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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2018-4-424-432</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-768</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ И ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL &amp; EXPERIMENTAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Изменение гомеостаза слезопродуцирующей системы на фоне применения косметологических процедур в периорбитальной области</article-title><trans-title-group xml:lang="en"><trans-title>Homeostasis Changes of Tear-Producing System with the Background of Cosmetic Procedures in Periorbital Area</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трубилин</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Trubilin</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p> доктор медицинских наук, профессор, заведующий кафедры офтальмологии</p><p>ул. Гамалеи, 15, Москва, 123098, Российская Федерация</p></bio><bio xml:lang="en"><p>МD, рrofessor, Head of the of Ophthalmology DepartmentGamalei str., 15, Moscow, 123098, Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8551-0661</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Полунина</surname><given-names>Е. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Poluninа</surname><given-names>E. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор кафедры офтальмологииул. Гамалеи, 15, Москва, 123098, Российская Федерация</p></bio><bio xml:lang="en"><p>MD, professorGamalei str., 15, Moscow, 123098, Russia</p></bio><email xlink:type="simple">lpolunina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Анджелова</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Andzhelova</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p> доктор медицинских наук, старший научный сотрудник</p><p>ул. Россолимо, 11а, б, Москва, 119021, Российская Федерация</p></bio><bio xml:lang="en"><p>MD, Senior Research OfficerRossolimo str., 11A, B, Moscow, 119021, Russia</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куренков</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kurenkov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p> доктор медицинских наук, профессор, руководитель Клиники</p><p>Рублевское шоссе, 48/1, Москва, 121609, Российская Федерация</p></bio><bio xml:lang="en"><p>МD, professor, Chief of Clinic Dr. KurenkovRublevskoe highway, 48, Moscow, 121609, Russia</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Капкова</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kapkova</surname><given-names>S. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, доцент кафедры офтальмологииул. Гамалеи, 15, Москва, 123098, Российская Федерация</p></bio><bio xml:lang="en"><p>PhD, assistant professor of the Department of OphthalmologyGamalei str., 15, Moscow, 123098, Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чиненова</surname><given-names>К. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Chinenova</surname><given-names>K. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-офтальмолог</p><p>Рублевское шоссе, 48/1, Москва, 121609, Российская Федерация</p></bio><bio xml:lang="en"><p>ophthalmologistRublevskoe highway, 48, Moscow, 121609, Russia</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБОУ ДПО «Институт повышения квалификации Федерального медико-биологического агентства»<country>Россия</country></aff><aff xml:lang="en">Federal Institute of the Professional Development of the Federal Medical and Biological Agency of Russia<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГБНУ «Научно-исследовательский институт глазных болезней»<country>Россия</country></aff><aff xml:lang="en">Research Institute of Eye Diseases<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Офтальмологическая клиника доктора Куренкова<country>Россия</country></aff><aff xml:lang="en">Ophthalmology Clinic of Dr. Kurenkov<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>08</day><month>01</month><year>2019</year></pub-date><volume>15</volume><issue>4</issue><fpage>424</fpage><lpage>432</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Трубилин В.