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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2025-1-191-199</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-2599</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL STUDIES</subject></subj-group></article-categories><title-group><article-title>Клинико-функциональные результаты комбинированного хирургического лечения пациента с кератоконусом: опыт 10-летнего наблюдения</article-title><trans-title-group xml:lang="en"><trans-title>Clinical and Functional Results of Combined Surgical Treatment of a Patient with Keratoconus: 10-year Follow-up Experience</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7624-7163</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Калинников</surname><given-names>Ю. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kalinnikov</surname><given-names>Yu. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Калинников Юрий Юрьевич, доктор медицинских наук, профессор кафедры офтальмологии</p><p>ул. Долгоруковская, 4, Москва, 127006</p></bio><bio xml:lang="en"><p>Kalinnikov Yuri Y., MD, Professor of the Ophthalmology Department</p><p>Dolgorukovskaya str., 4, Moscow, 127006</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3516-1774</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Измайлова</surname><given-names>С. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Izmailova</surname><given-names>S. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Измайлова Светлана Борисовна, доктор медицинских наук, врач высшей категории, заведующая отделом трансплантационной и оптико-реконструктивной хирургии переднего отрезка глазного яблока</p><p>Бескудниковский бульвар, 59а, Москва, 127486</p></bio><bio xml:lang="en"><p>Izmailova Svetlana B., MD, physician of the highest category, head of the transplantation and opticalreconstructive surgery of the anterior segment of the eyeball department</p><p>Beskudnikovsky blvd, 59A, Moscow, 127486</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3441-5434</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рагимова</surname><given-names>Л. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Ragimova</surname><given-names>L. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рагимова Ляман Фазил кызы, врач-офтальмолог, аспирант</p><p>ул. Долгоруковская, 4, Москва, 127006</p></bio><bio xml:lang="en"><p>Ragimova Lyaman Fazil, ophthalmologist, postgraduate</p><p>Dolgorukovskaya str., 4, Moscow, 127006</p></bio><email xlink:type="simple">Limanra@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Исмаилова</surname><given-names>З. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Ismailova</surname><given-names>Z. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Исмаилова Зури Муслимовна, врач-офтальмолог, аспирант</p><p>Бескудниковский бульвар, 59а, Москва, 127486</p></bio><bio xml:lang="en"><p>Ismailova Zuri M., ophthalmologist, postgraduate student</p><p>Beskudnikovsky blvd, 59A, Moscow, 127486</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9109-2400</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Калинникова</surname><given-names>С. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kalinnikova</surname><given-names>S. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Калинникова Светлана Юрьевна, кандидат медицинских наук, врач-офтальмолог, научный сотрудник лаборатории трансплантологии и клеточной биологии</p><p>Бескудниковский бульвар, 59а, Москва, 127486</p></bio><bio xml:lang="en"><p>Kalinnikova Svetlana Y., PhD, ophthalmologist, researcher at the transplantology and cell biology laboratory</p><p>Beskudnikovsky blvd, 59A, Moscow, 127486</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-6625-7965</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сагоненко</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sagonenko</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сагоненко Дмитрий Алексеевич, врач-офтальмолог, аспирант</p><p>ул. Долгоруковская, 4, Москва, 127006</p></bio><bio xml:lang="en"><p>Sagonenko Dmitry A., ophthalmologist, postgraduate</p><p>Dolgorukovskaya str., 4, Moscow, 127006</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Российский университет медицины» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian University of Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАУ НМИЦ «МНТК “Микрохирургия глаза” имени академика С.Н. Федорова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>S. Fyodorov Eye Microsurgery Federal State Institution</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>31</day><month>03</month><year>2025</year></pub-date><volume>22</volume><issue>1</issue><fpage>191</fpage><lpage>199</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Калинников Ю.Ю., Измайлова С.Б., Рагимова Л.Ф., Исмаилова З.М., Калинникова С.Ю., Сагоненко Д.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Калинников Ю.Ю., Измайлова С.Б., Рагимова Л.Ф., Исмаилова З.М., Калинникова С.Ю., Сагоненко Д.А.