Matrix Metalloproteinases in Predicting Nonproliferative Diabetic Retinopathy in Old Age

Abstract

The development of diabetic retinopathy is associated with matrix metalloproteinases, but they are rarely used to predict this pathology. The purpose of the study is to predict the development of nonproliferative diabetic retinopathy in old age based on the level of matrix metalloproteinases in blood plasma. The main group of the study consisted of 63 patients 60–74 years old with nonproliferative diabetic retinopathy, control consisted of 56 patients of the same age without the diabetic retinopathy and other ophthalmopathology at present and in history. Examination of patients in both groups included: tonometry, visiometry, standard fundus photography, optical coherence tomography, optical coherence tomography-A, fluorescence angiography. Determination of matrix metalloproteinases was carried out by the method of enzyme-linked immunosorbent assay. A statistically significant increase in matrix metalloproteinase was found — 9 in the main group of patients to 55,7 ± 2.6 ng / ml versus 40.2 ± 1.9 ng / ml in age control, matrix metalloproteinase — 2 to 269.8 ± 1.2 ng / ml versus 221.9 ± 3.6 ng / ml, respectively. Based on the level of matrix metalloproteinases — 2 (X₁) and (X₂) of the blood by the regressive method for predicting the development of diabetic retinopathy, which has the form Y = 28.315 + 3.892 × X1 + 2.453 × X₂, which will allow detecting the disease at an early stage.