Н., Полунина Е.Г., Анджелова Д.В., Куренков В.В., Капкова С.Г., Чиненова К.В., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Трубилин В.Н., Полунина Е.Г., Анджелова Д.В., Куренков В.В., Капкова С.Г., Чиненова К.В.</copyright-holder><copyright-holder xml:lang="en">Trubilin V.N., Poluninа E.G., Andzhelova D.V., Kurenkov V.V., Kapkova S.G., Chinenova K.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/768">https://www.ophthalmojournal.com/opht/article/view/768</self-uri><abstract><p>Современная офтальмологическая практика неразрывно связана с косметологией и эстетической медициной. С каждым годом возрастает число пациентов, особенно женского пола, прибегающих к различным видам косметологического воздействия (инъекции ботулотоксина, наращивание ресниц, татуаж век, инъекции дермальных филлеров и др.) в области лица, в частности, в периорбитальной зоне. Цель работы — провести комплексную оценку клинико-функциональных показателей, характеризующих состояние глазной поверхности и слезопродуцирующей системы при применении косметологических процедур в периорбитальной области (инъекции ботокса, татуаж век, наращивание ресниц). Пациенты и методы. В исследование вошли 106 женщин (212 глаз). Критерии исключения: ранний послеоперационный период после офтальмохирургического вмешательства, острые воспалительные заболевания переднего и заднего отрезка глаза, глаукома, наличие интраокулярных патологических изменений (гемофтальм, отслойка оболочек глаза, новообразования). Средний возраст пациентов, вошедших в исследование, составил 36,37 ± 9,0 года. Результаты и обсуждение. Результаты сравнительной оценки двух групп пациентов — группы с применением косметологических процедур в анамнезе (татуаж век, ботулотоксин, дермальные филлеры, наращивание ресниц) в периорбитальной зоне и группы пациентов, которые подобные процедуры не применяли, показали, что косметологические процедуры влияют на клинико-функциональное состояние глазной поверхности и морфофункциональное состояние мейбомиевых желез. Так, частота выявления симптомокомплекса синдрома сухого глаза на 36 % чаще была определена в группе пациентов с применением косметологических процедур. Показано, что сочетанное воздействие косметологических процедур (татуаж век, наращивание ресниц, инъекции дермальных филлеров и ботулотоксина в периорбитальной области) отягощает течение и прогноз синдрома ССГ и дисфункции мейбомиевых желез. Была выявлена прямая корреляционная связь между степенью выраженности жалоб, характерных для ССГ, и количеством процедур (r = 0,4982, p = 0,0000); частотой выявления жалоб на сухость и дискомфорт и количеством процедур (r = 0,6427, p = 0,0000); показателями компрессионной пробы и количеством процедур (r = –0,4712, p = 0,0000); частотой возникновения воспалительных реакций на глазной поверхности и количеством процедур (r = 0,3778, p = 0,0001). Риск развития нарушения слезопродукции — синдрома сухого глаза и дисфункции мейбомиевых желез — выше у пациентов с применением инъекций ботулотоксина и наращиванием ресниц по сравнению с пациентами, использующими татуаж век и инъекции филлеров на основе гиалуроновой кислоты в периорбитальной зоне. </p></abstract><trans-abstract xml:lang="en"><p>Modern ophthalmological practice is inseverable linked with cosmetology and esthetic medicine. Every year, the number of patients, especially women, who received various types of cosmetology procedures (botulinum toxin injections, eyelash extensions, eyelid tattooing, dermal