Studying the role of thyroid hormone receptor expression in the lacrimal gland in the autoimmune orbitopathy
https://doi.org/10.18008/1816-5095-2013-3-21-25
Abstract
Purpose: To explore the role of thyroid hormone’ receptors in the development of the autoimmune process in orbita.
Methods: The intraoperative biopsy material of the lacrimal gland obtained from orbital decompression in patients with autoimmune orbitopathy (AOP) was studied and compared with biopsy material of normal lacrimal gland.
Results: The expression of isoforms of thyroid hormone’ receptors in various cellular elements of the lacrimal gland is improved in normal, as well as change their expression when the AOP. This process is associated with change of structure of the lacrimal gland and organ infiltration cells.
Conclusion: The findings support the assumption that the lacrimal gland is the target organ, along with orbital and muscles for autoimmune aggression in the AOP.
About the Authors
V. G. Likhvantseva
ФФМ МГУ имени М. В. Ломоносова
Russian Federation
Russian Federation
O. A. Gontyurova
ФГБУ Институт глазных болезней РАМН
Russian Federation
Russian Federation
E. A. Rudenko
ФФМ МГУ имени М. В. Ломоносова
Russian Federation
Russian Federation
T. N. Saphonova
ФГУ Эндокринологический научный центр Росмедтехнологий
Russian Federation
Russian Federation
K. A. Kuzmin
ФФМ МГУ имени М. В. Ломоносова
Russian Federation
Russian Federation
N. Y. Sviridenko
ФФМ МГУ имени М. В. Ломоносова
Russian Federation
Russian Federation
References
1. Бровкина А. Ф Эндокринная офтальмопатия// ГЭОТАР-МЕД. — 2008. — 178 стр.
2. Bahn Rebecca S. Pathogenesis of Graves ophthalmopathy: the role of orbital thyroid-stimulating hormone receptor expression Current Opinion in Endocrinology & Diabetes: October 2003 — Volume 10 — Issue 5 — pp 353‑356.
3. Conley CA, Fowler VM. Localization of the human 64kD autoantigen D1 to myofibrils in a subset of extraocular muscle fibers. Curr Eye Res. — 1999. — Oct;19 (4):313‑22.
4. De Bellis A, Sansone D, Coronella C, Conte M, Iorio S, Perrino S, Serum antibodies to collagen XIII: a further good marker of active Graves’ ophthalmopathy.//ClinEndocrinol (Oxf). — 2005 — Jan;62 (1):24‑9.
5. Goh S. Y., S. C. Ho, L. L. Seah, K. S. Fong, D. H. C. Khoo Thyroid autoantibody profiles in ophthalmic dominant and thyroid dominant Graves’ disease differ and suggest ophthalmopathy is a multiantigenic disease. Clinical Endocrinology. —May 2004, — Vol. 60, No. 5: 600‑607.
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For citations:
Likhvantseva V.G., Gontyurova O.A., Rudenko E.A., Saphonova T.N., Kuzmin K.A., Sviridenko N.Y. Studying the role of thyroid hormone receptor expression in the lacrimal gland in the autoimmune orbitopathy. Ophthalmology in Russia. 2013;10(3):21-25. (In Russ.) https://doi.org/10.18008/1816-5095-2013-3-21-25
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