Results of Retinal Microcirculation Analysis in Patients with Diabetes Mellitus after COVID-19
https://doi.org/10.18008/1816-5095-2025-3-604-611
Abstract
Objective. Monitoring ophthalmological parameters and retinal microcirculation in patients with diabetes mellitus after COVID-19. Patients and methods. Traditional ophthalmological methods, including optical coherence tomography with angiography. Results: 86 patients (86 eyes) were examined and divided into 4 subgroups depending on the presence or absence of diabetes and COVID-19: subgroup Ia: T2DM (–) + Covid-19 (–) — 22 patients (22 eyes) — control; subgroup Ib: T2DM (+) + COVID-19 (–) — 21 patients (21 eyes); subgroup Ic: T2DM (–) + COVID-19 (+) — 20 patients (20 eyes); subgroup Ig: T2DM (+) + COVID-19 (+) — 23 patients (23 eyes). All patients had COVID-19 at home and were not hospitalized. BCVA in all patients was 0.9–1.0. A statistically significant increase in the foveal avascular zone and its highest values were found in the diabetes and COVID-19 subgroup. Thus, the foveal avascular zone area values in the T2DM + COVID-19 group (0.301 ± 0.004 mm2) were statistically significantly higher than in the COVID-19 group (0.260 ± 0.003 mm2) (p < 0.05), than in the T2DM group (0.244 ± 0.004 mm2) (p < 0.05), than in the control group (0.216 ± 0.005 mm2) (p < 0.05), and a statistically significant increase in C-reactive protein (p < 0.05) and D-dimer (p < 0.05) was also found. Treatment of the identified retinal microcirculation disorders in the diabetes and COVID-19 subgroup was carried out according to the new proposed method using drug therapy with Sulodexide at a dosage of 250 LE 2 times a day for forty days, when the values of the area and perimeter of the foveal avascular zone statistically significantly decrease (p < 0.05), which confirms the effectiveness of the proposed treatment method. Conclusion. It was revealed that in patients with diabetes mellitus after suffering COVID-19, there is a violation of retinal microcirculation, which is proven by the size of the foveal avascular zone, which is statistically higher in comparison with patients with diabetes mellitus (p < 0.05). It has been proven that against the background of treatment with Sulodexide at a dosage of 250 LE 2 times a day for forty days, the values of the area and perimeter of the foveal avascular zone of the retina statistically significantly decrease (p < 0.05).
About the Authors
M. A. Frolov
Patrice Lumumba Peoples’ Friendship University of Russia; Clinical and Diagnostic Center of the Patrice Lumumba Peoples’ Friendship University of Russia
Russian Federation
Russian Federation
Mikhail A. Frolov - MD, Professor, head of the Eye Diseases Department.
Miklukho-Maklaya str., 6, Moscow, 117198; Miklukho-Maklaya str., 10, Moscow, 117198
I. V. Vorobyeva
Patrice Lumumba Peoples’ Friendship University of Russia; Clinical and Diagnostic Center of the Patrice Lumumba Peoples’ Friendship University of Russia
Russian Federation
Russian Federation
Irina V. Vorobyeva - MD, Professor, Professor of the Eye Diseases Department.
Miklukho-Maklaya str., 6, Moscow, 117198; Miklukho-Maklaya str., 10, Moscow, 117198
A. M. Frolov
Patrice Lumumba Peoples’ Friendship University of Russia; Clinical and Diagnostic Center of the Patrice Lumumba Peoples’ Friendship University of Russia
Russian Federation
Russian Federation
Alexander M. Frolov - PhD, Associate Professor of the Eye Diseases Department.
Miklukho-Maklaya str., 6, Moscow, 117198; Miklukho-Maklaya str., 10, Moscow, 117198
D. A. Semina
Patrice Lumumba Peoples’ Friendship University of Russia; Clinical and Diagnostic Center of the Patrice Lumumba Peoples’ Friendship University of Russia
Russian Federation
Russian Federation
Daria A. Semina - assistant of the Eye Diseases Department.
Miklukho-Maklaya str., 6, Moscow, 117198; Miklukho-Maklaya str., 10, Moscow, 117198
A. S. Klimenko
Patrice Lumumba Peoples’ Friendship University of Russia; Clinical and Diagnostic Center of the Patrice Lumumba Peoples’ Friendship University of Russia
Russian Federation
Russian Federation
Anna S. Klimenko - PhD, Associate Professor of the Eye Diseases Department.
Miklukho-Maklaya str., 6, Moscow, 117198; Miklukho-Maklaya str., 10, Moscow, 117198
S. Shallah
Patrice Lumumba Peoples’ Friendship University of Russia
Russian Federation
Russian Federation
Sami Shallah - postgraduate of the Eye Diseases Department.
Miklukho-Maklaya str., 6, Moscow, 117198
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Review
For citations:
Frolov M.A., Vorobyeva I.V., Frolov A.M., Semina D.A., Klimenko A.S., Shallah S. Results of Retinal Microcirculation Analysis in Patients with Diabetes Mellitus after COVID-19. Ophthalmology in Russia. 2025;22(3):604-611. (In Russ.) https://doi.org/10.18008/1816-5095-2025-3-604-611
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