<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ophthalmology</journal-id><journal-title-group><journal-title xml:lang="ru">Офтальмология</journal-title><trans-title-group xml:lang="en"><trans-title>Ophthalmology in Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-5095</issn><issn pub-type="epub">2500-0845</issn><publisher><publisher-name>Ophthalmology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18008/1816-5095-2012-1-100-102</article-id><article-id custom-type="elpub" pub-id-type="custom">ophthalmology-98</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОФТАЛЬМОФАРМАКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PHARMACOLOGY</subject></subj-group></article-categories><title-group><article-title>Влияние ингибиторов эндотелиального фактора роста сосудов на хориоидею у пациентов с субмакулярной неоваскулярной мембраной при осложненной миопии (предварительное сообщение)</article-title><trans-title-group xml:lang="en"><trans-title>Effect of vascular endothelial growth factor inhibitors on choroid in patients with macular choroid neovascular membrane and degenerative myopia . Preliminary report</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соломин</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Solomin</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-офтальмолог Центра лазерной хирургии, Москва 127486, Бескудниковский бульвар, дом 59А</p></bio><email xlink:type="simple">drsolomin@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Магарамов</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Magaramov</surname><given-names>D. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Качалина</surname><given-names>Г. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Kachalina</surname><given-names>G. F.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГУ «МНТК «Микрохирургия глаза» им. акад. С.Н. Федорова Росмедтехнологии», Москва</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>10</day><month>07</month><year>2014</year></pub-date><volume>9</volume><issue>1</issue><fpage>100</fpage><lpage>102</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Соломин В.А., Магарамов Д.А., Качалина Г.Ф., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Соломин В.А., Магарамов Д.А., Качалина Г.Ф.</copyright-holder><copyright-holder xml:lang="en">Solomin V.A., Magaramov D.A., Kachalina G.F.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ophthalmojournal.com/opht/article/view/98">https://www.ophthalmojournal.com/opht/article/view/98</self-uri><abstract><p>Цель. Определить влияние ингибиторов эндотелиального фактора роста сосудов на хориоидею пациентов с миопиче- ской субмакулярной неоваскулярной мембраной.Методы. Исследовали 12 глаз пациентов с миопией в возрасте от 19 до 47 лет с наличием субмакулярной неоваскулярной мембраны (СНМ). Контролем служили парные глаза с начальной «сухой» макулярной дегенерацией. В условиях операцион- ной в глаза с СНМ проводилось однократное интравитреальное введение ингибитора эндотелиального фактора роста со- судов Ранибизумаба 0,5мг. Для сравнительного анализа состояния сетчатки и хориоидеи использовали прибор SPECtRALIS HRA+OCt фирмы Heidelberg Engineering. Исследования проводились перед введением Ранибизумаба (Луцентис), затем через 1 и 3 месяца.Результаты. Через 1 месяц после инъекции Ранибизумаба 0,5мг острота зрения с максимальной коррекцией в среднем увеличилась с 0.37±0.18 до 0.47±0.24, через 3 месяца она составила 0.53±0.24 с максимальной коррекцией. Средние значения толщины фовеальной зоны сетчатки через 1 и 3 месяца снизились с 311,4±57,2мкм до 229,1±41,8 мкм и 221,8±29,3 мкм, со- ответственно. Средняя толщина хориоидеи через 1 месяц уменьшилась с 54,4±23,7 мкм до 37,4±17,0 мкм, а через 3 месяца составила 48,9±20,1 мкм. В контрольной группе острота зрении с максимальной коррекцией составила 0.79±0.18, толщина фовеальной зоны сетчатки и хориоидеи равнялась 187,1±10,5 мкм и 93,7±24,5, соответственно.Заключение. После введения ингибитора эндотелиального фактора роста сосудов установлено транзиторное истонче- ние хориоидеи.</p></abstract><trans-abstract xml:lang="en"><p>Purpose: to assess the effect of vascular endothelial growth factor inhibitors on choroid in patients with myopic macular choroid neovascular membrane.Methods: 12 eyes (12 patients) aged 19-47 years with myopia and macular choroid neovascular membrane (mCNV) were enrolled in a study group. A control group included fellow eyes with early «dry» form age-related macular degeneration. Eyes with mCNV under- went one intravitreal injection of vascular endothelial growth factor inhibitor Ranibizumab 0.5 mg. Retina and choroid examination was performed with SPECtRALIS HRA+OCt (Heidelberg Engineering). Eyes were examined before treatment, in 1 month and in 3 months after treatment.Results: Mean best corrected visual acuity in 1 moth after ranibizumab 0.5 mg injection improved from 0.37±0.18 to 0.47±0.24. In 3 months after treatment best corrected visual acuity was 0.53±0.24. Mean foveal retinal thickness before treatment was 311.4±57.2 μm; 1 month and 3 months after treatment mean foveal retinal thickness decreased to 229.1±41.8 μm and 221.8±29.3 μm, respec- tively. Mean choroid thickness in 1 moth decreased from 54.4±23.7 μm to 37.4±17.0 μm, in 3 moths mean choroid thickness was 48.9±20.1 μm. In the control group best corrected visual acuity was 0.79±0.18, mean foveal retinal thickness and mean choroid thick- ness were 187.1±10.5 μm and 93.7±24.5 μm, respectively.Conclusion: Injection of vascular endothelial growth factor inhibitor allowed transient choroid thinning.