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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2025-4-901-907</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-2820</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL STUDIES</subject></subj-group></article-categories><title-group><article-title>Особенности оптической когерентной томографии области диска зрительного нерва у пациентов с миопией высокой степени</article-title><trans-title-group xml:lang="en"><trans-title>Features of Optical Coherence Tomography of the Optic Nerve Head in Patients with High Myopia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0516-0068</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Макаревич</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Makarevich</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Макаревич Екатерина Сергеевна – аспирант.</p><p>Пр-т Острякова, 2, Владивосток, 690002; ул. Борисенко, 100е, Владивосток, 690088</p></bio><bio xml:lang="en"><p>Makarevich Ekaterina S. – postgraduate.</p><p>Ostryakova ave., 2, Vladivostok, 690002; Borisenko str., 100e, Vladivostok, 690088</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2440-6059</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Федяшев</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Fedyashev</surname><given-names>G. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Федяшев Глеб Арнольдович - доктор медицинских наук, заведующий кафедрой офтальмологии и оториноларингологии.</p><p>Пр-т Острякова, 2, Владивосток, 690002; ул. Борисенко, 100е, Владивосток, 690088</p></bio><bio xml:lang="en"><p>Fedyashev Gleb A. - MD, head of the Ophthalmology and Otorhinolaryngology Department.</p><p>Ostryakova ave., 2, Vladivostok, 690002; Borisenko str., 100e, Vladivostok, 690088</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8966-3120</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ручкин</surname><given-names>М. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Ruchkin</surname><given-names>M. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ручкин Михаил Петрович - кандидат медицинских наук, ассистент кафедры офтальмологии и оториноларингологии.</p><p>Пр-т Острякова, 2, Владивосток, 690002; ул. Борисенко, 100е, Владивосток, 690088</p></bio><bio xml:lang="en"><p>Ruchkin Micheal P. - PhD, assistant of the Ophthalmology and Otorhinolaryngology Department.</p><p>Ostryakova ave., 2, Vladivostok, 690002; Borisenko str., 100e, Vladivostok, 690088</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Тихоокеанский государственный медицинский университет» Министерства здравоохранения Российской Федерации; ООО «Приморский центр микрохирургии глаза»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pacific State Medical University; Primorskii center of eye microsurgery</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>28</day><month>12</month><year>2025</year></pub-date><volume>22</volume><issue>4</issue><fpage>901</fpage><lpage>907</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Макаревич Е.С., Федяшев Г.А., Ручкин М.П., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Макаревич Е.С., Федяшев Г.А., Ручкин М.П.</copyright-holder><copyright-holder xml:lang="en">Makarevich E.S., Fedyashev G.A., Ruchkin M.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/2820">https://www.ophthalmojournal.com/opht/article/view/2820</self-uri><abstract><sec><title>Цель</title><p>Цель: определить различия структурных показателей диска зрительного нерва (ДЗН) и перипапиллярной области у пациентов с осевой миопией высокой степени в сравнении с пациентами без аномалий рефракции.</p></sec><sec><title>Пациенты и методы</title><p>Пациенты и методы. В первую группу вошли пациенты, имеющие эквивалент рефракционной ошибки ≥ -6,00 дптр и длину глаза ≥ 26,00 мм (74 глаза). Вторую группу составили пациенты с рефракцией -0,50 — +1,25 дптр и длиной глаза 22,50–24,20 мм (32 глаза). Проводили измерение аксиальной длины глаза (IOLMaster 700, Zeiss, Германия), оптическую когерентную томографию (ОКТ) области ДЗН (SOLIX, Optovue, США) с использованием программного модуля AngioAnalytics. Для статистического анализа результатов применяли непараметрический критерий Манна — Уитни, коэффициент ранговой корреляции по Спирмену.