Effect of Hemodialysis on Diabetic Retinopathy
https://doi.org/10.18008/1816-5095-2021-2-228-233
Abstract
Diabetes mellitus is a serious health problem in both developed and developing countries. It is expected that by 2040 the incidence of diabetes mellitus in the world will increase to 642 million people. With the increase in the incidence of diabetes mellitus, the incidence of diabetic vascular complications increases, which worsen the quality of life of patients and triple the risk of death. Diabetic retinopathy is one of the most common microvascular complications of diabetes mellitus, leading to progressive loss of visual function. Diabetic retinopathy occurs in conjunction with diabetic nephropathy. This fact is associated with the anatomical similarity of the blood-retinal barrier and the glomerular filtration barrier, as well as with the general pathogenetic mechanisms of the effect of hyperglycemia on peripheral microcirculation. On average, after 10–15 years, patients with decompensated diabetes mellitus develop end-stage renal failure, requiring renal replacement therapy, such as peritoneal dialysis, programmed hemodialysis, and kidney transplantation. This article highlights the latest data on the effect of programmed hemodialysis on the morphofunctional state of the retina in patients with diabetes mellitus.
About the Authors
I. V. VorobyevaRussian Federation
МD, Associate Professor of Ophthalmology department,
Barrikadnaya str., 2/1, Moscow, 125993
A. V. Pinchuk
Russian Federation
МD, Associate Professor of Transplantology and artificial organs department, head of the Scientific department of kidney and pancreas transplantation,
Bolshaya Sukharevskaya sq., 3, Moscow, 129090,
Delegatskaya str., 20/1, Moscow, 127473,
Bolshaya Tatarskaya str., 30, Moscow, 115184
E. V. Bulava
Russian Federation
postgraduate,
Barrikadnaya str., 2/1, Moscow, 125993
K. E. Lazareva
Russian Federation
PhD, endocrinologist,
Bolshaya Sukharevskaya sq., 3, Moscow, 129090,
Delegatskaya str., 20/1, Moscow, 127473
N. S. Zhuravel
Russian Federation
surgeon,
Bolshaya Sukharevskaya sq., 3, Moscow, 129090
References
1. Zimmet P.Z., Magliano D.J., Herman W.H., Shaw J.E. Diabetes: a 21st century challenge. The Lancet Diabetes & Endocrinology. 2014;2(1):56–64. DOI: 10.1016/S22138587(13)70112-8
2. International Diabetes Federation. IDF Diabetes Atlas. 7th edn. Brussels, Belgium: International Diabetes Federation, 2015. 3. American Diabetes Association. Economic Costs of Diabetes in the U.S. in 2017. Diabetes Care. 2018;41(5):917–928. DOI: 10.2337/dci18-0007
3. Solomon S.D., Chew E., Duh E.J., Sobrin L., Sun J.K., VanderBeek B.L., Wykoff C.C., Gardner T.W. Diabetic Retinopathy: A Position Statement by the American Diabetes Association. Diabetes Care. 2017;40(3):412–418. DOI: 10.2337/dc16-2641
4. International Diabetes Federation. IDF Diabetes Atlas. 8th edn. Brussels, Belgium: International Diabetes Federation, 2017.
