Preview

Ophthalmology in Russia

Advanced search

Features of Optical Coherence Tomography of the Optic Nerve Head in Patients with High Myopia

https://doi.org/10.18008/1816-5095-2025-4-914-918

Abstract

The article provides a detailed description of a unique clinical case in which a patient with cutaneous malignant melanoma of the lower extremity developed a rare and serious neurological complication — paraneoplastic syndrome (PNS), which affected the optic nerve. The key manifestation of this syndrome was optic neuropathy — damage to the optic nerve, which clinically presented as optic disc edema, identified during ophthalmoscopic examination. This case demonstrates how cancer can manifest with or be accompanied by severe complications in organs distant from the primary tumor, necessitating increased vigilance from physicians.

About the Authors

E. Yu. Krasyuk
Tambov ophthalmological university hospital
Russian Federation

Krasyuk Elena Yu. - PhD, chief physician.

Ryleeva str., 82, Tambov, 392024



O. G. Noskova
Tambov ophthalmological university hospital
Russian Federation

Noskova Olga G. - deputy chief physician.

Ryleeva str., 82, Tambov, 392024



E. G. Tokareva
Tambov ophthalmological university hospital
Russian Federation

Tokareva Elena G. – ophthalmologist.

Ryleeva str., 82, Tambov, 392024



References

1. Evtushenko SK. Paraneoplastic neurological syndromes (clinic, diagnostic, treatment). International Neurological Journal. 2011;8(46):9–21 (In Russ.).

2. Shakirova IN. Paraneoplastic syndromes. Journal of Neurology and Psychiatry. C.C. Korsakov 1999;10:55–62 (In Russ.).

3. Ripps H, Carr RE, Siegel IM, Greenstein VS. Functional abnormalities in vincristine induced night blindness. Invest. Ophthalmol. Vis. Sci. 1984;7(25):787–794.

4. Likhvantseva VG. Paraneoplastic ophthalmological syndromes. Palliativnaya meditsina i reabilitatsiya. 2002;4:25–31 (In Russ.).

5. Yoshino Y, Akiyama S, Ouchi K. Acute exacerbation of paraneoplastic neurological syndrome after massive tumor lysis of neuroendocrine carcinoma by chemoradiotherapy. Int. Cancer Conf. J. 2013;4(2):247–250. doi: 10.1007/s13691-0130100-3.

6. Wiggs JL, Albert DM, Jacobiech FA. Ocular syndromes associated with malignancy. In: Principles and Practice of Ophthalmology: Clinical Practice. Philadelphia: Saunders; 1994:3350–3355.

7. Heinemann S, Zabel P, Hauber HP. Paraneoplastic syndromes in lung cancer. Cancer Ther. 2008;6:687–698.

8. Rush JA. Paraneoplastic retinopathy malignant melanoma. Am. J. Ophthalmol. 1993;115(3):390–391. doi: 10.1016/s0002-9394(14)73594-9.

9. Keltner JL, Thirkill CE, Tyler NK, Roth AM. Management and monitoring of cancer associated retinopathy. Arch. Ophthalmol. 1992;110(1):48–53. doi: 10.1001/archopht.1992.01080130050025.

10. Ohkawa T, Kawashima H, Makino S., Shimizu Y, Shimizu H, Sekiguchi I, Tsuchida S. Cancer associated retinopathy in patient with endometrial cancer. Am. J. Ophthalmol. 1996;122(5):740–742. doi: 10.1016/s0002-9394(14)70501-x.

11. Tenti P, Aguzzi A, Riva C., Usellini L, Zappatore R, Bara J, Samloff IM, Solcia E. Ovarian mucinous frequently express markers of gastric, intestinal and pancreatic biliary epithelial cells. Cancer. 1992;69(8):2131–2142. doi: 10.1002/1097-0142(19920415)69:8<2131::aidcncr2820690820>3.0.co;2-a.

12. Santacrose L, Balducci L, Diomede L. Paraneoplastic Syndromes. Medscape Reference. 2014. Available at: http://emedicine.

13. Ikawa M, Kuriyama M. Paraneoplastic retinopathy and optic neuropathy. Brain Nerve. 2010;62(4):371–376.

14. Biousse V, Kerrison JB. Walsh and Hoyt’s Clinical Neuro-oph-thalmology. 6th Ed. 2004; Vol. 2.

15. Graus F, Delattre JY, Antoine JC. et al. Recommended diagnostic criteria for paraneoplastic neurological syndromes. J. Neurol. Neurosurg. Psychiatry. 2004;75(8):1135–1140. doi: 10.1136/jnnp.2003.034447.


Review

For citations:


Krasyuk E.Yu., Noskova O.G., Tokareva E.G. Features of Optical Coherence Tomography of the Optic Nerve Head in Patients with High Myopia. Ophthalmology in Russia. 2025;22(4):914-918. (In Russ.) https://doi.org/10.18008/1816-5095-2025-4-914-918

Views: 35


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1816-5095 (Print)
ISSN 2500-0845 (Online)