Preview

Ophthalmology in Russia

Advanced search

Individual Approach to the Treatment of Complicated Forms of Blepharitis: from Theory to Practice

https://doi.org/10.18008/1816-5095-2020-4-830-837

Abstract

High prevalence of blepharitis, multifactorial etiology and chronic course with the possibility of serious complications, including conjunctivitis, multiple chalazions, keratitis, dry eye syndrome — cause significant difficulties in the treatment of this disease. Prescribing treatment of the process only in case of exacerbation with the use of even modern antimicrobial and anti-inflammatory drugs gives only a short-term effect.

The aim is to present the clinical features of the blepharitis of different localization and the choice of the optimal treatment algorithm on the example of specific clinical cases. The article presents current data on the classification, etiology and mechanism of blepharitis development. Based on a detailed description of two clinical cases of blepharitis, the features of the clinical course, the range of necessary examinations and consultations of specialists are presented. The first case describes blepharitis associated with the severe rosacea in a teenager with a typical complication in the form of rosacea — keratitis. The second case is devoted to the features of the posterior blepharitis clinical course with meibomian gland dysfunction, complicated by multiple chalazions. The article explains in detail the stages of prescribing various medications, including eyelid hygiene, antibacterial, anti-inflammatory therapy and artificial tears, discusses possible side effects of the therapy and ways to restore the eye surface.

Conclusion. The basis of blepharitis treatment is regular three-component eyelid hygiene. In case of exacerbation it is advisable to prescribe antibacterial and anti-inflammatory drugs, taking into account the sensitivity and ability to destroy microbial biofilms. In order to increase patient adherence to treatment, the choice of hygiene products and moisturizing drops should take into account the tolerability of the drug and the convenience of its use. 

About the Authors

E. A. Drozdova
South-Ural State Medical University
Russian Federation

MD, Professor of the eye diseases department,

Vorovsky str., 64, Chelyabinsk, 454092



E. V. Mikhailova
Children’s city clinical hospital No. 1
Russian Federation

head of the ophthalmology department,

Gorkogo str., 28, Chelyabinsk, 454007



References

1. Schaumberg D.A., Nichols J.J., Papas E.B., Tong L., Uchino M., Nichols K.K. The International Workshop on Meibomian Gland Dysfunction: report of the subcommittee on the epidemiology of, and associated risk factors for, MGD. Invest Ophthalmol Vis Sci. 2011;52(4):1994–2005. DOI: 10.1167/iovs.10-6997e

2. McDonald M.B. The patient’s experience of blepharitis. Ocul Surf. 2009;7(2):17–18. DOI: doi.org/10.1016/S1542-0124(12)70622-5

3. Viswalingam M., Rauz S., Morlet N., Dart J.K. Blepharokeratoconjunctivitis in children: diagnosis and treatment. Br J Ophthalmol. 2005;89(4):400–403. DOI: 10.1136/ bjo.2004.052134

4. Speaker M.G., Milach F.A., Shah M.K., Eisner W., Kreiswirth B.N. Role of external bacterial flora in the pathogenesis of acute postoperative endophthalmitis. Ophthalmology. 1991;98(5):639–649. DOI: 10.1016/s0161-6420(91)32239-5

5. Yani E.V., Seliverstova K.E. Complex therapy of inflammatory diseases of the eyelids. Russian ophthalmological journal = Rossiyskiy oftal’mologicheskiy zhurnal. 2016;9(3):91–93 (In Russ.). DOI: 10.21516/2072-0076-2016-9-391-93

6. McCulley J.P., Dougherty J.M., Deneau D.G. Classification of chronic blepharitis. Ophthalmology.1982;89(10):1173–1180. DOI: 10.1016/s0161-6420(82)34669-2

7. Lemp M.A., Mahmood M.A., Weiler H.H. Association of rosacea and keratoconjunctivitis sicca. Arch Ophthalmol. 1984;102(4):556–557. DOI: 10.1001/archopht.1984.01040030434019

8. Shurubei V.A., Teplyuk N.P., Smirennaya E.V. Clinical manifestations and treatment of blepharitis and Dry eye syndrome in rosacea. Cataract and refractive surgery = Kataraktal’naya i refraktsionnaya khirurgiya. 2014;14(2):38–44 (In Russ.).