5. Dedov I.I., Shestakova M.V., Vikulova O.K. Epidemiology of diabetes mellitus in Russian Federation: clinical and statistical report according to the federal diabetes registry. Diabetes mellitus. 2017;20(1):13–41 (In Russ.). DOI: 10.14341/DM8664
6. Wong C.W., Wong T.Y., Cheng C.Y., Sabanayagam C. Kidney and eye diseases: common risk factors, etiological mechanisms, and pathways. Kidney International. 2014;85(6):1290–1302. DOI: 10.1038/ki.2013.491
7. Park S., Kang H.J., Jeon J.H., Kim M.J., Lee I.K. Recent advances in the pathogenesis of microvascular complications in diabetes. Archives of Pharmacal Research. 2019;42(3):252–262. DOI: 10.1007/s12272-019-01130-3
8. Got’e S.V. Type 1 diabetes mellitus, diabetic nephropathy: transplantology potential. Annals of the Russian academy of medical sciences = Vestnik Rossiyskoy akademii medicinskih nauk. 2012;67(1):54–60 (In Russ.). DOI: 10.15690/vramn.v67i1.111
9. Wong T.Y., Cheung C.M., Larsen M., Sharma S., Simó R. Diabetic retinopathy. Nature Reviews Disease Primers. 2016;2:16012. DOI: 10.1038/nrdp.2016.12
10. Wilkinson C.P., Ferris F.L. 3rd, Klein R.E., Lee P.P., Agardh C.D., Davis M., Dills D., Kampik A., Pararajasegaram R., Verdaguer J.T., Global Diabetic Retinopathy Project Group. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology. 2003;110(9):1677–1682. DOI: 10.1016/S0161-6420(03)00475-5
11. Umanath K., Lewis J.B. Update on Diabetic Nephropathy: Core Curriculum 2018. The American Journal of Kidney Diseases. 2018;71(6):884–895. DOI: 10.1053/j.ajkd.2017.10.026
12. Reutens A.T., Atkins R.C. Epidemiology of diabetic nephropathy. Contributions to Nephrology. 2011;170:1–7. DOI: 10.1159/000324934
13. Chen Y.H., Chen H.S., Tarng D.C. More impact of microalbuminuria on retinopathy than moderately reduced GFR among type 2 diabetic patients. Diabetes Care. 2012;35(4):803–808. DOI: 10.2337/dc11-1955
14. Wong T.Y., Coresh J., Klein R., Muntner P., Couper D.J., Sharrett A.R., Klein B.E., Heiss G., Hubbard L.D., Duncan B.B. Retinal microvascular abnormalities and renal dysfunction: the atherosclerosis risk in communities study. Journal of the American Society of Nephrology. 2004;15(9):2469–2476. DOI: 10.1097/01.ASN.0000136133.28194.E4
15. Edwards M.S., Wilson D.B., Craven T.E., Stafford J., Fried L.F., Wong T.Y., Klein R., Burke G.L., Hansen K.J. Associations between retinal microvascular abnormalities and declining renal function in the elderly population: the Cardiovascular Health Study. American Journal of Kidney Diseases. 2005;46(2):214–224. DOI: 10.1053/j.ajkd.2005.05.005
16. Yip W., Ong P.G., Teo B.W., Cheung C.Y., Tai E.S., Cheng C.Y., Lamoureux E., Wong T.Y., Sabanayagam C. Retinal Vascular Imaging Markers and Incident Chronic Kidney Disease: A Prospective Cohort Study. Scientific Reports. 2017;7(1):9374. DOI: 10.1038/s41598-017-09204-2
17. Deva R., Alias M.A., Colville D., Tow F.K., Ooi Q.L., Chew S., Mohamad N., Hutchinson A., Koukouras I., Power D.A., Savige J. Vision-threatening retinal abnormalities in chronic kidney disease stages 3 to 5. Clinical Journal of the American Society of Nephrology. 2011;6(8):1866–1871. DOI: 10.2215/CJN.10321110
18. Nowotny K., Jung T., Höhn A., Weber D., Grune T. Advanced glycation end products and oxidative stress in type 2 diabetes mellitus. Biomolecules. 2015;5(1):194– 222. DOI: 10.3390/biom5010194
19. Benigni A., Cassis P., Remuzzi G. Angiotensin II revisited: new roles in inflammation, immunology and aging. EMBO Molecular Medicine. 2010;2(7):247–257. DOI: 10.1002/emmm.201000080