</copyright-holder><copyright-holder xml:lang="en">Kalinnikov Y.Y., Izmailova S.B., Ragimova L.F., Ismailova Z.M., Kalinnikova S.Y., Sagonenko D.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/2599">https://www.ophthalmojournal.com/opht/article/view/2599</self-uri><abstract><p>Актуальность. Вопреки развитию современных технологий послойной кератопластики кератоконус (КК) остается одним из наиболее частых показаний к сквозной кератопластике (СКП). Однако прозрачного приживления донорской ткани недостаточно для достижения высокой остроты зрения. Актуальной проблемой остается послеоперационный астигматизм. В связи с этим в 2015 году нами был предложен способ интраоперационной профилактики посткератопластического астигматизма.Цель: представить отдаленные клинико-функциональные результаты лечения пациента с КК после проведения СКП с одномоментной имплантацией разомкнутого кольца в трансплантат.Пациент и методы. Пациент впервые обратился в клинику в 2012 году с миопией высокой степени (МВС) в анамнезе и жалобами на снижение остроты зрения (ОЗ) на оба глаза. Пациенту была выполнена комплексная первичная диагностика, по результатам которой был поставлен диагноз: МВС, КК 3–4 стадии обоих глаз. В 2012 году на OD была выполнена СКП, в 2015 году на OS — СКП с фемтосекундным сопровождением и одномоментной имплантацией разомкнутого кольца в трансплантат. В 2023 году на обоих глазах выполнили факоэмульсификацию катаракты (ФЭК) с имплантацией: OD — торической интраокулярной линзы (тИОЛ); OS — монофокальной асферичной ИОЛ.Результаты. Спустя 12 лет (OD) и 10 лет (OS) наблюдения после проведения многоэтапного хирургического лечения на обоих глазах — трансплантат прозрачный, ИОЛ в правильном положении; на OS интрастромальное кольцо в правильном положении, адаптировано в строме. ОЗ составила OD = 0,9 н/к; OS = 1,0, при этом величина астигматизма по данным кератотопографии на OS составила –0,9D, на OD -3,2D.Заключение. Данный клинический случай демонстрирует отдаленные клинико-функциональные результаты, при которых на сроке наблюдения более 10 лет отмечается отсутствие дислокации интрастромального кольца и реакции со стороны трансплантата, стабильное положение ИОЛ и минимальные значения астигматизма. Проведение СКП с одномоментной имплантацией разомкнутого кольца в трансплантат является безопасным и эффективным методом лечения пациентов с КК.</p></abstract><trans-abstract xml:lang="en"><p>Relevance. Despite the development of modern technologies of lamellar keratoplasty, keratoconus (KK) remains one of the most common indications for penetrating keratoplasty (PKP). However, transparent engraftment of donor tissue is not enough to achieve high visual acuity. Postoperative astigmatism remains an urgent problem. In this regard, in 2015 we proposed a method for intraoperative prevention of postkeratoplastic astigmatism.Objective: to present the long-term clinical and functional results of treating a patient with KK after PKP with one-stage implantation of an open ring into the graft.Patient and methods. First time the patient came to the clinic in 2012 with a history of high myopia (HM) and complaints of decreased visual acuity (VA) in both eyes. The patient underwent a comprehensive primary diagnosis, based on the results of which the following diagnosis was made: HM, KK stage 3–4 in both eyes. In 2012, PKP was performed on OD, in 2015, PKP with femtosecond accompaniment and one-stage implantation of an open ring into the graft on OS. In 2023, phacoemulsification of cataracts (PEC) was performed on both eyes with implantation of: OD — a toric intraocular lens (tIOL); OS — a monofocal aspheric IOL. Results. After 12 years (OD) and 10 years (OS) of follow-up after multi-stage surgical treatment, the graft is transparent, the IOL is in the correct position; on OS, the intrastromal ring is in the correct position, adapted in the stroma. VA was OD = 0.9 n/c; OS = 1.0, while the amount of astigmatism according to keratopography on OS was -0.9D, on OD -3.2D.Conclusion. This clinical case demonstrates remote clinical and functional results, where over a follow-up period of more than 10 years, there is no intrastromal ring dislocation and no graft reaction, stable IOL position, and minimal astigmatism. Carrying out SKP with one-stage implantation of an open ring into the graft is a safe and effective method of treating patients with CC.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>кератоконус</kwd><kwd>посткератопластический астигматизм</kwd><kwd>интрастромальная кератопластика</kwd><kwd>сквозная кератопластика</kwd><kwd>разомкнутое кольцо</kwd><kwd>факоэмульсификация катаракты</kwd><kwd>торическая интраокулярная линза</kwd></kwd-group><kwd-group xml:lang="en"><kwd>keratoconus</kwd><kwd>postkeratoplastic astigmatism</kwd><kwd>intrastromal keratoplasty</kwd><kwd>penetrating keratoplasty</kwd><kwd>open ring</kwd><kwd>cataract phacoemulsification</kwd><kwd>toric intraocular lens</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Vought R, Greenstein SA, Gelles J, Hersh PS. The Pathophysiology of Keratoconus. 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