9. Ficker L., Ramakrishnan M., Seal D., Wright P. Role of cell-mediated immunity to staphylococci in blepharitis. Am J Ophthalmol. 1991;111(4):473–479. DOI: 10.1016/s0002-9394(14)72383-9

10. Wu E.C., Kowalski R.P., Romanowski E.G., Mah F.S., Gordon Y.J., Shanks R.M.Q. AzaSite® Inhibits Staphylococcus aureus and Coagulase-Negative Staphylococcus Biofilm Formation In Vitro. J Ocul Pharmacol Ther. 2010;26(6):557–562. DOI: 10.1089/jop.2010.0097

11. Safonova T.N., Kintyukhina N.P., Petrenko A.E., Gladkova O.V., Sidorov V.V. Treatment of chronic blepharitis. Prevention of dry eye syndrome in chronic blepharitis of demodectic etiology. Russian Medical Journal. Clinical Ophthalmology = Rossijskij medicinskij zhurnal. Klinicheskaya oftal’mologiya. 2016;16(2):89–93 (In Russ.). DOI: 10.21689/2311-7729-2016-16-2-89-93

12. Liu J., Sheha H., Tseng S.C. Pathogenic role of Demodex mites in blepharitis. Curr Opin Allergy Clin Immunol. 2010;10(5):505–10. DOI: 10.1097/ACI.0b013e32833df9f4

13. Koo H., Kim T.H., Kim K.W., Wee S.W., Chun Y.S., Kim J.C. Ocular surface discomfort and Demodex: effect of tea tree oil eyelid scrub in Demodex blepharitis. J Korean Med Sci. 2012;27(12):1574–1579. DOI: 10.3346/jkms.2012.27.12.1574

14. Nicholls S.G., Oakley C.L., Tan A., Vote B.J. Demodex species in human ocular disease: new clinicopathological aspects. Int Ophthalmol. 2017;37(1):303–312. DOI: 10.1007/s10792-016-0249-9

15. Donaldson K.E., Karp C.L., Dunbar M.T. Evaluation and treatment of children with ocular rosacea. Cornea. 2007;26(1):42–46. DOI: 10.1097/ ICO.0b013e31802e3a54

16. Deeks E.D. Ivermectin: a review in rosacea. Am J Clin Dermatol. 2015;16(5):447– 452. DOI: 10.1007/s40257-015-0150-8

17. Trubilin V.N., Polunina E.G., Markova E.Yu., Kurenkov V.V., Kapkova S.G. Therapeutic hygiene of the eyelids in algorithms for the prevention and treatment of diseases of the eye surface. р. 1. Оphthalmology in Russia = Oftal’mologiya. 2016;13(2):122– 127 (In Russ.). DOI: 10.18008/1816-5095-2016-2-122-127

18. Behlau I., Gilmore M.S. Microbial biofilms in ophthalmology and infectious disease. Arch. Ophthalmol. 2008;126:1572–1581. DOI: 10.1001/archopht.126.11.1572

19. Luchs J. Efficacy of topical azithromycin ophthalmic solution 1% in the treatment of posterior blepharitis. Adv. Ther. 2008;25:858–870. DOI: 10.1007/s12325-008-0096-9

20. Okolov I.N. Monitoring the antimicrobial activity of antiseptic eye drops. Ophthalmology journal = Oftal’mologicheskie vedomosti. 2019;12(3):67–74 (In Russ.).

21. Luyckx J., Baudouin C. Trehalose: an intriguing disaccharide with potential for medical application in ophtalmology. Clinical Ophtalmology. 2011;5:577–581. DOI: 10.2147/OPTH.S18827

22. Wladis E.J., Bradley E.A., Bilyk J.R., Yen M.T., Mawn L.A. Oral Antibiotics for Meibomian Gland-Related Ocular Surface Disease: A Report by the American Academy of Ophthalmology. Ophthalmology. 2016;123:492–496. DOI: 10.1016/j.ophtha.2015.10.062

23. Aleksandrova O.I., Okolov I.N., Khorol’skaya Yu.I., Panova I.E., Blinova M.I. Evaluation of the cytotoxicity of tear replacement drugs using the in vitro system. Оphthalmology in Russia = Oftal’mologiya 2017;14(1):59–66. (In Russ.). DOI: 10.18008/1816-50952017-1-59-66


Review

For citations:


Drozdova E.A., Mikhailova E.V. Individual Approach to the Treatment of Complicated Forms of Blepharitis: from Theory to Practice. Ophthalmology in Russia. 2020;17(4):830-837. (In Russ.) https://doi.org/10.18008/1816-5095-2020-4-830-837

Views: 1362


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1816-5095 (Print)
ISSN 2500-0845 (Online)