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Ингибиторы карбоангидразы в лечении глаукомы. Обзор. Часть 1

https://doi.org/10.18008/1816-5095-2020-3S-542-549

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Аннотация

Глаукома — главная причина необратимой слепоты в мире. Ингибиторы карбоангидразы (ИКА), применяемые как системно, так и местно, эффективно снижают внутриглазное давление. В отличие от системных ИКА, 2%-ный дорозоламид и 1%-ный бринзоламид, проникая глубоко в ткани глаза, не приводят к системным эффектам, а поэтому эти  препараты нашли широкое применение в лечении глаукомы. В обзоре приводится характеристика различных изоформ карбоангидразы, рассмотрены механизмы действия препаратов, направленные на ее блокирование, анализируются результаты различных исследований по эффектам 2%-го дорозоламида и 1%-го бринзоламида, а также их фиксированных комбинаций. Рассмотрены эффекты ИКА как в качестве монотерапии, так и в сочетании с другими антиглаукомными препаратами. Представлен анализ данных о влиянии ИКА на глазной кровоток.

Об авторе

Н. И. Курышева
Медико-биологический университет инноваций и непрерывного образования ФГБУ ГНЦ РФ «Федеральный биофизический центр им. А.И. Бурназяна» Федерального медико-биологического агентства России; Консультативно-диагностический отдел Центра офтальмологии Федерального медико-биологического агентства, клиническая больница № 86
Россия

доктор медицинских наук, профессор, заведующая кафедрой, руководитель консультативно‑диагностического отдела

ул. Гамалеи, 15, Москва, 123098, Российская Федерация



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Для цитирования:


Курышева Н.И. Ингибиторы карбоангидразы в лечении глаукомы. Обзор. Часть 1. Офтальмология. 2020;17(3s):542-549. https://doi.org/10.18008/1816-5095-2020-3S-542-549

For citation:


Kurysheva N.I. Carbonic Anhydrase Inhibitors in the Treatment of Glaucoma. Review. Part I. Ophthalmology in Russia. 2020;17(3s):542-549. (In Russ.) https://doi.org/10.18008/1816-5095-2020-3S-542-549

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