</p></sec><sec><title>Результаты</title><p>Результаты. В первой группе значения отношения Э/Д по вертикали (VCDR) были меньше (0,38 (0,14–0,51), p &lt; 0,05), отмечалось снижение средней толщины слоя нервных волокон сетчатки (RNFL) (86,00 (80,00–94,00), p &lt; 0,01), а также толщины RNFL, измеряемой по отдельным секторам (p &lt; 0,01), при сравнении с показателями второй группы. Толщина RNFL в височном квадранте, в нижнем секторе височного квадранта (TI), наоборот, была больше (71,00 (58,05–87,25), p &lt; 0,01). Все значения относительной плотности капилляров (RPC VD) значимо не различались между группами (p &gt; 0,05). Наибольшая RPC VD отмечена в верхнем секторе височного квадранта (TS) (56,65 (51,72–59,47)). Плотность всех сосудов (VD) была достоверно ниже у пациентов с миопией высокой степени, кроме зон, соответствующих височному квадранту, и зоны ДЗН (ID) (p &gt; 0,05).</p></sec><sec><title>Заключение</title><p>Заключение. Между группами были выявлены достоверные различия VCDR, толщины RNFL и VD по всем исследуемым зонам, кроме височного квадранта. Снижение толщины RNFL в височном квадранте, TI, а также снижение толщины RPC VD в зоне ID и височном квадранте, TS, могут являться наиболее показательными параметрами для диагностики патологии зрительного нерва у пациентов с миопией высокой степени, не связанной с увеличением длины глазного яблока.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Purpose</title><p>Purpose: to evaluate the differences in the structural parameters of the optic nerve head (ONH) and peripapillary region in patients with high myopia in comparison with patients without refractive errors.</p></sec><sec><title>Patients and methods</title><p>Patients and methods. The first group included patients with an equivalent refractive error ≥ -6.00 diopters and an eye length ≥ 26.00 mm (74 eyes). The second group consisted of patients with a refraction of -0.5 diopters — +1,25 diopters and an eye length of 22,50–24,20 mm (32 eyes). Axial length measurements were carried out using an IOLMaster 700 (Zeiss, Germany). Optical coherence tomography (OCT) of the ONH was performed with SOLIX (Optovue, USA) using the AngioAnalytics software. For statistical analysis of the results, the nonparametric Mann-Whitney’s test and Spearman’s rank correlation coefficient were used. Results. In the first group, the cup-to-disc vertical ratio (VCDR) values were lower (0.38 (0.14–0.51), p &lt; 0.05), and there was a decrease in the average thickness of the retinal nerve fiber layer (RNFL) (86.00 (80.00–94.00), p &lt; 0.01), as well as RNFL thickness measured in individual sectors (p &lt; 0.01), compared with the second group. The thickness of the RNFL in the temporal quadrant, in the inferior sector of the temporal quadrant (TI), on the contrary, was greater (71.00 (58.05–87.25), p &lt; 0.01). All radial peripapillary capillary vessel density (RPC VD) values were not significantly different between groups (p &gt; 0.05). The highest RPC VD is in the upper sector of the temporal quadrant (TS) (56.65 (51.72–59.47)). The density of all vessels (VD) was significantly lower in patients with high myopia, except for the zones corresponding to the temporal quadrant and the inside disc zone (ID) (p &gt; 0.05).</p></sec><sec><title>Conclusion</title><p>Conclusion. Significant differences were revealed between the groups in VCDR, RNFL thickness and VD in all areas, except the temporal quadrant. A decrease in the thickness of the RNFL in the temporal quadrant, TI, as well as a decrease in the thickness of the RPC VD in the ID zone and the temporal quadrant, TS, can be the most indicative parameters for diagnosing optic nerve pathology in patients with high myopia, not associated with axial elongation of the eyeball.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>миопия высокой степени</kwd><kwd>глаукома</kwd><kwd>оптическая когерентная томография</kwd><kwd>радиальные перипапиллярные капилляры</kwd></kwd-group><kwd-group xml:lang="en"><kwd>high myopia</kwd><kwd>glaucoma</kwd><kwd>optical coherence tomography</kwd><kwd>radial peripapillary capillaries</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">работа выполнена в рамках научной темы рег. № НИОКТР 123100300082-8</funding-statement><funding-statement xml:lang="en">the work was carried out within the framework of the scientific topic reg. № НИОКТР 123100300082-8</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ohno-Matsui K, Kawasaki R, Jonas JB, Cheung CM, Saw SM, Verhoeven VJ, Klaver CC, Moriyama M, Shinohara K, Kawasaki Y, Yamazaki M, Meuer S, Ishibashi T, Yasuda M, Yamashita H, Sugano A, Wang JJ, Mitchell P, Wong TY. 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