ophthalmologyОфтальмологияOphthalmology in Russia1816-50952500-0845Ophthalmology10.18008/1816-5095-2025-1-5-15ophthalmology-2569Research ArticleОБЗОРЫREVIEWSСовременные возможности и перспективы нейропротекторной терапии при глаукоме. Обзор литературы. Часть 1Current Opportunities and Future Prospects of Neuroprotective Therapy in Glaucoma. Literature Review. Part 1https://orcid.org/0000-0002-2265-6671КурышеваН. И.KuryshevaN. I.

Курышева Наталия Ивановна, доктор медицинских наук, профессор, заведующая кафедрой, руководитель консультативно‑диагностического отдела

Живописная ул., 46, стр. 8, Москва, 123098

ул. Гамалеи, 15, Москва, 123098

Kurysheva Natalia I., MD, Professor, head of the Ophthalmology Department, head of the Consultative and Diagnostic Department

Zhivopisnaya str., 46-8, Moscow, 123098

Gamalei str., 15, Moscow, 123098

https://orcid.org/0000-0002-4435-8114КорнееваА. В.KorneevaA. V.

Корнеева Алина Владимировна, врач-офтальмолог, кандидат медицинских наук, ассистент кафедры

Живописная ул., 46, стр. 8, Москва, 123098

ул. Гамалеи, 15, Москва, 123098

Korneeva Alina V., ophthalmologist, PhD, department assistant

Zhivopisnaya str., 46-8, Moscow, 123098

Gamalei str., 15, Moscow, 123098

https://orcid.org/0000-0002-4608-0136ПономареваС. И.PonomarevaS. I.

Пономарева Саина Иннокентьевна, врач-офтальмолог

ул. Гамалеи, 15, Москва, 123098

Ponomareva Saina I., ophthalmologist

Gamalei str., 15, Moscow, 123098

https://orcid.org/0009-0004-9171-1955ПлиеваХ. М.PlievaH. M.

Плиева Хава Магомедовна, врач-офтальмолог, ассистент кафедры

Живописная ул., 46, стр. 8, Москва, 123098

ул. Гамалеи, 15, Москва, 123098

Plieva Hava M., ophthalmologist, department assistant

Zhivopisnaya str., 46-8, Moscow, 123098

Gamalei str., 15, Moscow, 123098

https://orcid.org/0000-0002-8400-2817КимВ. Е.KimV. E.

Ким Валерия Енгировна, врач-офтальмолог, ассистент кафедры

Живописная ул., 46, стр. 8, Москва, 123098

ул. Гамалеи, 15, Москва, 123098

Kim Valeriya E., ophthalmologist, department assistant

Zhivopisnaya str., 46-8, Moscow, 123098

Gamalei str., 15, Moscow, 123098

КимИ. Д.KimI. D.

Ким Игорь Дмитриевич, врач-офтальмолог, ассистент кафедры

Живописная ул., 46, стр. 8, Москва, 123098

ул. Гамалеи, 15, Москва, 123098

Kim Igor D., ophthalmologist, department assistant

Zhivopisnaya str., 46-8, Moscow, 123098

Gamalei str., 15, Moscow, 123098

https://orcid.org/0009-0000-8802-1794ЧеботареваМ. В.ChebotarevaM. V.

Чеботарева Мария Владимировна, врач-ординатор

Живописная ул., 46, стр. 8, Москва, 123098

Chebotareva Maria V., resident physician

Zhivopisnaya str., 46-8, Moscow, 123098

Медико-биологический университет инноваций и непрерывного образования ФГБУ Государственный научный центр «Федеральный медицинский биофизический центр имени А.И. Бурназяна» Федерального медико-биологического агентства; Центр офтальмологии, ФГБУ Государственный научный центр «Федеральный медицинский биофизический центр имени А.И. Бурназяна» Федерального медико-биологического агентстваРоссияMedical Biological University of Innovations and Continuing Education, Burnazyan Federal Biophysical Center, Federal Medical and Biological Agency; Ophthalmological Center, Burnazyan Federal Biophysical Center, Federal Medical and Biological AgencyRussian FederationЦентр офтальмологии, ФГБУ Государственный научный центр «Федеральный медицинский биофизический центр имени А.И. Бурназяна» Федерального медико-биологического агентстваРоссияOphthalmological Center, Burnazyan Federal Biophysical Center, Federal Medical and Biological AgencyRussian FederationМедико-биологический университет инноваций и непрерывного образования ФГБУ Государственный научный центр «Федеральный медицинский биофизический центр имени А.И. Бурназяна» Федерального медико-биологического агентстваРоссияMedical Biological University of Innovations and Continuing Education, Burnazyan Federal Biophysical Center, Federal Medical and Biological AgencyRussian Federation202528032025221515Copyright © Курышева Н.И., Корнеева А.В., Пономарева С.И., Плиева Х.М., Ким В.Е., Ким И.Д., Чеботарева М.В., 20252025Курышева Н.И., Корнеева А.В., Пономарева С.И., Плиева Х.М., Ким В.Е., Ким И.Д., Чеботарева М.В.Kurysheva N.I., Korneeva A.V., Ponomareva S.I., Plieva H.M., Kim V.E., Kim I.D., Chebotareva M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.ophthalmojournal.com/opht/article/view/2569

Данный литературный обзор посвящен одной из наиболее сложных проблем офтальмологии — нейропротекторному и нейрорегенераторному лечению глаукомы и состоит из двух частей. В первой части рассматриваются основные механизмы нейродегенерации и важнейшие аспекты терапевтического контроля, имеющие отношение к данным механизмам (эксайтотоксичность, митохондриальная дисфункция, оксидативный стресс). Основной задачей проведенного анализа литературы является предоставление всестороннего обзора как имеющихся нейропротекторных стратегий, так и перспективных направлений терапии на основе нейропротекторных препаратов в потенциальном лечении глаукомы. Многогранность подходов к нейропротекции демонстрирует большой потенциал разработки и внедрения в клиническую практику эффективного лечения нейродегенерации с целью сохранения зрительных функций у пациентов с глаукомой.

This literature review is devoted to one of the most complex ophthalmology problems — neuroprotective and neuroregenerative treatment of glaucoma and consists of two parts. The first part considers the main mechanisms of neurodegeneration and the main aspects of therapeutic control related to these mechanisms (excitotoxicity, mitochondrial dysfunction, oxidative stress). The main aim of the conducted literature analysis is to provide a comprehensive overview of both existing neuroprotective strategies and promising areas of therapy based on neuroprotective agents in the potential treatment of glaucoma. A wide range of approaches to neuroprotection demonstrates the great potential for effective treatment of neurodegeneration in order to preserve visual functions in patients with glaucoma.

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The authors declare that there are no conflicts of interest present.