20. Yokota H., Nagaoka T., Tani T., Takahashi A., Sato E., Kato Y., Yoshida A. Higher levels of prorenin predict development of diabetic retinopathy in patients with type 2 diabetes. Journal of the Renin-Angiotensin-Aldosterone System. 2011;12(3):290–294. DOI: 10.1177/1470320310391327
21. Turkmen K. Inflammation, oxidative stress, apoptosis, and autophagy in diabetes mellitus and diabetic kidney disease: the Four Horsemen of the Apocalypse. International Urology and Nephrology. 2017;49(5):837–844. DOI: 10.1007/s11255-0161488-4
22. Sahajpal N.S., Goel R.K., Chaubey A., Aurora R., Jain S.K. Pathological Perturbations in Diabetic Retinopathy: Hyperglycemia, AGEs, Oxidative Stress and Inflammatory Pathways. Current Protein & Peptide Science. 2019;20(1):92–110. DOI: 10.2 174/1389203719666180928123449. PMID: 30264677
23. Ahsan H. Diabetic retinopathy-biomolecules and multiple pathophysiology. Diabetes & Metabolic Syndrome. 2015;9(1):51–54. DOI: 10.1016/j.dsx.2014.09.011
24. Afarid M., Ghattavi N., Johari M. Serum Levels of Vitamin D in Diabetic Patients With and Without Retinopathy. Journal of Ophthalmic and Vision Research. 2020;15(2):172–177. DOI: 10.18502/jovr.v15i2.6734
25. Payne J.F., Ray R., Watson D.G., Delille C., Rimler E., Cleveland J., Lynn M.J., Tangpricha V., Srivastava S.K. Vitamin D insufficiency in diabetic retinopathy. Endocrine Practice. 2012;18(2):185–193. DOI: 10.4158/EP11147.OR
26. Zhou B., Zou H., Xu G. Clinical Utility of Serum Cystatin C in Predicting Diabetic Nephropathy Among Patients with Diabetes Mellitus: a Meta-Analysis. Kidney and Blood Pressure Research. 2016;41(6):919–928. DOI: 10.1159/000452593
27. Canaud B., Chazot C., Koomans J., Collins A. Fluid and hemodynamic management in hemodialysis patients: challenges and opportunities. The Brazilian Journal of Nephrology. 2019;41(4):550–559. DOI: 10.1590/2175-8239-JBN-2019-0135
28. Mineshima M. The past, present and future of the dialyzer. Contributions to Nephrology. 2015;185:8–14. DOI: 10.1159/000380965
29. National Kidney Foundation. KDOQI Clinical Practice Guideline for Hemodialysis Adequacy: 2015 update. American Journal of Kidney Diseases. 2015;66(5):884–930. DOI: 10.1053/j.ajkd.2015.07.015
30. Schneditz D., Schilcher G., Ribitsch W., Zierler E., Jantscher A. Sensitivity of Hematocrit to Osmotic Effects Induced by Changes in Dialysate Conductivity: Implications for Relative Blood Volume Measurement and Control. ASAIO Journal. 2015;61(5):583–588. DOI: 10.1097/MAT.0000000000000056
31. Pahor D. Retinal light sensitivity in haemodialysis patients. Eye. 2003;17(2):177– 1782. DOI: 10.1038/sj.eye.6700292
32. Tomazzoli L., De Natale R., Lupo A., Parolini B. Visual acuity disturbances in chronic renal failure. Ophthalmologica. 2000;214(6):403–405. DOI: 10.1159/000027533
33. Pelit A., Zümrütdal A., Akova Y. The effect of hemodialysis on visual field test in patients with chronic renal failure. Current Eye Research. 2003;26(5):303–306. DOI: 10.1076/ceyr.26.4.303.15425
34. Matsuo T. Disappearance of diabetic macular hard exudates after hemodialysis introduction. Acta Medica Okayama. 2006;60(3):201–205. DOI: 10.18926/AMO/30746
35. Perkovich B.T., Meyers S.M. Systemic factors affecting diabetic macular edema. American Journal of Ophthalmology. 1988;105(2):211–212. DOI: 10.1016/00029394(88)90190-0
36. Tokuyama T., Ikeda T., Sato K. Effects of haemodialysis on diabetic macular leakage. British Journal of Ophthalmology. 2000;84(12):1397–1400. DOI: 10.1136/bjo.84.12.1397
37. Moreira R.O., Trujillo F.R., Meirelles R.M., Ellinger V.C., Zagury L. Use of optical coherence tomography (OCT) and indirect ophthalmoscopy in the diagnosis of macular edema in diabetic patients. International Ophthalmology. 2001;24(6):331– 336. DOI: 10.1023/b:inte.0000006784.52885.e9