fillers injections, etc.) in facial area increases, in particular in the periorbital zone. Purpose: to conduct a comprehensive assessment of clinical and functional parameters characterizing the state of the ocular surface and the tear-producing system in case applying cosmetic procedures in the periorbital area (Botox injections, eyelid tattooing, eyelash extension). Patients and methods. The study included 106 women (212 eyes). Exclusion criteria: early postoperative period after ophthalmosurgical intervention, acute inflammatory diseases of anterior and posterior eye segment, glaucoma, the presence of intraocular pathological changes (hemophthalmia, detachment of the eye membranes, tumors). The average age of the patients included in the study was 36.37 ± 9.0 years. Results and discussion. The results of a comparative evaluation of two groups of patients — a group with a history of cosmetic procedures (tattooing the eyelids, botulinum toxin, dermal fillers, eyelash extensions) in the periorbital zone and patients who did not use such procedures, has showed that cosmetic procedures affect on the clinical and functional eye surfaces state and on morphofunctional state of meibomian glands. Thus, the frequency of detection of symptomocomplex of dry eye syndrome was on 36 % more often determined in the group of patients received cosmetic procedures. It has been shown that the combined effect of cosmetological procedures (tattooing the eyelids, eyelash extensions, injections of dermal fillers and botulinum toxin in the periorbital region) aggravates the course and prognosis of Dry Eye Syndrome and meibomian glands dysfunction. A direct correlation between the severity of complaints characteristic of Dry Eye Syndrome and the number of procedures was found (r = 0.4982, p = 0.0000); the frequency of detecting complaints of dryness and discomfort and the number of procedures (r = 0.6427, p = 0.0000); compression test indices and the number of procedures (r = –0.4712, p = 0.0000); the frequency of occurrence of inflammatory reactions of ocular surface and the number of procedures (r = 0.3778, p = 0.0001). The risk of tear production disturbance — dry eye syndrome and dysfunction of the meibomian glands is higher in patients using botulinum toxin injections and eyelash extension in comparison with patients using eyelid tattooing and injections of fillers with hyaluronic acid in the periorbital zone. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>офтальмология</kwd><kwd>синдром сухого глаза</kwd><kwd>косметология</kwd><kwd>ботулотоксин</kwd><kwd>дермальные филлеры</kwd><kwd>татуаж век</kwd><kwd>наращивание ресниц</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ophthalmology</kwd><kwd>dry eye syndrome</kwd><kwd>cosmetology</kwd><kwd>botulinum toxin</kwd><kwd>dermal fillers</kwd><kwd>eye tattoing</kwd><kwd>eyelash extensions</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Gomes J.A.P., Azar D.T., Baudouin C., Efron N., Hirayama M., Horwath-Winter J., Kim T., Mehta J.S., Messmer E.M., Pepose J.S., Sangwan V.S., Weiner A.L., Wilson S.E., Wolffsohn J.S. TFOS DEWS II iatrogenic report. Ocul Surf. 2017 Jul;15(3):511–538. DOI: 10.1016/j.jtos.2017.05.004. Epub 201</mixed-citation><mixed-citation xml:lang="en">Gomes J.A.P., Azar D.T., Baudouin C., Efron N., Hirayama M., Horwath-Winter J., Kim T., Mehta J.S., Messmer E.M., Pepose J.S., Sangwan V.S., Weiner A.L., Wilson S.E., Wolffsohn J.S. TFOS DEWS II iatrogenic report. Ocul Surf. 2017 Jul;15(3):511–538. DOI: 10.1016/j.jtos.2017.05.004. Epub 201</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Kojima T., Dogru M., Matsumoto Y., Goto E., Tsubota K. Tear film and ocular surface abnormalities after eyelid tattooing. Ophthal Plast Reconstr Surg. 2005 Jan;21(1):69–71.