Structure of Oncological Pathology and Survival of Patients with Malignant Tumors of the Eye and Adnexa (C69) Taking into Account Sex, Age and Histological Characteristics (Population Study)

Objective. In February 2019, we completed work on creating a unified database of the population cancer registry of the NorthWestern Federal district of the Russian Federation. The development of data on the material of a large area significantly increases the reliability of the material under study, especially for RARE localities of malignant tumors, which include tumors of the eye and and adnexa.For the first time in Russia to present an analysis of the effectiveness of anti-cancer activities in relation to malignant tumors of the eye and adnexa (C69) at the Federal district level with calculations of 5-year survival rates of patients taking into account sex, age and histological structure of tumors.

Methods. The development of the 5-year survival rate of patients with malignant tumors of the eye (C69) included information from the database created by us Population cancer register of all administrative territories of the North-Western Federal district of Russia for the period from 1999 to 2013, more than 1000 observations (1022).

Results. The study revealed a positive dynamics of survival in patients of the North-Western Federal district of Russia with malignant tumors of the eye. The 5-year survival rate increased among males from 58.8 to 63.1 %, and among females from 64.7 to 69.6 %. A significant overestimation of the proportion of early stages among primary patients with malignant tumors of the eye and adnexa (C69) was found, which may be due to medical errors. Calculations of patient survival (with careful tracking of the deceased) allow us to get a more objective picture.

Conclusion. Excellent achievements in the treatment of patients of advanced research centers and institutes can be welcomed only if similar successes are recorded at the population level and are available to all patients. Our in-depth development of population data in the Federal district confirmed the success in the treatment of patients with the malignant tumors of the eye and adnexa (C69), and the patterns we found first in the database of the Population cancer register of St. Petersburg, and now in the North-Western Federal district of the Russian Federation. Similar studies in other Federal districts could be an important component in the planning, monitoring and evaluation of anti-cancer measures in relation to the malignant tumors of the eye and adnexa (C69).

1. Merabishvili V.M., Merabishvili E.N. Malignant tumors of the eye and adnexa, morbidity, mortality (population-based study). Ophthalmology in Russia = Oftal’mologiya 2012;9(3):71–76.(In Russ.). DOI: 10.18008/1816-5095-2012-3-71-76

2. Merabishvili V.M., Merabishvili E.N. Survival of patiens with malignant tumors of the eye by sex, age and histological structure of neoplasms. Ophthalmology in Russia = Oftal’mologiya. 2016;13(1):38–43 (In Russ.). DOI: 10.18008/18165095-2016-1-38-43

3. Merabishvili V.M. Survival of cancer patients. Saint-Petersburg: KOSTA, 2006. 440 р. (In Russ.). https://www.niioncologii.ru/science/protivorak/science-works

4. Merabishvili V.M. Survival of cancer patients. Issue 2. P. 1. Saint-Petersburg: KOSTA, 2011. 332 р. (In Russ.). https://www.niioncologii.ru/science/protivorak/science-works

5. Merabishvili V.M. Cancer in the North-West Federal Region of Russia (morbidity, mortality, prevalence rate, survival). Express-information. Is. 1. Saint-Petersburg: Ladoga, 2014. 138 р. (In Russ.). https://www.niioncologii.ru/science/protivorak/science-works

6. Merabishvili V.M. Malignant tumors in the North-West Federal Region of Russia (morbidity, mortality, prevalence rate, survival). Express-information. Is. 3. Saint-Petersburg: Izdatel’skie tekhnologii, 2017. 282 р. (In Russ.). https://www.niioncologii.ru/science/protivorak/science-works

7. Merabishvili V.M. Malignant tumors in the North-West Federal Region of Russia (morbidity, mortality, prevalence rate, survival). Expressinformation. Is. 4. Saint-Petersburg: Izdatel’skie tekhnologii, 2018. 444 р. (In Russ.)] https://www.niioncologii.ru/science/protivorak/science-works

8. Belyaev A.M., Merabishvili V.M. Methodological approaches to the analysis of the activities of the cancer service based on state reporting forms and the created database of the population cancer register of the North-West Federal district of the Russian Federation. P. 1. Problems in oncology = Voprosy onkologii. 2019;65(5):653–663 (In Russ.).

9. Merabishvili V.M., Belyaev A.M. Methodological approaches to the analysis of cancer services based on state reporting forms and a database created in the population cancer register of the North-West Federal district of the Russian Federation. P. 2. Problems in oncology = Voprosy onkologii. 2019;65(6):807–815 (In Russ.).

10. Kaprin A.D., Starinskii V.V., Petrova G.V., eds. Malignant tumors in Russia in 2018 (morbidity and mortality). Moscow: MNIOI im. P.A. Gertsena, 2019. 250 р. (In Russ.).

11. Sant M., Aareleid T., Berrino F., Bielska Lasota M., Carli P.M., Faivre J., Grosclaude P., Hedelin G., Matsuda T., Moller H., Moller T., Verdecchia A., Capocaccia R., Gatta G., Micheli A., Santaquilani M., Roazzi P., Lisi D., eds. Eurocare-3: survival of cancer diagnosed 1990–1994, results and commentary. Annals of Oncology. 2003;14(5):v61–118. DOI: 10.1093/annonc/mdg754

12. Sant M., Allemani C., Santaquilani M., Knijn A., Marchesi F., Capocaccia R., eds. Eurocare-4. Survival of Cancer patients diagnosed in 1995–1999. Results and commentary. European Journal of Cancer. 2009;45(6):931–991. DOI: 10.1016/j.ejca.2008.11.018

13. Kaprin A.D., Starinskii V.V., Petrova G.V., eds. State of cancer care in Russia in 2018. Moscow: MNIOI im. P.A. Gertsena.2018. 250 p. (In Russ.).