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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2013-1-4-7</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-44</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Общие вопросы</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>General Issues</subject></subj-group></article-categories><title-group><article-title>Автоматизированный дистанционный скрининг заболеваний глазного дна</article-title><trans-title-group xml:lang="en"><trans-title>Automated screening for retinopathy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Родин</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Rodin</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра офтальмологии факультета фундаментальной медицины</p><p>www.elitvision.ru</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Акопян</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Akopyan</surname><given-names>V. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра офтальмологии факультета фундаментальной медицины</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Семенова</surname><given-names>Н. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Semenova</surname><given-names>N. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра офтальмологии факультета фундаментальной медицины</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крылов</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Krylov</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лаборатория математических методов обработки изображений</p><p>Факультет высшей математики и кибернетики</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>МГУ им. М. В. Ломоносова</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>10</day><month>07</month><year>2014</year></pub-date><volume>10</volume><issue>1</issue><fpage>4</fpage><lpage>7</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Родин А.С., Акопян В.С., Семенова Н.С., Крылов А.С., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Родин А.С., Акопян В.С., Семенова Н.С., Крылов А.С.</copyright-holder><copyright-holder xml:lang="en">Rodin A.S., Akopyan V.S., Semenova N.S., Krylov A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/44">https://www.ophthalmojournal.com/opht/article/view/44</self-uri><abstract><sec><title>Цель</title><p>Цель. Подтверждение возможностей удаленной оценки снимков сетчатки с помощью автоматизированной компьютерной программы и оценка показателей ее клинической информативности (чувствительность, специфичность) при выявлении разнородной патологии сетчатки.</p></sec><sec><title>Методы</title><p>Методы. Разработанная программа автоматизированного распознавания снимков сетчатки была установлена на удаленный компьютер, находящийся на расстояние более чем 7400 километров. С помощью установленной программы проводилось распознавание признаков патологических процессов на 70 фотоизображениях сетчатки.</p></sec><sec><title>Результаты</title><p>Результаты. Исследование продемонстрировало возможности дистанционного скрининга ретинопатии с использованием дистанционных телемедицинских систем. Клиническая нформативность дистанционного скрининга с использованием разработанной компьютерной программы может быть выражена показателями чувствительности и специфичности, достигающими 73 % и 72 %, соответственно.</p></sec><sec><title>Заключение</title><p>Заключение. Разработанный программный модуль позволяет за короткий период времени провести обработку большого количества изображений глазного дна, полученных при скрининговой диагностике. При этом с высокой точностью могут быть выявлены признаки наиболее распространенных и социально значимых заболеваний сетчатки глаза, таких как диабетическая ретинопатия, возрастная макулярная дегенерация и хориоретиниты.</p></sec></abstract><trans-abstract xml:lang="en"><p>Retinal pathology is a common cause of an irreversible decrease of central vision commonly found amongst senior population. Detection of the earliest signs of retinal diseases can be facilitated by viewing retinal images available from the telemedicine networks. To facilitate the process of retinal images, screening software applications based on image recognition technology are currently on the various stages of development.</p><sec><title>Purpose</title><p>Purpose: To develop and implement computerized image recognition software that can be used as a decision support technologyfor retinal image screening for various types of retinopathies.</p></sec><sec><title>Methods</title><p>Methods: The software application for the retina image recognition has been developed using C++ language. It was tested on dataset of 70 images with various types of pathological features (age related macular degeneration, chorioretinitis, central serous chorioretinopathy and diabetic retinopathy).</p></sec><sec><title>Results</title><p>Results: It was shown that the system can achieve a sensitivity of 73 % and specificity of 72 %.