Asymmetric Intrastromal Corneal Ring Segments in the Surgical Treatment of Keratoconus. Review
https://doi.org/10.18008/1816-5095-2025-4-750-757
Abstract
Keratoconus (KC) is a chronic progressive disease of the cornea characterized by thinning and cone-shaped protrusion, leading to a significant reduction in visual acuity. It is often difficult to correct optically using glasses or soft contact lenses. Surgical methods depend on the stage of KC and the rate of its progression. In the early stages, corneal collagen crosslinking (CXL) with various protocol modifications is most used, along with intralamellar keratoplasty (ILKP) with the implantation of corneal ring segments (ICRS) or rings. At later stages, penetrating (PKP) or deep anterior lamellar keratoplasty (DALK) may be required. However, despite the wide range of treatment options for KC, few methods are personalized and achieve high visual acuity outcomes. The issue of residual ametropia and irregular astigmatism remains unresolved, making the development of new approaches to the surgical treatment of KC a relevant and pressing challenge to this day.
Keywords
About the Authors
D. A. SagonenkoRussian Federation
Sagonenko Dmitry A. – postgraduate.
Yablochkova str., 21, bld. 3, Moscow, 127322
Yu. Yu. Kalinnikov
Russian Federation
Kalinnikov Yury Yu. - MD, Professor.
Delegatskaya str., 20, Moscow, 127473
S. Yu. Kalinnikova
Russian Federation
Kalinnikova Svetlana Yu. - PhD, researcher.
Beskudnikovsky ave., 59А, Moscow, 127486
L. F. Ragimova
Russian Federation
Rahimova Laman F. - postgraduate.
Delegatskaya str., 20, Moscow, 127473
Z. M. Ismailova
Russian Federation
Ismailova Zuri M. – postgraduate.
Beskudnikovsky ave., 59А, Moscow, 127486
References
1. Fuller DG, Wang Y. Safety and Efficacy of Scleral Lenses for Keratoconus. Optom Vis Sci. 2020 Sep;97(9):741–748. doi: 10.1097/OPX.0000000000001578.
2. Angelo L, Gokul Boptom A, McGhee C, Ziaei M. Corneal Crosslinking: Present and Future. Asia Pac J Ophthalmol (Phila). 2022 Sep 1;11(5):441–452. doi: 10.1097/APO.0000000000000557.
3. Sakellaris D, Balidis M, Gorou O, Szentmary N, Alexoudis A, Grieshaber MC, Sagri D, Scholl H, Gatzioufas Z. Intracorneal Ring Segment Implantation in the Management of Keratoconus: An Evidence-Based Approach. Ophthalmol Ther. 2019 Oct;8(Suppl 1):5–14. doi: 10.1007/s40123-019-00211-2.
4. David C, Kallel S, Trinh L, Goemaere I, Borderie V, Bouheraoua N. Les anneaux intra-cornéens dans la prise en charge du kératocône [Intracorneal ring segments in keratoconus management]. J Fr Ophtalmol. 2021 Jun;44(6):882–898. French. doi: 10.1016/j.jfo.2020.10.021.
5. He C, Joergensen JS, Knorz MC, McKay KN, Zhang F. Three-Step Treatment of Keratoconus and Post-LASIK Ectasia: Implantation of ICRS, Corneal Cross-linking, and Implantation of Toric Posterior Chamber Phakic IOLs. J Refract Surg. 2020 Feb 1;36(2):104–109. doi: 10.3928/1081597X-20191217-01.
6. Kalinnikov YuYu, Nevrov DV, Kalinnikova SYu, Tkachenko IS. Clinical and Functional Results of a Combined Surgical Treatment of Pellucid Marginal Degeneration. Ophthalmology in Russia. 2021;18(1):54–60 (In Russ.). doi: 10.18008/1816-5095-2021-1-54-60.
7. Deshmukh R, Ong ZZ, Rampat R, Alió Del Barrio JL, Barua A, Ang M, Mehta JS, Said DG, Dua HS, Ambrósio R Jr, Ting DSJ. Management of keratoconus: an updated review. Front Med (Lausanne). 2023 Jun 20;10:1212314. doi: 10.3389/fmed.2023.1212314.
8. Barugel R, David C, Kallel S, Borderie M, Cuyaubère R, Goemaere I, Borderie V, Bouheraoua N. Comparative Study of Asymmetric Versus Non-asymmetric Intrastromal Corneal Ring Segments for the Management of Keratoconus. J Refract Surg. 2021 Aug;37(8):552–561. doi: 10.3928/1081597X-20210526-01.
