Optical Coherence Tomography-Angiography in Pediatric Ophthalmological Practice (Review)

Data from sources of domestic and foreign literature for 2016–2019 is presented in the review of literature. This data concerned of applying the method of optical coherent tomography-angiography in pediatric ophthalmic practice. OCT-A is a non-invasive research method, without the use of fluorescent dyes. The procedure is performed relatively quickly, with the possibility of additional repetition. The method allows to conduct visualization of the vascular network of the retina layer-by-layer, perform its quantitative analysis: to evaluate the density of the microvascular bed and measure the area of non-perfusion zones. Having appeared as a result of a qualitative modernization of OCT, a new method of visualization of vessels OCT-A is actively used in the diagnosis of pathologies such as glaucoma, diabetic retinopathy, post-thrombotic retinopathy, age-related macular degeneration, central serous chorioretinopathy, etc. In present time OCT-A being performed in adult medicine, it is actively used in various areas of pediatric ophthalmology. Presently, pediatric patients with diabetes mellitus, sickle cell anemia, amblyopia, retinal artery occlusion, and coats disease have been performed with OCT-A studies. Retinopathy of prematurity (ROP) is required a special attention among children’s eye diseases. However, mentioning about OCT angiographic studies in patients with ROP are quite rare in the literature. Nevertheless, the available data indicate the enormous diagnostic potential of OCT-A in this severe vasoproliferative disease. The method give possibility for fully control the pathological process, to evaluate the effectiveness of the treatment and timely prevent the development of severe stages of ROP. Due to the information and diagnostic potential, it is necessary to continue research on the possibilities of the OCT-A method in the diagnosis, analysis of treatment results and prediction of ROP.

1. Sidorenko E.I., Guseva M.R., Markova E.Yu., Astasheva I.B. Fluorescent angiography in the diagnosis of fundus pathology in children. Annals of Ophthalmology = Vestnik oftal’mologii. 2003;119(2):15–17. (In Russ.).

2. Zaitsev N.A., Somov E.E. The nature of possible complications during fluorescence angiography in children of different ages. Ophthalmological statements = Oftal’mologicheskie vedomosti. 2010;3(3):14–17 (In Russ.).

3. Anikina M.A., Matnenko T.Yu., Lebedev O.I. Optical coherence tomography-angiography: a promising method in ophthalmological diagnosis. Practical medicine = Prakticheskaya medicina. 2018;114(3):7–10 (In Russ.).

4. Mezu-Ndubuisi O.J., Taylor L.K., Schoephoerster J.A. Simultaneous Fluorescein Angiography and Spectral Domain Optical Coherence Tomography Correlate Retinal Thickness Changes to Vascular Abnormalities in an In Vivo Mouse Model of Retinopathy of Prematurity. J Ophthalmol. 2017;2017:9620876. DOI: 10.1155/2017/9620876

5. Gołębiewska J., Olechowski A., Wysocka-Mincewicz M., Odrobina D., BaszyńskaWilk M., Groszek A., Szalecki M., Hautz W. Optical coherence tomography angiography vessel density in children with type 1 diabetes. PLoS One. 2017 Oct 20;12(10):e0186479. DOI: 10.1371

6. Inanc M., Tekin K., Kiziltoprak H., Ozalkak S., Doguizi S., Aycan Z. Changes in Retinal Microcirculation Precede the Clinical Onset of Diabetic Retinopathy in Children with Type 1 Diabetes Mellitus. Am J Ophthalmol. 2019 Apr 19. PII: S00029394(19)30186-2. DOI: 10.1016/j.ajo.2019.04.011

7. Roemer S., Bergin C., Kaeser P.F., Ambresin A. Assessment of macular vasculature of children with sickle cell disease compared to that of healthy controls using optical coherence tomography angiography. Retina. 2018 Oct 16. DOI: 10.1097/IAE.0000000000002321

8. Lonngi M., Velez F.G., Tsui I., Davila J.P., Rahimi M., Chan C., Sarraf D., Demer J.L., Pineles S.L. Spectral-Domain Optical Coherence Tomographic Angiography in Children With Amblyopia. JAMA Ophthalmol. 2017 Oct 1;135(10):1086–1091. DOI: 10.1001/jamaophthalmol.2017.3423

9. Sobral I., Rodrigues T.M., Soares M., Seara M., Monteiro M., Paiva C., Castela R. OCT angiography findings in children with amblyopia. J AAPOS. 2018 Aug;22(4):286–289.e2. DOI: 10.1016/j.jaapos.2018.03.009

10. Borrelli E., Lonngi M., Balasubramanian S., Tepelus T.C., Baghdasaryan E., Pineles S.L., Velez F.G., Sarraf D., Sadda S.R., Tsui I. Increased choriocapillaris vessel density in amblyopic children: a case-control study. J AAPOS. 2018;22(5):366– 370. DOI: 10.1016/j.jaapos.2018.04.005

11. Hautz W., Gołębiewska J., Czeszyk-Piotrowicz A. Optical Coherence TomographyBased Angiography in Retinal Artery Occlusion in Children. Ophthalmic Res. 2018;59(4):177–181. DOI: 10.1159/000484351

12. Rabiolo A., Marchese A., Sacconi R., Cicinelli M.V., Grosso A., Querques L., Querques G., Bandello F. Refining Coats’ disease by ultra-widefield imaging and optical coherence tomography angiography. Graefes Arch Clin Exp Ophthalmol. 2017;255(10):1881–1890. DOI: 10.1007/s00417-017-3794-7

13. Vinekar A., Chidambara L., Jayadev C., Sivakumar M., Webers C.A., Shetty B. Monitoring neovascularization in aggressive posterior retinopathy of prematurity using optical coherence tomography angiography. J AAPOS. 2016;20(3):271–274. DOI: 10.1016/j.jaapos.2016.01.013

14. Campbell J.P., Nudleman E., Yang J., Tan O., Chan R.V.P., Chiang M.F., Huang D., Liu G. Handheld Optical Coherence Tomography Angiography and Ultra-WideField Optical Coherence Tomography in Retinopathy of Prematurity. JAMA Ophthalmol. 2017;135(9):977–981. DOI: 10.1001/jamaophthalmol.2017.2481

15. Bowl W., Bowl M., Schweinfurth S., Holve K., Knobloch R., Stieger K., AndrassiDarida M., Lorenz B. OCT Angiography in Young Children with a History of Retinopathy of Prematurity. Ophthalmol Retina. 2018;2(9):972–978. DOI: 10.1016/j.oret.2018.02.004

16. Chen Y.C., Chen Y.T., Chen S.N. Foveal microvascular anomalies on optical coherence tomography angiography and the correlation with foveal thickness and visual acuity in retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol. 2019;257(1):23–30. DOI: 10.1007/s00417-018-4162-y