Novel complex therapy of autumnal allergic blepharoconjuctivitis

Aim. To assess the effectivity of autumnal allergic blepharoconjuctivitis complex therapy.

Methods. 25 autumnal allergic blepharoconjuctivitis patients (50 eyes) were examined before and after complex treatment that included olopatadine hydrochloride 1 mg / ml (instillations 2 times a day), cetirizine 10 mg (1 tablet a day), and steroid drug (insufflations 2 times a day). Dry eye patients additionally received hyaluronic acid 1 mg / ml (instillations 2 times a day). 10 controls (20 eyes) were prescribed only the above-mentioned treatment. In 15 study group patients (30 eyes), Blepharogel 1 was applied on lid margins. Routine eye examination, clinical symptom assessment, Schirmer’s and Norn’s tests, xerosis meter and lissamine green staining evaluation, and anterior segment photography with computed morphometry were performed.

Results. Compositae allergy was diagnosed in all patients. Dry eye due to tear film instability, lipid deficiency, and mucin deficiency and epitheliopathy were diagnosed in 55 %, 35.5 % and 28.3 %, respectively. In study group, the treatment significantly and rapidly reduced patient-reported symptoms and blepharoconjunctivitis signs as well as significantly improved tear stability, lipid deficiency, mucin deficiency, and epitheliopathy as compared with controls.

Conclusion. Blepharogel 1 as a component of complex therapy increases the efficacy of autumnal allergic blepharoconjuctivitis treatment.

1. Avetisov S. E., Egorov E. A., Moshetova L. K., Neroev V. V., Tahchidi H. P. Ed. [Ophthalmology: national manual]. Oftal’mologija: nacionalnoe rukovodstvo. Moscow, GEOTAR-Media, 2014. 736 p. (in Russ.).

2. Maichuk Yu. F. [Allergic diseases of the eye] Allergicheskie zabolevaniya glaz. Russkij medicinskij zhurnal [Russian Medical Journal]. 1999; 7 (1): 20. (In Russ.).

3. Maichuk D. Yu. [Modern possibilities of therapeutic treatment of allergic conjunctivitis] Sovremennie voznozhnosti terapevticheskogo lecheniya allergicheskih con’yuctivitov. [Ophthalmology]. Oftal’mologija 2014; 11 (2): 19‑26 (In Russ.).

4. Haitov R. M., Ignatieva G. A., Sidorovich I. G. [Immunology] Immunologiya. Moscow; 2000, 430 p. (in Russ.).

5. Abah E. R., Oladigbolu K. K., Samaila E., Gani-Ikilama A. Ocular disorders in children in Zaira children,s school. Nigerian J of Cl Pract. 2011; 14 (4): 473‑476.

6. Alamaliotis D., Michailopoulos P., Gioulekas D., Giouleka P., Papakosta D., Siempis T., Karampatakis V. Allergic conjunctivitis and the most common allergens in Northern Greece. WAО J. 2013; 6: 12.

7. Calderon M. A., Demoly P., Gerk van Wijk R., Bousquet J., Sheikh A. et al. EAACI: A European Declaration on Immunotherapy. Clinical and Translational Allergy. 2012; 2:20. Available at: http://www.ctajournal.com / content / 2 / 1 / 20

8. Katelaris C. Ocular allergy in the Asia Pacific region. Asia Pacific region. 2011; 1: 108‑114.

9. Singla J. P., Parashr Y. Prevalence of allergic rhinitis, allergic conjunctivitis and dermatitis in children with recurrent wheeze. Indian Ped. 2009; 58 (3): 262.

10. Singh K., Bielory L. Occular allergy: a national epidemiological study. J Allergy Clin Immunol. 2007; 119 (1 Suppl 1): S154.

11. Singh K., Axelrod S., Bielory L. The epidemiology of ocular and nasal allergy in the United States (1988-1994). J Allergy Clin Immunol. 2010; 126: 778

12. Grigorieva V. V., Hanferyan R. A., Sundatova T. V. [Prevalence of allergic diseases in Krasnodar Region]. Rasprostranennost’ allergichskih zabolevaniy v Krasnoarskom kraye. [Kuban Research Medical Annals]. Kubanskiy nauchniy meditsinskiy nauchniy vestnic 2006; 84‑85 (3-4): 23‑27. (in Russ.).