9. Sakellaris D, Balidis M, Gorou O, Szentmary N, Alexoudis A, Grieshaber M, Sag ri D, Scholl H, Gatzioufas Z. . Intracorneal ring segment implantation in the management of keratoconus: an evidence-based approach. Ophthalmol Ther. 2019;8(Suppl. 1):5–14. doi: 10.1007/s40123-019-00211-2.
10. Niazi S, Gatzioufas Z, Doroodgar F. Keratoconus: exploring fundamentals and future perspectives — a comprehensive systematic review. Therapeutic Advances in Ophthalmology. 2024;16:1–26. doi: 10.1177/25158414241232258.
11. Costa JV, Monteiro T, Franqueira N, Faria-Correia F, Alfonso J, Vaz F. Five-year long-term outcomes of intrastromal corneal ring segment implantation using the manual technique for keratoconus management. J Cataract Refract Surg. 2021 Jun 1;47(6):713–721. doi: 10.1097/j.jcrs.0000000000000500.
12. Heikal MA, Abdelshafy M, Soliman TT, Hamed AM. Refractive and visual outcomes after Keraring intrastromal corneal ring segment implantation for keratoconus assisted by femtosecond laser at 6 months follow-up. Clin Ophthalmol. 2016 Dec 23;11:81–86. doi: 10.2147/OPTH.S120267.
13. Tuychibaeva DМ, Kim AA. Comparative evaluation of the effectiveness of the method of surgical treatment of keratoconus by implantation of intrastromal corneal segments. Modern Technologies In Ophthalmology. 2023:2. doi: 10.25276/23124911-2023-2-217-223.
14. Montalt JC, Porcar E, España-Gregori E, Peris-Martínez C. Visual quality with corneo-scleral contact lenses after intracorneal ring segment (ICRS) implantation for keratoconus management. Cont Lens Anterior Eye. 2019 Feb;42(1):111–116. doi: 10.1016/j.clae.2018.07.006.
15. Yildirim A, Uslu H, Kara N, Ozgurhan EB. Treatment of visual problems after intracorneal ring implantation. Clin Ophthalmol. 2013;7:1251–1255. doi: 10.2147/OPTH.S45773.
16. Benoist d’Azy C, Pereira B, Chiambaretta F, Dutheil F. Efficacy of Different Procedures of Intra-Corneal Ring Segment Implantation in Keratoconus: a Systematic Review and Meta-Analysis. Transl Vis Sci Technol. 2019 Jun 11;8(3):38. doi: 10.1167/tvst.8.3.38.
17. Emerah SH, Sabry MM, Saad HA, Ghobashy WA. Visual and refractive outcomes of posterior chamber phakic IOL in stable keratoconus. Int J Ophthalmol. 2019 May 18;12(5):840–843. doi: 10.18240/ijo.2019.05.22.
18. Prisant O, Pottier E, Guedj T, Hoang Xuan T. Clinical Outcomes of an Asymmetric Model of Intrastromal Corneal Ring Segments for the Correction of Keratoconus. Cornea. 2020 Feb;39(2):155–160. doi: 10.1097/ICO.0000000000002160.
19. Alejandre N, Pérez-Merino P, Velarde G, Jiménez-Alfaro I, Marcos S. Optical Evaluation of Intracorneal Ring Segment Surgery in Keratoconus. Transl Vis Sci Technol. 2022 Mar 2;11(3):19. doi: 10.1167/tvst.11.3.19.
20. Vega-Estrada A, Chorro E, Sewelam A, Alio JL. Clinical Outcomes of a New Asymmetric Intracorneal Ring Segment for the Treatment of Keratoconus. Cornea. 2019 Oct;38(10):1228–1232. doi: 10.1097/ICO.0000000000002062.
21. Coşkunseven E, Ambrósio R Jr, Smorádková A, Sánchez León F, Sahin O, Kavadarli I, Jankov MR 2nd. Visual, refractive and topographic outcomes of progressive thickness intrastromal corneal ring segments for keratoconic eyes. Int Ophthalmol. 2020 Nov;40(11):2835–2844. doi: 10.1007/s10792-020-01467-5. Epub 2020 Jun 13. Erratum in: Int Ophthalmol. 2020 Aug 27.PMID: 32535750.
22. Baptista PM, Marques JH, Neves MM, Gomes M, Oliveira L. Asymmetric Thickness Intracorneal Ring Segments for Keratoconus. Clin Ophthalmol. 2020 Dec 16;14:4415–4421. doi: 10.2147/OPTH.S283387.
23. Alfonso JF, Lisa C, Fernández-Vega Cueto L, Poo A, Madrid D. Clasificación del queratocono basada en fenotipos clínicos. In: Del Buey Sayas MA, Peris Martínez C, editors. Influencia del astigmatismo congénito en la morfología del queratocono. Biomecánica y arquitectura corneal. Elsevier: Vol Monografias SECOIR. España, Barcelona; 2014:165–184.
