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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2026-1-129-139</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-2884</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL STUDIES</subject></subj-group></article-categories><title-group><article-title>Пупиллометрия при заболеваниях сетчатки и зрительного нерва</article-title><trans-title-group xml:lang="en"><trans-title>Pupillometry in Diseases of the Retina and Optic Nerve</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9833-6236</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фролов</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Frolov</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Фролов Михаил Александрович – доктор медицинских наук, профессор, заведующий кафедрой глазных болезней; директор Офтальмологического центра Клинико‑диагностического центра </p><p>ул. Миклухо-Маклая, 6, Москва, 117198; ул. Миклухо-Маклая, 10, Москва,117198</p></bio><bio xml:lang="en"><p>Frolov Michael A., MD, Professor, head of the Eye Diseases Department; director of the Ophthalmology Center</p><p>Miklukho-Maklaya str., 6, Moscow, 117198; Miklukho-Maklaya str., 10, Moscow,117198</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2707-8417</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Воробьева</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vorobyova</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Воробьева Ирина Витальевна – доктор медицинских наук, профессор кафедры глазных болезней; врач‑офтальмолог Офтальмологического центра Клинико‑диагностического центра </p><p>ул. Миклухо-Маклая, 6, Москва, 117198; ул. Миклухо-Маклая, 10, Москва,117198</p></bio><bio xml:lang="en"><p>Vorobyeva Irina V., MD, Professor, Professor of the Eye Diseases Department; ophthalmologist of the Ophthalmology Center </p><p>Miklukho-Maklaya str., 6, Moscow, 117198; Miklukho-Maklaya str., 10, Moscow,117198</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0988-1361</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фролов</surname><given-names>A. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Frolov</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Фролов Александр Михайлович – кандидат медицинских наук, доцент кафедры глазных болезней; врач‑офтальмолог Офтальмологического центра Клинико‑диагностического центра </p><p>ул. Миклухо-Маклая, 6, Москва, 117198; ул. Миклухо-Маклая, 10, Москва,117198</p></bio><bio xml:lang="en"><p>Frolov Alexandr M., PhD, Associate Professor of the Eye Diseases Department; ophthalmologist of the Ophthalmology Center </p><p>Miklukho-Maklaya str., 6, Moscow, 117198; Miklukho-Maklaya str., 10, Moscow,117198</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3956-6362</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Супонева</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Suponeva</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Супонева Наталья Александровна – доктор медицинских наук, профессор, член‑корреспондент РАН, директор</p><p>Волоколамское шоссе, 80, Москва, 125367</p></bio><bio xml:lang="en"><p>Suponeva Natalia A., MD, Professor, Corresponding Member of RAS, head of Institute</p><p>Volokolamsk highway, 80, Moscow, 125367</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-6567-8779</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Семина</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Semina</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Семина Дарья Андреевна – ассистент кафедры глазных болезней; врач‑офтальмолог Офтальмологического центра Клинико‑диагностического центра </p><p>ул. Миклухо-Маклая, 6, Москва, 117198; ул. Миклухо-Маклая, 10, Москва,117198</p></bio><bio xml:lang="en"><p>Semina Daria A., assistant of the Eye Diseases Department; ophthalmologist of the Ophthalmology Center </p><p>Miklukho-Maklaya str., 6, Moscow, 117198; Miklukho-Maklaya str., 10, Moscow,117198</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-0574-9068</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Якубовский</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Yakubovsky</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Якубовский Леонид Владимирович – ординатор 2‑го года кафедры глазных болезней </p><p>ул. Миклухо-Маклая, 6, Москва, 117198</p></bio><bio xml:lang="en"><p>Yakubovskiy Leonid V., second‑year medical resident of the Eye Diseases Department </p><p>Miklukho-Maklaya str., 6, Moscow, 117198</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-4659-8988</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сабих</surname><given-names>Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Sabih</surname><given-names>E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сабих Эван – ординатор 2‑го года кафедры глазных болезней </p><p>ул. Миклухо-Маклая, 6, Москва, 117198</p></bio><bio xml:lang="en"><p>Sabih Evan, second‑year medical resident of the Eye Diseases Department </p><p>Miklukho-Maklaya str., 6, Moscow, 117198</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-7543-1185</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маала</surname><given-names>К. Х.К.</given-names></name><name name-style="western" xml:lang="en"><surname>Maala</surname><given-names>K. H.K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Маала Каррар Хайдер Карим – ординатор 1‑го года кафедры глазных болезней </p><p>ул. Миклухо-Маклая, 6, Москва, 117198</p></bio><bio xml:lang="en"><p>Maala Karrar H.K., first‑year medical resident of the Eye Diseases Department </p><p>Miklukho-Maklaya str., 6, Moscow, 117198</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-3678-2588</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Григорян</surname><given-names>Г. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Grigoryan</surname><given-names>G. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Григорян Григорий Левонович – научный сотрудник </p><p>Ленинские горы, 1, Москва, 119234</p></bio><bio xml:lang="en"><p>Grigoryan Grigorii L., research fellow</p><p>Leninskie Gory, 1, Moscow, 119234</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-6162-2665</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бокарев</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bokarev</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бокарев Сергей Александрович – офтальмолог</p><p>Зеленый проспект, 66/2, Москва, 111396</p></bio><bio xml:lang="en"><p>Bokarev Sergey A., ophthalmologist</p><p>Green ave., 66/2, Moscow, 111396</p></bio><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Российский университет дружбы народов имени Патриса Лумумбы; &#13;