13. Maichuk Yu. F. [Seasonal conjunctivitis — the most common form of eye allergies]. Sesonniy con’junctivit — naibolee tchastaya forma glaznih allergozov. [Russian Ophthalmological Journal]. Rossijskij oftal’mologicheskij zhurnal 2010; 1: 37‑41. (in Russ.).

14. Kovalevskaya M. A., Maichuk D. Yu., Brzheskiy V. V., Maichuk Yu. F. Sindrom «krasnogo glaza»: prakt.rukovodstvo [Red-eye syndrome: a practical manual]. Moscow, 2010. 108 p. (in Russ.).

15. Yanchenko S. V. [Age form of «dry eye»: incidence, risk factors]. Vozrastnaya forma suhogo glaza: rasprostranennost, factori riska. [Fund. research]. Fundamental’nye issledovanija 2010; 9: 7‑13. (in Russ.).

16. Egorov E. A., Alexeev V. N., Astahov Yu. S., Brzheskiy V. V., Ed. [Rational pharmacotherapy in ophthalmology]. Racional’naja farmakoterapija v oftal’mologii. Moscow, 2011. 1072 p. (in Russ.).

17. Polunin G. S., Safonova T. N., Fedorov A. A. [Clinical features of the various forms of dry eye — the basis for the development of adequate therapies]. Osobennosti clinicheskogo techeniya razlichnih form suhogo glaza — osnova dlya razrabotki adekvatnoy terapii. [Annals of ophthalmology]. Vestnik oftal’mologii 2006; (5): 17‑20 (in Russ.).

18. Polunin G. S., Zabegaylo A. O., Makarov A. A., Polunina E. G. [Effectiveness of eye lid hygiene in patients with blefarokonjunctival form of dry eye]. Effektivnost gigeni vek u pacientov s blefaroconyunktivalnoy formoy suhogo glaza. [Annals of ophthalmology]. Vestnik oftal’mologii 2011; (1):37‑41. (in Russ.).

19. Eremenko A. I., Yanchenko S. V. [Optimization of the demodex blefarits-relatid dry eye treatment]. Optimizaciya lechebnogo vozdeystviya u bolnih blefarokonyunktivalnoy formoy sindroma suhogo glaza demodekozoi etiologii. [Refractive surgery and ophthalmology]. Refrakcionnaja hirurgija i oftal’mologija 2010; 10 (3): 51‑56. (in Russ.).

20. Sakhnov S. N., Yanchenko S. V., Rudashova A. S., Malyshev A. V. [Non-infectious chronic blepharitis pharmacotherapy] Farmakoterapiya hronicheskogo blefarita neinfekcionnoy etiologii. [Ophthalmology]. Oftal’mologija 2013; 10 (3): 75‑79. (in Russ.).

21. Brzheskiy V. V., Somov E. E. Rogovichno-konjunktival’nyj kseroz (diagnostika, klinika, lechenie) [Corneal-conjunctival xerosis (diagnosis, clinical, treatment)]. SPb, 2003. 119 p. (in Russ.).

22. Korb D. R. The tear film — its role today and in the future. In The Tear Film, structure, function and examination. Butterworth-Heimann; 2002.

23. Bijesterveld O. P. Diagnostic tests in the sicca syndrome. Arch. Ophthalmol. 1969; 82: 10‑14.

24. Yanchenko S. V., Shipilov V. A., Sachnov S. N., Malyshev A. V., Exuzyan Z. A. Fiksator ustrojstva dlja poluchenija fotoizobrazhenij glaznoj poverhnosti [Locking device for producing photographic images of the ocular surface]: Patent RU 129393, priority 20.12.2012. (in Russ.).

25. Yanchenko S. V., Shipilov V. A., Sachnov S. N., Malyshev A. V., Exuzyan Z. A. Ocenka pokazatelja kseroza kon#junktivy i rogovicy glaza [Evaluation index xerosis of the conjunctiva and cornea] Certificate RU of state registration of computer program № 2013614392, priority 30.01.2013. (in Russ.).