38. Kwan C.C., Fawzi A.A. Imaging and Biomarkers in Diabetic Macular Edema and Diabetic Retinopathy. Current Diabetes Reports. 2019;19(10):95. DOI: 10.1007/s11892-019-1226-2
39. Pahor D., Gracner B., Gracner T., Hojs R. Optische Kohärenztomografie bei hämodialysierten Patienten. Klinische Monatsblatter Für Augenheilkunde. 2008;225(8):713–717. DOI: 10.1055/s-2007-963761
40. Theodossiadis P.G., Theodoropoulou S., Neamonitou G., Grigoropoulos V., Liarakos V., Triantou E., Theodossiadis G.P., Vlahakos D.V. Hemodialysis-induced alterations in macular thickness measured by optical coherence tomography in diabetic patients with end-stage renal disease. Ophthalmologica. 2012;227(2):90–94. DOI: 10.1159/000331321
41. Auyanet I., Rodríguez L.J., Bosch E., Sánchez A.Y., Esparza N., Lago M.M., Ramírez A., Checa M.D. Measurement of foveal thickness by optical coherence tomography in adult haemodialysis patients with diabetic nephropathy. Nefrologia. 2011;31(1):66–69. DOI: 10.3265/Nefrologia.pre2010.Oct.10392
42. Azem N., Spierer O., Shaked M., Neudorfer M. Effect of Hemodialysis on Retinal Thickness in Patients with Diabetic Retinopathy, with and without Macular Edema, Using Optical Coherence Tomography. Journal of Ophthalmology. 2014;2014:709862. DOI: 10.1155/2014/709862
43. Yang S.J., Han Y.H., Song G.I., Lee C.H., Sohn S.W. Changes of choroidal thickness, intraocular pressure and other optical coherence tomographic parameters after haemodialysis. Clinical and Experimental Optometry. 2013;96(5):494–499. DOI: 10.1111/cxo.12056
44. Ulaş F., Doğan Ü., Keleş A., Ertilav M., Tekçe H., Celebi S. Evaluation of choroidal and retinal thickness measurements using optical coherence tomography in nondiabetic haemodialysis patients. International Ophthalmology. 2013;33(5):533–539. DOI: 10.1007/s10792-013-9740-8
45. Hwang H., Chae J.B., Kim J.Y., Moon B.G., Kim D.Y. Changes in optical coherence tomography findings in patients with chronic renal failure undergoing dialysis for the first time. Retina. 2019;39(12):2360–2368. DOI: 10.1097/IAE.0000000000002312
46. Takamura Y., Matsumura T., Ohkoshi K., Takei T., Ishikawa K., Shimura M., Ueda T., Sugimoto M., Hirano T., Takayama K., Gozawa M., Yamada Y., Morioka M., Iwano M., Inatani M. Functional and anatomical changes in diabetic macular edema after hemodialysis initiation: One-year followup multicenter study. Scientific Reports. 2020;10(1):7788. DOI: 10.1038/s41598-020-64798-4
47. Janssen M.J, van der Meulen J. The bleeding risk in chronic haemodialysis: preventive strategies in high-risk patients. The Netherlands Journal of Medicine. 1996;48(5):198–207. DOI: 10.1016/0300-2977(96)00005-8
48. Kameda Y., Hanai K., Uchigata Y., Babazono T., Kitano S. Vitreous hemorrhage in diabetes patients with proliferative diabetic retinopathy undergoing hemodialysis. Journal of Diabetes Investigation. 2020;11(3):688–692. DOI: 10.1111/jdi.13161
49. Diskin C.J., Stokes T.J., Dansby L.M., Radcliff L., Carter T.B. A hypothesis: can erythropoietin administration affect the severity of retinopathy in diabetic patients with renal failure? The American Journal of the Medical Sciences. 2007;334(4):260– 264. DOI: 10.1097/MAJ.0b013e3180a5e8ed. PMID: 18030182
Review
For citations:
Vorobyeva I.V., Pinchuk A.V., Bulava E.V., Lazareva K.E., Zhuravel N.S. Effect of Hemodialysis on Diabetic Retinopathy. Ophthalmology in Russia. 2021;18(2):228-233. (In Russ.) https://doi.org/10.18008/1816-5095-2021-2-228-233