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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2015-4-27-33</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-273</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ И ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL &amp; EXPERIMENTAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Новая методика формирования фрагмента внутренней пограничной мембраны в хирургическом лечении больших идиопатических макулярных разрывов</article-title><trans-title-group xml:lang="en"><trans-title>A new technique of inverted internal limiting membrane flap formation in a surgical treatment for large idiopathic macular holes</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белый</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Belyi</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ул. Святослава Федорова, 5, г. Калуга, 248007</p></bio><bio xml:lang="en"><p>Svyatoslav Fyodorov Street, 5, Kaluga, Russia, 248007</p></bio><email xlink:type="simple">nauka@mntk.kaluga.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Терещенко</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tereshchenko</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ул. Святослава Федорова, 5, г. Калуга, 248007</p></bio><bio xml:lang="en"><p>Svyatoslav Fyodorov Street, 5, Kaluga, Russia, 248007</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шкворченко</surname><given-names>Д. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Shkvorchenko</surname><given-names>D. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бескудниковский б-р, 59А, Москва, 127486</p></bio><bio xml:lang="en"><p>Beskudnikovskiy b-d, 59a, Moscow, Russia, 127486</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ерохина</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Erokhina</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ул. Святослава Федорова, 5, г. Калуга, 248007</p></bio><bio xml:lang="en"><p>Svyatoslav Fyodorov Street, 5, Kaluga, Russia, 248007</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шилов</surname><given-names>Н. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Shilov</surname><given-names>N. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ул. Святослава Федорова, 5, г. Калуга, 248007</p></bio><bio xml:lang="en"><p>Svyatoslav Fyodorov Street, 5, Kaluga, Russia, 248007</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Калужский филиал ФГБУ «МНТК «Микрохирургия глаза» им. акад. С.Н. Федорова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kaluga branch of FSBI «IRTC «Eye Microsurgery» named after Academician S.N. Fedorov» of the Russian Federation Public Health Ministry</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ «МНТК «Микрохирургия глаза» им. акад. С.Н. Федорова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FSBI «IRTC «Eye Microsurgery» named after Academician S.N. Fedorov» of the Russian Federation Public Health Ministry</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>08</day><month>01</month><year>2016</year></pub-date><volume>12</volume><issue>4</issue><fpage>27</fpage><lpage>33</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Белый Ю.А., Терещенко А.В., Шкворченко Д.Р., Ерохина Е.В., Шилов Н.М., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Белый Ю.А., Терещенко А.В., Шкворченко Д.Р., Ерохина Е.В., Шилов Н.М.</copyright-holder><copyright-holder xml:lang="en">Belyi I.A., Tereshchenko A.V., Shkvorchenko D.O., Erokhina E.V., Shilov N.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/273">https://www.ophthalmojournal.com/opht/article/view/273</self-uri><abstract><p>Цель — разработать технологию хирургического лечения больших идиопатических макулярных разрывов с применением новой методики поэтапного формирования фрагмента внутренней пограничной мембраны для закрытия макулярного отверстия.</p><sec><title>Пациенты и методы</title><p>Пациенты и методы. Под наблюдением находились 19 пациентов в возрасте от 56 лет до 71 года (средний возраст 63,8±5,3 года) с идиопатическими макулярными разрывами (МР) III стадии по классификации J. Gass. Всем пациентам, помимо стандартных методов исследования, проводили спектральную оптическую когерентную томографию и микропериметрию. Сроки наблюдения — до лечения и 2 недели, 1 и 3 месяца после операции. Особенностью операции явилась техника формирования фрагмента внутренней пограничной мембраны (ВПМ), напоминающая удаление лепестков у цветка, которую выполняют в несколько этапов, включающих пошаговое отделение локальных участков ВПМ вокруг МР с сохранением фовеолярного фрагмента и одного фрагмента ВПМ. Затем его частично отсепаровывают по направлению к МР, останавливаясь на расстоянии 0,1‑0,2мм от края МР, переворачивают и укладывают на МР, таким образом, закрывая его.</p></sec><sec><title>Результаты</title><p>Результаты. Хирургические вмешательства выполнены в полном объеме без осложнений во всех случаях. За период наблюдения у всех пациентов отмечали постепенное увеличение остроты зрения с 0,1‑0,4 до 0,3‑0,7 (в среднем 0,39±0,15). Во всех случаях было достигнуто улучшение анатомического состояния сетчатки в фовеальной области: у 8‑ми пациентов — полное закрытие дефекта, у 11‑ти — частичное. У всех пациентов наблюдали смещение точки фиксации по направлению к центру fovea на расстояние от 153 до 369мкм, также имела место стабилизация фиксации, исчезновение абсолютной скотомы в центре fovea.