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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2024-3-451-455</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-2417</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Новые аспекты применения антибиотиков в офтальмологии: взгляд клинического фармаколога</article-title><trans-title-group xml:lang="en"><trans-title>New Aspects of the Antibiotics Use in Ophthalmology: the View of a Clinical Pharmacologist</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4391-2889</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кнорринг</surname><given-names>Г. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Knorring</surname><given-names>G. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кнорринг Герман Юрьевич - кандидат медицинских наук, доцент кафедры терапии, клинической фармакологии и скорой медицинской помощи лечебного факультета.</p><p>Ул. Долгоруковская, 4, Москва, 127006</p></bio><bio xml:lang="en"><p>Knorring German Yu. - PhD, Associate Professor of the Therapy, Clinical Pharmacology and Emergency Medical Care Department, Faculty of Medicine</p><p>Dolgorukovskaya str., 4, Moscow, 127006</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-образовательный институт клинической медицины им. Н.А. Семашко ФГБОУ ВО «Российский университет медицины»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific and Educational Institute of Clinical Medicine named after Semashko of Russian University of Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>01</day><month>10</month><year>2024</year></pub-date><volume>21</volume><issue>3</issue><fpage>451</fpage><lpage>455</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кнорринг Г.Ю., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Кнорринг Г.Ю.</copyright-holder><copyright-holder xml:lang="en">Knorring G.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/2417">https://www.ophthalmojournal.com/opht/article/view/2417</self-uri><abstract><p>При инфекционно-воспалительных поражениях глаз к основным способам контроля возбудителей относят антибактериальные средства различных классов и антисептики. Однако применение антисептиков имеет ряд ограничений: они способны оказывать действие преимущественно на поверхности тканей глаза и в соответствии с клиническими рекомендациями должны использоваться как дополнение к антибактериальной терапии. Антибактериальная терапия остается основной рекомендацией при лечении бактериальных инфекций глаза, как его переднего отрезка, так и при более глубоких поражениях. В большинстве стран эмпирически чаще назначают препараты из группы фторхинолонов и аминогликозидов, к которым сохраняется приемлемый уровень чувствительности микроорганизмов. Среди аминогликозидов бо´льшая чувствительность возбудителей инфекции глаз на данный момент определяется к нетилмицину. В обзоре рассматриваются вопросы перспективы и эффективности использования нетилмцина в виде монотерапии, а также в комбинации с фторхинолонами для топической терапии бактериальных инфекций в офтальмологии, приведены также примеры успешного применения нетилмицина.</p></abstract><trans-abstract xml:lang="en"><p>For infectious and inflammatory eye lesions, the main methods of controlling pathogens include antibacterial agents of various classes and antiseptics. However, the use of these agents has a number of limitations: they are able to act primarily on the surface of the eye tissue, and in accordance with clinical recommendations, they should be used as an addition to antibacterial therapy.</p><p>Antibacterial therapy remains the main recommendation for the treatment of bacterial eye infections, both in the anterior segment and in deeper lesions. In most countries, drugs from the group of fluoroquinolones and aminoglycosides are more often prescribed empirically, to which an acceptable level of sensitivity of microorganisms remains. Among aminoglycosides, the greatest sensitivity of eye infection pathogens is currently determined to netilmicin.</p><p>The review examines the prospects and effectiveness of using netilmicin as monotherapy, as well as in combination with fluoroquinolones for topical treatment of bacterial infections in ophthalmology, and provides examples of the successful use of netilmicin.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>инфекции в офтальмологии</kwd><kwd>нетилмицин</kwd><kwd>аминогликозиды</kwd><kwd>фторхинолоны</kwd><kwd>антибиотикорезистентность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>infections in ophthalmology</kwd><kwd>netilmicin</kwd><kwd>aminoglycosides</kwd><kwd>fluoroquinolones</kwd><kwd>antibiotic resistance</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">статья подготовлена при поддержке компании ООО «Бауш Хелс». Позиция автора статьи может отличаться от позиции компании ООО «Бауш Хелс»</funding-statement><funding-statement xml:lang="en">the article was prepared with the support of Bausch Health LLC. The position of the author of the article may differ from the position of Bausch Health LLC</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Поляк МС, Околов ИН, Пирогов ЮИ. Антибиотикотерапия в офтальмологии. СПб.: Нестор‑История, 2015. 352 с.</mixed-citation><mixed-citation xml:lang="en">Polyak MS, Okolov IN, Pirogov YI. Antibiotic therapy in ophthalmology. Saint Petersburg; 2015. 352 p. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Vontobel SF, Abad‑Villar EM, Kaufmann C, Zinkernagel AS, Hauser PC, Thiel MA. Corneal Penetration of Polyhexamethylene. 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