</mixed-citation><mixed-citation xml:lang="en">Kojima T., Dogru M., Matsumoto Y., Goto E., Tsubota K. Tear film and ocular surface abnormalities after eyelid tattooing. Ophthal Plast Reconstr Surg. 2005 Jan;21(1):69–71.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Trubilin V.N., Poluninа E.G., Andzhelova D.V., Kurenkov V.V., Kapkova S.G., Chinenova K.V. Effect of cosmetic procedures in the periorbital area on the organ of vision. Overview. Ophthalmology in Russia. 2018;15(3):233–241. DOI: 10.18008/1816-5095-2018-3-233-241</mixed-citation><mixed-citation xml:lang="en">Trubilin V.N., Poluninа E.G., Andzhelova D.V., Kurenkov V.V., Kapkova S.G., Chinenova K.V. Effect of cosmetic procedures in the periorbital area on the organ of vision. Overview. Ophthalmology in Russia. 2018;15(3):233–241. DOI: 10.18008/1816-5095-2018-3-233-241</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Amano Y., Nishiwaki Y. National survey on eyelash extensions and their related health problems. Nihon Eiseigaku Zasshi. 2013;68(3):168–174.</mixed-citation><mixed-citation xml:lang="en">Amano Y., Nishiwaki Y. National survey on eyelash extensions and their related health problems. Nihon Eiseigaku Zasshi. 2013;68(3):168–174.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Abah E.R., Oladigbolu K.K., Rafindadi ALRafindadi A.L., Audu O. Eyelash extension use among female students in a Tertiary Institution in Nigeria: A study of kaduna polytechnic, Kaduna. Niger J Clin Pract. 2017 Dec;20(12):1639–1643. DOI: 10.4103/njcp.njcp_124_17</mixed-citation><mixed-citation xml:lang="en">Abah E.R., Oladigbolu K.K., Rafindadi ALRafindadi A.L., Audu O. Eyelash extension use among female students in a Tertiary Institution in Nigeria: A study of kaduna polytechnic, Kaduna. Niger J Clin Pract. 2017 Dec;20(12):1639–1643. DOI: 10.4103/njcp.njcp_124_17</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ullrich K., Saha N. Semipermanent eyelash extensions causing bacterial keratitis: a case report. Semipermanent eyelash extensions causing bacterial keratitis: a case report. Can J Ophthalmol. 2013 Jun;48(3):e50-1. DOI: 10.1016/j.jcjo.2012.12.010</mixed-citation><mixed-citation xml:lang="en">Ullrich K., Saha N. Semipermanent eyelash extensions causing bacterial keratitis: a case report. Semipermanent eyelash extensions causing bacterial keratitis: a case report. Can J Ophthalmol. 2013 Jun;48(3):e50-1. DOI: 10.1016/j.jcjo.2012.12.010</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Michaels J.P., Macdonald P. Ignition of eyelash extensions during routine minor eyelid surgery. Ophthalmic Plast Reconstr Surg. 2014 May-Jun;30(3):e61-2. DOI: 10.1097/IOP.0b013e31829bb476</mixed-citation><mixed-citation xml:lang="en">Michaels J.P., Macdonald P. Ignition of eyelash extensions during routine minor eyelid surgery. Ophthalmic Plast Reconstr Surg. 2014 May-Jun;30(3):e61-2. DOI: 10.1097/IOP.0b013e31829bb476</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Dowlut M.S., Ahmed Y., Knox A. Ocular Inflammation Associated With Fibers From Eyelash Extensions. JAMA Ophthalmol. 2018 Jan 11;136(1):e175723. DOI: 10.1001/jamaophthalmol.2017.5723. Epub 2018 Jan 11.</mixed-citation><mixed-citation xml:lang="en">Dowlut M.S., Ahmed Y., Knox A. Ocular Inflammation Associated With Fibers From Eyelash Extensions. JAMA Ophthalmol. 2018 Jan 11;136(1):e175723. DOI: 10.1001/jamaophthalmol.2017.5723. Epub 2018 Jan 11.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Lindström I., Suojalehto H., Henriks-Eckerman M.L., Suuronen K. Occupational asthma and rhinitis caused by cyanoacrylate-based eyelash extension glues. Occup Med (Lond). 2013 Jun;63(4):294–297. DOI: 10.1093/occmed/kqt020</mixed-citation><mixed-citation xml:lang="en">Lindström I., Suojalehto H., Henriks-Eckerman M.L., Suuronen K. Occupational asthma and rhinitis caused by cyanoacrylate-based eyelash extension glues. Occup Med (Lond). 