Early detection of choroidal neovascularization in age related macular degeneration
https://doi.org/10.18008/1816-5095-2012-2-24-28
Abstract
Purpose: to identify factors associated with early detection of choroidal neovascularization CNV in clinical practice.
Methods: Seventy six AMD patients who had history of CNV in one eye and presented with CNV in the second eye and evaluated for association with visual acuity (VA) at time of presentation. Demographics, clinical data and lesion characteristics were retrospectively collected.
Results: Better VA was associated with history of CNV in the fellow eye (p<0.0001), adherence to follow-up every four-months (p=0.015), younger age (p=0.03), smaller lesion (p<0.0001), and non-subfoveal localization (p=0.048). VA of the fellow eye did not correlate with VA at presentation with CNV.
Conclusion: these data suggest that experience of CNV, regardless of VA, facilitates early diagnosis in the fellow eye. Adherence to follow-up in the routine clinic setting also facilitates early detection of CNV.
About the Author
Tural Galbinur
Университет Иврит, Хадассах Медицинский Центр, Иерусалим, Израиль
Israel
Israel
References
1. Asleh SA, Chowers I. Ethnic background as a risk factor for advanced age‐re- lated macular degeneration in Israel // Isr Med Assoc J. — 2007. — Vol. 9. — P. 656‐658.
2. Querques G, Avellis FO, Querques L, et al. Age‐related macular degeneration // Clin Ophthalmol. — 2011. — Vol. 5. — P. 593‐601.
3. Rosenfeld PJ, Brown DM, Heier JS, et al. Ranibizumab for neovascular age‐relat- ed macular degeneration // N Engl J Med. — 2006. — Vol. 355. — P. 1419‐1431.
4. Brown DM, Kaiser PK, Michels M, et al. Ranibizumab versus verteporfin for neo- vascular age‐related macular degeneration // N Engl J Med. — 2006. — Vol. 355. — P. 1432‐1444.
5. Avery RL, Pieramici DJ, Rabena MD, et al. Intravitreal bevacizumab (Avastin) for neovascular age‐related macular degeneration // Ophthalmology. — 2006. — Vol. 113. — P. 363‐372.
6. Rosenfeld PJ, Moshfeghi AA, Puliafito CA. Optical coherence tomography find- ings after an intravitreal injection of bevacizumab (avastin) for neovascular age‐ related macular degeneration // Ophthalmic Surg Lasers Imaging. — 2005. — Vol. 36. — P. 331‐335.
7. Waisbourd M, Goldstein M, Loewenstein A. National survey of the ophthalmic use of anti‐vascular endothelial growth factor drugs in Israel // Isr Med As- soc J. — 2011. — Vol. 13. — P. 141‐146.
8. Acharya N, Lois N, Townend J, et al. Socio‐economic deprivation and visual acu- ity at presentation in exudative Age Related Macular Degeneration // Br J Oph- thalmol. — 2009. — Vol. 93. — P. 627‐629.
9. Olsen TW, Feng X, Kasper TJ, et al. Fluorescein angiographic lesion type fre- quency in neovascular age‐related macular degeneration // Ophthalmology. — 2004. — Vol. 111. — P. 250‐255.
10. Moisseiev J, Alhalel A, Masuri R, et al. The impact of the macular photocoagula- tion study results on the treatment of exudative age‐related macular degenera- tion // Arch Ophthalmol. — 1995. — Vol. 113. — P. 185‐189.
11. Choroidal neovascularization in the choroidal neovascularization prevention tri- al. The Choroidal Neovascularization Prevention Trial Research Group // Oph- thalmology. — 1998. — Vol. 105. — P. 1364‐1372.
12. Maguire MG, Alexander J, Fine SL. Characteristics of choroidal neovasculariza- tion in the complications of age‐related macular degeneration prevention trial // Ophthalmology. — 2008. — Vol. 115. — P. 1468‐1473.
13. Solomon SD, Jefferys JL, Hawkins BS, et al. Incident choroidal neovasculariza- tion in fellow eyes of patients with unilateral subfoveal choroidal neovascular- ization secondary to age‐related macular degeneration: SST report No. 20 from the Submacular Surgery Trials Research Group // Arch Ophthalmol. — 2007. — Vol. 125. — P. 1323‐1330.
14. A randomized, placebo‐controlled, clinical trial of high‐dose supplementation with vitamins C and E, beta carotene, and zinc for age‐related macular degen- eration and vision loss: AREDS report no. 8 // Arch Ophthalmol. — 2001. — Vol. 119. — P. 1417‐1436.
15. Chowers I, Cohen Y, Goldenberg‐Cohen N, et al. Association of complement fac- tor H Y402H polymorphism with phenotype of neovascular age related macular degeneration in Israel // Mol. Vis. — 2008. — Vol. 14. — P. 1829‐1834.
16. Cervantes‐Castaneda RA, Banin E, Hemo I, et al. Lack of benefit of early aware- ness to age‐related macular degeneration // Eye. — 2008. — Vol. 22. — P. 777‐781.
17. Freund KB, Yannuzzi LA, Sorenson JA. Age‐related macular degeneration and choroidal neovascularization // Am J Ophthalmol. — 1993. — Vol. 115. — P. 786‐791.
18. Loewenstein A, Malach R, Goldstein M, et al. Replacing the Amsler grid: a new method for monitoring patients with age‐related macular degeneration // Oph- thalmology. — 2003. — Vol. 110. — P. 966‐970.
19. Lai Y, Grattan J, Shi Y, et al. Functional and morphologic benefits in early detec- tion of neovascular age‐related macular degeneration using the preferential hy- peracuity perimeter // Retina. — 2011. — Vol. 31. — P. 1620‐1626.
Review
For citations:
Galbinur T. Early detection of choroidal neovascularization in age related macular degeneration. Ophthalmology in Russia. 2012;9(2):24-28. (In Russ.) https://doi.org/10.18008/1816-5095-2012-2-24-28
Views:
3429
Email this article 