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>миопическая субмакулярная неоваскулярная мембрана</kwd><kwd>миопия</kwd><kwd>Ранибизумаб</kwd></kwd-group><kwd-group xml:lang="en"><kwd>myopic macular choroid neovascular membrane</kwd><kwd>myopia</kwd><kwd>Ranibizumab</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Измайлов А. С., Балашевич Л. И. Хориоидальная неоваскуляризация (диагно‐ стика и лечение). Учебное пособие — СПб., 2001.</mixed-citation><mixed-citation xml:lang="en">Измайлов А. С., Балашевич Л. И. Хориоидальная неоваскуляризация (диагно‐ стика и лечение). Учебное пособие — СПб., 2001.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Blinder KJ, Blumenkranz MS, Bressler NM, et al. Verteporfin therapy of subfoveal choroidal neovascularization in pathologic myopia: 2‐year results of a random‐ ized clinical trial — VIP report no 3 // Ophthalmology. — 2003. — Vol. 110. — P. 667‐673.</mixed-citation><mixed-citation xml:lang="en">Blinder KJ, Blumenkranz MS, Bressler NM, et al. Verteporfin therapy of subfoveal choroidal neovascularization in pathologic myopia: 2‐year results of a random‐ ized clinical trial — VIP report no 3 // Ophthalmology. — 2003. — Vol. 110. — P. 667‐673.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Gharbiya M, Allievi F, Mazzeo L, et al. Intravitreal bevacizumab treatment for choroidal neovascularization in pathologic myopia: 12‐month results // Am J Ophthalmol. — 2009. — Vol. 147. — P. 84‐93.</mixed-citation><mixed-citation xml:lang="en">Gharbiya M, Allievi F, Mazzeo L, et al. Intravitreal bevacizumab treatment for choroidal neovascularization in pathologic myopia: 12‐month results // Am J Ophthalmol. — 2009. — Vol. 147. — P. 84‐93.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Inan U. U., Avei В., Kusbeci Т. Preclinical safety evaluation of intravitreal injec‐ tion of full‐ length humanized vascular endothelial growth factor antibody in rat eyes // Invest. Ophthalmol. Vis. Sci. — 2007. — Vol. 48. — P. 1773‐1781.</mixed-citation><mixed-citation xml:lang="en">Inan U. U., Avei В., Kusbeci Т. Preclinical safety evaluation of intravitreal injec‐ tion of full‐ length humanized vascular endothelial growth factor antibody in rat eyes // Invest. Ophthalmol. Vis. Sci. — 2007. — Vol. 48. — P. 1773‐1781.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Manzano RP, Peyman GA, Khan P, et al. Testing intravitreal toxicity of bevaci‐ zumab (Avastin) // Retina. — 2006. — Vol. 26. — P. 257‐261.</mixed-citation><mixed-citation xml:lang="en">Manzano RP, Peyman GA, Khan P, et al. Testing intravitreal toxicity of bevaci‐ zumab (Avastin) // Retina. — 2006. — Vol. 26. — P. 257‐261.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Marneros A. G., Fan J., Yokoyama Y., et al. Vascular endothelial growth factor ex‐ pression in retinal pigment epithelium is essential for choriocapillaris develop‐ ment and vision function // Am. J. Pathol. — 2005. — Vol. 167. — P. 1451‐1459.</mixed-citation><mixed-citation xml:lang="en">Marneros A. G., Fan J., Yokoyama Y., et al. Vascular endothelial growth factor ex‐ pression in retinal pigment epithelium is essential for choriocapillaris develop‐ ment and vision function // Am. J. Pathol. — 2005. — Vol. 167. — P. 1451‐1459.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Fujiwara T, Imamura Y, Margolis R, et al. Enhanced depth imaging optical coher‐ ence tomography of the choroid in highly myopic eyes // Am J Ophthalmol. — 2009. — Vol. 148. — P. 445‐450.</mixed-citation><mixed-citation xml:lang="en">Fujiwara T, Imamura Y, Margolis R, et al. Enhanced depth imaging optical coher‐ ence tomography of the choroid in highly myopic eyes // Am J Ophthalmol. — 2009. — Vol. 148. — P. 445‐450.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ikuno Y, Tano Y. Retinal and choroidal biometry in highly myopic eyes with spec‐ tral‐domain optical coherence tomography // Invest Ophthalmol Vis Sci. — 2009. — Vol. 50. — P. 3876‐3880.</mixed-citation><mixed-citation xml:lang="en">Ikuno Y, Tano Y. Retinal and choroidal biometry in highly myopic eyes with spec‐ tral‐domain optical coherence tomography // Invest Ophthalmol Vis Sci. — 2009. — Vol. 50. — P. 3876‐3880.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Margolis R, Spaide RF. A pilot study of enhanced depth imaging optical coher‐ ence tomography of the choroid in normal eyes // Am J Ophthalmol. — 2009. — Vol. 147. — P. 811‐815.</mixed-citation><mixed-citation xml:lang="en">Margolis R, Spaide RF. A pilot study of enhanced depth imaging optical coher‐ ence tomography of the choroid in normal eyes // Am J Ophthalmol. — 2009. — Vol. 147. — P. 811‐815.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
