Clinical and Functional Criteria for the State of Vital Activity and the Possibility of Rehabilitation of Patients and Disabled People with Age-related Cataracts
https://doi.org/10.18008/1816-5095-2025-2-443-448
Abstract
The purpose of the study was to evaluate the therapeutic effect of the drug Quinax when administered by the method of three instillations for 6 months to patients with initial age-related cataracts.
Patients and methods. Treatment was given to 80 patients with an average age of 63 ± 2 years suffering from initial age-related cataracts. At the same time, the main group consisted of 40 patients who were injected with Quinax when it was administered by triplicate instillations for 6 months, the comparison group was 40 people who were treated with age-related cataracts using other conservative methods. Each patient underwent an ophthalmological study, which included: visometry, perimetry, refractometry, biomicroscopy, ophthalmoscopy, visual performance study, dark adaptation, and also analyzed the complaints presented in order to establish their impact on the quality of life of patients and disabled people with cataracts.
Results. The results of the study showed the effectiveness of the use of the drug Quinax when administered by the method of three instillations for 6 months and revealed stabilization of visual functions: visual acuity and visual field to white, red and green colors, a decrease in visual fatigue, due to a decrease in glare, stabilization of dark adaptation and refraction.
Conclusion. Assessment of the effectiveness of the use of the drug Quinax when administered by the method of three instillations for 6 months to patients with initial age-related cataracts showed a statistically significant positive therapeutic effect (89 %) in the form of stabilization of visual functions, and a positive ergonomic effect in the form of increased visual performance was noted. No side effects were observed among patients who received Quinax instillations.
About the Authors
Yu. A. KorovyanskyRussian Federation
Korovyansky Yuri A. PhD, ophthalmologist
Dzhambul lane, 3, St. Petersburg, 191180
A. M. Razumovskaya
Russian Federation
Razumovskaya Anna M. MD, Professor
Bestuzhevskaya str., 50, St. Petersburg, 195067
V. S. Spiridonova
Russian Federation
Spiridonova Vera S. PhD, Associate Professor, head of the Department of surgery
Bestuzhevskaya str., 50, St. Petersburg, 195067
S. R. Kidraleeva
Russian Federation
Kidraleeva Svetlana R. PhD, medical adviser
Karamyshevskaya emb., 44, Moscow, 123423
References
1. Бранчевский СЛ, Малюгин БЭ. Распространенность нарушения зрения вследствие катаракты по данным исследования RAAB в Самаре. Офтальмохирургия. 2013;3:82–85. Branchevskiy SL, Malyugin BE. The prevalence of visual impairment due to cataracts according to the RAAB study in Samara. Fyodorov journal of ophthalmic surgery. 2013;3:82–85 (In Russ.).
2. Flaxman SR, Bourne RRA, Resnikoff S, Ackland P, Braithwaite T, Cicinelli MV, Das A, Jonas JB, Keeffe J, Kempen JH, Leasher J, Limburg H, Naidoo K, Pesudovs K, Silvester A, Stevens GA, Tahhan N, Wong TY, Taylor HR; Vision Loss Expert Group of the Global Burden of Disease Study. Global causes of blindness and distance vision impairment 1990–2020: a systematic review and metaanalysis. Lancet Glob Health. 2017 Dec;5(12): e1221–e1234. doi: 10.1016/S2214‑109X(17)30393‑5.
3. Universal eye health: a global action plan 2014–2019. Geneva: World Health Organization; 2013. https://www.who.int/publications/i/item/universal‑eye‑healthaglobal‑action‑plan‑2014‑2019
4. Brian G, Taylor H. Cataract blindness — challenges for the 21 century. Bulletin of the World Health Organization. 2001;79:249–256.
5. Hong T, Mitchell P, Burlutsky G, Gopinath B, Liew G, Wang JJ. Visual impairment and depressive symptoms in an older Australian cohort: longitudinal findings from the Blue Mountains Eye Study. Br J Ophthalmol. 2015 Aug;99(8):1017–1021. doi: 10.1136/bjophthalmol‑2014‑306308.
6. Thomas BJ, Sanders DS, Oliva MS, Orrs MS, Glick P, Ruit S, Chen W, Luoto J, Tasfaw AK, Tabin GC. Blindness, cataract surgery and mortality in Ethiopia. Br J Ophthalmol. 2016 Sep;100(9):1157–1162. doi: 10.1136/bjophthalmol‑2015‑308328.
7. Skinner C, Miraldi Utz V. Pharmacological approaches to restoring lens transparency: Real world applications. Ophthalmic Genet 2017;38:201–205. doi: 10.1080/13816810.2016.1214971.
8. Serebryany E, King JA. The βγ‑crystallins: native state stability and pathways to aggregation. Prog Biophys Mol Biol. 2014 Jul;115(1):32–41. doi: 10.1016/j.pbiomolbio.2014.05.002.
9. Schafheimer N, Wang Z, Schey K, King J. Tyrosine/cysteine cluster sensitizing human γD‑crystallin to ultraviolet radiation‑induced photoaggregation in vitro. Biochemistry 2014;53:979–990. doi: 10.1021/bi401397g.
10. Schafheimer N, King J. Tryptophan cluster protects human γD‑crystallin from ultraviolet radiation‑induced photoaggregation in vitro. Photochem. Photobiol. 2013;89;1106–1115. doi: 10.1111/php.12096.
11. Acosta‑Sampson L, King J. Partially folded aggregation intermediates of human gammaD‑, gammaC‑, and gammaS‑crystallin are recognized and bound by human alphaB-crystallin chaperone. J Mol Biol. 2010;401:134–152. doi: 10.1016/j.jmb.2010.05.067.
12. Li B, Kim J‑Y, Martis RM, Donaldson PJ, Lim JC. Characterisation of Glutathione Export from Human Donor Lenses. Transl. Vis. Sci. Technol. 2020 Jul 28;9(8):37. doi: 10.1167/tvst.9.8.37.
13. Инструкция к лекарственному препарату Квинакс ЛП‑008536. URL: https://www.vidal.ru/drugs/quinax
Review
For citations:
Korovyansky Yu.A., Razumovskaya A.M., Spiridonova V.S., Kidraleeva S.R. Clinical and Functional Criteria for the State of Vital Activity and the Possibility of Rehabilitation of Patients and Disabled People with Age-related Cataracts. Ophthalmology in Russia. 2025;22(2):443-448. (In Russ.) https://doi.org/10.18008/1816-5095-2025-2-443-448