PERSONALIZED (LOCAL) UV-CROSSLINKING AS A TREATMENT OF KERATOCONUS AND CORNEAL ECTASIA
https://doi.org/10.18008/1816-5095-2017-3-195-199
Abstract
There is no doubts that problem of keratoconus treatment is high relevant. The number of diagnosed ectasia, including iatrogenic ectasia, increased — in recent years. The amount of post-LASIK and ectasia after RK in late postoperative period multiplies significantly. It is associated not only with inception of new ways of treatment into practice, but also with the upgrade of diagnostic methods and equipment. A new method of local personalized crosslinking (LCXL) was integrated into clinical practice using Laplace’s equation, pachymetry and topography maps data, It exceeds usual Dresden protocol on several parameters. This article shows the reaction of patients’ eyes on the treatment and the effectiveness of technique is provided. Materials and methods: topographic indications were evaluated (Orbscan II (B+L)) of 28 patients (40 eyes) aged 18 — 44 with keratoconus stages I-IV (12 eyes — I stage; 16 eyes — II stage; 9 eyes — III stage; 3 eyes — IV stage classified by Abugova T.D.), as well as UCVA, BCVA for 12 months after surgery. Normal values were estimated by characteristics of 30 eyes without any refractive errors. Results: LCXL is an effective way of treatment of corneal ectasia; it’s more effective in early stages. This technique has a strong controlled refractive impact and allows to reduce inflammatory after procedure.
About the Authors
S. I. Anisimov
Moscow State Medical and Dental University named A.I. Evdokimov; ООО Eye Center «East Sight Recovery»
Russian Federation
Russian Federation
professor, MD; Delegatskaya Str., 20/1, Moscow, 127473, Russia; B.Tishinskiy per., 38, Moscow, 123557, Russia
S. Y. Anisimova
Moscow State Medical and Dental University named A.I. Evdokimov
Russian Federation
professor, MD; Delegatskaya Str., 20/1, Moscow, 127473, Russia
Russian Federation
professor, MD; Delegatskaya Str., 20/1, Moscow, 127473, Russia
A. S. Mistryukov
Moscow State Medical and Dental University named A.I. Evdokimov; ООО Eye Center «East Sight Recovery»
Russian Federation
Postgraduate; Delegatskaya Str., 20/1, Moscow, 127473, Russia; B.Tishinskiy per., 38, Moscow, 123557, Russia
Russian Federation
Postgraduate; Delegatskaya Str., 20/1, Moscow, 127473, Russia; B.Tishinskiy per., 38, Moscow, 123557, Russia
References
1. Wollensak G., Spoerl E., Seiler T. Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Cornea. 2003;5(135):620–627.
2. Spoerl E., Mrochen M., Sliney D., Trokel S., Seiler T. Safety of UVA-Riboflavin Cross-Linking of the Cornea. Cornea. 2007;4 (26):385–389. doi: 10.1097/ ICO.0b013e3180334f78.
3. Sorkin N., Varssano D. Corneal Collagen Crosslinking: A Systematic Review. Issue 1. Ophthalmologica. 2014;1(232):10–27. doi: 10.1159/000357979.
4. Raiskup F, Theuring A, Pillunat LE, Spoerl E. [Corneal collagen crosslinking with riboflavin and ultraviolet-A light in progressive keratoconus: ten-year results]. Journal of Cateract and Refractive Surgery. 2015:1(41):41–6. doi: 10.1016/j. suronc.2014.12.002.
5. Jones-Jordan L.A., Walline J.J., Sinnott L.T., Kymes S.M., Zadnik K. Asymmetry in Keratoconus and Vision-Related Quality of Life. Cornea. 2013;3(32):267–272. doi: 10.2147/OPTH.S44741
6. Piñero D.P., Alio J.L., Barraquer R.I., Michael R. Corneal Biomechanical Changes After Intracorneal Ring Segment Implantation in Keratoconus. Cornea. 2012;5(31):491–499. doi: 10.1097/ICO.0b013e31821ee9f4
7. Zadok D., Schwarts S., Marcovich A., Barkana Y., Morad Y., Eting E., Avni I. Penetrating Keratoplasty for Keratoconus: Long-Term Results. Cornea. 2005;8(24):959–961.
8. Bhatt U.K., Fares U., Rahman I., Said D.G., Maharajan S.V., Dua H.S. Outcomes of deep anterior lamellar keratoplasty following successful and failed ‘big bubble’. British Journal of Ophthalmology. 2014;4(96):564–9. doi:10.1136/ bjophthalmol-2015-306686.
9. Alnawaiseh M., Rosentreter A., Böhm M.R.R., Eveslage M., Eter N., Zumhagen L. Accelerated (18 mW/cm2 ) Corneal Collagen Cross-Linking for Progressive Keratoconus. Cornea. 2015;11(34):1427-1431. doi: 10.1097/ICO.0000000000000578
10. Elbaz U., Shen C., Lichtinger A., Zauberman N.A., Goldich Y., Chan C.C., Slomovic A.R., Rootman D.S. [Accelerated (9-mW/cm2) corneal collagen crosslinking for keratoconus-A 1-year follow-up]. Cornea. 2014;8(33):769–73. doi: 10.1097/ ICO.0000000000000154.
11. Cınar Y., Cingü A.K., Türkcü F.M., Çınar T., Yüksel H., Özkurt Z.G., Çaça I. Comparison of accelerated and conventional corneal collagen cross-linking for progressive keratoconus. Cutaneous and Ocular Toxicology. 2014;3(33):218–22.
12. Нестеров А.П., Бунин А.Я., Кацнельсон Л.А. Внутриглазное давление. Физиология и патология. Москва, Наука, 1974. [Nesterov A.P., Bunin A.Ya., Katsnel’son L.A. Intraocular pressure. Physiology and pathology. Moscow, Nauka, 1974. (in Russ.)
13. Greenstein S.A., Fry K.L., Bhatt J., Hersh P.S. Natural history of corneal haze after collagen crosslinking for keratoconus and corneal ectasia: Scheimpflug and biomicroscopic analysis. Journal of Cataract and Refractive Surgery. 2010;12(36):2105–14. doi: 10.1016/j.jcrs.2010.06.067.
Review
For citations:
Anisimov S.I., Anisimova S.Y., Mistryukov A.S. PERSONALIZED (LOCAL) UV-CROSSLINKING AS A TREATMENT OF KERATOCONUS AND CORNEAL ECTASIA. Ophthalmology in Russia. 2017;14(3):195-199. (In Russ.) https://doi.org/10.18008/1816-5095-2017-3-195-199
Views:
2040
Email this article 