</p></sec><sec><title>Заключение</title><p>Заключение. Разработанная методика является перспективной в лечении больших идиопатических макулярных разрывов. Необходимо проведение дальнейших исследований.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Purpose</title><p>Purpose. To develop a surgical treatment for large idiopathic macular holes using a new technique of internal limiting membrane fragment formation to close the macular hole.</p></sec><sec><title>Material and methods</title><p>Material and methods. We observed 19 patients, from 56 to 71 years old (average age was 63,8±5,3 years old) with idiopathic macular holes (IMH) stage III according to J. Gass classification. Standard ophthalmologic examination and spectral optical coherence tomography and microperimetry were performed in all cases. The follow-up was before treatment and 2 weeks, 1 and 3 months after surgery. A new technique of internal limiting membrane (ILM) fragment formation reminds the process of removal petals from a flower and is performed in several steps, including step-by-step separation of local areas ILM around MH preserving foveolar fragments and one ILM fragment, which is then partially separated towards MH, stopping at a distance of 0,1‑0,2 mm from the edge of the MH, inverted and covered on MH, closing it.</p></sec><sec><title>Results</title><p>Results. Surgical interventions were made in full volume without complications in all cases. During follow-up visual acuity increased from 0.1‑0.4 to 0.3‑0.7 (mean 0,39±0,15). An improvement of the retina anatomical condition in foveal zone was observed in all cases: complete closure of MH was achieved in 8 patients, and partial closure of MH was achieved in 11 patient. Fixation point offset on 153‑369 mm toward the center of the fovea and fixation stabilization, and disappearance of absolute scotoma in the fovea center was observed in all patients.</p></sec><sec><title>Conclusion</title><p>Conclusion. The developed technique is perspective in the treatment of large idiopathic macular holes. Further investigations are necessary.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>идиопатический макулярный разрыв</kwd><kwd>хирургическое лечение</kwd><kwd>внутренняя пограничная мембрана</kwd></kwd-group><kwd-group xml:lang="en"><kwd>idiopathic macular holes</kwd><kwd>surgical treatment</kwd><kwd>internal limiting membrane</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Alpatov S.A., Shchuko A.G., Malyshev V.V. [Regularities of idiopathic macular holes formation]. Zakonomernosti formirovanija idiopaticheskih makuljarnyh razryvov. [Annals of ophthalmology]. Vestnik Oftalmologii. 2001; 5: 30‑33. (in Russ.).</mixed-citation><mixed-citation xml:lang="en">Alpatov S.A., Shchuko A.G., Malyshev V.V. [Regularities of idiopathic macular holes formation]. Zakonomernosti formirovanija idiopaticheskih makuljarnyh razryvov. [Annals of ophthalmology]. Vestnik Oftalmologii. 2001; 5: 30‑33. (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Alpatov S.A., Shchuko A.G., Malyshev V.V. Idiopaticheskiye makulyarnyye razryvy [Idiopatic macular holes]. Novosibirsk: Nauka, 2002. 109 p. (in Russ.).</mixed-citation><mixed-citation xml:lang="en">Alpatov S.A., Shchuko A.G., Malyshev V.V. Idiopaticheskiye makulyarnyye razryvy [Idiopatic macular holes]. Novosibirsk: Nauka, 2002. 109 p. (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Lyskin P.V., Zakharov V.D., Lozinskaya O.L. [Idiopatic macular holes: pathogenesis and treatment. Evolution of the question]. Patogenez i lechenie idiopaticheskih makuljarnyh razryvov. Jevoljucija voprosa. [Ophthalmosurgery]. Oftalmokhirurgiya. 2010; 3: 52‑55. (in Russ.).</mixed-citation><mixed-citation xml:lang="en">Lyskin P.V., Zakharov V.D., Lozinskaya O.L. [Idiopatic macular holes: pathogenesis and treatment. Evolution of the question]. Patogenez i lechenie idiopaticheskih makuljarnyh razryvov. Jevoljucija voprosa. [Ophthalmosurgery]. Oftalmokhirurgiya. 2010; 3: 52‑55. (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Oh H. Idiopathic macular hole. Dev Ophthalmol. 2014; 54: 150‑158.</mixed-citation><mixed-citation xml:lang="en">Oh H. Idiopathic macular hole. Dev Ophthalmol. 2014; 54: 150‑158.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Theodossiadis G., Petrou P., Eleftheriadou M. et al. Focal vitreomacular traction: a prospective study of the evolution to macular hole: the mathematical approach. Eye (Lond). 2014; 28 (12): 1452‑1460.</mixed-citation><mixed-citation xml:lang="en">Theodossiadis G., Petrou P., Eleftheriadou M. et al. Focal vitreomacular traction: a prospective study of the evolution to macular hole: the mathematical approach. Eye (Lond). 2014; 28 (12): 1452‑1460.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Gass J. Reappraisal of biomicroscopic classification of stages of development of a macular hole. Am J Ophthalmol. 1995; 119 (6): 752‑759.</mixed-citation><mixed-citation xml:lang="en">Gass J. Reappraisal of biomicroscopic classification of stages of development of a macular hole. Am J Ophthalmol. 1995; 119 (6): 752‑759.