Antioxidant activity of dorzolamide/timolol fixed combination in neuroprotective therapy in glaucoma
https://doi.org/10.18008/1816-5095-2012-4-47-51
Abstract
Purpose: to study the antioxidant activity of carbonic anhydrase inhibitors and timolol fixed combinations and to compare it with other fixed combinations.
Methods: Antioxidant activity (AOA) of dorzolamide/timolol (Cosopt), dorzolamide/timolol (Dorzopt Plus), latanoprost/timolol, brimonidine/timolol, travoprost/timolol and bimatoprost/timolol fixed combinations was measured in vitro using the model of oxida- tive hemolysis.
Results: Dorzolamide/timolol (Cosopt) AOA was higher than that of other fixed combinations and increased with the quantity of the drugs added to the model system: 40%, 52% and 75% in 30 μl, 60 μl and 90 μl respectively.
Conclusion: these findings suggest that dorzolamide/timolol fixed combination has potential advantages over the other fixed combinations due to its high antioxidant activity and might be used as the neuroptotective agent for glaucoma treatment.
About the Authors
N. I. Kurysheva
Центр офтальмологии ФМБА России
Russian Federation
Russian Federation
O. A. Azizova
НИИ физико-химической медицины ФМБА России, Москва
Russian Federation
Russian Federation
A. P. Piryazev
НИИ физико-химической медицины ФМБА России, Москва
Russian Federation
Russian Federation
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Review
For citations:
Kurysheva N.I., Azizova O.A., Piryazev A.P. Antioxidant activity of dorzolamide/timolol fixed combination in neuroprotective therapy in glaucoma. Ophthalmology in Russia. 2012;9(4):47-51. (In Russ.) https://doi.org/10.18008/1816-5095-2012-4-47-51
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