Immunosuppressive therapy in non-infections uveitis and retinovasculitis
https://doi.org/10.18008/1816-5095-2012-2-58-61
Abstract
Purpose: to evaluate the efficacy and safety of the immunosuppressive therapy for severe forms of non-infections uveitis and retinovasculitis.
Methods: 107 patients (62 males and 45 females aged 9 to 54 years) who received low dose methotrexate — 7.5-20 mg once a week (n=79) cyclosporine A 3.5-5.0 mg/kg/d (n=21) with prednisone or other antimetabolites and local corticosteroid therapy for severe forms of inflammatory eye diseases.
Results: the efficacy of methotrexate as monotherapy was 51.8% of patients with chronic uveitis. Control of acute inflammation was achived in 71.1% patients, who received methotrexate in combination with prednisolone. Cyclosporine A was more effective in controlling inflammatory of the eye: remission of uveitis was achived in 85.7% in combination with glucocorticoids. No significant side effects have been noted.
Conclusion: Methotrexate and cyclosporine A with low dose of prednisolone are well tolerated immunosuppressive agents and
rather effective in the treatment of non-infectious uveitis and retinovasculitis that fails to respond to conventional steroid treatment.
About the Author
E. A. Drozdova
Государственное бюджетное образовательное учреждение высшего профессионального образования «Челябинская государственная медицинская академия» Минздравсоцразвития России, Челябинск, Россия, 454092 Челябинск, ул. Воровского, 64
Russian Federation
Russian Federation
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Review
For citations:
Drozdova E.A. Immunosuppressive therapy in non-infections uveitis and retinovasculitis. Ophthalmology in Russia. 2012;9(2):58-61. (In Russ.) https://doi.org/10.18008/1816-5095-2012-2-58-61
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