Topographic Localization of the Demarcation Line after UV Corneal Crosslinking in Progressive Keratoconus
https://doi.org/10.18008/1816-5095-2018-1-32-37
Abstract
Purpose: To assess the topographic location of the demarcation line in in different areas of the cornea after standard corneal crosslinking.
Patients and methods. 12 patients (15 eyes) with keratoconus of stages 1–2 of Amsler-Kruimerich classification were observed. UV cross-linking was performed in all patients according to the standard Dresden protocol with 0.1% aqueous solution of riboflavin. The patients underwent optical coherence tomography of the anterior segment of the eye on “DRI OCT Triton” (“Topcon”, Japan) in different areas of the cornea to assess the location of the demarcation line. Results. Demarcation line was revealed in
1 month after standard corneal cross-linking in most cases (87%). Biomicroscopy showed that DL limited the anterior and middle
laers of the stroma from the posterior one. The stromal demarcation line depth according to OCT averaged 305.73 ± 41.08 μm (range of 282–345 μm) at the center, nasally — 215.16 ± 35.5 μm (range of 160–289 μm) and temporally 205,23 ± 32.81 μm (range of 190–276 μm). A significant difference in the depth of DL localization in the central zone of the cornea and a 6 mm zone (p < 0.001) was noted. Conclusion. The corneal stromal (обычно) demarcation line is one of the indicators of the depth of photochemical process of corneal cross-linking. Optimal timing of detection of DL following corneal collagen crosslinking is 2 weeks — 3 months. The depth of DL in the corneal studied areas is different; it is deeper in the central zone than in the peripheral ones.
About the Authors
M. M. Bikbov
Ufa Eye Research Institute
Russian Federation
MD, professor, Head
Russian Federation
MD, professor, Head
V. K. Surkova
Ufa Eye Research Institute
Russian Federation
MD, professor, Leading Research Officer
Russian Federation
MD, professor, Leading Research Officer
A. R. Khalimov
Ufa Eye Research Institute
Russian Federation
PhD, Head of Department
Russian Federation
PhD, Head of Department
E. L. Usubov
Ufa Eye Research Institute
Russian Federation
PhD, Leading Research Officer
Russian Federation
PhD, Leading Research Officer
L. I. Khalimova
Ufa Eye Research Institute
Russian Federation
Junior Research Officer
Russian Federation
Junior Research Officer
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Review
For citations:
Bikbov M.M., Surkova V.K., Khalimov A.R., Usubov E.L., Khalimova L.I. Topographic Localization of the Demarcation Line after UV Corneal Crosslinking in Progressive Keratoconus. Ophthalmology in Russia. 2018;15(1):32-37. (In Russ.) https://doi.org/10.18008/1816-5095-2018-1-32-37
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