</p></sec><sec><title>Conclusion</title><p>Conclusion: Automated detection of macular lesions using proposed software can significantly reduce manual grading workflow. In addition, automated detection of retinal lesions can be implemented as a clinical decision support system for telemedicine screening. It is anticipated that further development of this technology can become a part of diagnostic image analysis system for the electronic health records.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>заболевания сетчатки</kwd><kwd>скрининговая диагностика</kwd><kwd>дистанционные телемедицинские системы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>retinal pathology</kwd><kwd>diagnostics</kwd><kwd>telemedicine screening</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Whited J. D., Datta S. K., Aiello L. M. A modeled economic analysis of a digital tele-ophthalmology system as used by three federal health care agencies for detecting proliferative diabetic retinopathy // Telemed J E Health. 2005. V. 1.P. 641‑651.</mixed-citation><mixed-citation xml:lang="en">Whited J. D., Datta S. K., Aiello L. M. A modeled economic analysis of a digital tele-ophthalmology system as used by three federal health care agencies for detecting proliferative diabetic retinopathy // Telemed J E Health. 2005. V. 1.P. 641‑651.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Dua S., Acharya R. Computational analysis of the human eye with applications 2011, World Scientific, Singapore.</mixed-citation><mixed-citation xml:lang="en">Dua S., Acharya R. Computational analysis of the human eye with applications 2011, World Scientific, Singapore.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Антонов Е. А., Акопян В. С., Родин А. С. и др. Методы автоматизированной обработки изображений сетчатки в телемедицинском скрининге диабетической ретинопатии. Обзор литературы // Офтальмология. 2011. Т. 8, № 3. С.4‑8.</mixed-citation><mixed-citation xml:lang="en">Антонов Е. А., Акопян В. С., Родин А. С. и др. Методы автоматизированной обработки изображений сетчатки в телемедицинском скрининге диабетической ретинопатии. Обзор литературы // Офтальмология. 2011. Т. 8, № 3. С.4‑8.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Chernomorets A. A., Krylov A. S., Nasonov A. V., et al. Automated processing of retinal images // In: 21‑th International Conf. Computer Graphics GraphiCon’2011. Moscow, Russia, 2011. P. 78−81.</mixed-citation><mixed-citation xml:lang="en">Chernomorets A. A., Krylov A. S., Nasonov A. V., et al. Automated processing of retinal images // In: 21‑th International Conf. Computer Graphics GraphiCon’2011. Moscow, Russia, 2011. P. 78−81.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">National Institute of Diabetes and Digestive and Kidney Diseases. National Diabetes Statistics. http://diabetes.niddk.nih.gov / dm / pubs / statistics / index. htm#12. (Дата обращения 11.07.2012).</mixed-citation><mixed-citation xml:lang="en">National Institute of Diabetes and Digestive and Kidney Diseases. National Diabetes Statistics. http://diabetes.niddk.nih.gov / dm / pubs / statistics / index. htm#12. (Дата обращения 11.07.2012).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Cavallerano A. A., Cavallerano J. D., Katalinic P. Use of Joslin Vision Network digitalvideo nonmydriatic retinal imaging to assess diabetic retinopathy in a clinical programme // Retina. 2003. V. 23. P. 215‑223.</mixed-citation><mixed-citation xml:lang="en">Cavallerano A. A., Cavallerano J. D., Katalinic P. Use of Joslin Vision Network digitalvideo nonmydriatic retinal imaging to assess diabetic retinopathy in a clinical programme // Retina. 2003. V. 23. P. 215‑223.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Lin D. Y., Blumenkranz M. S., Brothers R. J. The sensitivity and specificity of singlefield nonmydriatic monochromatic digital fundus photography with remote interpretation for diabetic retinopathy screening: a comparison with ophthalmoscopy and standardized mydriatic color photography // Am J Ophthalmol. 2002. V. 134. P. 204‑213.</mixed-citation><mixed-citation xml:lang="en">Lin D. Y., Blumenkranz M. S., Brothers R. J. The sensitivity and specificity of singlefield nonmydriatic monochromatic digital fundus photography with remote interpretation for diabetic retinopathy screening: a comparison with ophthalmoscopy and standardized mydriatic color photography // Am J Ophthalmol. 2002. V. 134. P. 204‑213.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Zimmer-Galler I. E., Zeimer R. Feasibility of screening for high-risk age-related macular degeneration with an Internet-based automated fundus camera // Ophthalmic Surg Lasers Imaging. 2005. V. 36. P. 228‑236.</mixed-citation><mixed-citation xml:lang="en">Zimmer-Galler I. E., Zeimer R. Feasibility of screening for high-risk age-related macular degeneration with an Internet-based automated fundus camera // Ophthalmic Surg Lasers Imaging. 2005. V. 36. P. 228‑236.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Mason J. National screening for diabetic retinopathy: Clear vision needed // Diabet. Med. 2003. V. 20. P. 959‑961.</mixed-citation><mixed-citation xml:lang="en">Mason J. National screening for diabetic retinopathy: Clear vision needed // Diabet. Med. 2003. V. 20. P. 959‑961.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