Клинико-диагностический центр ФГАОУ ВО «Российский университет дружбы народов имени Патриса Лумумбы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>RUDN University; &#13;
Clinical and diagnostic center of the RUDN University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБНУ «Российский центр неврологии и нейронаук</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Сenter of Neurology and Neurosciences</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГАОУ ВО «Российский университет дружбы народов имени Патриса Лумумбы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>RUDN University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБОУ ВО «Московский государственный университет имени М.В. Ломоносова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Lomonosov Moscow State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>Клиника «Мать и дитя»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Mother and Child Clinic</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>29</day><month>03</month><year>2026</year></pub-date><volume>23</volume><issue>1</issue><fpage>129</fpage><lpage>139</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Фролов М.А., Воробьева И.В., Фролов A.М., Супонева Н.А., Семина Д.А., Якубовский Л.В., Сабих Э., Маала К.Х., Григорян Г.Л., Бокарев С.А., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Фролов М.А., Воробьева И.В., Фролов A.М., Супонева Н.А., Семина Д.А., Якубовский Л.В., Сабих Э., Маала К.Х., Григорян Г.Л., Бокарев С.А.</copyright-holder><copyright-holder xml:lang="en">Frolov M.A., Vorobyova I.V., Frolov A.M., Suponeva N.A., Semina D.A., Yakubovsky L.V., Sabih E., Maala K.H., Grigoryan G.L., Bokarev S.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/2884">https://www.ophthalmojournal.com/opht/article/view/2884</self-uri><abstract><p>Изменение параметров зрачкового рефлекса зависит от состояния зрительного анализатора и нервной системы. Пупиллометрия является точным и простым в применении методом диагностики зрачкового рефлекса, с помощью которого можно выявить патологию на доклиническом уровне. Анализ литературных источников показал, что ученые по всему миру интересуются изменениями зрачковых параметров у пациентов с различной офтальмологической патологией: пигментным ретинитом, диабетической ретинопатией, возрастной макулярной дегенерацией, глаукомой, окклюзией центральной вены сетчатки, невритом зрительного нерва, ишемической оптической нейропатией. Установлено, что при поражении ганглиозного комплекса, нервных волокон сетчатки, а также головки зрительного нерва при различных офтальмологических заболеваниях происходит дисфункция зрачковой реакции. Степень выраженности изменений параметров пупиллометрии сопоставима с тяжестью поражения сетчатки и зрительного нерва, что подтверждается протоколами оптической когерентной томографии. Исследователи учитывали также и то, что палочки, колбочки и ганглиозные клетки имеют разные пороги активации и различаются по свойствам реакции, поэтому для оценки их функции предложили использовать стимулы разного цвета и разной интенсивности, что способствовало появлению такого способа диагностики, как хроматическая пупиллометрия. Цветовые стимулы также использовались для изучения реакции зрачков при заболеваниях зрительного нерва. Была отмечена разница в параметрах зрачкового рефлекса при воздействии стимулов красного и синего цвета. Изучение возможности применения пупиллометрии как эффективного скринингового метода в диагностике офтальмологических заболеваний относится к перспективному научному направлению.</p></abstract><trans-abstract xml:lang="en"><p>Changes in pupillary reflex parameters depend on the state of the visual analyzer and nervous system. Pupillometry is an accurate and</p><p>easy-to-use method for diagnosing pupillary reflex, which can detect pathology at the preclinical level. An analysis of literary sources showed that scientists around the world are interested in changes in pupil parameters in patients with various ophthalmological pathologies: pigment retinitis, diabetic retinopathy, age-related macular degeneration, glaucoma, central retinal vein occlusion, optic neuritis, and ischemic optic neuropathy. Determined that when the ganglion complex and nerve fibers of the retina and the optic nerve head are affected, pupillary reaction dysfunction occurs in various ophthalmological diseases. The severity of changes in pupillometry parameters is comparable to the severity of damage to the retina and optic nerve, which is confirmed by optical coherence tomography protocols. Scientists also took into account the fact that rods, cones, and ganglion cells have different activation thresholds and differ in reaction properties, so to assess their function, they proposed using stimuli of different colors and different intensities, which contributed to the emergence of such a diagnostic method as chromatic pupillometry. Color stimuli were also used to study pupillary response in optic nerve diseases; scientists noted differences in pupillary reflex parameters when exposed to red or blue stimuli. Studying the possibility of using pupillometry as an effective screening method in diagnosing ophthalmological diseases is a promising scientific direction.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>пупиллометрия</kwd><kwd>глаукомная оптическая нейропатия</kwd><kwd>диабетическая ретинопатия</kwd><kwd>неврит зрительного нерва</kwd><kwd>ишемическая оптическая нейропатия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pupillometry</kwd><kwd>glaucoma optic neuropathy</kwd><kwd>diabetic retinopathy</kwd><kwd>neuritis optic nervus</kwd><kwd>ischemic optic neuropathy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Gibertoni G, Hromov A, Piffaretti F, Geiser MH. Development of an Innovative Pupillometer Able to Selectively Stimulate the Eye’s Fundus Photoreceptor Cells. 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