2013 Jun;63(4):294–297. DOI: 10.1093/occmed/kqt020</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Lee Y.B., Kim J.J., Hyon J.Y., Wee W.R., Shin Y.J. Eyelid Tattooing Induces Meibomian Gland Loss and Tear Film Instability. Cornea. 2015 Jul;34(7):750–755. DOI: 10.1097/ICO.0000000000000452</mixed-citation><mixed-citation xml:lang="en">Lee Y.B., Kim J.J., Hyon J.Y., Wee W.R., Shin Y.J. Eyelid Tattooing Induces Meibomian Gland Loss and Tear Film Instability. Cornea. 2015 Jul;34(7):750–755. DOI: 10.1097/ICO.0000000000000452</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Bo Ram Seol, Ji Won Kwon, Won Ryang Wee, Young Keun Han. A Case of Meibomian Gland Dysfunction after Cosmetic Eyelid Tattooing Procedure. Korean Ophthalmol Soc. 2013 Aug;54(8):1309–1313. Korean Published online August 14, 2013. DOI: 10.3341/jkos.2013.54.8.1309</mixed-citation><mixed-citation xml:lang="en">Bo Ram Seol, Ji Won Kwon, Won Ryang Wee, Young Keun Han. A Case of Meibomian Gland Dysfunction after Cosmetic Eyelid Tattooing Procedure. Korean Ophthalmol Soc. 2013 Aug;54(8):1309–1313. Korean Published online August 14, 2013. DOI: 10.3341/jkos.2013.54.8.1309</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Beleznay K., Humphrey S., Carruthers J.D., Carruthers A. Vascular compromise from soft tissue augmentation: Experience with 12 cases and recommendations for optimal outcomes. J Clin Aesthet Dermatol. 2014;7:37–43.</mixed-citation><mixed-citation xml:lang="en">Beleznay K., Humphrey S., Carruthers J.D., Carruthers A. Vascular compromise from soft tissue augmentation: Experience with 12 cases and recommendations for optimal outcomes. J Clin Aesthet Dermatol. 2014;7:37–43.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Beleznay K., Carruthers J.D., Humphrey S., Jones D. Avoiding and treating blindness from fillers: A review of the world literature. Dermatol Surg. 2015;41:1097–1117.</mixed-citation><mixed-citation xml:lang="en">Beleznay K., Carruthers J.D., Humphrey S., Jones D. Avoiding and treating blindness from fillers: A review of the world literature. Dermatol Surg. 2015;41:1097–1117.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Hwang J.C. Periorbital Injectables: Understanding and Avoiding Complications. J Cutan Aesthet Surg. 2016 Apr-Jun;9(2):73–79. DOI: 10.4103/0974-2077.184049</mixed-citation><mixed-citation xml:lang="en">Hwang J.C. Periorbital Injectables: Understanding and Avoiding Complications. J Cutan Aesthet Surg. 2016 Apr-Jun;9(2):73–79. DOI: 10.4103/0974-2077.184049</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Xiu Zhuo Hu, Jun Yan Hu, Peng Sen Wu, Sheng Bo Yu, Don O. Kikkawa, Wei Lu. Posterior Ciliary Artery Occlusion Caused by Hyaluronic Acid Injections into the Forehead. Medicine (Baltimore). 2016 Mar;95(11):e3124. Published online 2016 Mar 18. DOI: 10.1097/MD.0000000000003124</mixed-citation><mixed-citation xml:lang="en">Xiu Zhuo Hu, Jun Yan Hu, Peng Sen Wu, Sheng Bo Yu, Don O. Kikkawa, Wei Lu. Posterior Ciliary Artery Occlusion Caused by Hyaluronic Acid Injections into the Forehead. Medicine (Baltimore). 2016 Mar;95(11):e3124. Published online 2016 Mar 18. DOI: 10.1097/MD.0000000000003124</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Carruthers J. et al. The treatment of congenital nystagmus with Botox. J Pediatr Ophthalmol Strabismus. 1995;32(5):306–308. Review.</mixed-citation><mixed-citation xml:lang="en">Carruthers J. et al. The treatment of congenital nystagmus with Botox. J Pediatr Ophthalmol Strabismus. 1995;32(5):306–308. Review.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Emel Başar, Ceyhun Arıcı. Use of Botulinum Neurotoxin in Ophthalmology. Turk J Ophthalmol. 