24. Arbelaez JG, Arbelaez MC. Efficacy of progressive thickness intrastromal corneal ring segments in the treatment of duck phenotype keratoconus. Eur J Ophthalmol. 2021 Sep;31(5):2191–2199. doi: 10.1177/11206721211001722.
25. Fernández-Vega-Cueto L, Lisa C, Alfonso-Bartolozzi B, Madrid-Costa D, Alfonso JF. Intrastromal corneal ring segment implantation in paracentral keratoconus with perpendicular topographic astigmatism and comatic axis. Eur J Ophthalmol. 2021 Jul;31(4):1540–1545. doi: 10.1177/1120672120952346.
26. Cuiña Sardiña R, Arango A, Alfonso JF, Álvarez de Toledo J, Piñero DP. Clinical evaluation of the effectiveness of asymmetric intracorneal ring with variable thickness and width for the management of keratoconus. J Cataract Refract Surg. 2021 Jun 1;47(6):722–730. doi: 10.1097/j.jcrs.0000000000000525.
27. García de Oteyza G, Álvarez de Toledo J, Barraquer RI, Kling S. Refractive changes of a new asymmetric intracorneal ring segment with variable thickness and base width: A 2D finite-element model. PLoS One. 2021 Sep 15;16(9):e0257222. doi: 10.1371/journal.pone.0257222.
28. García de Oteyza G, Álvarez de Toledo J, Barraquer RI, Kling S. Localized Refractive Changes Induced by Symmetric and Progressive Asymmetric Intracorneal Ring Segments Assessed with a 3D Finite-Element Model. Bioengineering (Basel). 2023 Aug 27;10(9):1014. doi: 10.3390/bioengineering10091014.
29. Jacob S, Patel SR, Agarwal A, Ramalingam A, Saijimol AI, Raj JM. Corneal allogenic intrastromal ring segments (CAIRS) combined with corneal cross-linking for keratoconus. J Refract Surg. 2018;34:296–303. doi: 10.3928/1081597X20180223-01.
30. Jacob S, Agarwal A, Awwad ST, Mazzotta C, Parashar P, Jambulingam S. Customized corneal allogenic intrastromal ring segments (CAIRS) for keratoconus with decentered asymmetric cone. Indian J Ophthalmol. 2023 Dec 1;71(12):3723–3729. doi: 10.4103/IJO.IJO_1988_23.
31. Osipyan GA, Khrayst Kh. Possibilities of Intralamellar Keratoplasty in Rehabilitation of Keratoconus Patients. Ophthalmology in Russia. 2019;16(2):169–173 (In Russ.). doi: 10.18008/1816-5095-2019-2-169-173.
32. Alyaeva OO, Ryabenko OI, Tananakina EM, Yushkova IS. Zenlens scleral lenses for visual rehabilitation of patients with irregular cornea: a usage experience. Russian Ophthalmological Journal. 2018;11(4):68–74 (In Russ.). doi: 10.21516/2072-00762018-11-4-68-74.
33. Mushtaq A, Alvi I. Long-Term Effectiveness of Scleral Lens Treatment in the Management of Keratoconus: A Systematic Review. Cureus. 2025 Jan 7;17(1):e77102. doi: 10.7759/cureus.77102.
34. Liu XL, Li PH, Fournie P, Malecaze F. Investigation of the efficiency of intrastromal ring segments with cross-linking using different sequence and timing for keratoconus. Int J Ophthalmol. 2015 Aug 18;8(4):703–708. doi: 10.3980/j.issn.22223959.2015.04.11.
35. Ghaith AA. Patient satisfaction after femtosecond-assisted intracorneal ring segment implantation in the treatment of keratoconus. The Egyptian Journal of Cataract and Refractive Surgery. 23 2017;23:11–16.
36. D’Oria F, Abdelghany AA, Ledo N, Barraquer RI, Alio JL, Incidence And Reasons For Intrastromal Corneal Ring Segment Explantation. Am J Ophthalmol. 2021 Feb;222:351–358. doi: 10.1016/j.ajo.2020.09.041.
Review
For citations:
Sagonenko D.A., Kalinnikov Yu.Yu., Kalinnikova S.Yu., Ragimova L.F., Ismailova Z.M. Asymmetric Intrastromal Corneal Ring Segments in the Surgical Treatment of Keratoconus. Review. Ophthalmology in Russia. 2025;22(4):750-757. (In Russ.) https://doi.org/10.18008/1816-5095-2025-4-750-757




































