on the basis of correlation analysis in experiment. The analysis of proliferative signs being made when using different study methods (pathomorphological, indirect ophthalmoscopy, optical coherence tomography, ultrasound examination and MRI) proved their application as PVR markers possible. The interchangeability of the study methods used for PVR diagnosis was also justified.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>магнитно­резонансная томография</kwd><kwd>маркеры пролиферативной витреоретинопатии</kwd><kwd>моделирование открытой травмы глаза</kwd><kwd>офтальмотравматология</kwd><kwd>предикторы пролиферативной витреоретинопатии</kwd><kwd>многофокусность повреждений глаза</kwd><kwd>фибронектин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>magnetic resonance imaging</kwd><kwd>proliferative vitreoretinopathy markers</kwd><kwd>open globe injury simulation</kwd><kwd>ophthalmotraumatology</kwd><kwd>proliferative vitreoretinopathy predictors</kwd><kwd>large number of damage foci in the eye</kwd><kwd>fibronectin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Степанов А.В., Джиоева А.В. 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