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Jančo L., Vida R., Bartoš M., Villémová K. Surgical treatment of the idiopatic macular hole — our experience. Cesk Slov Oftalmol. 2013; 69 (3): 102‑105.</mixed-citation><mixed-citation xml:lang="en">Jančo L., Vida R., Bartoš M., Villémová K. Surgical treatment of the idiopatic macular hole — our experience. Cesk Slov Oftalmol. 2013; 69 (3): 102‑105.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Spiteri Cornish K., Lois N., Scott N. Vitrectomy with internal limiting membrane peeling versus no peeling for idiopathic full-thickness macular hole. Ophthalmology. 2014; 121 (3): 649‑655.</mixed-citation><mixed-citation xml:lang="en">Spiteri Cornish K., Lois N., Scott N. Vitrectomy with internal limiting membrane peeling versus no peeling for idiopathic full-thickness macular hole. Ophthalmology. 2014; 121 (3): 649‑655.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Bikbov M.M., Altynbayev U.R., Gilmanshin T.R., Chernov M.S. [Intraoperative closure method choice for large idiopathic macular holes]. Vybor sposoba intraoperacionnogo zakrytija idiopaticheskogo makuljarnogo razryva bol’shogo diametra. [Ophthalmosurgery]. Oftalmokhirurgiya 2010; 1: 25‑28. (in Russ.).</mixed-citation><mixed-citation xml:lang="en">Bikbov M.M., Altynbayev U.R., Gilmanshin T.R., Chernov M.S. [Intraoperative closure method choice for large idiopathic macular holes]. Vybor sposoba intraoperacionnogo zakrytija idiopaticheskogo makuljarnogo razryva bol’shogo diametra. [Ophthalmosurgery]. Oftalmokhirurgiya 2010; 1: 25‑28. (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Kusuhara S., Negi A. Predicting visual outcome following surgery for idiopathic macular holes. Ophthalmologica. 2014; 231 (3): 125‑132.</mixed-citation><mixed-citation xml:lang="en">Kusuhara S., Negi A. Predicting visual outcome following surgery for idiopathic macular holes. Ophthalmologica. 2014; 231 (3): 125‑132.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Steel D., Dinah C., Habib M., White K. ILM peeling technique influences the degree of a dissociated optic nerve fibre layer appearance after macular hole surgery. Graefes Arch Clin Exp Ophthalmol. 2014; 16: [Epub ahead of print].</mixed-citation><mixed-citation xml:lang="en">Steel D., Dinah C., Habib M., White K. ILM peeling technique influences the degree of a dissociated optic nerve fibre layer appearance after macular hole surgery. Graefes Arch Clin Exp Ophthalmol. 2014; 16: [Epub ahead of print].</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Williams A. Relationship between macular hole size and the potential benefit of internal limiting membrane peeling. Br.J. Ophthalmol. 2006; 90: 1216‑1217.</mixed-citation><mixed-citation xml:lang="en">Williams A. Relationship between macular hole size and the potential benefit of internal limiting membrane peeling. Br.J. Ophthalmol. 2006; 90: 1216‑1217.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Kuriyama S., Hayashi H., Jingami Y. et al. Efficacy of inverted internal limiting membrane flap technique for the treatment of macular hole in high myopia. Am J Ophthalmol. 2013; 156 (1): 125‑131.</mixed-citation><mixed-citation xml:lang="en">Kuriyama S., Hayashi H., Jingami Y. et al. Efficacy of inverted internal limiting membrane flap technique for the treatment of macular hole in high myopia. Am J Ophthalmol. 2013; 156 (1): 125‑131.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Mahalingam P., Sambhav K. Surgical outcomes of inverted internal limiting membrane flap technique for large macular hole. Indian J Ophthalmol. 2013; 61 (10): 601‑603.</mixed-citation><mixed-citation xml:lang="en">Mahalingam P., Sambhav K. Surgical outcomes of inverted internal limiting membrane flap technique for large macular hole. Indian J Ophthalmol. 2013; 61 (10): 601‑603.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Michalewska Z., Michalewski J., Adelman R., Nawrocki J. Inverted internal limiting membrane flap technique for large macular holes. Ophthalmology. 2010; 117 (10): 2018‑2025.</mixed-citation><mixed-citation xml:lang="en">Michalewska Z., Michalewski J., Adelman R., Nawrocki J. Inverted internal limiting membrane flap technique for large macular holes. Ophthalmology. 2010; 117 (10): 2018‑2025.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Michalewska Z., Michalewski J., Dulczewska-Cichecka K., Nawrocki J. Inverted internal limiting membrane flap technique for surgical repair of myopic macular holes. Retina. 2014; 34 (4): 664‑669.</mixed-citation><mixed-citation xml:lang="en">Michalewska Z., Michalewski J., Dulczewska-Cichecka K., Nawrocki J. Inverted internal limiting membrane flap technique for surgical repair of myopic macular holes. Retina. 2014; 34 (4): 664‑669.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Shin M., Park K., Park S. Perfluoro-n-octane-assisted single-layered inverted internal limiting membrane flap technique for macular hole surgery. Retina. 2014; 34 (9): 1905‑1910.</mixed-citation><mixed-citation xml:lang="en">Shin M., Park K., Park S. Perfluoro-n-octane-assisted single-layered inverted internal limiting membrane flap technique for macular hole surgery. Retina. 2014; 34 (9): 1905‑1910.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