2016 Dec;46(6):282–290. Published online 2016 Dec 1. DOI: 10.4274/tjo.57701</mixed-citation><mixed-citation xml:lang="en">Emel Başar, Ceyhun Arıcı. Use of Botulinum Neurotoxin in Ophthalmology. Turk J Ophthalmol. 2016 Dec;46(6):282–290. Published online 2016 Dec 1. DOI: 10.4274/tjo.57701</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Coté T.R., Mohan A.K., Polder J.A., Walton M.K., Braun M.M. Botulinum toxin type A injections: adverse events reported to the US Food and Drug Administration in therapeutic and cosmetic cases. J Am Acad Dermatol. 2005 Sep;53(3):407–415.</mixed-citation><mixed-citation xml:lang="en">Coté T.R., Mohan A.K., Polder J.A., Walton M.K., Braun M.M. Botulinum toxin type A injections: adverse events reported to the US Food and Drug Administration in therapeutic and cosmetic cases. J Am Acad Dermatol. 2005 Sep;53(3):407–415.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Evidente V.G., Truong D., Jankovic J., Comella C.L., Grafe S., Hanschmann A. IncobotulinumtoxinA (Xeomin®) injected for blepharospasm or cervical dystonia according to patient needs is well tolerated. J Neurol Sci. 2014 Nov 15;346(1–2):116–20. DOI: 10.1016/j.jns.2014.08.004</mixed-citation><mixed-citation xml:lang="en">Evidente V.G., Truong D., Jankovic J., Comella C.L., Grafe S., Hanschmann A. IncobotulinumtoxinA (Xeomin®) injected for blepharospasm or cervical dystonia according to patient needs is well tolerated. J Neurol Sci. 2014 Nov 15;346(1–2):116–20. DOI: 10.1016/j.jns.2014.08.004</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Маркова Е.Ю., Полунина Е.Г., Иойлева Е.Э. Аллергические заболевания глаз у детей. Современный взгляд на патогенез и лечение. Офтальмология. 2017;14(2):125–129 [Markova E.Y., Polunina E.G., Ioileva E.E. Аllergic eye diseases in children. modern view on pathogenesis and treatment. Ophthalmology in Russia = Oftal’mologiya. 2017;14(2):125–129 (In Russ.)]. DOI: 10.18008/1816-5095-2017-2-125-129</mixed-citation><mixed-citation xml:lang="en">Маркова Е.Ю., Полунина Е.Г., Иойлева Е.Э. Аллергические заболевания глаз у детей. Современный взгляд на патогенез и лечение. Офтальмология. 2017;14(2):125–129 [Markova E.Y., Polunina E.G., Ioileva E.E. Аllergic eye diseases in children. modern view on pathogenesis and treatment. Ophthalmology in Russia = Oftal’mologiya. 2017;14(2):125–129 (In Russ.)]. DOI: 10.18008/1816-5095-2017-2-125-129</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Каспарова Е.А., Зайцев А.В., Каспарова Е.А., Каспаров А.А. Микродиатермокоагуляция в лечении инфекционных язв роговицы. Офтальмология. 2016;13(3):157–162 [Kasparova E.A., Zajcev A.V., Kasparova E.A., Kasparov A.A. Мicro diathermocoagulation in the treatment of infectious corneal ulcers. Ophthalmology in Russia = Oftal’mologiya. 2016;13(3):157–162 (In Russ.)]. DOI: 10.18008/1816-5095-2016-3-157-162</mixed-citation><mixed-citation xml:lang="en">Каспарова Е.А., Зайцев А.В., Каспарова Е.А., Каспаров А.А. Микродиатермокоагуляция в лечении инфекционных язв роговицы. Офтальмология. 2016;13(3):157–162 [Kasparova E.A., Zajcev A.V., Kasparova E.A., Kasparov A.A. Мicro diathermocoagulation in the treatment of infectious corneal ulcers. Ophthalmology in Russia = Oftal’mologiya. 2016;13(3):157–162 (In Russ.)]. DOI: 10.18008/1816-5095-2016-3-157-162</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Ho M.C., Hsu W.C., Hsieh Y.T. Botulinum toxin type a injection for lateral canthal rhytids: effect on tear film stability and tear production. JAMA Ophthalmology. 2014;132(3):332–337.</mixed-citation><mixed-citation xml:lang="en">Ho M.C., Hsu W.C., Hsieh Y.T. Botulinum toxin type a injection for lateral canthal rhytids: effect on tear film stability and tear production. JAMA Ophthalmology. 2014;132(3):332–337.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
